Chinese medicinal composition for treating perianal eczema and preparation method thereof

A perianal eczema and composition technology, applied in the field of traditional Chinese medicine composition for treating perianal eczema and its preparation, can solve problems such as unsatisfactory effects, improve autoimmunity, accelerate blood circulation, and improve capillary permeability sexual effect

Inactive Publication Date: 2011-09-14
南通市星期七旅游开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, there is no lack of still using certain traditional Chinese medicines to treat various skin diseases, but the effect is not satisfactory.

Method used

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  • Chinese medicinal composition for treating perianal eczema and preparation method thereof
  • Chinese medicinal composition for treating perianal eczema and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0066] The preparation method of capsule of the present invention is: get Acorus 1000g, Radix Paeoniae Rubra 1000g, Atractylodes Rhizoma 1000g, Flos Lonicerae 1000g, Radix Codonopsis 1000g, Peach Kernel 1000g, Rhubarb 1000g, Schisandra 1000g, Poria cocos 1000g, Cortex paeonol 1000g, Alisma 1000g, Tongcao 1000g, Cangzhu 1000g, Danshen 1000g, Schizonepeta 1000g, Scutellaria baicalensis 1000g;

[0067] First crush the raw material drug for oral administration into a coarse powder, then further pulverize, pass through a 100-120 mesh sieve, so that the amount of fine powder that can pass through the sieve reaches 30%, and collect the fine powder that passes through the sieve to obtain fine powder a; Coarse powder that cannot pass through a 120-mesh sieve is put into a multi-functional extraction tank for extraction twice. For the first time, add 10 times the amount of water to decoct for 1 hour, and for the second time add 8 times the amount of water to decoct for 1 hour. Combine th...

experiment example 2

[0088] Experimental example 2: long-term toxicity test data

[0089] 1. Experimental method

[0090] The guinea pigs were randomly divided into 4 groups, 15 in each group. Apply the depilatory agent evenly on both sides of the back spine of the guinea pig, so that the range of depilation is about 40 square centimeters. Clean the depilatory agent, observe each group of guinea pigs after 24 hours to be coated with respectively 0.2,0.4 and 0.8ml of the present invention's orally administered traditional Chinese medicine preparation Honey Refined Pills, contain crude drug 92,184 and 368mg respectively, another group is coated with vehicle 0.8ml twice a day, For 30 consecutive days, the general condition of the guinea pigs was observed. After the experiment, the animals were sacrificed for hematology, blood biochemical and pathological examinations.

[0091] 2. Results

[0092] No edema, hyperemia, erythema, bleeding spots and ulcers were found in the depilated trunk area of ​​g...

experiment example 3

[0093] Experimental example 3: Cumulative toxicity test:

[0094] Traditional Chinese medicine preparation of the present invention is taken orally honey refined pills to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 3 weeks after stopping the drug, there was no significant change in the organs of the rats. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

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Abstract

The invention discloses a Chinese medicinal composition for treating perianal eczema. The medicament for oral administration comprises the following Chinese herbal medicines in part by weight: 10 to 15 parts of grassleaf sweelflag rhizome, 10 to 20 parts of red paeony root, 10 to 20 parts of largehead atractylodes rhizome, 10 to 20 parts of honeysuckle flower, 10 to 20 parts of Szechuan tangshen root, 10 to 20 parts of peach seed, 10 to 20 parts of rhubarb, 10 to 20 parts of Chinese magnoliavine fruit, 10 to 20 parts of red Indian buead, 10 to 20 parts of cortex moutan, 10 to 20 parts of oriental waterplantain rhizome, 10 to 20 parts of ricepaperplant pith, 10 to 20 parts of swordlike atractylodes rhizome, 10 to 20 parts of root of red-rooted salvia, 10 to 20 parts of fineleaf schizonepeta herb and 10 to 20 parts of baical skullcap root; and the medicament for external application comprises the following Chinese herbal medicines in part by weight: 10 to 30 parts of prepared frankincense, 10 to 30 parts of lightyellow sophora root, 10 to 30 parts of common cnidium fruit, 10 to 30 parts of spreading hedyotis herb, 10 to 30 parts of Sinkiang arnebia root, 10 to 30 parts of densefruit pittany root-bark, 10 to 30 parts of cicada slough, 10 to 30 parts of dahurian patrinia herb, 10 to 30 parts of phellodendron, 10 to 30 parts of alum, 10 to 30 parts of belvedere fruit, 10 to 30 parts of fineleaf schizonepeta herb and 10 to 30 parts of divaricate saposhnikovia root. By the Chinese medicines of the Chinese medicinal composition, liquid medicine can reach the lesion site directly, local blood circulation and lymphatic return can be accelerated, and capillary permeability can be improved so as to achieve the effects of clearing heat and drying dampness, nourishing blood and promoting blood circulation and dispelling wind and arresting itching; and the Chinese medicinal composition is easy to prepare and is worthy of clinical popularization.

Description

[0001] technical field [0002] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine composition for treating perianal eczema and a preparation method thereof. Background technique [0003] Perianal eczema is a common non-infectious skin disease. The lesions are mostly limited to the skin around the anus, and occasionally spread to the buttocks, perineum and clitoris. Local erythema, erythema, erosion, exudation, crusting, and desquamation may appear. crumbs. The course of the disease is long, and the skin around the anus is often thickened, grayish white or dark red, rough, resulting in chapped, oozing, itching, and recurrent attacks as the main features, and the disease can occur at any age. Perianal eczema is familiar to many patients. There are internal and external causes of perianal eczema. The specific reasons are: 1. External factors: external stimuli, such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K36/756A61K9/00A61K9/06A61P17/00A61K33/06A61K35/64
Inventor 孔建陈守强部帅张梦贺董玉江韩艳丽陈晓京高冲边晓媛陈延强田林林时维武张铁峰段长利
Owner 南通市星期七旅游开发有限公司
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