328 results about "Erigeron breviscapus" patented technology

The present invention relates to a medicine composition formed from breviscapine which is effective component extracted from Chinese medicinal material erigeron breviscapus and cynarin and its new application for curing acute and chronic hepatitides. The breviscapine and cynarin are mixed according to a certain proportion, and proper auxiliary material can be added, and can be made into various preparations for curing and preventing the diseases of fibrosis of liver, cirrhosis of liver and fatty liver, etc.

A fast disintegrant tablet using the extract of Erigeron breviscapus as its active components for oral cavity contains the said active component (5-20 wt.%), disintegrant (2-10), lubricant (0.2-2), flowing aid (0.1-1.5), additive (0-0.5) and filter (the rest). The features fast disintegrating speed (60 seconds after it encounters saliva).

A slow-releasing Erigeron breviscapus capsule for treating coronary heart disease, angine pectoris and myocardial infarction is prepared through putting the empty pill core in granulating machine, adding breviscapine, spraying adhesive, granulating, and coating. Said adhesive and coating are prepared from polyvinyl pyrrolidone and ethylcellulose.

A dripping pill of breviscapine is prepared from breviscapine and polyethylene glycol (PEG 4000) 5-8 times through conventional process. Its advantages are high curative effect and high biological utilization rate.

A technique for cultivating fleabane as a Chinese-medicinal material for treating cardiovascular disease includes such steps as immersing seeds in the solution of carbendazim, culturing seedling, applying base fertilizer, transplanting, applying top application, preventing and eliminating diseases and pests and picking up flower and flower bud.

The invention relates to the field of the quality control on traditional Chinese medicine, specifically to a quality control method for erigeron breviscapus(Vant.) hand-mazz. The method comprises a fingerprint detection method and a multiple-indicative content detection method for erigeron breviscapus (Vant.) hand-mazz, wherein the fingerprint detection method employs UPLC detection method, through which 24 characteristic peaks are found and 8 characteristic peaks are ascribed. By using content detection method for erigeron breviscapus(Vant.) hand-mazz., the UPLC-PDA method, contents of following constituents are determined: erigeroside, chlorogenic acid, breviscpini glycoside, Scutellarin, 3,4-0-dicaffeoylquinic acid, 3,5-0-dicaffeoylquinic acid and 4,5-0-dicaffeoylquinic acid. Compared with the prior art, the fingerprint detection method and the multiple-indicative content detection method for erigeron breviscapus (Vant.) hand-mazz are improved in the invention, so that the quality of erigeron breviscapus (Vant.) hand-mazz. can be controlled in a convenient, rapid and accurate manner, thereby ensuring the quality of erigeron breviscapus (Vant.) hand-mazz. stable, uniform and controllable.

The invention relates to plastic-tunnel erigeron breviscapus (vant.) low-tunnel direct seeding planting technology. The technology is characterized by changing transplanting to direct seeding and adopting such technical measures as arching, film mulching and the like. The technology has the following advantages: the moisture is controlled in rainy seasons and the temperature is raised in winter, thus providing better growth environment for erigeron breviscapus (vant.) low-tunnel; the yield and quality are improved; more than 340-360kg of dry products of erigeron breviscapus (vant.) low-tunnelcrude drugs are obtained per mu; the average scutellarin is 2.8%; the content of the impurities is below 2%; the pesticide residual quantity is low; various diseases caused by pathogen infection of roots are effectively controlled; and meanwhile, the cost input in the transplanting process can be saved by direct seeding, thus lowering the planting cost.

The invention relates to a sieving method of active ingredients of a traditional Chinese medicine, in particular provides a method for sieving active ingredients playing a protection role in cranial nerve from erigeron breviscapus. The method comprises the following steps of: dividing an erigeron breviscapus extract into components with different polarities by adopting a modern separation technology; forming a composition from the components according to different proportions; carrying out finger-print analysis and nerve cell damaged model protection role test on the composition, carrying out statistical treatment on finger-print chemical information and pharmacological activity information data, and sieving active ingredients and active components in erigeron breviscapus by utilizing finger-print pharmacology correlation research. The method can be used for rapidly, simply, conveniently and accurately sieving active ingredients playing protection role in cranial nerve from erigeron breviscapus, has the advantages of high sieving efficiency, lower cost and favorable application prospect and is expected to develop an effective drug for treating senile dementia by erigeron breviscapus through deep research.

An application of breviscapine B aglycone in preparing medicines for preventing and treating cerebral apoplexy and cardiovascular and cerebrovascular diseases with high curative effect is disclosed.

A caffeciate type compound, erigeron ester B, used as the medicine for treating cardiovascular and cerebrovascular diseases is prepared from the dried herb of erigeron breviscapus through extracting and separating.

An erigeron breviscapus planting and field managing method belongs to a medicinal plant cultivating technique. By the erigeron breviscapus planting and field managing method, the whole planting process of erigeron breviscapus can be managed and controlled through subtle changes of the procedures such as land selecting, ploughing, ditching, film covering, seed dressing, sowing, fertilizing, weed removing, watering, and disease preventing. Thus, the most serious problems in an existing erigeron breviscapus planting process are solved, the emergence rate is greatly improved, and the mortality is reduced. Physical and manual weed removal is utilized in the whole planting process, so that the weed removal cost is greatly reduced, and the difficulty with labor using is solved. The most serious problem of root rot, the most headache, is fundamentally solved. Small investment, large output and high yield of farmers are guaranteed. Calculated by per acre, the total investment is 3000 yuan, the output generally reaches 3000-4500kg; if the price is 3 yuan per kilogram, the gain is 9000-135000 yuan, and the net income is 6000-9000 yuan.

The invention discloses an erigeron breviscapus. The erigeron breviscapus comprises polypeptides selected from the following (a)-(c): (a) a polypeptide composed of an amino acid sequence represented by SEQ ID NO.2; (b) a polypeptide which is formed by substituting, deleting or adding one or more amino acids in the amino acid sequence in the (a) and provided with a polysaccharide transfer function on a flavone compound or flavonoid 7-hydroxy and derived from the (a); and (c) a polypeptide which has the amino acid sequence having more than 95% identity with the amino acid in the (a) and is provided with a polysaccharide transfer function on a flavone compound or flavonoid 7-hydroxy.

The invention discloses a seedling and transplanting method of erigeron breviscapus seeds as well as a seedling medium and a seedling culture liquid special for the erigeron breviscapus seeds. The seedling medium is formed by mixing peat, vermiculite, a composite fertilizer and composted chicken manure in a mass ratio of 2:1:0.5:1; the seedling medium is filled in foam plug holes, and 3-5 erigeron breviscapus seeds are sown in each hole; floating seedling is adopted; in a culture pool, the seedling culture liquid consists of a mixed fertilizer, potassium permanganate and water, wherein the concentration of potassium permanganate is 1000-1500ppm, the amount of the mixed fertilizer is 5-8% the mass of water, and the mixed fertilizer is formed by mixing the composite fertilizer with the composted chicken manure in a mass ratio of 1:1; the temperature in a greenhouse is 25-28 DEG C, 2500-3000kg / mu of composted farm manures are applied before transplantation is carried out; and 4000-4500 clump seedlings per mu are transplanted, and a clump seedling has 3-5 young plants. By using the method, the germination rate is averagely improved by 27.7%, germination and seedling rates reach more than 98%, and the amount of seeds per mu is averagely saved by 51g.

The invention discloses a preparation method of scutellarin, comprising the following steps of: (1) refluxing and extracting a medicinal material of erigeron breviscapus with ethanol; (2) filtering a leaching solution in the last step and carrying out pressure reduction to recover ethanol to obtain extract for later use; (3) respectively extracting with petroleum ether, ethyl acetate and normal butanol to obtain a petroleum ether extraction part, an ethyl acetate extraction part and a normal butanol extraction part; (4) dissolving the ethyl acetate part with ethanol; (5) adding silica gel and stirring, naturally drying, porphyrizing and sieving to obtain fine powder; (6) through gel column chromatography, carrying out gradient elution on the petroleum ether and the ethyl acetate and collecting by section; and (7) carrying out gel column chromatography on the ethyl acetate extraction part and elution by the petroleum ether and isopropanol and checking and combining same speckle parts according to a thin layer to obtain a compound of scutellarin. The scutellarin extract is used as an active component and is used for preparing a medicine for preventing and treating neurodegenerative diseases. The method can be used for preparing the scutellarin the purity of which is as high as 95 percent; and the raw material can be used for preparing a medicine for treating senile dementia and serves the human health.

The invention discloses a traditional Chinese medicine preparation for treating gastric ulcer. The traditional Chinese medicine preparation is prepared from the following raw medicines in parts by weight: 10-20 parts of milk vetch, 10-20 parts of Chinese yam, 10-20 parts of hyacinth bletilla, 10-20 parts of bupleurum, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of white peony root, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of tuckahoe, 10-20 parts of licorice, 10-20 parts of costus root, 10-20 parts of pericarpium arecae, 10-20 parts of coptis, 10-20 parts of dried orange peel, 10-20 parts of golden-rod, 10-20 parts of notoginseng, 10-20 parts of bitter orange, 10-20 parts of giant knotweed, 10-20 parts of ginger, 10-20 parts of erigeron breviscapus, 10-20 parts of red sage root and 10-20 parts of cuttlebone. The traditional Chinese medicine preparation disclosed by the invention has the functions of calming the liver, relieving pain, regulating the flow of qi, strengthening the spleen, reinforcing the spleen, lung and kidney, strengthening the middle-jiao, invigorating qi, stopping bleeding and preventing people from vomiting, and is mainly used for treating deficiency of the spleen and stomach and weakness of the spleen and stomach. The traditional Chinese medicine preparation disclosed by the invention can achieve the purposes of relieving diarrhoea, diminishing inflammation, relieving spasm and pain, improving local blood circulation and metabolism, enhancing the immunologic function of the intestinal tract, and promoting ulcer healing. The invention has the advantages that the preparation processes are simple and convenient, the toxic side effects are small, the administration is convenient, the traditional Chinese medicine preparation can be prepared easily, and the cost is low.

The invention relates to a standardized planting method for Erigeron breviscapus and belongs to the technical field of Chinese medicine planting. The standardized planting method for Erigeron breviscapus consists of: seedling selection; seed sowing, theseed sowing is divided into three stages, namely preparation, seed treatment and seed sowing; seedling breeding period administration after the seed sowing, in the seedbed management process, covering turning over, weeding, pest control and seedling hardening are conducted; Erigeron breviscapus soil preparation and transplanting and timely disbudding. The standardized planting method for Erigeron breviscapus overcomes the defects of low Erigeron breviscapus yield, high planting cost, low active ingredient content and small good variety shortage caused by the existing planting method.

A process for preparing the shortscape fleabane injection used to treat the cardiovascular and cerebrovascular ischemic diseases features that the ultrafiltration with ceramic membrane is used to remove the vegetative macro-molecular impurities, and the macroreticular adsorption resin is used to enrich, separate and purify the active components in shorts cape fleabane, including flavonoside, breviscapine B, and caffeoyl compounds.

A dispersing tablet of Erigeron breviscapine for treating obesity and diabetes is prepared from breviscapine, aspartame, cross-linked, polyvidone, magnesium stearte, microcrystalline cellulose, and pregelatinized starch.

The invention provides a medicament for treating infectious diseases, a preparation method and the application thereof. The medicament is prepared from scutellaria baicalensis, jasmine, erigeron breviscapus and cholic acid, and has the following effects: by aiming at the central link--inflammatory reaction of an infectious disease, removing harmful substances such as inflammatory mediators, free radicals and the like, and improving the local microcirculation state, thereby alleviating the pathological damages caused by inflammations; meanwhile, the medicament has the function of regulating the overall internal environment, and can effectively treat lower respiratory tract infection and acute lung injury induced by infection; and the effective substances and functional mechanism of the medicament are relatively clear.

A breviscapine-glucose injection for treating apoplexy sequelae, coronary heat disease and angina pectoris is prepared through depositing breviscapine in acid, cold storage, ultrafiltration, mixing with Na2EDTA, pouring in containers, sterilizing and lamp examining.

The invention relates to a seedling culture matrix for gumbos. The seedling culture matrix is prepared from, by weight, wormcast, fermented fish viscera, canal mud, livestock manure, humus, pine sawdust, urea, frit, sweet potato leaves, activated carbon powder, fructus viticis extracts, cortex ailanthi extracts, erigeron breviscapus extracts and water. A use method of the fertilizer special for gumbo planting is simple, a large amount of abandoned ort, canal mud and the like are added to the fertilizer, cost can be reduced, pollution caused when the abandoned ort is abandoned at will can be prevented, excellent environments and nutrition can be provided for gumbo seedling culture, organic fertilizer and inorganic fertilizer are used in cooperation, and the utilization rate of the fertilizer is increased.

The invention relates to an artificial cultivation method to control the content of total flavone and total caffeic acid ester of breviscpini, belonging to the technical field of Chinese herbal medicine cultivation. The invention is characterized in that, in the fertilization steps of the method, the classes, amount and time of fertilization are determined by the N content of the planting soil substrate; that is to say, (1) when the N content of the planting soil is lower than 0.1%, the application amount of fertilizer per mu for the first time is 5Kg N fertilizer, 5Kg P fertilizer and 10Kg K fertilizer; the application amount of fertilizer for the second time is the same as the first time; the application amount of fertilizer for the third time is 5Kg P fertilizer and 5Kg K fertilizer; (2) when the N content of the planting soil is higher than 0.1%, N fertilizer does not to be used, and only K fertilizer and P fertilizer are used to improve quality and yield; the application amount of fertilizer per mu for the first time is 5Kg P fertilizer and 10Kg K fertilizer; the application amount of fertilizer for the second time is the same as the first time; the application amount of fertilizer for the third time is 2.5Kg P fertilizer and 10Kg K fertilizer. The method has the advantages of easy operation, low cost, good economic benefit, good quality and high yield; the medicinal active ingredient of total flavone is improved by 25% to 30%, and the total caffeic acid ester is improved by 20% to 25%.

A dried suspension for treating cardiovascular and cerebrovascular diseases is prepared from breviscapine, filler, suspending aid, flowing aid, lubricant and flavouring through drying, pulverizing and proportional mixing. It is mixed with water before used.

The invention provides a preparation method for high-purity breviscapine extract as well as preparations and application thereof. The method disclosed by the invention comprises the following steps: taking erigeron breviscapus as a raw material, performing dynamic ultrasonic countercurrent extraction or heating reflux extraction, filtering, centrifuging, adjusting the pH value to 2.0-7.0, performing macroporous resin column chromatography, preparing by using dynamic axial compression industrial chromatographic separation, or preparing by adopting high-speed counter-current chromatography, freezing or performing spray drying, thereby obtaining the high-purity breviscapine extract. According to the method disclosed by the invention, extraction can be completed in a short time at a low temperature, the separation cycle is short, the efficiency is high, the occupied volume for extraction is reduced, the production cost is lowered, the energy consumption and environmental pollution can be reduced, and the purity of the obtained breviscapine can be 95% or higher. Added with various added pharmaceutical adjuvants, the high-purity breviscapine extract can be prepared into ordinary tablets, thin membrane coated tablets, capsules, dispersible tablets, dropping pills, granules, sustained-release preparations and other solid oral preparations, as well as spray, aerosol, lyophilized powder for injection and injection, and the preparations can be used for treating cardiovascular and cerebrovascular diseases and are obvious in curative effects, safe and reliable.

The invention discloses a medicine composition for treating cardio-cerebrovascular diseases, which is prepared from at least one of ginseng, ginseng leaves and ginseng stem leaves, erigeron breviscapus and borneol as raw materials. The medicine composition not only can promote blood circulation to remove blood stasis, but also can tonify qi to promote blood circulation, and especially has good curative effect on ischemic cerebrovascular diseases.

The present invention discloses an application of methanol extract of breviscapine in the skin whitening and spot removing, which takes the breviscapine extract as the active ingredient to prepare the skin whitening or / and spot removing cosmetics, the medical supplies and foods for the inhibition of tyrosinase activity or / and melanin biosynthesis. The trials prove that the methanol extract of breviscapine can effectively inhibit the tyrosinase activity and the melanin formation without the side effects on the skin and whiten the tanned skin after the ultraviolet radiation, as well as prevent, improve and treat the age spots, freckles, red spots and other skin pigment deposition symptoms caused by the sun. The present invention explores a new usage of the methanol extract of breviscapine and has excellent application prospect.

The invention relates to a new compound with a structural formula (I). The compound can be extracted and separated from the dry complete grass of Erigeron Breviscapus (Vant.) Hand.-Mazz. The compound has the effects of inflammatory reaction resistance, platelet aggregation resistance, thrombus resistance and blood vessel extension and can be used for preparing a medicament for treating a heart cerebrovascular disease. The structural formula (I) is shown in the specification.

The invention relates to a pharmaceutical composition for treating apoplexy hemiplegia and a preparation method of the pharmaceutical composition. The pharmaceutical composition for treating apoplexy hemiplegia selectively comprises astragalus, erigeron breviscapus, hawthorn, bidentate achyranthes, bighead atractylodes rhizome, safflower, red peony roots, Szechuan lovage rhizome, Chinese angelica, cassia twig, leech, tall gastrodia tuber and earthworm. Required formulations prepared by a conventional preparation method by the aid of the modern preparation technology have effects of supplementing qi, activating blood circulation, dispersing blood stasis and dredging collaterals, and are used for treating apoplexy hemiplegia symptoms of hemiplegia, facial paralysis, limbs numbness and the like caused by apoplexy. The pharmaceutical composition for treating apoplexy hemiplegia is applied to clinical treatment and is effective in treatment.

The invention relates to the technical field of feed, in particular to a special feed for a turkey. The feed is prepared from the following raw materials in parts by weight: 80-100 parts of yellow corn, 15-20 parts of black glutinous rice, 15-20 parts of corn bran, 20-25 parts of soybean straw, 18-20 parts of rice bran, 8-10 parts of soybean, 18-20 parts of flaxseed pulp, 22-25 parts of palm pulp, 1-2 parts of coconut oil, 12-15 parts of oat hull, 3-4 parts of erigeron breviscapus, 0.5-1 part of whole milk powder, 1-2 parts of garlic bulblet, 1-2 parts of shell powder, 1-2 parts of freshwater shrimp, 1-2 parts of small crucian carp, 1-2 parts of chicken liver meal, 2-3 parts of potato, 2-3 parts of luffa, 3-4 parts of sweet potato vine, a proper quantity of salt, and 0.2-0.5 part of phagostimulant. The special feed for the turkey provided by the invention is of nutrition balance in the formula, can completely meet the requirement of turkey for nutrition during the quick growth and development process; erigeron breviscapus, garlic bulblet and other raw materials can enhance the disease resistance of chicken flock, and reduce the probability of disease, so that the chicken flock is free from disease, gains weight quickly, and is full of nutrition, delicious in meat taste, and the flavor of the chicken is kept well.

The invention relates to a fertilizing technique for improving yield of erigeron breviscapus and provides a fertilizing technique for artificially planting the erigeron breviscapus aiming at the defects that the existing artificial planting yield of the erigeron breviscapus is lower and planting cost is high. The fertilizing technique comprises the following steps: based on 1500-3000kg of cured farmyard manure and 40kg of superphosphate as base fertilizers per Mu, carrying out top application five times in different growth periods of erigeron breviscapus seedlings, with reasonable field management. By using the fertilizing technique in the invention, the farmyard manure for the planted erigeron breviscapus product can be saved by 1500kg per Mu, top application is carried out five times, 7kg of urea per Mu can be saved, 3kg of calcium superphosphate per Mu can be saved, and the use cost of the fertilizer is reduced, yield per Mu is increased by 50kg, the content of breviscapine is improved by 0.2%, and the content of impurities is reduced by 1%.