Dexketoprofen tromethamine capsule and preparation process thereof

A technology of dexketoprofen tromethamine and ketoprofen tromethamine, which is applied in the field of dexketoprofen tromethamine capsule and its preparation, can solve the problems of dependence, insufficient analgesic effect and the like, and achieves the Small side effects, good analgesic effect, small difference effect

Inactive Publication Date: 2021-04-06
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Moderate pain is a common clinical symptom, with a wide range of patients, such as various postoperative pain, cancer pain, etc. For such cases, the analgesic effect of non-steroidal anti-inflammatory analgesics is not enough, usually Requires narcotic analgesics, but often requires repeated dosing and is prone to dependence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] To produce 200,000 tablets, the required amount of dexketoprofen trometamol is calculated according to the pure formula: raw material × (1-loss on drying) × content = 3.7kg, then take pregelatinized starch successively: 6.0kg, microcrystalline Cellulose: 14.0kg, hypromellose: 1.0kg, and then divide the above-mentioned components into 8 parts, that is, each part of dexketoprofen tromethamine: 462.5g, pregelatinized starch: 0.75kg, microcrystalline Cellulose: 1.75kg, hypromellose: 0.125kg; an appropriate amount of magnesium stearate and talcum powder with a weight ratio of 1:6, and an appropriate amount of 30% ethanol were prepared.

[0024] making process:

[0025] Step 1. Mixing: Turn on the multifunctional fluidized granulation coating machine, preheat the pot body, and divide the dexketoprofen trometamol, pregelatinized starch, microcrystalline cellulose and hydroxypropyl Put methyl cellulose in a multi-functional fluidized granulation coating machine, set the temper...

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PUM

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Abstract

The invention discloses a dexketoprofen tromethamine capsule which is characterized by being prepared from the following components, by weight: 3.7 parts of dexketoprofen tromethamine, 6 parts of pregelatinized starch, 14 parts of microcrystalline cellulose, 1 part of hydroxypropyl methyl cellulose, a proper amount of magnesium stearate, a proper amount of talcum powder and a proper amount of 30% ethanol. The preparation method comprises the following steps of mixing, granulating, granule straightening, total mixing, sampling and inspecting to obtain a finished product. Compared with the prior art, the dexketoprofen tromethamine capsule has the advantages of quick response, better analgesic effect and small side effect.

Description

technical field [0001] The invention relates to the technical field of capsule medicines, in particular to dexketoprofen trometamol capsules and a preparation process thereof. Background technique [0002] Dexketoprofen tromethamine is used for all pains, and is suitable for short-term elimination of trauma and postoperative pain, swelling pain, severe pain and pain caused by various reasons. Tablet or injection may be used to relieve moderate to severe postoperative pain, including abdominal, chest, gynecological, oral, orthopedic, and urological procedures. In addition, it can also relieve acute renal pain, biliary colic, toothache, trauma pain, trigeminal neuralgia, cancer visceral pain, and all kinds of pain that required morphine or pethidine to take effect in the past. [0003] Moderate pain is a common clinical symptom, with a wide range of patients, such as various postoperative pain, cancer pain, etc. For such cases, the analgesic effect of non-steroidal anti-infla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/192A61K31/205A61K47/38A61K47/36A61K47/02A61P19/02A61P25/04A61P29/00
CPCA61K9/4866A61K9/485A61K9/4833A61K31/192A61K31/205A61P29/00A61P19/02A61P25/04A61K2300/00
Inventor 付德昭付建家付立家武俊杰
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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