Dexketoprofen tromethamine gel patch and preparation method thereof

A technology of dexketoprofen trometamol gel patch and ketoprofen tromethamine, which is applied in the direction of ointment delivery, pharmaceutical formula, medical preparations of non-effective ingredients, etc., and can solve the problem of unretrieved dexketoprofen tromethamine Issues such as research reports on the preparation of profen tromethamine gel patch, etc., achieved the effects of stable transdermal absorption, high permeability, and improved curative effect
CN111789832BActive Publication Date: 2022-02-08HUNAN JIUDIAN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUNAN JIUDIAN PHARMA
Publication Date
2022-02-08

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Abstract

The invention discloses a dexketoprofen tromethamine gel plaster and a preparation method thereof. The gel plaster contains 0.1% to 3.0% dexketoprofen tromethamine by weight percentage and gel matrix. The dexketoprofen trometamol gel plaster of the present invention is improved through the prescription of the gel matrix, does not contain a penetration enhancer, has high permeability, fast transdermal absorption, can be administered continuously for 24 hours, and has stable quality , in line with drug marketing requirements, suitable for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, and various acute and chronic pains such as cancer pain, acute sprain, soft tissue contusion pain, etc. The product has high curative effect, less side effects, and is safe and reliable.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an acrylic non-steroidal anti-inflammatory drug dexketoprofen tromethamine gel plaster and a preparation method thereof. Background technique

[0002] Ketoprofen is an acrylic non-steroidal anti-inflammatory drug, mainly used for the treatment of rheumatic or rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and postoperative pain. The structural formula of ketoprofen has a chiral carbon atom, and the drug has been generally used in the form of racemate for a long time. It has been found through research that the L-form of ketoprofen is almost inactive, while the anti-inflammatory effect of the D-form is twice that of the racemic form of ketoprofen. However, dexketoprofen has low solubility and poor absorption, so it is often used as tromethamine salt.

[0003] Dexketoprofen trometamol tablets were first developed by The Menarini Group and first lau...

Claims

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