16 results about "Propylparaben" patented technology

The invention discloses an oral care desensitization paste and a preparation method thereof, and mainly relates to the technical field of dental medicines. The oral care desensitization cream is prepared from the following components: bioactive glass, strontium chloride, sodium chloride, silicon dioxide, sodium carboxymethyl cellulose, polyethylene glycol 400, a xanthan gum solution, sodium lauryl sulfate, sodium lauroyl sarcosinate, titanium dioxide, beta-glucan, saccharin sodium salt, sorbitol, methylparaben, propyl hydroxybenzoate, edible essence and water. Compared with the prior art, the oral care desensitization paste disclosed by the invention can be used for sealing dentinal tubules and treating hemodia; the traditional Chinese medicine composition can also be used for treating plaque gingivitis, relieving and reducing gingival bleeding and inhibiting and reducing dental plaque; and meanwhile, the condition of mistakenly swallowing and eating in the using process is reduced.

The invention provides a dexketoprofen trometamol oral solution and a preparation method thereof. According to the dexketoprofen trometamol oral solution, polyethylene glycol 400 and hydroxypropyl methylcellulose are used as stabilizing agents, methylparaben and propyl hydroxybenzoate are used as bacteriostatic agents, sucralose and ammonium glycyrrhizinate are used as sweetening agents, essence is used as a flavoring agent, and the pH value of the solution is controlled to be 6.2-6.8 through a pH value regulator. The increase of the impurity A, the impurity B, the impurity C, the impurity E and the total impurity is obviously reduced, so that the product stability is obviously improved.

The present invention relates to the field of pharmaceutical technology, and more particularly to a compound sodium picosulfate oral solution and a preparation method thereof. The oral solution comprises the following components: sodium picosulfate, anhydrous citric acid, magnesium oxide, a stabilizer, an antibacterial agent, and a pH adjuster, wherein the antibacterial agent comprises methylparaben and propylparaben in a mass ratio of 15:1-6:1. The present invention has the advantages of high stability and good antibacterial efficacy.

The invention provides an essence lotion with an anti-aging function and a preparation method thereof, and belongs to the technical field of cosmetics, the essence lotion comprises a phase A, a phase B, a phase C and a phase D, wherein the phase A consists of glyceryl distearate, jojoba oil and vitamin E; the phase B is prepared from deionized water, glycerol, 1, 3-propylene glycol, methylparaben and polyoxyethylene sorbitan monooleate; the phase C is a citric acid solution; and the phase D consists of exosomes from four fruit sources of blueberries, pomegranates, lemons and grapefruits. According to the technical scheme, exosomes from blueberries, pomegranates, lemons and grapefruits are scientifically compounded, an anti-aging network with a synergistic effect is constructed, good stability and biocompatibility are achieved, and many problems existing in traditional anti-aging cosmetic ingredients are solved.

The invention relates to the technical field of biological medicine, in particular to mussel mucin and hyaluronic acid cross-linked self-repairing eye health care cream and a 4D forming method thereof. The composition comprises stearic acid, cetostearyl alcohol and the like, a lactic acid bacteria fermentation extract, a jasmine flower extract, a wolfberry extract, a pseudo-ginseng extract, a cassia seed extract, a polygonum cuspidatum extract, a chrysanthemum extract, a leontopodium leontopodum extract, ethylparaben, methylparaben and the like, decapeptide-4, mussel mucin, proteoglycan protein and modified graphene. Modified graphene in the self-repairing eye health care cream can effectively promote crosslinking of mussel mucin and hyaluronic acid and improve the repairing effect, the micro-current effect of graphene can also promote skin tissue to absorb traditional Chinese medicine components and deeply repair eyes, the effect can be more obvious according to personal eye conditions and requirements, and the self-repairing eye health care cream has a good application prospect. The composition has the effects of relieving asthenopia, dryness and soreness, effectively delaying excessive growth of an ocular axis, relieving temporary myopia drift, relieving asthenopia and protecting near vision.

This invention provides an birepiperazole oral solution, wherein the solution comprises birepiperazole 0.4-0.6 mg / ml, disodium edetate 0.1-0.5 mg / ml, methylparaben 1.5-2.0 mg / ml, propylparaben 0.15-0.25 mg / ml, an acidic pH adjuster 2.5-3.5 mg / ml, a flavoring agent 0.8-1.2 mg / ml, propylene glycol 40-60 mg / ml, glycerin 120-180 mg / ml, and a sodium hydroxide solution to adjust the pH to 2.9-3.3. The drug exhibits high stability during preparation, storage, and clinical formulation.

The invention relates to the technical field of medicines, in particular to an intelligent response type cervical auxiliary fertility gel which comprises the following components in percentage by mass: 0.1-2% of a gel matrix which is selected from one or more of hydroxypropyl methyl cellulose, hydroxyethyl cellulose, sodium alginate and gellan gum; 0.05%-0.5% of a gel adjusting auxiliary agent which is selected from zinc chloride or calcium lactate; the osmotic pressure regulator is selected from one or more of glycerol, glucose, sodium chloride, mannitol, sorbitol, polyethylene glycol and propylene glycol; 0.1%-2% of an acid-base regulator which is selected from one or more of disodium hydrogen phosphate, sodium dihydrogen phosphate, dipotassium phosphate and potassium dihydrogen phosphate; according to the present invention, the toxicity grade of the gel on cervical cells is less than or equal to grade 2 (ISO 10993-5 standard), the cell survival rate is more than or equal to 70%, and the safety is high.

The application discloses a gynecological antibacterial gel and a preparation method thereof, relates to the technical field of biological medicine manufacturing, and belongs to the patent classification A61K38 / 47. The preparation method comprises the following steps: mixing methylparaben, propylparaben and propylene glycol, and stirring and heating until completely dissolved to obtain component B; adding carbomer into deionized water, stirring and dissolving, then adding lysozyme sustained-release composite microspheres, continuously stirring and uniformly dispersing, and then adding cocamidopropyl betaine, cocoglycoside, lauryl glucoside, poloxamer, glycerol, disodium ethylenediaminetetraacetate and triethanolamine, stirring and uniformly dissolving to obtain component A; and adding component B into component A, stirring and uniformly mixing to obtain the gynecological antibacterial gel. The application can delay the release speed of lysozyme in the gynecological antibacterial gel, so that the antibacterial performance of the gynecological antibacterial gel can be stably exerted for a long time.

This invention discloses a gel formulation containing human platelet-derived growth factor (PDGF). The components and dosages are as follows: PDGF 50,000-300,000 IU / mL, sodium carboxymethyl cellulose 3.0-4.5%, polyvinyl alcohol 0.5-3%, disodium hydrogen phosphate dodecahydrate 0.258-0.774%, sodium dihydrogen phosphate monohydrate 0.039-0.116%, sodium chloride 0.6-0.95%, methylparaben 0.15-0.18%, propylparaben 0.015-0.020%, and protein protectant 0.4-0.6%. This invention, through optimization of the gel matrix combination and ratio, enables the gel to possess excellent stability and skin adhesion, improves the biological activity of the formulation, and promotes cell proliferation and wound repair at the wound site. It also offers advantages such as a pleasant user experience and simple processing.

The invention discloses a stable isoniazide oral solution. The stable isoniazide oral solution comprises isoniazide, methylparaben, propylparaben, a pH regulator and a solvent. The isoniazide oral solution with good stability is prepared, the absorption and utilization rate of the medicament is improved, and the isoniazide oral solution tastes good and has a good market prospect.

The preparation method specifically comprises the following steps: 1) preparing a solution A: dissolving 4-6 parts by weight of edetate disodium in water, adding 50-70 parts by weight of pectin, and stirring; 2) preparation of a solution B: stirring 70-90 parts by weight of methylparaben and 15-25 parts by weight of propyl hydroxybenzoate in 280-320 parts by weight of propylene glycol, adding water, and adding 70-80 parts by weight of nitrohydroxyethyl into the solution; 3) mixing: mixing the solution A and the solution B to obtain a mixed solution C; and 4) adding a sodium hydroxide solution into the mixed solution C, and adjusting the pH value to 4.0-6.5. The freeze-thaw resistance and light stability of the prepared nitro-hydroxyethyl gel are remarkably improved, and the stability of medicine components is favorably improved.

The invention discloses gynecological antibacterial gel and a preparation method thereof, relates to the technical field of biological medicine manufacturing, and belongs to the patent classification number A61K38 / 47. The preparation method comprises the following steps: mixing the methylparaben, the propylparaben and the propylene glycol, heating and stirring until the methylparaben, the propylparaben and the propylene glycol are completely dissolved to obtain a component B; carbomer is added into deionized water and stirred to be dissolved, then lysozyme slow-release composite microspheres are added and continuously stirred to be dispersed uniformly, then cocamidopropyl betaine, coco-glucoside, lauryl glucoside, poloxamer, glycerin, disodium ethylene diamine tetraacetate and triethanolamine are added and heated, stirred and dissolved uniformly, and a component A is obtained; and adding the component B into the component A, and uniformly stirring and mixing to obtain the gynecological antibacterial gel. According to the invention, the release speed of the lysozyme in the gynecological antibacterial gel can be delayed, so that the antibacterial performance can be stably exerted for a long time.

This invention discloses a perming composition based on thermosensitive regulation, comprising the following components: an aqueous phase including disodium EDTA, urea, glycerin, methylparaben, propylparaben, and phenoxyethanol; a reducing buffer phase including cysteine ​​hydrochloride, cysteine, sodium bicarbonate, ammonium carbonate, and ammonia; an emulsified oil phase including caprylic / capric triglyceride, polydimethylsiloxane, sodium lauroyl glutamate, cocamidopropyl betaine, and PEG-40 hydrogenated castor oil; an active repair phase including phosphatidylcholine, hydrogenated lecithin, ceramide, tocopherol, ascorbyl palmitate, ethoxydiethylene glycol, p-hydroxyacetophenone, and 1,2-hexanediol; a conditioning and repair phase including hydrolyzed keratin, arginine, methylisothiazolinone, and a daily fragrance; and the remainder being deionized water. This invention simplifies the judgment and operation process of softening through the synergistic effect of thermosensitive regulation and the cysteine-based reducing system. This invention also includes a method for preparing the perming composition.

The invention belongs to the technical field of anti-human papilloma virus, and particularly relates to anti-human papilloma virus gel and a preparation method thereof.The anti-human papilloma virus gel comprises NK cell exosome freeze-dried powder and gel, and the gel comprises carbomer, beta-glucan, triethanolamine, methylparaben and propylparaben; the preparation method comprises the following steps: S1, preparation of an NK cell exosome: centrifugally separating NK cells and a supernatant culture medium, collecting the supernatant for later use, treating cell precipitate with Triton X-100, mixing the treated cell precipitate with a culture supernatant, detecting an NK cell culture, and immediately performing ultrafiltration centrifugation to collect the exosome after the NK cell culture passes the detection; s2, preparation of freeze-dried powder: sub-packaging the NK cell exosome prepared in S1 into a freeze-drying cabin; freeze-dried powder is prepared after freezing, and the freeze-drying cabin containing the freeze-dried powder is refrigerated and temporarily stored; s3, preparing gel: weighing carbomer, soaking the carbomer in ultrapure water, dissolving the carbomer, and sterilizing the carbomer; the preparation method comprises the following steps: weighing beta-glucan, dissolving the beta-glucan, respectively adding methylparaben and propylparaben into the beta-glucan, uniformly mixing, uniformly mixing a mixed solution of carbomer, triethanolamine and beta-glucan, adding sterile water to a constant volume to prepare gel, and filling the gel into a gel tube. The activity of the active ingredients of the NK cell exosome can be maintained to the greatest extent.

This invention discloses a whitening and freckle-removing nano-cream and its preparation method using supergravity technology. The whitening and freckle-removing nano-cream comprises the following raw materials in parts by weight: 2-5 parts of water-in-oil emulsifier, 2-5 parts of oil-in-water emulsifier, 3-5 parts of liquid oil, 1-3 parts of solid oil, 1-3 parts of tocopheryl acetate, 0.5-2 parts of laurocapram, 0.1-0.25 parts of propylparaben, 10-30 parts of glycerin, 0.2-0.3 parts of methylparaben, 0.05-0.1 parts of sodium lauryl sulfate, 0.5-1 parts of antioxidant, 1.8-4 parts of whitening and freckle-removing active ingredients, and deionized water added to a total of 100 parts. The present invention also discloses a method for preparing the whitening and freckle-removing nano-cream. The whitening and freckle-removing nano-cream of the present invention has a particle size between 70-130nm. Under the conditions of storage at room temperature, 40℃ and 4℃ for ≥90 days, the appearance, particle size and content of whitening and freckle-removing active ingredients do not change significantly.

The invention provides a method for detecting a compound sodium picosulfate oral solution. The method is used for detecting at least one of methylparaben, propylparaben and 4-hydroxybenzoic acid in the compound sodium picosulfate oral solution. A high performance liquid chromatography method is adopted for determination, and the chromatographic conditions of the high performance liquid chromatography method are as follows: a chromatographic column comprises a reverse C18 chromatographic column or an efficacy equivalent column; the mobile phase comprises a mobile phase A and a mobile phase B, the mobile phase A is a mixed solution of an ammonium acetate buffer solution and methanol, and the mobile phase B is acetonitrile; the elution mode is gradient elution. According to the detection method, methylparaben, propylparaben and 4-hydroxybenzoic acid can be effectively separated and accurately quantified, interference generated by a blank solvent and an auxiliary material solution can be eliminated, and the quality controllability of a product is ensured.