31 results about "Liver triglyceride" patented technology

The present invention relates to a chicory extract for allowing reduction or control of body weight or limitation of body weight gain, reduction or limitation of increase of fat storage, of fatty liver, of liver triglycerides level, of hypertriglyceridemia, of glycemia level, of insulinemia level, of insulin resistance, and / or of different factors of metabolic syndrome, and to a composition comprising such an extract.

The invention relates to the technical field of microorganisms, and discloses complex probiotic and use thereof. The complex probiotic consists of bifidobacterium adolescentis CCFM8630, lactobacillusreuteri CCFM8631, lactobacillus rhamnosus CCFM1044 and lactobacillus casei CCFM711. The effect of relieving metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 used alone or in combination, especially in the reduction of low-density lipoprotein, total cholesterol and liver triglyceride in serum and glutamic-pyruvic transaminase, glutamic oxalacetic transaminase, alkaline phosphatase, IFN-gamma content in the serum and increase the glutathione and superoxide dismutase content in the liver. The decrease or increase range is improved by 7.91%-837.11% compared with the single or double-bacteria combination formula of the CCFM8630 and the CCFM8631. The four-bacteria combination can achieve the remarkable synergistic interaction.

The invention discloses bifidobacterium longum for relieving insulin resistance and application of the bifidobacterium longum, and belongs to the technical field of microorganisms. The bifidobacterium longum NSP008 disclosed by the invention can be used for inhibiting the increase of the body weight and the body fat of an insulin-resistant mouse on the premise of not influencing the food intake; the glucose tolerance of an insulin-resistant mouse is improved, and meanwhile, the blood sugar, serum insulin and an insulin resistance index of the mouse are reduced; the insulin-resistant mouse liver triglyceride and inflammation level can be adjusted, and liver tissue damage can be relieved; the intestinal flora structure is improved, and the growth of intestinal probiotics is promoted. The bifidobacterium longum NSP008 disclosed by the invention is used for preparing a pharmaceutical composition and fermented food for relieving insulin resistance, and has a very wide application prospect.

The invention discloses a traditional Chinese medicine composition for treating simple obesity, and a preparation method and an application thereof. The traditional Chinese medicine composition is prepared by using 5-30 parts by mass of white atractylodes rhizome, 10-30 parts by mass of fried turtle shell, 10-20 parts by mass of inula flowers, 10-20 parts by mass of curcuma zedoary and 10-20 parts by mass of giant knotweed rhizome as raw materials. Specifically, the preparation method comprises the following steps of weighing all medicines according to the above proportions; smashing the fried turtle shell; adding water 10 times by volume that of the fried turtle shell; decocting for 30 minutes; adding traditional Chinese medicinal materials; adding water and decocting for two times, wherein the volume of added water in each time is 8-10 times that of a total mass of the medicines; and the time for each decoction is 0.5-1 hour; merging extract solutions obtained by the two times of decoction; filtering, concentrating, and drying to obtain a dry extract. Animal experiments show that the composition can significantly reduce body weight, liver weight and fat weight of high-fat obese rats, significantly reduce the contents of liver cholesterol and liver triglyceride in the high-fat obese rats, regulate lipid metabolism and improve liver functions. The medicine effects are related to the fact that the composition can increase bile flow, regulate and increase bile acid subfractions that can promote bile secretion and the lipid metabolism.

The present invention relates to a composition useful in the prevention and treatment of non-alcoholic fatty liver diseases caused by fat accumulated in the liver due to excessive nutrient ingestion or metabolic syndrome, regardless of alcohol consumption. The composition of the present invention can significantly improve the increased liver weight, accumulated liver triglycerides, increased serum ALT level, reduced liver SOD activity, and reduced liver total antioxidative capacity in experimental animals raised with a high-fat diet for a long period of time. Since the fatty liver diseases induced by the high-fat diet in the experimental animals shows similar pathological and immunological findings to human non-alcoholic fatty liver diseases, the composition of the present invention can be provided as an excellent pharmaceutical preparation or health supplement food used in the prevention and treatment of non-alcoholic fatty liver diseases.

The invention discloses an application of interleukin-38 in preparing products for preventing and treating obesity and metabolic syndrome. Furthermore, the metabolic syndrome is diabetes and fatty liver; the dosage of interleukin-38 is 2.5 microgram DNA / g weight, and the effective using form is pcDNA3.1-1L-38-His plasmid; the plasmid is structured by using KpnI and XbaI double digest pc DNA 3.1 (+) and interleukin-38 PCR product, and the recombinant plasmid formed by linking enzyme-digested products of the both is pcDNA3.1-1L-38-His plasmid. The interleukin-38 can effectively delay the fat happening and developing progresses, effectively inhibit the mice weight increase, reduce the cell hypertrophy of adipose tissue, effectively regulate the mice adjusting ability to sugar, inhibit the expression of inflammatory cells, and reduce the generation of the liver triglyceride; the application provides a high-efficient, toxic-free and safe new concept for the prevention and treatment of obesity and metabolic syndrome, and has wide application prospect.

The invention discloses application of usnea or extract thereof in preparation of a medicine for treating and / or preventing abnormal lipids metabolism. Pharmacological experiments indicate that usnea aqueous extract and alcohol extract can be used for remarkably reducing rise of serum and liver triglyceride and low density lipoprotein and increasing serum high density lipoprotein so as to prevent and treat hyperlipoproteinemia and atherosclerosis. Furthermore, the usnea alcohol extract can be used for remarkably reducing the content of TBA, ALT and AST of serum, and the usnea aqueous extract can be used for reducing the content of AST of serum and protecting liver injury caused by lipid metabolism disorders and has an effect of preventing and treating fatty liver. Usnea is wide in source, has an exact pharmacological effect for preventing and treating abnormal lipids metabolism, and has wide clinical application prospect.

The invention discloses a Chinese medicinal composition for preventing and treating hyperlipaemia and fatty liver and a preparation method thereof. The Chinese medicinal composition is prepared from raw materials of 3 to 9 weight parts of root of red-rooted salvia and 1 to 1.5 weight parts of chingma abutilon seed. A common method for traditional Chinese medicine preparations is adopted, the Chinese medicinal composition is added into various substrates and auxiliary materials required by preparing different oral preparations to prepare oral preparations in any common formulation. Experimental results show that the root of red-rooted salvia and chingma abutilon seed composition can obviously reduce serum triglyceride, total cholesterol level, and liver triglyceride and total cholesterol content and obviously reduce liver fat lesion degree and has good treatment effect on hyperlipaemia and fatty liver. The root of red-rooted salvia and chingma abutilon seed composition has the effects of reducing serum TC and TG levels and reducing liver fat lesion superior to those of single root of red-rooted salvia and single chingma abutilon seed.

The invention discloses a Chinese medicinal composition for preventing and treating hyperlipaemia and fatty liver and a preparation method thereof. The Chinese medicinal composition is prepared from raw materials of 3 to 9 weight parts of root of red-rooted salvia and 1 to 1.5 weight parts of chingma abutilon seed. A common method for traditional Chinese medicine preparations is adopted, the Chinese medicinal composition is added into various substrates and auxiliary materials required by preparing different oral preparations to prepare oral preparations in any common formulation. Experimental results show that the root of red-rooted salvia and chingma abutilon seed composition can obviously reduce serum triglyceride, total cholesterol level, and liver triglyceride and total cholesterol content and obviously reduce liver fat lesion degree and has good treatment effect on hyperlipaemia and fatty liver. The root of red-rooted salvia and chingma abutilon seed composition has the effects of reducing serum TC and TG levels and reducing liver fat lesion superior to those of single root of red-rooted salvia and single chingma abutilon seed.

The invention discloses an application of litchi peel polyphenol in preparing a drug or healthcare product for reducing liver cholesterol. A great amount of experiments show that the litchi peel polyphenol from litchi peel can effectively reduce the liver cholesterol, liver triglyceride and liver low density lipoprotein cholesterol, so that the fat accumulation in liver can be effectively reduced, and relevant liver diseases such as non-alcoholic fatty liver can be treated.

The invention belongs to the field of animal experimental models, and relates to application of ultrasonic detection equipment in semiquantitatively determining a sheep fatty liver. The application comprises the steps that a sheep fatty liver model is built by simulating negative balance of energy in the natural state; by means of characteristic analysis on liver ultrasonic images and corresponding data analysis on liver triglyceride content, a sheep fatty liver ultrasonic diagnosis method for semiquantitatively diagnosing that the liver triglyceride content is smaller than 4%, between 4% and 10% and larger than 10% is determined according to the liver echo brightness enhancing degree, the liver and kidney echo ratio increasing degree, the hepatic vessel visualization weakening degree and the acoustic shadow visualization fuzzy degree of hepatic portal veins, postcaval veins, rumen walls, intestines and diaphragms at the far field of the liver. The method is high in sensitivity, high in specificity and good in repeatability and has an ideal application prospect.

The invention provides a composition containing resveratrol and application of the composition, and belongs to the technical field of medicine and biology. The composition is prepared from topiramateand resveratrol, wherein the mass ratio of topiramate to resveratrol is (1-5) to1. The composition can be used for lowering liver triglyceride, liver cholesterol, pyruvate transaminase, aspartate aminotransferase and triglyceride, thereby treating nonalcoholic fatty liver.

The invention discloses an application of formononetin to treatment of nonalcoholic fatty liver disease. An in vitro and an in vitro cell model are adopted, formononetin is used for treating animals,and the improvement effect of the formononetin on metabolic syndromes of nonalcoholic fatty liver, obesity, insulin resistance, lipid disorders and the like can be observed. Experiment proves that theformononetin can notably reduce weight, liver weight / body mass indexes, liver triglyceride(TG), liver lipidoses, liver function damage criterion-millet straw aminopherase (AST) and alanine aminotransferase (ALT) of organisms suffering from nonalcoholic fatty liver, and besides, can improve insulin resistance. Blood biochemistry detection indicates that the formononetin can also reduce the level of triglyceride (TG), cholesterol (TC) and low intensity lipoprotein (LDL-C) of HFD mice, and can improve the lipid disorders. The formononetin has important effects on treatment of nonalcoholic fattyliver.

The invention discloses application of a curcumin derivative to preparation of medicines for resisting diabetes and complication thereof and in particular relates to application of (1E,6E)-1,7-di(3,5-ditertbutyl-4-hydroxyl phenyl)heptyl-1,6-diene-3,5-diketone to preparation of medicines, health-care products and food for preventing and treating diabetes and complication thereof. The (1E,6E)-1,7-di(3,5-ditertbutyl-4-hydroxyl phenyl)heptyl-1,6-diene-3,5-diketone can obviously reduce serum, liver triglyceride, total cholesterol and low-density lipoprotein of high fat feed and streptozotocin induced diabetes model mice, can reduce fasting blood glucose and glycated hemoglobin of the model mice, can improve glucose tolerance of the model mice, can obviously improve glycometabolism and lipid metabolism of the diabetes model mice, and can obviously reduce fatty degeneration of liver and aortic arch and lesion of atherosclerosis.

A method of assessing the level of triglycerides in the liver of a subject comprises determining the amount of a first lipid metabolite in a sample from the subject. The sample can be blood, plasma, serum, isolated lipoprotein fraction, saliva, urine, lymph fluid, bile, or cerebrospinal fluid. The first lipid metabolite is a fatty acid present in a lipid class. The lipid class is selected from the group consisting of free fatty acids, total fatty acids (TL), triglycerides (TG), cholesterol esters (CE), phosphatidylcholines (PC), and phosphatidylethanolamines (PE).

The invention discloses the application of litchi peel polyphenols in the preparation of medicines or health care products for lowering liver triglycerides. The inventor found through a large number of experiments that polyphenols from lychee peel can effectively reduce liver cholesterol, liver triglyceride, and liver low-density lipoprotein cholesterol, thereby effectively reducing fat accumulation in the liver, and can be used to treat non-alcoholic fatty liver and other related liver diseases.

The invention discloses a traditional Chinese medicine composition for treating simple obesity, and a preparation method and an application thereof. The traditional Chinese medicine composition is prepared by using 5-30 parts by mass of white atractylodes rhizome, 10-30 parts by mass of fried turtle shell, 10-20 parts by mass of inula flowers, 10-20 parts by mass of curcuma zedoary and 10-20 parts by mass of giant knotweed rhizome as raw materials. Specifically, the preparation method comprises the following steps of weighing all medicines according to the above proportions; smashing the fried turtle shell; adding water 10 times by volume that of the fried turtle shell; decocting for 30 minutes; adding traditional Chinese medicinal materials; adding water and decocting for two times, wherein the volume of added water in each time is 8-10 times that of a total mass of the medicines; and the time for each decoction is 0.5-1 hour; merging extract solutions obtained by the two times of decoction; filtering, concentrating, and drying to obtain a dry extract. Animal experiments show that the composition can significantly reduce body weight, liver weight and fat weight of high-fat obese rats, significantly reduce the contents of liver cholesterol and liver triglyceride in the high-fat obese rats, regulate lipid metabolism and improve liver functions. The medicine effects are related to the fact that the composition can increase bile flow, regulate and increase bile acid subfractions that can promote bile secretion and the lipid metabolism.

The invention discloses Bifidobacterium pseudosmallis CCFM1048, its composition, fermented food, application, bacterial agent and preparation method thereof. The Bifidobacterium pseudoserinus CCFM1048 can tolerate human gastrointestinal environment and significantly improve high-fat diet The resulting increase in liver triglyceride content in mice with metabolic syndrome; alleviated weight gain in mice with metabolic syndrome; significantly improved fasting blood glucose and abnormal oral glucose tolerance in mice with metabolic syndrome, and reduced the area under the curve of glucose tolerance drugs. Improve serum insulin levels; significantly improve serum low-density lipoprotein cholesterol levels in mice with metabolic syndrome caused by high-fat diets; significantly improve the increase in intestinal Proteus species caused by high-fat diets, CCFM1048 is used to prepare and relieve metabolism Syndrome, reducing Parkinson's disease, intestinal infection, urinary tract, kidney infection and other diseases, the pharmaceutical composition and fermented food have a very wide application prospect.

The present invention discloses bifidobacterium pseudosmall chain CCFM1047, its composition, fermented food, application, bacterial agent and preparation method thereof. Bifidobacterium pseudosmall chain CCFM1047 can tolerate human gastrointestinal environment and significantly improve metabolic syndrome Fasting blood glucose and oral glucose tolerance in mice, reduce the area under the curve of glucose tolerance drugs, reduce serum insulin levels; significantly alleviate the weight gain of mice; significantly improve the low density of serum in mice with metabolic syndrome caused by high-fat diet Elevated lipoprotein cholesterol and liver triglyceride content; significantly alleviated the increase of Proteus genus in the intestine caused by high-fat diet, pseudosmall chain Bifidobacterium CCFM1047 was used to prepare and relieve metabolic syndrome, reduce Parkinson's, intestinal infection and The pharmaceutical composition and fermented food for urinary tract, kidney infection and other diseases have very broad application prospects.

The invention relates to a composition with an effect of reducing the content of triglyceride of liver and a preparation method thereof and further relates to an application of the composition in foods, health foods or drugs. The composition with the effect of reducing the content of triglyceride of liver is prepared from the following components in parts by weight: 15-40 parts of lalang grass rhizome, 40-60 parts of roots of kudzu vines, 15-40 parts of mulberries, 5-15 parts of smoked plums, 1-8 parts of tea and 50-110 parts of corn oligopeptide. The technical point of the composition provided by the invention lies in that traditional medicinal varieties which has a long edible history and novel resource food raw materials are used together, the medicines are matched to be used according to the effect characteristics of the materials; the combination and proportion of the composition with a remarkable effect for reducing the weight of the liver and the content of triglyceride in the liver can be discovered by virtue of activity screening through zoological experiments.

The invention discloses application of betulinic acid as a leptin sensitizer in preparation of related drugs for treating leptin resistance. According to the invention, high-fat, ob / ob and db / db obesemice are taken as research objects and treated with the betulinic acid, and the weight, serum leptin concentration, liver triglyceride, insulin tolerance and glucose tolerance tests and blood fat indexes are measured. The results show that the betulinic acid can significantly reduce the weight, improve the leptin resistance, lower the liver triglyceride, improve the insulin resistance and lower the blood fat in the high-fat obese mice, the ob / ob and db / db mice treated with the betulinic acid can not reduce the weight and improve the metabolism of glycolipid, and the cellular level proves thatthe combination of the betulinic acid and the leptin can enhance the expression of p-STAT3. The invention provides a basis for treating obesity, a non-alcoholic fatty liver disease, type 2 diabetes and hyperlipidemia by using the betulinic acid as the leptin sensitizer, and also provides a new treatment direction for developing more natural active pharmaceutical ingredients for treating diseasesrelated to the leptin resistance.

The invention belongs to the field of pharmaceutical biology. The estrogen plays an important role in the liver glucolipid metabolism process, has a protection effect to livers and can be used for preparing medicines for treating fatty liver and particularly non-alcoholic fatty liver diseases. A receptor regulated by the estrogen is an SHP (Small Heterodimer Partner) gene, and by adjusting the expression of the liver SHP gene, the synthesis of liver triglyceride and fatty acid is inhibited, and the function of alleviating the fatty liver is brought into play. According to the invention, a specific target is provided for screening a medicine for treating fatty liver, the regulation effect of the estrogen to SHP gene is confirmed, and the relevant relationship between the regulation effect and the NAFLD (Non-Alcoholic Fatty Liver Disease) provides reliable basis and indexes for researching the prevention and treating target points of the fatty liver; and furthermore, from the aspect of endocrine regulation, a new way is provided for preventing and treating glycolipid metabolic diseases.

The present invention discloses bifidobacterium pseudosmall chain CCFM1046, its composition, fermented food, application, bacterial agent and preparation method thereof. Bifidobacterium pseudosmall chain CCFM1046 can tolerate human gastrointestinal environment and significantly improve high-fat diet The resulting increase in liver triglyceride content in mice with metabolic syndrome; alleviated weight gain in mice with metabolic syndrome; significantly improved fasting blood glucose and abnormal oral glucose tolerance in mice with metabolic syndrome, and reduced the area under the curve of glucose tolerance drugs. Improve serum insulin levels; significantly improve the serum low-density lipoprotein cholesterol level in mice with metabolic syndrome caused by high-fat diet; significantly improve the increase in intestinal Proteus caused by high-fat diet, used to prepare and relieve metabolic syndrome The medicinal composition and fermented food that reduce Parkinson's disease, intestinal infection, urinary tract, kidney infection and other diseases have very broad application prospects.

The invention discloses the application of coptisine or its salt in the preparation of medicines for preventing and treating fatty liver injury. Coptisine has been proved by pharmacological studies to have the effect of lowering blood lipids and improving lipid metabolism, and can inhibit the accumulation of triglycerides in liver cells; it can significantly reduce blood triglycerides, cholesterol and LDL-C in experimental hyperlipidemia, and reduce Triglyceride content in liver tissue; and reduce liver damage caused by fat accumulation in liver tissue; Fatty liver caused by excessive use of cortisol can reduce liver triglyceride accumulation and glutamic acid transaminase GPT and aspartate aminotransferase (GOT) activity increase High, reduce liver damage, have excellent prevention and treatment of fatty liver, some indicators have obvious advantages over lipid-lowering drugs simvastatin, fenofibrate and liver-protecting drugs tiopronin, Gantyle, etc., can be used in clinical fatty liver disease.

The invention relates to the technical field of microorganisms, and discloses a compound probiotic and its application. The composite probiotics of the present invention are composed of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631, Lactobacillus rhamnosus CCFM1044 and Lactobacillus casei CCFM711, the effect of alleviating metabolic syndrome is obviously better than CCFM8630 or CCFM8631 used alone and Combined, especially in reducing serum low-density lipoprotein, total cholesterol, liver triglycerides and serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, IFN-γ levels and increasing liver glutathione and superoxide dismutase In terms of content, etc., its decline or increase ranges from 7.91% to 837.31% compared with CCFM8630 and CCFM8631 single-bacteria or double-bacteria combination formula. The combination of four bacteria can achieve significant synergistic effect.

The invention discloses application of a curcumin derivative to preparation of medicines for resisting diabetes and complication thereof and in particular relates to application of (1E,6E)-1,7-di(3,5-ditertbutyl-4-hydroxyl phenyl)heptyl-1,6-diene-3,5-diketone to preparation of medicines, health-care products and food for preventing and treating diabetes and complication thereof. The (1E,6E)-1,7-di(3,5-ditertbutyl-4-hydroxyl phenyl)heptyl-1,6-diene-3,5-diketone can obviously reduce serum, liver triglyceride, total cholesterol and low-density lipoprotein of high fat feed and streptozotocin induced diabetes model mice, can reduce fasting blood glucose and glycated hemoglobin of the model mice, can improve glucose tolerance of the model mice, can obviously improve glycometabolism and lipid metabolism of the diabetes model mice, and can obviously reduce fatty degeneration of liver and aortic arch and lesion of atherosclerosis.