32 results about "Dexketoprofen" patented technology

The invention discloses a gel type dexketoprofen plaster and method for preparation, which comprises backing material, gel type medicament material and anti-sticking material, wherein the medicament material contains 0.5-30.0 wt% of active medicinal constituents, 0.5-40.0 wt% of medicinal solvent, 0.5-30.0 wt% of humectant, and 0.5-8.0 wt% of transderrnal absorption promoting agent, the gel type medicinal material includes high- and low-molecular-weight poly vinyl pyrrolidone or copolymer containing vinyl pyrrolidone unit, polyvinyl alcohol, or polyvinyl alcohol and polyethylene glycol, cross linking agent and water. The invention also discloses its preparation.

The present invention relates to a dextroketoprofen glucoseoctylamine, its preparation method and medicine composition containing said active component. Its preparation method includes: preparing dextroketoprofen glucoseoctyline salt crude crystal, recrystallization to obtain dextroketoprofen glucoseoctylamine salt and recovering process of (-)-ketoprofen and N-octyl glucosamine. Said compound possesses the actions of clearing away heat, stopping pain and resisting inflammation, its medicine composition can be used for curing rheumatic and rheumatoid arthritis, ankylosing spondylitis, gouty arthritis and various pains.

The present invention relates to water-soluble formulations comprising the active agent dexketoprofen and to a process for production of said formulations. The present invention also relates to pharmaceutical formulations comprising dexketoprofen which is used in symptomatic treatment of mild to moderate pains such as musculoskeletal pains, dysmenorrhoea, toothache, post-operative pains. The formulations are characterized in being in effervescent form.

This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier. The combinations and compositions of this invention are useful as methods for treating metabolic disorders including diabetes, particularly Type I and Type II diabetes, as well as diseases and disorders associated with diabetes, including but not limited to atherosclerosis, cardiovascular disease, inflammatory disorders, nephropathy, neuropathy, retinopathy, β-cell dysfunction, dyslipidemia, LADA, metabolic syndrome, hyperglycemia, insulin resistance, and / or chronic obstructive pulmonary disease in a mammal, particularly a diabetic mammal, and specifically a human patient. This invention is particularly directed to pharmaceutical compositions comprising an lipoic acid, one or more anti-inflammatories selected from the group consisting of diflunisal, diclofenac, dexibuprofen, dexketoprofen, naproxen, and salicylate, and optionally one or more pharmaceutically acceptable carriers. The compositions of this invention are useful as methods for treating metabolic disorders including type II diabetes, insulin resistance, beta-cell dysfunction, and hyperglycemia in a patient, particularly a diabetic patient.

The invention relates to dexketoprofen trometamol sustained-release tablets and a preparation method thereof. The tablets are prepared from a framework material, a lubricant, a flow aid and composition of PC-10 and Eudragit EPO. A direct compression manner is adopted in a technology, the composition comprising fully mixed PC-10 and Eudragit EPO is selected as filler, the condition of sudden release after release stagnation due to limitations of the framework material at different pH values and the solubility of raw materials at different pH values or differences of release speeds in different release media is relieved, and the prepared dexketoprofen trometamol sustained-release tablets have similar release curves in the release media with the different pH values and can be uniformly released. The technology is simple, and the method is suitable for large-scale production.

A liquid pharmaceutical composition for oral administration comprising a complex of ketoprofen, dexketoprofen or their salts, a β-cyclodextrin and a hydroxyalkylamine, having good palatability and improved chemico-physical and microbiological stability.

The invention discloses a dexketoprofen injection which contains dexketoprofen, an alkaline latent solvent and water for injection, wherein 25g dexketoprofen is contained in the dexketoprofen injection per 1000mL; the molar ratio of the dexketoprofen to the alkaline latent solvent is (1: 0.5)-1.5; and the alkaline latent solvent is alkaline amino acid. In addition, the invention further discloses a preparation method of the injection. In the injection, racemic ketoprofen is replaced by the dexketoprofen, so dosage is little, and side effect is small; and alkaline amino acid is used as a latent solvent, which solves the solubility problem of the dexketoprofen and also overcomes the shortcomings of other latent solvents used in the current preparation; furthermore, the injection can be administered in an intravenous drip way owing to no use of painkiller phenylcarbinol in the injection, thus increasing the medicine administration way; and better safety is ensured because an organic solvent is not used.

The invention discloses a dexketoprofen tromethamine gel plaster and a preparation method thereof. The gel plaster contains 0.1% to 3.0% dexketoprofen tromethamine by weight percentage and gel matrix. The dexketoprofen trometamol gel plaster of the present invention is improved through the prescription of the gel matrix, does not contain a penetration enhancer, has high permeability, fast transdermal absorption, can be administered continuously for 24 hours, and has stable quality , in line with drug marketing requirements, suitable for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, and various acute and chronic pains such as cancer pain, acute sprain, soft tissue contusion pain, etc. The product has high curative effect, less side effects, and is safe and reliable.

The invention provides a dexketoprofen trometamol gastroretentive sustained-release tablet and a preparation method thereof, and belongs to the field of medicines. Dexketoprofen trometamol is a non-steroidal analgesic and anti-inflammatory drug. Ordinary tablets of dexketoprofen trometamol need to be administered frequently, and taking of 1-2 tablets of the ordinary tablets 3-4 times a day is inconvenient for patients. The dexketoprofen trometamol gastroretentive sustained-release tablet can fully absorb gastric juice after being orally taken, and expands to form a hydrogel, so the drug release rate is controlled, the water absorbing expanded hydrogel preparation generates a gastroretentive effect by the comprehensive action of floatation, mucous membrane adherence and the expansion volume, and has a continuous sustained release effect for 24 h in vivo and in vitro; the dexketoprofen trometamol gastroretentive sustained-release tablet can be well absorbed in beagle dogs, reduces the plasma concentration change, achieves one dose per day, and increases the administration compliance of patient; and the gastroretentive sustained-release tablet is prepared by a direct powder tabletingprocess, so the method has the advantages of simple technology, and facilitation of industrial production.

The invention belongs to the technical field of medicines, and particularly relates to a method for synthesizing a dexketoprofen intermediate. The dexketoprofen intermediate is prepared by asymmetricsynthesis of Darzens reaction. The method can improve the selectivity of the reaction, reduce the loss of raw materials, improve the yield and simplify the operation process, and is conducive to industrial production.

The invention provides a dexketoprofen coated sustained-release microparticle capsule and a preparation method thereof. It belongs to the technical field of chemical pharmaceutical preparations. The coated sustained-release microparticle capsule of the present invention is composed of coated sustained-release microparticles and a capsule shell, and the coated sustained-release microparticles are made of core particles containing dexketoprofen main drug through a coating process. The coated sustained-release microparticle capsule of the present invention can reduce the stimulating effect of dexketoprofen on the gastrointestinal tract, reduce the number of times of taking, thereby improving the patient's medication compliance, and can also reduce the fluctuation of dexketoprofen blood drug concentration and improve Bioavailability, thereby improving the therapeutic effect and reducing adverse reactions.

The invention discloses a gel plaster matrix containing dexketoprofen or a medicinal salt thereof and a preparation method thereof. The gel plaster matrix, by weight percentage, comprises: dexketoprofen or a medicinal salt thereof 0.3 ~1.2%, polymer hydrophilic gel skeleton material 5~10%, humectant 20~40%, thickener 1~5%, filler 2~5%, surfactant 0.5~2%, pH regulator 0.2~1%, crosslinking agent 0.01~0.6%, crosslinking regulator 0.01~0.2%, solvent 40~55%, among them, the moisturizing agent is polyethylene glycol and sorbitol. In the present invention, by improving the matrix system of the gel plaster, polyethylene glycol and sorbitol are combined as a moisturizer, which reduces the increase of related substances and the The risk of content decline, while improving the moisturizing performance of the gel patch base and the storage stability of the formulation.

The invention relates to a dexketoprofen trometamol quick-release / sustained-release double-layer tablet and a preparation method thereof, and provides a simple and convenient preparation process method for pressing the double-layer tablet consisting of a quick-release layer and a sustained-release layer, wherein the quick-release layer mainly comprises dexketoprofen trometamol, a sustained-release, a diluent, a binding agent and a lubricant. According to the dexketoprofen trometamol quick-release / sustained-release double-layer tablet provided by the invention, due to release of the quick-release part, the medicine is enabled to rapidly achieve effective blood concentration, the sustained-release part can be released slowly, and the effect that the dexketoprofen trometamol can be continuously released for 12 hours when being taken once is achieved. The defects that the conventional dexketoprofen trometamol preparation needs to be taken for multiple times in clinical treatment, and the blood concentration is not stable are made up, so that the effects of improving compliance of patients, stable curative effect and small toxic and side effects are achieved. The tablet is simple in preparation method, raw materials and auxiliaries can be easily obtained, and the tablet is applicable to industrial production and has a good application prospect.

The invention discloses a dexketoprofen tromethamine capsule which is characterized by being prepared from the following components, by weight: 3.7 parts of dexketoprofen tromethamine, 6 parts of pregelatinized starch, 14 parts of microcrystalline cellulose, 1 part of hydroxypropyl methyl cellulose, a proper amount of magnesium stearate, a proper amount of talcum powder and a proper amount of 30% ethanol. The preparation method comprises the following steps of mixing, granulating, granule straightening, total mixing, sampling and inspecting to obtain a finished product. Compared with the prior art, the dexketoprofen tromethamine capsule has the advantages of quick response, better analgesic effect and small side effect.