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Erigeron breviscapus oral caving fast disintegration tablet and its preparation method

A technology of scutellaria breviscapus and disintegrating tablets, which is applied in the direction of medical formula, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of shortening the dissolution time of drugs, achieve shortening of drug dissolution time, simple preparation process, and convenient packaging Effect

Inactive Publication Date: 2003-07-16
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a rapidly disintegrating tablet of breviscapine and its preparation method. For patients, especially for stroke, hemiplegia patients and bedridden patients who have difficulty swallowing, the extract of breviscapine is prepared into an oral rapidly disintegrating dosage form , the patient only needs to put the disintegrating tablet into the mouth, and the tablet can be disintegrated into a suspension in the oral cavity without swallowing, chewing, sucking, etc., which is convenient for administration and shortens the dissolution time of the drug. Helps the drug take effect quickly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The tablets were prepared by direct compression process. Components are shown in Table 1

[0033] Table 1 Prescription of breviscapine orally rapidly disintegrating tablets Example 1

[0034] Component Feeding amount (mg / t) Composition ratio of tablet (%)

[0035] Erigeron breviscapine raw material medicine powder 60.0 16.7

[0036] D-mannitol powder 110.5 30.7

[0037] Microcrystalline Cellulose PH102 162.5 45.1

[0038] Sodium carboxymethyl starch 18.0 5.0

[0039] Micronized silica gel 5.5 1.5

[0040] Magnesium stearate 2.0 0.6

[0041] Mango essence 1.5 0.4

[0042] Total 360 100.0

[0043] Tablets are prepared as follows:

[0044] All adjuvants are dried and sieved; the active ingredient is mixed with all adjuvants except magnesium stearate in a dry mixer, and then the magnesium stearate is further mixed in to obtain a molded object.

[0045] The compression molding material is pressed into tablets wi...

Embodiment 2

[0048] The tablets were prepared by direct compression process. Components are shown in Table 2

[0049] Table 2 Prescription of breviscapine orally rapidly disintegrating tablets Example 2

[0050] Component Feeding amount (mg / t) Composition ratio of tablet (%)

[0051] Breviscapine API powder 7.0 5.0

[0052] D-mannitol powder 81.8 58.4

[0053] Microcrystalline Cellulose PH101 32.7 23.4

[0054] Croscarmellose Sodium 14.0 10.0

[0055] Micronized silica gel 1.7 1.2

[0056] Magnesium stearate 2.8 2.0

[0057] Total 140.0 100.0

[0058] The tablet preparation method is as in Example 1, and the tablet is directly compressed after mixing the ingredients.

[0059] The tablet that this example makes, tablet diameter 7mm, sheet thickness 3.2mm, sheet weight difference is below 4%. The hardness of the obtained tablet is 50-60N. The disintegration time limit is 25-35 seconds, and it ...

Embodiment 3

[0061] The tablets were prepared by direct compression process. Components are shown in Table 3

[0062] Table 3 Prescription of breviscapine orally rapidly disintegrating tablets Example 3

[0063] Component Feeding amount (mg / t) Composition ratio of tablet (%)

[0064] Breviscapine API powder 40.0 11.8

[0065] D-mannitol powder 151.0 44.4

[0066] Microcrystalline cellulose PH101 124.0 36.5

[0067] Croscarmellose Sodium 17.0 5.0

[0068] Micronized silica gel 5.0 1.4

[0069] Magnesium stearate 2.0 0.6

[0070] Lemon essence 1.3 0.3

[0071] Total 340.0 100.0

[0072] The tablet preparation method is as in Example 1, and the tablet is directly compressed after mixing the ingredients.

[0073] The tablet that this example makes, sheet diameter 10mm, sheet thickness 4.6mm, sheet weight difference is below 3%. The hardness of the obtained tablet is 40-50N. The disintegration time lim...

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Abstract

A fast disintegrant tablet using the extract of Erigeron breviscapus as its active components for oral cavity contains the said active component (5-20 wt.%), disintegrant (2-10), lubricant (0.2-2), flowing aid (0.1-1.5), additive (0-0.5) and filter (the rest). The features fast disintegrating speed (60 seconds after it encounters saliva).

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine tablet, in particular to an orally rapidly disintegrating tablet with scutellaria breviscapus extract as an active ingredient and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique: [0002] Erigeron brevisca (Vant) Hand-Mass, the original plant of Erigeron brevisca (Vant) Hand-Mass. Erigeron breviscapus refers to the flavonoid extract extracted from Erigeron breviscapus, and scutellarin is a mixture of scutellarin and scutellarin extracted from scutellaria breviscapus. Pharmacological studies have shown that breviscapine extract (including breviscapine or breviscapine) has the effect of dilating cerebral blood vessels, can reduce cerebrovascular resistance, increase cerebral blood flow, improve microcirculation, and have the effect of resisting platelet aggregation. Good medicine for cardiovascular and cerebrovascular diseases. T...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7048A61P9/10
Inventor 罗国安叶磊王义明
Owner TSINGHUA UNIV
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