83 results about "Baicalein" patented technology

The invention belongs to the technical field of nano material synthesis, and particularly relates to baicalein-copper nano microgel as well as a preparation method and application thereof. According to the invention, copper ions and baicalein are coordinated to form nanowires, and the nanowires are coated with hyaluronic acid (HA) to prepare the nano microgel. The method is carried out at normal temperature, is simple in process and high in yield, and does not need toxic solvents; the obtained microgel has high stability (gastric acid resistance), targeted delivery (CD44 receptor mediation) and multiple biological activities (oxidation resistance and inflammation resistance). Animal experiments show that the pharmaceutical composition can significantly relieve ulcerative colitis, the dosage is as low as 5 mg / kg, the pharmaceutical composition is non-toxic, and a new strategy is provided for treatment of inflammatory diseases.

The invention belongs to the technical field of medicines, and discloses a common goldenrop decoction active ingredient composition and application thereof in prevention and treatment of human respiratory syncytial virus. The invention relates to application of an active ingredient composition (isoliquiritigenin, baicalein, 6-shogaol, schisandrin B, ferulic acid and methyl salicylate) of Xiaochaihu decoction and / or a derivative of the active ingredient or a pharmaceutically acceptable salt thereof in preparation of medicines for preventing, relieving and / or treating RSV (Respiratory Syndrome Virus) infectious diseases. According to the invention, by establishing a mouse RSV infection model, the effect and the action mechanism of the composition in preventing and treating RSV infection are evaluated. Results show that each dose group can inhibit replication of RSV in mouse lung tissues, relieve pulmonary edema, improve pathological changes of the lung, inhibit expression of inflammatory factors and improve humoral immunity, and the effect is equivalent to that of ribavirin. The radix bupleuri granules have better effects on relieving pulmonary edema and inhibiting virus proliferation compared with small radix bupleuri granules. The composition of the effective components of the common goldenrop can provide a new drug treatment scheme for clinical RSV infectious diseases.

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for monitoring a baicalein-betaine eutectic process based on terahertz spectroscopy, and the method comprises the following steps: mixing and ball-milling baicalein and betaine to obtain powder samples, collecting the powder samples with different ball-milling times, drying, mixing with a dispersing agent, tabletting, and drying to obtain the baicalein-betaine eutectic crystal. The method comprises the following steps: measuring spectral data by using terahertz time-domain spectroscopy equipment, selecting a characteristic peak and tracking intensity change to obtain a curve, carrying out nonlinear fitting on the curve, obtaining a molecular vibration mode through a density functional theory, and analyzing the eutectic process by combining the two modes. The terahertz spectrum technology is combined with theoretical calculation, complete analysis of the baicalein-betaine eutectic process from macrodynamics monitoring to microcosmic molecular action mechanism analysis is achieved, and an effective means is provided for eutectic formation research and process optimization.

The invention relates to a traditional Chinese medicine composition which comprises more than 1.09 permillage of ephedrine hydrochloride, more than 0.86 permillage of pseudoephedrine hydrochloride, more than 0.17 permillage of peiminine, more than 0.03 permillage of peimine, more than 0.17 permillage of chrysin-7-O-glucuronide, more than 0.002 permillage of glycyrrhetinic acid, more than 11.87 permillage of amygdalin and more than 0.01 permillage of neotuberostemonine. The oral liquid is prepared from more than 2.16 per mill of glycyrrhizic acid, more than 1.97 per mill of oroxylin A, more than 1.97 per mill of oroxylin B, more than 1.23 per mill of liquiritin, more than 0.59 per mill of apiose liquiritin, more than 0.55 per mill of baicalin, more than 0.23 per mill of chlorogenic acid, more than 0.18 per mill of praeruptorin A, more than 0.15 per mill of wild melanosin, more than 0.14 per mill of methyephedrine hydrochloride, more than 0.13 per mill of isoliquiritin, more than 0.13 per mill of neochlorogenic acid and more than 0.13 per mill of cryptochlorogenic acid. The composition is prepared from more than 0.10% of peimine, more than 0.08% of baicalein, more than 0.05% of praeruptorin B, more than 0.04% of praeruptorin C, more than 0.011% of xanthoxylin and more than 0.0006% of formononetin.

This invention belongs to the field of baicalin crystallization technology, and relates to a leaf-shaped baicalin crystal, its preparation method, and its application. The crystal has a leaf-like microstructure with a length ranging from 1 μm to 17 μm; the bulk density of the crystal is 0.1-0.2 g / mL, and the compactness is 0.2-0.4 g / mL. The leaf-shaped baicalin crystals provided by this invention are easy to compress into tablets and have a high surface area / volume ratio, which is beneficial for its adsorption and dissolution in vivo. The preparation process is simple to operate and can directionally prepare leaf-shaped baicalin crystals. The purity of the obtained leaf-shaped baicalin crystals can reach 93% or higher, significantly improving the chemical purity and forming a unique low bulk density physical property.

The application discloses a three-channel fluorescence sensor array based on sulfur quantum dots and a preparation method and detection application thereof. The sensor array is composed of three kinds of sulfur quantum dots, namely C-SQDs, PSS-SQDs and beta-SQDs. When target objects exist, the three kinds of sensing units generate differentiated fluorescence responses, forming a unique "fingerprint map". By using principal component analysis to analyze the response mode, the array can successfully distinguish between structurally similar baicalein, fiscetin, myricetin, quercetin and rutin in a concentration range of 8.0-56 muM. In addition, the array can also perform semi-quantitative analysis on a single flavone compound in a range of 4.0-56 muM, and the first principal component has a good linear relationship with the logarithm of the concentration of the target object.

The application discloses a kind of Baicalein-loaded mPEG-PLGA nanoparticles based on tumor microenvironment and its preparation method and application.The method is: ultrasonic dispersion preparation Baicalein uniform solution;Then mPEG-PLGA is prepared;Emulsion evaporation method is prepared Baicalein-loaded mPEG-PLGA nanoparticles (PMs-Ba);The nanoparticles can be accumulated in tumor site, improve tumor microenvironment, so as to enhance the sensitivity of breast cancer to chemotherapeutic drugs.The method is simple to operate, provides a new idea for traditional Chinese medicine to be used as adjuvant therapy, and the method has great application potential in early cancer clinical treatment.

This invention provides a magnesium baicalein hydrogel with whitening and anti-skin aging effects and its preparation method. The formulation includes magnesium baicalein, sodium hyaluronate, carbomer, propylene glycol, niacinamide, a pH adjuster, and purified water. The hydrogel uses magnesium baicalein as the main active ingredient, overcoming the traditional deficiency of baicalein's poor water solubility and exhibiting good gel phase stability. The magnesium baicalein in the hydrogel can effectively scavenge free radicals and prevent collagen degradation to combat aging; simultaneously, it inhibits tyrosinase, synergistically achieving a dual whitening effect with niacinamide.

The invention discloses a method for extracting and separating baicalin and baicalein, which comprises the following steps: S1, weighing thymol and menthol, adding the thymol and the menthol into a three-neck flask, and heating and stirring to form uniform and transparent liquid as an extracting agent thymol-menthol eutectic solvent; s2, mixing the radix scutellariae powder with a 50% ethanol solution, heating, condensing and refluxing twice to obtain an extracting solution, centrifuging, taking supernate, and concentrating to obtain a radix scutellariae extracting solution. And S3, putting the scutellaria baicalensis extracting solution and an extracting agent into a high-pressure extraction kettle, carrying out pressurized extraction, transferring to a separating funnel, standing for layering, and respectively collecting. And S4, adding water into the lower-layer water phase for dilution, filtering, heating and stirring, standing at low temperature for crystallization, carrying out suction filtration, washing and drying to obtain purified baicalin. And S5, adding ethyl acetate into the upper-layer extraction phase, oscillating and standing, collecting the lower-layer ethyl acetate, adding anhydrous sodium sulfate, filtering, concentrating, adding absolute methanol, standing at low temperature, crystallizing, carrying out suction filtration, washing and drying to obtain purified baicalein. According to the method for extracting and separating the baicalin and the baicalein, the yield and the purity of the baicalin and the baicalein can be improved.

The application belongs to the technical field of biological medicine, and provides application of combined use of tocopherol and mulberroside C in preparation of a drug for treating liver cancer, which is combined use of tocopherol and mulberroside C in preparation of a drug for treating liver cancer. Through in-vitro cell experiments, the growth inhibition effect of tocopherol and mulberroside C on liver cancer cells is evaluated; the results show that tocopherol and mulberroside C can inhibit the growth activity of liver cancer cells to achieve the purpose of treating liver cancer.

This invention discloses a core-shell microneedle with both antibacterial and exudate-absorbing properties, and its preparation method, belonging to the field of microneedle drug delivery systems and acne treatment technology. The microneedle comprises: a core layer containing an exudate-absorbing component for absorbing exudate; and a shell layer covering the core layer, containing a microenvironment-responsive drug delivery unit and antibacterial nanoparticles loaded within the drug delivery unit. The drug delivery unit responds to the microenvironment of the acne lesion by releasing the antibacterial nanoparticles. This invention combines baicalein and surfactant into nanoparticles, loaded into a ROS-responsive shell layer formed by TSPBA and polyvinyl alcohol. Sodium polyglutamate is introduced into the core layer as an exudate-absorbing component. The core-shell microneedle is prepared by a two-step centrifugation method. This invention solves the problems of poor drug permeability, uncontrollable release, and exudate affecting treatment efficacy in traditional acne treatments. It achieves targeted drug release and exudate adsorption synergistic effects on acne lesions, improves drug bioavailability, reduces systemic side effects, and is suitable for the treatment of acne, especially inflammatory and purulent acne.

The present application relates to the technical field of plant extraction, and particularly relates to a process method for jointly preparing baicalein and wogonin, comprising the following steps: (1) crushing the roots of Scutellaria baicalensis Georgi, adding boiling water to extract, and combining the extract; (2) concentrating the extract and adjusting the pH; (3) heating, cooling and adjusting the pH of the concentrated solution to obtain a lysis solution; (4) introducing the lysis solution into a resin column, eluting with purified water and an organic solvent, and concentrating the collected desorption solution; (5) adjusting the pH of the concentrated solution, filtering, drying and crushing the collected first filter cake to obtain a baicalein product; (6) adjusting the pH of the first filtrate and concentrating; (7) cooling, filtering and eluting the concentrated solution, and collecting the second filtrate and second filter cake; (8) adding purified water to the second filter cake to make a pulp, filtering, drying and collecting the third filter cake to obtain a wogonin product; and (9) spray drying the second filtrate to obtain a Scutellaria baicalensis Georgi flavone product. The above process method can simultaneously obtain high-yield baicalein, wogonin and Scutellaria baicalensis Georgi flavone products.

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for simultaneously determining the contents of various components in Shuanling antidiarrheal granules based on a UPLC-QQQ-MS / MS. The contents of 18 components in the Shuanling antidiarrheal granules are simultaneously determined by using an ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometer. The 18 components comprise adenosine, gallic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, liquiritin, ellagic acid, kaempferitrin, narirutin, hesperidin, baicalin, oroxylin A-7-O-beta-D-glucuronide, wogonin, baicalein, wogonin, pachymic acid B and pachymic acid A. The invention further discloses a preparation method of the pharmaceutical composition. Through the UPLC-QTRAP-MS / MS combined technology, the technical prejudice that single component depends on in quality control of the traditional Chinese medicine compound preparation is broken through, the key problems that multiple components in a complex matrix are difficult to separate, low-content components are difficult to detect and the like are solved, efficient, accurate and synchronous determination of 18 components is achieved, and the method is suitable for large-scale popularization and application. A new reference path is opened up for modernized quality control of the traditional Chinese medicine compound preparation.

The present application relates to the technical field of freeze-dried powder, and in particular to a freeze-dried powder composition for hair regeneration and a preparation method thereof. The freeze-dried powder composition comprises 5-15 parts of vascular endothelial growth factor, 3-10 parts of platelet-derived growth factor, 1-5 parts of copper peptide, 0.5-3 parts of acetyl tetrapeptide-3, 2-8 parts of baicalein, 1-5 parts of asiaticoside, 20-40 parts of freeze-drying protectant, and 1-3 parts of nano-silicon dioxide. The preparation method comprises mixing the pretreated vascular endothelial growth factor, platelet-derived growth factor, copper peptide, acetyl tetrapeptide-3, baicalein, and asiaticoside with the freeze-drying protectant and nano-silicon dioxide, and then freeze-drying. The freeze-dried powder composition can promote the growth of hair, improve the microenvironment of the scalp, and provide long-lasting support for the healthy growth of hair. The preparation method improves the stability and biological activity of the active ingredients, and enhances the overall performance and safety of the product.

The present application relates to the technical field of traditional Chinese medicine, and specifically discloses a composition for preventing and treating calf diarrhea, a preparation method and application thereof. The composition for preventing and treating calf diarrhea provided by the present application selects baicalein, forrestimine and traditional Chinese medicine polysaccharide as active ingredients, and the three can produce a synergistic effect, can significantly enhance the inhibitory effect of the composition on bacteria and viruses; at the same time, can also enhance the immunity of the calf by increasing the content of immunoglobulin and cytokine; in addition, can regulate the intestinal flora of the calf, improve the intestinal flora structure, and promote the intestinal health of the calf, thereby effectively preventing and treating the occurrence of calf diarrhea and promoting the health of the calf. The composition provided by the present application effectively prevents and treats calf diarrhea by selecting raw materials with different mechanisms, is not prone to drug resistance, has stable prevention and treatment effect, and has great popularization value.

The invention belongs to the field of feed, and discloses a functional antioxidant which comprises resveratrol, baicalein and taurine. The weight ratio of the resveratrol to the baicalein to the taurine is (100 to 500): (100 to 500): 10000. The functional antioxidant adopts resveratrol, baicalein and taurine as active ingredients, and can comprehensively improve the reproductive performance and lactation performance of sows under the condition of high-temperature stress. In addition, the invention also discloses a related application of the functional antioxidant.

The invention belongs to the technical field of biology and new medicine, and discloses a preparation method of acoustic resonance driven glycyrrhizic acid nano-composite responsive gel, glycyrrhizic acid is used as a drug carrying system, berberine, ursolic acid, baicalein, luteolinin, curcumin, baicalin or ginsenoside Rh2 is used as a water-insoluble natural small molecule drug, and the acoustic resonance driven glycyrrhizic acid nano-composite responsive gel is prepared. Glycyrrhizic acid is an amphiphilic compound composed of one molecule of glycyrrhetinic acid and two molecules of glucuronic acid, a hydrophobic cavity can be formed in a water environment to wrap the water-insoluble natural small molecule medicine, a glycyrrhizic acid nano-composite solution is formed, and meanwhile the solubility of the water-insoluble natural small molecule medicine such as baicalein is improved.

This invention discloses a differentiated fertilization method for Scutellaria baicalensis, belonging to the field of traditional Chinese medicinal herb cultivation technology. This method selects a corresponding ratio from multiple predetermined nitrogen, phosphorus, and potassium fertilizer application ratios based on the accumulation requirements of the target medicinal components, thereby achieving targeted regulation of different medicinal components. The multiple predetermined nitrogen-phosphorus-potassium ratios include a first ratio that increases baicalin, a second ratio that increases baicalein, a third ratio that increases wogonin, and a fourth ratio that increases wogonein. This invention allows for flexible selection of ratios according to production targets, achieving precise regulation of different medicinal components while simultaneously increasing Scutellaria baicalensis yield, and has good prospects for widespread application.

The invention provides a method for co-producing baicalin, baicalein and wogonin from scutellaria baicalensis extraction waste residues, which comprises the following steps: firstly, extracting the waste residues by adopting an ethanol solution, heating an extracting solution, adjusting the pH value, crystallizing to obtain a crude baicalin product, and refluxing and purifying by using ethanol to obtain the baicalin; the method comprises the following steps: respectively adjusting the pH value of mother liquor, concentrating, combining, extracting by using a water-saturated ethyl acetate-n-butyl alcohol mixed solvent, concentrating an extract phase, diluting by using ethanol, heating, adjusting the pH value, and crystallizing to obtain baicalein; and further adjusting the pH value of the residual filtrate, dealcoholizing, concentrating, cooling and crystallizing, and refining the obtained solid to obtain wogonin. According to the method disclosed by the invention, extraction, fractional precipitation and solvent extraction are combined for use, and the process conditions of each stage are optimized, so that high-purity baicalin, baicalein and wogonin are prepared from the scutellaria baicalensis extraction waste residues, and the utilization value of the waste residues is improved.

The invention discloses a functional coating for the surface of an orthopedic implant material as well as a preparation method and application thereof, the coating comprises core-shell structure nanoparticles, copper oxide nanoparticles with the particle size of 200nm are taken as a core, and a compound of polydopamine and baicalein is taken as a shell. The preparation method comprises the following steps: dissolving baicalein in ethanol, dispersing copper oxide nanoparticles in water, mixing to obtain a suspension, adding dopamine hydrochloride, adjusting to alkalinity, and immersing the implant material matrix for reaction. The coating is applied to an orthopedic implant material for preventing and treating periprosthetic infection, and the core-shell structure of the coating can realize continuous release of baicalein and intelligent response release of copper ions in an acidic infection environment, so that the synergistic effect of early-stage antibacterial immune regulation and late-stage enhanced antibacterial is exerted; the compound has multiple functions of long-acting antibiosis, biofilm resistance, promotion of M2 polarization of macrophages and reduction of bone destruction.

The invention belongs to the technical field of animal husbandry epidemic disease prevention and control, and particularly discloses application of scutellaria baicalensis flavone in prevention and treatment of PRRSV (porcine reproductive and respiratory syndrome virus) induced ferroptosis. It is confirmed for the first time that baicalein can play a role in resisting PRRSV by inhibiting ferroptosis in vitro, EC50 is 10.20 [mu] g / mL, a safety window is wide, and the role covers three modes of prevention, co-treatment and treatment; scutellaria baicalensis flavone can improve oxidative stress, iron metabolism disorder and mitochondrial injury of PRRSV (porcine reproductive and respiratory syndrome virus) infected piglet lung tissues in vivo, and the core target is p53. The invention also provides a pig feed containing scutellaria baicalensis flavone / baicalein, and the additive amounts of the scutellaria baicalensis flavone / baicalein are 50-250 mg / kg and 0.1-0.5 g / kg respectively. The invention provides a novel natural traditional Chinese medicine and feed additive for prevention and control of PRRSV, and has the advantages of high safety, definite mechanism, exact in-vivo and in-vitro effects and the like.

The invention provides a method for detecting the contents of multiple index components of a coughing oral liquid, which comprises the following steps of: determining the contents of nine key pharmacodynamic index components, namely ephedrine hydrochloride, pseudoephedrine hydrochloride, apiose liquiritin, isoliquiritin, baicalin, huperzin A glycoside, wogonin, baicalein and wogonin; the detection method has the advantages of simplicity and convenience in operation, high stability, high pertinence and high practicability, can be used as a detection and evaluation method for production and internal quality components of the coughing oral liquid, and has a good market application prospect.

The invention belongs to the technical field of traditional Chinese medicine composite exosomes, and particularly relates to a traditional Chinese medicine exosome composition with hair-growing and hair-loss-preventing functions and hair-growing and hair-loss-preventing essence prepared from the traditional Chinese medicine exosome composition. The composition is prepared from the following raw materials in parts by weight: 5 to 10 parts of resveratrol exosome, 5 to 10 parts of baicalein exosome, 5 to 10 parts of radix polygoni multiflori exosome, 5 to 10 parts of radix angelicae sinensis exosome, 8 to 15 parts of humectant, 0.5 to 1.5 parts of solubilizer, 5 to 10 parts of skin conditioner, 1 to 5 parts of surfactant and 2 to 8 parts of grease. On the basis of the traditional Chinese medicine synergistic hair-growing theory, resveratrol, baicalein, polygonum multiflorum and angelica sinensis exosomes are systematically integrated as main functional components for the first time, a synergistic anti-hair-loss hair-growing essence system is constructed, and the whole-process intervention from anti-inflammation and anti-oxidation to activation of hair follicle regeneration and improvement of scalp microenvironment is achieved; and a more efficient, safer and more targeted technical path is provided for hair growth and hair loss prevention.

The present application relates to a kind of preservative solution for prolonging the in vitro storage period of platelet and its preparation method, containing baicalin 4.50~6.00g, baicalein 3.00~3.40g, sodium citrate 1.50~2.00g, citric acid 0.20~0.50g, glucose 7.90~8.50g per liter of preservative solution, and the remaining component is distilled water.The preservative solution of the present application adds a certain proportion of baicalin and baicalein, and the composition has a synergistic effect on inhibiting platelet activation, protection and inhibition of platelet aggregation, can prolong the in vitro platelet normal temperature storage time, and the normal temperature storage time can reach 16d.

The application discloses a composition for treating radiation enteropathy and application thereof, and belongs to the technical field of biological medicine, and solves the problem that there is no effective treatment drug for radiation enteropathy at present. The composition comprises puerarin, baicalein, berberine and glycyrrhetinic acid. The composition for treating radiation enteropathy can regulate Wnt / beta-catenin, NF-kappa B and Caspase-9 / 3 signal pathways and the like, promote the proliferation of intestinal cells after radiation damage, reduce the inflammation level of intestinal tissues after radiation, reduce the apoptosis of intestinal cells after radiation and the like, improve the radiation damage of intestinal epithelial cells, play an anti-radiation enteropathy role, and has a remarkable effect on treating radiation enteropathy.

The invention relates to the field of molecular pharmacology and biological medicine, and particularly discloses a new application of a natural flavonoid compound baicalein as a catalase direct activator and an application of the natural flavonoid compound baicalein in preparation of drugs for preventing and treating oxidative stress related diseases. The invention proves that baicalein is directly combined with catalase and the thermal stability and hydrolysis resistance of the catalase are enhanced through cell thermal migration experiment (CETSA), drug affinity reaction targeted stability technology (DARTS), molecular docking and other experiments. An enzymatic reaction experiment shows that baicalein can enhance catalase activity in a dose-dependent manner in a concentration range of 5-25 [mu] mol / L, and the efficiency of catalytic decomposition of hydrogen peroxide is improved. A free fatty acid (FFA)-induced hepatocyte lipid accumulation model is adopted for cell experiment, and the result shows that by means of baicalein treatment, the activity of catalase in cells can be enhanced, the content of lipid peroxidation product malondialdehyde (MDA) can be reduced, meanwhile, the level of triglyceride (TG) can be reduced, the effect is reversed by a catalase inhibitor aminotriazole, and the activity of the catalase in the cells can be improved. It is proved that baicalein can remove hydrogen peroxide in cells by activating catalase activity, oxidative stress injury is relieved, and then the process of the non-alcoholic fatty liver disease (NAFLD) is delayed. The invention defines that baicalein can directly activate the activity of catalase, and the baicalein has an important application prospect in preparation of drugs for treating or preventing oxidative stress related diseases such as NAFLD, type 2 diabetes mellitus and neurodegenerative diseases as a natural-source catalase activator.

The invention provides a baicalin carbon dot / silver-based metal organic framework composite material and a drug delivery system. The composite material B-CDs (at) Ag-MOF comprises a silver-based metal organic framework and baicalin carbon dots loaded on the silver-based metal organic framework; the drug delivery system comprises hydrogel and a composite material dispersed in the hydrogel, and the composite material is the B-CDs (at) Ag-MOF. According to the composite material and the drug delivery system provided by the invention, the problems that pure baicalin carbon dots are difficult to release in a controllable manner and the targeting property is insufficient can be solved.

The invention relates to an external pain-relieving composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. A formula of the external pain-relieving composition comprises the following components in parts by weight: 10-20 parts of loquat extract, 10-20 parts of folium artemisiae argyi extract, 0.3-0.5 part of radix sophorae flavescentis extract, 5-10 parts of a composite penetrant and 3-5 parts of fermented organic acid. Wherein the compound penetrating agent is prepared from the following components in parts by weight: 0.5 to 1 part of baicalein-glycyrrhetinic acid nano eutectic crystal, 6 to 10 parts of chemical penetration enhancer, 0.5 to 2 parts of carbomer and 0.1 to 0.3 part of betaine; the composition prepared by the invention has the characteristics of efficient permeability and effective relief of local pain.

This invention belongs to the pharmaceutical field, specifically relating to a composition for enhancing innate immunity and exerting anti-infective effects, and its uses. Specifically, this invention selects ALOX15 enzyme activity inhibitors, including baicalin; compounds that promote ALOX15 transcriptional activity, including aconitine; and compounds that inhibit ALOX15 protein degradation, including forsythoside A / E / I, and combines them in a multi-strategy scientific formulation. Experimental studies have shown that the composition containing ALOX15 enzyme activity inhibitors, ALOX15 transcriptional activity promoters, and ALOX15 protein degradation inhibitors can effectively enhance the body's innate immunity, increase the synthesis and secretion of IFN-β, and exert anti-pathogen infection effects. The composition of this invention can also inhibit the production of pathogen-induced inflammatory factors and has a therapeutic effect on pathogen-induced secondary inflammatory symptoms, showing great promise for clinical application.

The present application relates to viscose fiber technical field, disclose the functional viscose fiber containing traditional Chinese medicine component and its preparation method;The present application is prepared by wrapping baicalin in the inside of gamma-cyclodextrin to obtain cyclodextrin microcapsule containing traditional Chinese medicine component;Through the oxidation of guanosine under the action of 2-iodine acyl benzoic acid to prepare guanosine end-capping agent. With polyethylene glycol as modifier main chain, guanosine end-capping agent successfully grafted guanosine on both ends of polyethylene glycol, then cyclodextrin microcapsule and guanosine end-capping polyethylene glycol are grafted on the polyethylene glycol main chain, and then reacted with diphenyl chlorophosphate to graft on the surface of cyclodextrin microcapsule to prepare a polyethylene glycol modifier containing traditional Chinese medicine component with antibacterial and flame retardant properties;Finally, the amino group in the guanosine molecule at both ends of the polyethylene glycol modifier is reacted with the carboxyl group in the carboxylated viscose fiber to form an amide bond to prepare a functional viscose fiber containing traditional Chinese medicine component.