The invention relates to the technical field of depilatories, and discloses a depilatory cream and a production method thereof. The depilatory cream comprises a mixture A, a mixture B, a mixture C anda component D, wherein the mixture A comprises the following components in parts by weight: 4-6 parts of cetostearyl alcohol, 2-4 parts of a mineral oil, 2-5 parts of ethylhexyl palmitate, 3-5 partsof ceteareth-9, 2-5 parts of glyceryl stearate and 0.1-0.5 part of butylated hydroxytoluene; the mixture B comprises the following components in parts by weight: 60-70 parts of water, 3-7 parts of glycerin, 2-5 parts of potassium hydroxide, 0.5-1 part of glycine betaine, 0.1-0.5 part of hydroxyethyl cellulose, 0.1-0.3 part of methylparaben and 0.1-0.3 part of propylparaben; the mixture C comprises6-10 parts of calcium thioglycolate and 5-7 parts of nano-active carbon; and the component D is 0.3-0.5 part of essence. The depilatory cream is safe and odourless, does not cause stimulation or damage to skin during use, does not cause symptoms of skin folliculitis, redness, itching, pain and the like, and has the efficacy of moisturizing and caring the skin.