332 results about "Baicalein" patented technology

This is a kind of baicalin total flavones glucoside distillation, baicalin monomer flavones glucoside and its preparation method and application, belonging to the Chinese native medicine drugs manufacturing technology field. The invention obtains the baical in total flavones glucoside distillation mainly containing biacalein, or baical in flavones glucoside monomer compound mainly containing biacalein or wogonoside or oroxylin; comminute baixcal, add water, have alcoholysis reaction at 41 -46 Deg. C, the baialinase and baicalin flavones glucoside naturally existing in baixcal directly have alcoholysis reaction without distillation and separation. The pharmacy preparation includes various pharmacy preparations comprised of officinal auxiliary materials with baicalin total flavones glucoside distillation or monomer flavones glucoside as pharmacy active components, and are used to prepare drugs for curing liver diseases and AIDS. The reaction condition of the invention is mild, and it has high distilling rate, good product quality, low energy waste simple craft, no pollution and low production cost.

The invention relates to the technical field of preparation of extracting agents and deep-eutectic solvents, and relates to application of an extracting agent and a deep-eutectic solvent in determining of effective ingredients in traditional Chinese medicine, in particular to application in determining of flavonoid ingredient in radix scutellariae, and application of an extracting agent and a deep-eutectic solvent in determining of effective ingredients of baicalin, baicalein, wogonoside, wogonin and scutellarin in radix scutellariae. The application is characterized in that the radix scutellariae is used as the raw material, the deep-eutectic solvent, especially choline deep-eutectic solvent, is used as the extracting agent, the water is used as a thinner for reducing the system viscosity, and the flavonoid compound is forcibly extracted under the ultrasonic condition. An extracting method has the advantages that the extracting efficiency of the flavonoid ingredient is higher, the extracting conditions are moderate, and the operation is simple and convenient. The extracting agent has the characteristics of no burning explosion and volatizing, small loss, low energy consumption andthe like. The extracting method is also suitable for extracting the flavonoid-containing traditional Chinese medicines, such as radix astragali seu hedysari, liquorice root, radix puerariae and radixsophorae flavescentis.

The invention relates to a natural environmental friendly dynamic disinfectant, which is characterized by comprising the following materials: patchouli oil, artemisia vulgaris oil, nepeta oil, rosemary oil, clove oil, lavender oil, eucalyptus oil, pine needle oil, ginger oil, tea tree oil, ethanol, houttuynia, pasqueflower, rush, diethyl fumarate, baicalein, alliin and nano-silver. The disinfectant is prepared by the following steps: weighing materials by weight percent; fine grinding houttuynia, pasqueflower and rush to 20-100nm grade; distilling all materials after mixing and adding them into a distiller; then crystalling by cooling after inputting the materials into cooling pot. According to the invention, the disinfectant can realize continuous dynamic bacteriostasis in crowded public places and prevent cross infection. Besides, the disinfectant can completely volatilize without any residues, which solves the problem that traditional disinfection solutions generate corrosive goods and pollute products and has no secondary pollution.

A powder injection for treating upper respiratory tract infection, acute tonsillitis, and pharyngitis is prepared from the honeysuckle flower's extract whose main component is chlorogenic acid, baicalein and water-soluble additive for injection. Its advantages are high curative effect and stability, and long storage time.

The invention discloses baical skullcap tea and a preparation method thereof, which aims at solving common problems, for example, baical skullcap leaves can not be utilized. The baical skullcap tea is prepared from the baical skullcap leaves, wherein the baical skullcap leaves are 4-month to 6-month baical skullcap tender buds. The baical skullcap tea is a pure natural drink, is quietly elegant and tasty and is suitable for both young and old people. The baical skullcap tea not only cleanses the palate and quenches thirsty, but also protects health and nourishes life. Assay results show that the baical skullcap tea contains abundant effective ingredients of baical skullcap alkali, baicalein, benzoic acid, flavone and the like. Drinking the baical skullcap tea frequently can enhance immunity and defer senility.

The invention relates to a pharmaceutical composition having alpha-glucosidase inhibition activity, wherein the pharmaceutical composition comprises a flavone compound and an alpha-glucosidase inhibitor, the flavone compound is at least one selected from a monomer such as baicalein, quercetin, luteolin, baicalein-7-O-glucoside and catechin, an organic salt of the monomer, and an inorganic salt of the monomer, and the alpha-glucosidase inhibitor is at least one selected from a monomer such as acarbose, voglibose and miglitol, an organic salt of the monomer, and an inorganic salt of the monomer. According to the present invention, the pharmaceutical composition can effectively reduce postprandial blood glucose, can inhibit the activity of alpha-glucosidase adopting starch, maltose and sucrose as substrates, and less uses the alpha-glucosidase inhibitor, such that the efficacy can be improved, the side effect of the alpha-glucosidase inhibitor can be effectively reduced, and hypoglycemia and other problems easily caused by drug combination are effectively solved.

The invention discloses a method preparing baicalein. In the method, 3,4,5-trimethoxyphenol serving as a starting raw material undergoes four steps to obtain the high-purity baicalein, and in particular, the method comprises the following steps of: 1) in the presence of lewis acid, performing acylation of the 3,4,5-trimethoxyphenol and an acetylation reagent to form an ester, and obtaining a compound II due to the rearrangement of phenolic ester; 2) under an alkaline condition, performing chalcone cyclization of the compound II and benzaldehyde to obtain a compound III; 3) in the presence of a catalyst, performing the cyclization reaction of the compound III to obtain a compound IV; and 4) under conditions of oxygen separation and acid, heating the compound IV to remove methoxyl groups to obtain the target compound I. The method has the advantages of rich raw materials, high yield, good purity quality of products, simple process, low cost and wide application prospect.

The present invention relates to medicine technology and is especially new use of baicalein, which is one kind of effective components extracted from skullcap root and has been used in treating various kinds of inflammation, as antifungal medicine synergist. Baicalein is added into antifungal pyrrole medicine in the added amount of 4-16 mcg/ml. Experiments show that adding baicalein into antifungal medicine of fluconazole, ketocanazole, miconazole, etc can ensure the treating effect on fungal inflection and resist the drug tolerance of drug resisting fungi, so that baicalein may be used as the synergist of antifungal medicine.

The present invention provides a compound emodin baicalein injection for curing acute pancreatitis and its preparation method. Said invention adopts the combination of ultrasonic wave method and conventional method to respectively extract effective component emodin and baicalein pure products from rhubarb and scutellaria root, then adopts the following steps: adding the emodin and baicalein pure products and required correspondent auxiliary material into hot injection water, using NaOH solution to regulate pH, adding active carbon, heating to foiling, cooling and filtering by using microporous filtration membrane, adding injection water to total quantity, filling and sterilizing for 30 min at 115 deg.C so as to obtain the injection, cold-storing said injection for 1 week, filtering, filling and freeze-drying, sealing so as to obtain the freeze-dried powder injection finished product.

The invention discloses a method for extracting scutellaria baiculensis total flavonoid by graphene oxide-ethanol synergy, which is a method for extracting total flavonoid from scutellaria baiculensis drugs by using grapheme oxide serving as a catalyst and synergized with ethanol water solution. When scutellaria baiculensis total flavonoid is extracted by adopting the method, the yield of scutellaria baiculensis total flavonoid in the product is 20-25 percent, the content is 40-70 percent, wherein the yield of baicalein is 7-14 percent, and the content is 10-20 percent, so that the content of baicalein in the product is greatly increased while the yield of total flavonoid and content are increased. According to the method, the extraction rate of the total flavonoid can be 96 percent in primary extraction by the method, the drug is not needed to be extracted for multiple times, and the process is simple. Furthermore, the graphene oxide is adopted as a catalyst, the extraction process is green and environment-friendly, other separations are not needed after extraction, and the problems of high extraction temperature, low extraction rate, equipment corrosion, wastewater pollution and high production cost in the catalytic extraction process by using inorganic acid can be solved.

The invention discloses a method for compounding a novel baicalein derivative as shown in a formula I, wherein R can be H, hydroxyl, alkyl, alkoxy, nitro and the like. By modifying a baicalein B-ring skeleton, the baicalein derivative which has greatly-improved dissolubility and anticancer activity and the like compared with baicalein is compounded. In the method, the B-ring substituted baicalein derivative is prepared by using benzaldehyde or substituted benzaldehyde and 3,4,5-trimethoxy-phenol as basic raw materials through four steps. The method comprises the detailed steps: the benzaldehyde or the substituted benzaldehyde is subjected to a condensation reaction with anhydride under the action of a basic catalyst to obtain substituted cinnamylate; the substituted cinnamylate is subjected to a halogenating reaction under the action of a catalyst to obtain substituted cinnamoyl chloride; the substituted cinnamoyl chloride is subjected to an acylation reaction with the 3,4,5-trimethoxy-phenol under the action of a catalyst to obtain a chalcone compound; and the chalcone compound is subjected to a ring-closure reaction under the action of a catalyst to obtain the baicalein derivative. The method has the advantages of simple process, rich raw materials, high yield, good product purity and low cost, and has broad application prospect. The formula I is shown in the specification.

The invention provides a method for simultaneously separating wogonin and baicalein monomers from scutellaria baicalensis. The method comprises the steps of crushing a scutellaria baicalensis medicinal material, adding a proper amount of water and edible enzyme to carry out enzymolysis, supercritically extracting the medicinal material subjected to the enzymolysis, fractionally collecting the medicinal material by using an entrainer, and re-crystallizing to respectively obtain baicalein and wogonin. By using the method, baicalein compound monomers can be simultaneously extracted from the scutellaria baicalensis medicinal material, the yield is increased by over 3 times than the yield of wogonin and baicalein monomers obtained by using a direct separation method, and the purities of the prepared wogonin and baicalein monomers are both over 98%; moreover, the method is simple and convenient in flow, environment-friendly, very important in production practical significance, and suitable for large-scale industrial production.

The invention relates to a botanical pesticide. The botanical pesticide is prepared from the following raw materials in parts by weight: 10-20 parts of tobacco leaf extract, 1-5 parts of baicalein, 0.5-2 parts of garlic oil, 2-6 parts of sophocarpidine, 1-5 parts of starch, 4-30 parts of onion, 1-15 parts of pepper seed extract and 2-6 parts of dogwood seed extract. The botanical pesticide is prepared by use of the plant raw materials as the major materials; the adopted raw materials are proportioned simply, and the botanical pesticide is environment-friendly and low in cost.

The invention relates to the technical field of biological medicine, and discloses an NMN (Beta-Nicotinamide Mononucleotide) beneficial bacterium health composition and a preparation method and application thereof. The composition comprises in parts by weight: 20 to 40 parts of NMN, 10 to 15 parts of beneficial bacterium powder, 0 to 8 parts of betaine, 0 to 5 parts of grape seed extract, 0 to 5 parts of baicalein, 0 to 5 parts of apigenin, 0 to 8 parts of astaxanthin, 0 to 8 parts of ginsenoside, and 0 to 8 parts of ganoderma lucidum polysaccharide (GLP); beneficial bacteria in the NMN beneficial bacterium health composition prepared by the invention can effectively improve the microecology of intestinal floras of a user, not only can improve the metabolic syndrome caused by the intestinal floras of the user, but also can improve the intestinal absorption efficiency, and is beneficial to the absorption of the NMN in the intestinal tract; the ginsenoside and the GLP are mainly matchedto improve the immunity of the user, so that the user can better adapt to various changes of the metabolic pathway level, which are caused by the case that the NAD + level is improved after the NMN enters the human body, and the organism has higher buffering capacity on the changes; and AMPK activators (the betaine, the baicalein and the apigenin) have a synergistic effect with the NMN, so that the NMN beneficial bacterium health composition is better in effect and has no side effects.

The invention discloses a method for simultaneously extracting baicalin, baicalein and wogonin from scutellaria baicalensis. The method comprises the following steps: extracting scutellaria baicalensis with water and concentrating to obtain a concentrated solution; rinsing the concentrated solution on a macroporous adsorption resin column till the solution is colorless, and then respectively eluting by using 60-70vol% ethyl alcohol and 75-80vol% ethyl alcohol and collecting eluants respectively; concentrating the eluant containing baicalin under reduced pressure, regulating pH, preserving the heat, standing, filtering to obtain pure baicalin; and evaporating the eluant containing baicalein and wogonin to dryness, eluting with methyl alcohol on a gel column, collecting baicalein fraction and wogonin fraction, and removing methyl alcohol out of the fractions to obtain pure baicalein and pure wogonin. The method has the advantages that the extraction rate is high, the loss of active ingredients is reduced and the resource utilization rate of scutellaria baicalensis is improved.

The invention relates to a method for preparing anti-virus and anti-bacterial inflammatory medicine baicalein. According to the method, phenol serves as a starting material, and a key chalcone intermediate is prepared through bromination, methoxy substitution, Friedel-crafts acylation and aldol condensation; the key intermediate is subjected to oxidative cyclisation and methyl removal reaction, and high-purity baicalein can be prepared. According to the new method, adopted raw reagents are cheap and easy to obtain, the number of synthesis steps is small, reaction operation is easy and convenient, production control is easy, the product yield is high, purity is good, and the method is suitable for production and application of baicalein.

The present invention is directed to analogs of baicalein according to formula (I): where R⁵ is H, (C₁-C₁₂)alkyl, (C₂-C₁₃)acyl, or an optionally substituted phenyl or benzyl group, an acyl group, a C₁-C₂₀ alkyl or ether group, a phosphate, diphosphate, triphosphate or phosphodiester group; R⁶ and R⁷ are each independently H, (C₁-C₁₂)alkyl, (C₂-C₁₃)acyl, or an optionally substituted phenyl or benzyl or together form a —OCR¹R²O— group wherein each of R¹ and R² is independently H, a C₁-C₃ alkyl group or an optionally substituted phenyl or benzyl group; and R⁸ is H, OH, an O-acyl group, a C₁,-C₄ alkyl or alkoxy group, F, Cl, Br or I, or a pharmaceutically acceptable salt thereof, which exhibit anti-P-glycoprotein activity and methods of enhancing the bioavailability of active compounds, especially orally administered compounds, by inhibition of P-glycoprotein 170 (P-gp 170) and/or CYP450 enzyme, especially CYP450 3A4 enzyme. Pharmaceutical compositions based upon these novel derivatives according to the present invention are also described herein.

The invention relates to the medical technology field, and particularly relates to a solid self-microemulsion based on a spherical crystallization technique and a preparation method thereof. The solid self-microemulsion is characterized in that: with the use of the spherical crystallization technique, the solid self-microemulsifying micoparticles are prepared from poorly water soluble drugs in a liquid phase by one step. The solid self-microemulsion with the poorly water soluble drugs comprises the components, by weight: 0.1 to 1.5 g of the poorly water soluble drugs, 4.0 g of a polyoxyethylene hydrogenated castor oil, 2.0 g of capric caprylic triglyceride, 2.0 g of tpropylene glycol, 1.0 ml of ethanol, 4.0 ml of dichloromethane, 0.5 to 1.1 g of ethylcellulose (or Eudragit RS100, RL100), 0.05 g of PEG4000, and 0.5 g of colloidal silicon dioxide. The poorly water soluble drugs include cyclosporine A, fenofibrate, glimepiride, cilnidipine, isradipine, simvastatin, baicalein, neogambogic acid, puerarin, cyclovirobuxine D, silymarin and the like.

The invention discloses new application of scullcapflavone in preparing a medicament for treating enterovirus infection, in particular new application of scullcapflavone in preparing a medicament for treating or preventing a hand-foot-and-mouth disease caused by enterovirus infection. The scullcapflavone comprises an extract of baicalein, baicalin or scutellaria baicalensis general flavone; and the enterovirus indicates a coxsackie virus A group, a coxsackie virus B group, echovirus or enterovirus EV71 which causes the hand-foot-and-mouth disease. The scullcapflavone as an active substance is mixed with a pharmaceutically allowable excipient and made into a preparation which can be accepted by a patient and can be used for treating and preventing the hand-foot-and-mouth disease by injection administration, mucosa administration, oral administration or inhalation and has obvious treating effect and high safety.

The invention discloses a kind of baicalein derivatives and a preparation method and application thereof. Pharmacological tests prove that the compounds have the obvious function of dilating bronchi and can be used to prepare the medicines used for preventing or curing chronic obstructive emphysema caused by bronchial constriction.

The invention discloses a synthetic method for a kind of polysubstituted baicalein derivatives shown as a formula I, and in the formula I, R1, R2 and R3 are H, hydroxyl, alkyl, alkoxy and the like. By modifying baicalein B-ring skeleton, the baicalein derivatives are synthesized, which are substantially improved in dissolvability, anticancer activity and other aspects compared with baicalein. The method employs substituted benzaldehyde and 3,4,5-trimethoxyphenol as basic raw materials, and the B-ring polysubstituted baicalein derivatives are prepared through 3 steps. The method concretely comprises performing condensation reaction on the substituted benzaldehyde and an acid anhydride under the effect of an alkali catalyst, so as to obtain substituted cinnamic acid, and further synthesizing substituted cinnamoyl chloride, performing acylation reaction on the substituted cinnamoyl chloride and 3,4,5-trimethoxyphenolunder the effect of a catalyst, so as to obtain a chalcone compound, and performing cyclization reaction on the chalcone compound under the effect of a catalyst, so as to obtain the corresponding polysubstituted baicalein derivative. The method is simple in technology, abundant in raw materials, high in yield, good in product purity and low in cost, and has wide application prospect.

The invention provides a detection method of a traditional Chinese medicine preparation for preventing infectious bronchitis. The traditional Chinese medicine preparation is prepared from roots of Baikal skullcap, fructus forsythia, cape jasmine fruits, honeysuckle, pogostemon cablin, Chinese thorowax roots and Thunberg fritillary bulb. The quality detection method includes identification and content determination projects. The thin-layer chromatography identification method for seven traditional Chinese medicines is clear in spot, good in repeatability, negative and free from interference, and can serve as a traditional Chinese medicine composition quality control method. A built baicalein content determination method is high in precision and accurate in measuring result, and product quality can be effectively controlled, so that clinical curative effects are ensured.

The invention discloses a traditional Chinese medicine Annao pill and a detection method of preparations prepared from the raw materials in the formula of the Annao pill. The detection method disclosed by the invention comprises identifying and/or content measuring methods, wherein the identifying methods are one or more of methods for identifying cholic acid and hyodeoxycholic acid, identifying rhizoma coptidis, identifying geniposide and identifying baicalein; and the content measuring methods are one or more of methods for measuring contents of geniposide, baicalein, rhizoma coptidis, menthol and borneol. The detection method disclosed by the invention has good linear relation, precision, stability, repeatability and recovery and is of great importance for strictly controlling the quality of the Annao pill and the preparations of the Annao pill.