Dexketoprofen Tromethamine Sustained Release Tablets for Gastric Retention

Abstract

The invention provides a dexketoprofen trometamol gastroretentive sustained-release tablet and a preparation method thereof, and belongs to the field of medicines. Dexketoprofen trometamol is a non-steroidal analgesic and anti-inflammatory drug. Ordinary tablets of dexketoprofen trometamol need to be administered frequently, and taking of 1-2 tablets of the ordinary tablets 3-4 times a day is inconvenient for patients. The dexketoprofen trometamol gastroretentive sustained-release tablet can fully absorb gastric juice after being orally taken, and expands to form a hydrogel, so the drug release rate is controlled, the water absorbing expanded hydrogel preparation generates a gastroretentive effect by the comprehensive action of floatation, mucous membrane adherence and the expansion volume, and has a continuous sustained release effect for 24 h in vivo and in vitro; the dexketoprofen trometamol gastroretentive sustained-release tablet can be well absorbed in beagle dogs, reduces the plasma concentration change, achieves one dose per day, and increases the administration compliance of patient; and the gastroretentive sustained-release tablet is prepared by a direct powder tabletingprocess, so the method has the advantages of simple technology, and facilitation of industrial production.

Description

technical field

[0001] The invention relates to a dexketoprofen trometamol gastric retention sustained-release tablet and a preparation method thereof, belonging to the field of medicine. Background technique

[0002] Gastro-retentive drug delivery systems (Gastro-retentive drug delivery systems) is a sustained and controlled release system for oral drugs, as well as a site-specific release system for the gastrointestinal tract. Compared with ordinary tablets, it has the ability to prolong the residence time of the drug release system (DDS) in the stomach, release the drug to the stomach, duodenum and small intestine and other gastrointestinal absorption sites in a continuous and controlled release manner, and reduce the blood drug Concentration fluctuations, reduce the frequency of medication, reduce mucosal irritation, improve bioavailability and other advantages. Drug delivery systems for gastric retention include (a) gastric buoyant DDS, which has a low density and floa...

Images