32 results about "Dexketoprofen" patented technology

The present invention relates to a dextroketoprofen glucoseoctylamine, its preparation method and medicine composition containing said active component. Its preparation method includes: preparing dextroketoprofen glucoseoctyline salt crude crystal, recrystallization to obtain dextroketoprofen glucoseoctylamine salt and recovering process of (-)-ketoprofen and N-octyl glucosamine. Said compound possesses the actions of clearing away heat, stopping pain and resisting inflammation, its medicine composition can be used for curing rheumatic and rheumatoid arthritis, ankylosing spondylitis, gouty arthritis and various pains.

This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier. The combinations and compositions of this invention are useful as methods for treating metabolic disorders including diabetes, particularly Type I and Type II diabetes, as well as diseases and disorders associated with diabetes, including but not limited to atherosclerosis, cardiovascular disease, inflammatory disorders, nephropathy, neuropathy, retinopathy, β-cell dysfunction, dyslipidemia, LADA, metabolic syndrome, hyperglycemia, insulin resistance, and / or chronic obstructive pulmonary disease in a mammal, particularly a diabetic mammal, and specifically a human patient. This invention is particularly directed to pharmaceutical compositions comprising an lipoic acid, one or more anti-inflammatories selected from the group consisting of diflunisal, diclofenac, dexibuprofen, dexketoprofen, naproxen, and salicylate, and optionally one or more pharmaceutically acceptable carriers. The compositions of this invention are useful as methods for treating metabolic disorders including type II diabetes, insulin resistance, beta-cell dysfunction, and hyperglycemia in a patient, particularly a diabetic patient.

The invention provides a dexketoprofen trometamol gastroretentive sustained-release tablet and a preparation method thereof, and belongs to the field of medicines. Dexketoprofen trometamol is a non-steroidal analgesic and anti-inflammatory drug. Ordinary tablets of dexketoprofen trometamol need to be administered frequently, and taking of 1-2 tablets of the ordinary tablets 3-4 times a day is inconvenient for patients. The dexketoprofen trometamol gastroretentive sustained-release tablet can fully absorb gastric juice after being orally taken, and expands to form a hydrogel, so the drug release rate is controlled, the water absorbing expanded hydrogel preparation generates a gastroretentive effect by the comprehensive action of floatation, mucous membrane adherence and the expansion volume, and has a continuous sustained release effect for 24 h in vivo and in vitro; the dexketoprofen trometamol gastroretentive sustained-release tablet can be well absorbed in beagle dogs, reduces the plasma concentration change, achieves one dose per day, and increases the administration compliance of patient; and the gastroretentive sustained-release tablet is prepared by a direct powder tabletingprocess, so the method has the advantages of simple technology, and facilitation of industrial production.

The invention provides a dexketoprofen coated sustained-release microparticle capsule and a preparation method thereof. It belongs to the technical field of chemical pharmaceutical preparations. The coated sustained-release microparticle capsule of the present invention is composed of coated sustained-release microparticles and a capsule shell, and the coated sustained-release microparticles are made of core particles containing dexketoprofen main drug through a coating process. The coated sustained-release microparticle capsule of the present invention can reduce the stimulating effect of dexketoprofen on the gastrointestinal tract, reduce the number of times of taking, thereby improving the patient's medication compliance, and can also reduce the fluctuation of dexketoprofen blood drug concentration and improve Bioavailability, thereby improving the therapeutic effect and reducing adverse reactions.