Traditional Chinese medicine formula for preventing and treating cerebrovascular diseases

Abstract

The invention discloses a traditional Chinese medicine formula for preventing and treating cerebrovascular diseases. The traditional Chinese medicine formula comprises Yulangsan, bauhinia championii, corydalis amabilis, lumbricus, astragalus membranaceus, ligusticum chuanxiong hort, cassia twig, radix paeoniae rubra, safflower, rhizoma acori graminei and erigeron breviscapus. The traditional Chinese medicine composition has good clinical effects on treating cerebral atherosclerosis, stenosis, infarction, atherosclerosis and apoplexy sequelae, hemiplegia, aphasia and the like caused by cerebral atherosclerosis, stenosis, infarction and atherosclerosis, and can gradually or basically recover the apoplexy sequelae caused by cerebral atherosclerosis, stenosis, infarction and atherosclerosis; yulangsan and bauhinia championii have the effects of relaxing tendons and activating collaterals, and corydalis amabilis, ligusticum wallichii, radix paeoniae rubra and safflower have the effects of promoting blood circulation and removing blood stasis and are The earthworm, the cassia twig, the rhizoma acori graminei and the erigeron breviscapus are used for dredging brain collaterals and are assistant and guide; the whole formula has the effects of tonifying qi, activating blood, dispersing blood stasis, dredging collaterals, inducing resuscitation and inducing resuscitation.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine formula for preventing and treating cerebrovascular diseases. BACKGROUND

[0002] Cerebrovascular diseases are common diseases that seriously endanger human health. Among them, cerebral atherosclerosis, stenosis, infarction (cerebral infarction) and its sequelae (such as hemiplegia, aphasia, etc.) have the characteristics of high incidence, high disability rate and high mortality, which brings heavy burden to patients, families and society.

[0003] At present, the western medicine treatment mainly adopts the methods of anti-platelet aggregation, antihypertensive, lipid-lowering, thrombolytic and surgical intervention, although it has certain curative effect, but there are problems of large side effects, high cost, high risk of invasive treatment and the like. Traditional Chinese medicine has unique advantages of multi-target, overall regulation and small side effects in preventing and treating cerebrovascular diseases.

[0004] There are some traditional Chinese medicine compounds for treating cerebrovascular diseases in the prior art, but they generally have problems of insufficient curative effect, slow effect or poor recovery effect on sequelae of stroke. SUMMARY

[0005] An object of the present application is to provide a traditional Chinese medicine formula for preventing and treating cerebrovascular diseases, which at least solves any aspect of the above technical problems.

[0006] A further object of the present application is to avoid poor recovery effect.

[0007] Another further object of the present application is to improve the bioavailability and clinical curative effect of the drug.

[0008] In particular, the present application provides a traditional Chinese medicine formula for preventing and treating cerebrovascular diseases, which is prepared from the following raw medicinal materials in a weight ratio: Yulangsan 90-110 parts, Jiulongteng 90-110 parts, Xiatiannuo 90-110 parts, Dilong 90-110 parts, Huangqi 90-110 parts, Chuanqiong 50-70 parts, Guizhi 50-70 parts, Chishao 50-70 parts, Honghua 50-70 parts, Shichangpu 50-70 parts, Dengzhaoha 50-70 parts.

[0009] Further, it is prepared from the following raw medicinal materials in a weight ratio: Yulangsan 100 parts, Jiulongteng 100 parts, Xiatiannuo 100 parts, Dilong 100 parts, Huangqi 100 parts, Chuanqiong 60 parts, Guizhi 60 parts, Chishao 60 parts, Honghua 60 parts, Shichangpu 60 parts, Dengzhaoha 60 parts.

[0010] Further, the process of the traditional Chinese medicine formula comprises the following steps: S1: ultrafine grinding: the mixed raw materials are mixed and ultrafine ground to obtain 600-1000 mesh ultrafine powder; S2: mixing and water extraction: pure water is added to the ultrafine powder obtained in step S1, the mass-volume ratio (g:ml) of the ultrafine powder to water is 1:1 ~ 1:1.5, the mixture is uniformly mixed and then heated and boiled for 20-40 minutes; S3: drying and forming: the mixture after boiling in step S2 is dried at a temperature not exceeding 60℃, and then is made into pills or granules.

[0011] Further, the heating and boiling time in step S2 is 30 minutes.

[0012] Further, the mass-volume ratio (g:ml) of the ultrafine powder to water in step S2 is 1:1.16.

[0013] Further, the present application provides a traditional Chinese medicine preparation prepared by the above preparation process.

[0014] Technical effects and advantages of the present application: The present application takes Huangqi as the monarch drug for tonifying primordial qi and benefiting qi and promoting blood flow; Yulangsan and Jiulongteng for relaxing muscles and tendons; Xiatianwu, Chuanxiong, Chishao and Honghua for activating blood and resolving stasis; Dilong for dredging meridians and collaterals; Guizhi for warming and dredging meridians; Shichangpu for resolving phlegm and opening orifices; Dengzhanhua for dredging brain collaterals, all of which are auxiliary drugs. The whole prescription has the effects of benefiting qi, activating blood, resolving stasis, dredging collaterals, opening orifices and refreshing the mind, which directly targets the core pathogenesis of "qi deficiency, blood stasis and unsmooth collaterals" of cerebrovascular diseases, and can treat both the symptoms and the root cause.

[0015] The present application uses ultrafine grinding technology of 600-1000 mesh, which greatly increases the specific surface area of medicinal materials, making the effective components more easily dissolved. The subsequent boiling and low-temperature drying process aims to efficiently extract and maximize the retention of volatile and heat-sensitive effective components, significantly improving the bioavailability and clinical efficacy of the drug. BRIEF DESCRIPTION OF DRAWINGS

[0016] Some specific embodiments of the present application will be described in detail hereinafter with reference to the accompanying drawings, which are shown by way of example and are not limiting. Identical reference signs in the drawings denote identical or similar components or parts. It should be understood by those skilled in the art that the drawings are not necessarily drawn to scale. In the drawings: Figure 1 The flow chart of the preparation process of the present application. DETAILED DESCRIPTION

[0017] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative effort belong to the scope of protection of the present application.

[0018] Embodiment 1 The scheme of the present embodiment provides a traditional Chinese medicine formula for preventing and treating cerebrovascular diseases, which is prepared from the following raw medicinal materials in a weight ratio: Yulangsan 90-110 parts, Jiulongteng 90-110 parts, Xiatiannuo 90-110 parts, Dilong 90-110 parts, Huangqi 90-110 parts, Chuanqiong 50-70 parts, Guizhi 50-70 parts, Chishao 50-70 parts, Honghua 50-70 parts, Shichangpu 50-70 parts, Dangguhua 50-70 parts.

[0019] Preferably, the traditional Chinese medicine formula is prepared from the following raw medicinal materials in a weight ratio: Yulangsan 100 parts, Jiulongteng 100 parts, Xiatiannuo 100 parts, Dilong 100 parts, Huangqi 100 parts, Chuanqiong 60 parts, Guizhi 60 parts, Chishao 60 parts, Honghua 60 parts, Shichangpu 60 parts, Dangguhua 60 parts.

[0020] Embodiment 2: Preparation process All the traditional Chinese medicine raw materials weighed in Embodiment 1 are mixed uniformly and put into a super-micro grinder to process into super-micro powder of 800 mesh, obtaining a total weight of about 860 g of medicinal powder.

[0021] All the super-micro powder (860 g) is taken and 1000 ml of purified water is added and stirred uniformly.

[0022] The mixture is heated to boiling and kept in a state of micro-boiling for 30 minutes.

[0023] The heating is stopped and it is naturally cooled to room temperature (about 25℃).

[0024] The paste after cooking is transferred to a vacuum drying oven for low-temperature drying at 55℃ until the water content is less than 5%.

[0025] The dried solid block is crushed and passed through a 100 mesh sieve to obtain dry extract powder.

[0026] An appropriate amount of medicinal adjuvant (such as starch, dextrin) is added to the dry extract powder, which is stirred uniformly, and then ethanol is used as a wetting agent to prepare granules by using a conventional granulator, and the granules are packaged. Alternatively, an appropriate amount of honey is added to prepare pills.

[0027] Embodiment 3: Select 100 cases of patients diagnosed as cerebral infarction recovery period with hemiplegia, aphasia, randomly divided into treatment group and control group, 50 cases each. The treatment group takes the granules prepared in Example 2 of the application, 5g each time, 3 times a day; the control group takes a certain recognized effective positive control drug. The course of treatment is 3 months. The results show that the treatment group is significantly better than the control group in the improvement of neurological deficit and the score of daily life ability (P<0.05), and the total effective rate reaches 92%, and no obvious adverse reactions are found.

[0028] Comparative example: The same prescription is prepared by traditional water decoction method (the medicinal materials are not super-micro pulverized, but directly added with water and decocted twice, 1 hour each time). The content of effective components (such as astragaloside, ligustrazine) in the preparation prepared by the super-micro powder water extraction process of the application is compared with that in the preparation prepared by the traditional water decoction method. High performance liquid chromatography (HPLC) is used for determination, and the results show that the content of effective components in the preparation prepared by the process of the application is significantly higher than that in the preparation prepared by the traditional water decoction method, which confirms the superiority of the process of the application.

[0029] Working principle of the application: In use, Huangqi is used to tonify primordial qi and benefit qi and move blood; Yulangsan and Jiulongteng are used to relax the tendons and collaterals; Xiatianwu, Chuanxiong, Chishao and Honghua are used to activate blood and resolve stasis; Dilong is used to dredge the channels and collaterals; Guizhi is used to warm and dredge the channels; Shichangpu is used to resolve phlegm and open the orifices; Dengzhanhua is used to dredge the brain collaterals; all of them are used as auxiliary drugs. The whole prescription can tonify qi, activate blood, resolve stasis, dredge collaterals, open orifices and awaken the spirit, which is in line with the core pathogenesis of cerebral vascular disease, i.e. qi deficiency, blood stasis and obstruction of collaterals. It can treat both the symptoms (dredge collaterals and open orifices) and the root cause (tonify qi and activate blood). The super-micro pulverization technology with 600-1000 meshes greatly increases the specific surface area of the medicinal materials, so that the effective components are more easily dissolved. The subsequent steaming and low-temperature drying process is aimed at efficient extraction and maximum retention of volatile and heat-sensitive effective components, which significantly improves the bioavailability and clinical efficacy of the drug.

[0030] Finally, it should be pointed out that the above description is only the preferred embodiments of the application and is not intended to limit the application. Although the application has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments or make equivalent replacements to some technical features, as long as they are within the spirit and principles of the application. Any modification, equivalent replacement, improvement, etc. made shall be included in the protection scope of the application.

Claims

1. A traditional Chinese medicine formula for the prevention and treatment of cerebrovascular diseases, characterized in that, Made from the following raw materials in the indicated weight ratios: 90-110 parts of Yulangsan, 90-110 parts of Jiulongteng, 90-110 parts of Xiatianwu, 90-110 parts of Dilong, 90-110 parts of Huangqi, 50-70 parts of Chuanxiong, 50-70 parts of Guizhi, 50-70 parts of Chishao, 50-70 parts of Honghua, 50-70 parts of Shichangpu, and 50-70 parts of Dengzhanhua.

2. The traditional Chinese medicine formula for the prevention and treatment of cerebrovascular diseases according to claim 1, characterized in that, It is made from the following raw materials in the indicated weight ratios: 100 parts of *Gynostemma pentaphyllum*, 100 parts of *Ipomoea quamoclit ...Earthworm*, 100 parts of *Astragalus membranaceus*, 60 parts of *Ligusticum chuanxiong*, 60 parts of *Cinnamomum cassia*, 60 parts of *Paeonia lactiflora*, 60 parts of *Carthamus tinctorius*, 60 parts of *Acorus tatarinowii*, and 60 parts of *Erigeron breviscapus*.

3. A process for preparing the traditional Chinese medicine formula as described in claim 1 or 2, characterized in that, Includes the following steps: S1: Ultrafine grinding: The raw materials in the proportions described in claim 1 or 2 are mixed and ultrafinely ground to obtain ultrafine powder of 600-1000 mesh; S2: Mixing and water extraction: Add purified water to the ultrafine powder obtained in step S1. The mass-volume ratio (g:ml) of ultrafine powder to water is 1:1 ~ 1:1.

5. After mixing evenly, heat and cook, keeping it boiling for 20-40 minutes. S3: Drying and shaping: The mixture after cooking in step S2 is dried at a temperature not exceeding 60°C, and then made into pills or granules.

4. A traditional Chinese medicine formula for the prevention and treatment of cerebrovascular diseases according to claim 3, characterized in that, The heating and steaming time in step S2 is 30 minutes.

5. A traditional Chinese medicine formula for the prevention and treatment of cerebrovascular diseases according to claim 3, characterized in that, The mass-volume ratio (g:ml) of the ultrafine powder to water in step (2) is 1:1.

16.

6. A traditional Chinese medicine preparation, characterized in that, It is prepared by the preparation process described in any one of claims 3 to 5.

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