22 results about "Drug permeability" patented technology

The invention belongs to the technical field of pharmaceutical preparations, and relates to a compound I patch composition, a compound I patch and a preparation method thereof. The patch composition comprises the following components in parts by weight: 0.5-12 parts of a pharmaceutical active component, 10-30 parts of a penetration enhancer, 15-56 parts of a crystal inhibitor and 35-57 parts of an acrylic acid pressure-sensitive adhesive, the patch composition also comprises solvent dimethyl sulfoxide and absolute ethyl alcohol, and the residual quantity of the dimethyl sulfoxide is not less than 2.0%; wherein the active pharmaceutical ingredient is a compound I, and the structural formula of the compound I is shown in the specification. According to the patch composition containing the compound I, the medicine stability is high, medicine crystallization and impurity generation are effectively avoided or reduced, and the patch containing the compound I has higher stability and safety; the patch composition containing the compound I has more appropriate drug permeability, so that the patch containing the compound I has higher drug effectiveness.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine spray for treating rhinitis and a preparation method thereof.The traditional Chinese medicine spray is prepared from flos magnoliae liliflorae, fructus xanthii, herba ephedrae, fructus forsythiae, flos lonicerae, radix angelicae, herba asari, menthol, herba centipedae and herba menthae. Refining to obtain a fluid extract; and mixing the fluid extract with a penetration enhancer consisting of aminoketone and menthol, a sodium hyaluronate mucous membrane repairing agent, a pH regulator, an isoosmotic adjusting agent and a preservative to prepare spray liquid medicine, and finally performing sterile filtration and filling. Through efficient extraction and synergism of composite auxiliary materials, the permeability and bioavailability of the medicine are remarkably improved, and the symptoms such as nasal obstruction and running nose can be quickly relieved; meanwhile, the anti-inflammatory function and the function of actively repairing the damaged nasal mucosa are achieved, and the recurrence rate is reduced from the source; the pH and osmotic pressure of the preparation are precisely adjusted, the use is comfortable, and the quality is stable and controllable.

A self-powered intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs is applied to detection and treatment of skin wound infection and can detect the temperature of a wound and surrounding skin in real time and conduct dosing according to needs. According to the intelligent adhesive bandage, the piezoelectric nanometer generator is combined, mechanical energy generated in the daily activity process of a wearer can be converted into electric energy, and the electric energy is used for driving the whole intelligent adhesive bandage to operate. The two temperature measuring units are used for detecting the temperature of the wound and the surrounding skin at the same time, the temperature difference value serves as a relative index for judging whether the wound is infected or not, and the influence of environmental factors on detection is reduced. A three-electrode structure is adopted, on-demand drug delivery is achieved through iontophoresis, and high drug permeability, dosage controllability and drug delivery uniformity are all considered. After the intelligent adhesive bandage is used for treating a mouse with wound infection for three days, the wound recovery rate of the mouse reaches 90.3%, and the realization of temperature detection and on-demand administration is proved. The intelligent adhesive bandage has a good application prospect in detection and treatment of wound infection.

This invention discloses a core-shell microneedle with both antibacterial and exudate-absorbing properties, and its preparation method, belonging to the field of microneedle drug delivery systems and acne treatment technology. The microneedle comprises: a core layer containing an exudate-absorbing component for absorbing exudate; and a shell layer covering the core layer, containing a microenvironment-responsive drug delivery unit and antibacterial nanoparticles loaded within the drug delivery unit. The drug delivery unit responds to the microenvironment of the acne lesion by releasing the antibacterial nanoparticles. This invention combines baicalein and surfactant into nanoparticles, loaded into a ROS-responsive shell layer formed by TSPBA and polyvinyl alcohol. Sodium polyglutamate is introduced into the core layer as an exudate-absorbing component. The core-shell microneedle is prepared by a two-step centrifugation method. This invention solves the problems of poor drug permeability, uncontrollable release, and exudate affecting treatment efficacy in traditional acne treatments. It achieves targeted drug release and exudate adsorption synergistic effects on acne lesions, improves drug bioavailability, reduces systemic side effects, and is suitable for the treatment of acne, especially inflammatory and purulent acne.

The invention discloses a gel plaster for treating chronic soft tissue injury and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations, the gel plaster comprises a backing material, a covering film, a traditional Chinese medicine extract and a matrix; the traditional Chinese medicine extract is prepared from the following raw medicinal materials: radix angelicae pubescentis, ligusticum wallichii, common vladimiria root, fennel, cinnamon, frankincense, myrrh, radix aconiti preparata, prepared kusnezoff monkshood root, dragon's blood and borneol; the matrix comprises the following components: a humectant, a thickening agent, a framework material, a cross-linking agent, a pH regulator and an adhesive. As a drug delivery carrier, the nano-emulsion gel paste disclosed by the invention greatly improves the drug permeability, increases the absorption capacity, provides an efficient and safe novel transdermal drug delivery scheme for treating chronic soft tissue injury, and solves the problem of low viscosity in a skin application process.

The present application relates to a transdermal patch containing colchicine and a preparation method and use thereof. The transdermal patch comprises a matrix layer, wherein the matrix layer comprises an active ingredient colchicine, a hot melt pressure sensitive adhesive and optionally other pharmaceutically acceptable adjuvants, wherein the content of the colchicine is 0.1% to 5%, the content of the hot melt pressure sensitive adhesive is 1.9% to 99.9%, and the content of the other pharmaceutically acceptable adjuvants is 0% to 98% based on the total weight of the matrix layer. The transdermal patch containing colchicine of the present application has no local irritation during and after application, no gastrointestinal side effects, high patient compliance, strong drug permeability, good therapeutic effect, and can be used for preventing and / or treating gout and / or pericarditis.

The invention discloses application of lipoic acid trisulfide, and belongs to the technical field of medicines. The invention discloses application of lipoic acid trisulfide or salt, isomer and derivative thereof as a drug penetration enhancer or / and an efflux inhibitor. The invention also discloses a medicinal preparation which comprises a medicine penetration enhancer or / and an efflux inhibitor, and the medicine penetration enhancer or / and the efflux inhibitor is lipoic acid trisulfide or salt and isomer thereof. The lipoic acid trisulfide is scientific in design and ingenious in conception, it is found for the first time that the lipoic acid trisulfide or the salt, isomer and derivative thereof not only can improve the drug permeability, but also shows an excellent drug excretion inhibition effect, and has a dual regulation function. As a drug penetration enhancer or / and an excretion inhibitor, the compound can significantly improve the bioavailability of drugs.

The present invention relates to a method using low intensity pulsed ultrasound (LIPUS) in order to improve drug delivery efficiency in a hypoxic tumor microenvironment (TME) of cholangiocarcinoma (CCA), and more specifically, to a method for confirming the drug permeability and cancer cell apoptosis of cholangiocarcinoma through the irradiation of low intensity pulsed ultrasound (LIPUS) under a tumor microenvironment, and a combination regimen, of gemcitabine and cisplatin with low-intensity pulsed ultrasound, for inhibiting cholangiocarcinoma growth. To this end, provided is the method for confirming the drug permeability and cancer cell apoptosis of cholangiocarcinoma through the irradiation of low intensity pulsed ultrasound (LIPUS) under a tumor microenvironment, the method comprising: a step (S100) for administering a drug and a fluorescent material to cholangiocarcinoma (CCA) under a tumor microenvironment; a step (S120) for allowing a predetermined time to elapse; a step (S140) for irradiating the cholangiocarcinoma (CCA) low intensity pulsed ultrasound (LIPUS); a step (S160) for acquiring a 3D image by performing tissue-clearing on the cholangiocarcinoma (CCA); and a step (S180) for confirming the in vivo drug permeability of a drug and a fluorescent material from the 3D image.

The invention discloses a traditional Chinese medicine external application composition prescription and a combined patch for treating lumbago, and the traditional Chinese medicine external application composition prescription comprises the following raw materials by weight: 1-5 parts of garden balsam stem, 0.5-2.5 parts of lycopodium clavatum, 0.5-2.5 parts of Chinese violet, 0.2-2 parts of clematis root, 0.2-2 parts of frankincense, 0.2-2 parts of myrrh, 0.2-2 parts of achyranthes root, 0.2-2 parts of ligusticum wallichii, 0.2-2 parts of cassia twig, 0.2-2 parts of ground beetle, 0.2-2 parts of notopterygium root, and 0.2-2 parts of radix angelicae pubescentis. The traditional Chinese medicine composition is prepared from 0.2-2 parts of radix angelicae sinensis, 0.2-1 part of flos carthami, 0.2-2 parts of radix aconiti preparata, 0.2-2 parts of radix aconiti kusnezoffii preparata, 0.2-2 parts of radix salviae miltiorrhizae, 0.2-2 parts of cortex eucommiae and 0.2-2 parts of radix glycyrrhizae. The medicinal composition provided by the invention is more comprehensive than other similar components for treating lumbago, has the main effects of dispelling wind and eliminating dampness, and promoting blood circulation to remove meridian obstruction, also has the effects of tonifying liver and kidney, and is suitable for arthralgia, soreness and weakness of waist and knees and other symptoms caused by wind-cold damp evil and stagnation of qi and blood stasis. Medicine permeability is improved and accelerated by means of the heating function, blood circulation is promoted, blood stasis is removed, channel warming and cold dispelling are facilitated, meanwhile, traditional Chinese medicine safety is guaranteed to a certain extent through traditional Chinese medicine sterilizing liquid, and allergy is reduced.

The application discloses a hot compress magnetotherapy glove with drug penetration assistance, and belongs to the technical field of arthritis treatment gloves.The hot compress magnetotherapy glove comprises a main body, a hot compress magnetotherapy mechanism is arranged in the main body, the hot compress magnetotherapy mechanism comprises a bracelet controller, one end of the bracelet controller is connected with a peristaltic pump through a wire, one side of the peristaltic pump is connected with a medicine bag through a catheter, both sides of the peristaltic pump are connected with medicine guide tubes, the medicine guide tubes are attached to the inner wall of a glove cavity, and one end of the glove cavity is connected with a finger cavity.The hot compress magnetotherapy glove generates ultrasonic waves of a specific frequency through a regulated micro ultrasonic transducer; the mechanical effect of the ultrasonic waves makes the cell gap of the cutin layer of the skin larger, the thermal effect promotes blood circulation of the skin, the cavitation effect forms micro cavities on the surface of the skin, and the three auxiliary combinations of the neodymium-iron-boron permanent magnet and the heating layer enhance the drug permeability, so that the drug molecules diffuse and absorb to the joint tissue, and the use of the patient is facilitated.

The invention discloses a preparation method of a hyaluronic acid modified lactoferrin nano transmission system, which is specifically implemented according to the following steps: step 1, weighing lactoferrin, dissolving the lactoferrin in water, and stirring on a magnetic stirrer; step 2, weighing paclitaxel, dissolving paclitaxel in an absolute ethyl alcohol solution, slowly adding into the LF solution, magnetically stirring, carrying out ultrasonic emulsification, and then filtering and freeze-drying; step 3, preparing HA-LF (at) PTX; and step 4, carrying out freeze-drying on the prepared HA-LF (at) PTX to obtain HA-LF (at) PTX powder. The invention also discloses application of the lactoferrin nano delivery system prepared by the method in treatment of bladder cancer. According to the invention, the problems of insufficient targeting and poor drug permeability in the existing bladder perfusion therapy are solved.

Microphysiological platforms are configured for measuring kinetic rates relating to drug absorption. These kinetic rates include GI region-specific kinetic rates of drug absorption. The kinetic rates include bioavailability of the drug over time in various tissues. The kinetic rates include drug permeability in various tissues. The kinetic rates include measurements of microbial transformations that occur. The kinetic rates include measured effects of gastric emptying and transit times. The kinetic rates include measurements of fasting and fed states for various tissues.

The present invention relates to a gradient microfluidic chip for drug screening, a drug screening method using same, and a drug screening method for preventing or treating Fabry disease by using same. More specifically, the present invention relates to a gradient microfluidic chip having a structure capable of culturing and differentiating organoids at four constant drug concentration gradients together with continuous medium flow. When the gradient microfluidic chip for drug screening according to the present invention is used, the physiological function of organoids is improved by inducing the vascularization and differentiation of the organoids, thereby enabling reproduction of an organ at a human body level better than existing organoids, nutrients and various concentrations of a drug are smoothly supplied, and drug permeability is increased. Thus, a concentration-dependent therapeutic effect of a drug can be confirmed with high drug sensitivity, and therefore the gradient microfluidic chip enables rapid and effective drug screening.

The invention belongs to the technical field of biological medicines, and particularly relates to a spermidine functionalized Janus hydrogel microneedle system as well as a preparation method and application thereof. The Janus hydrogel microneedle system is composed of a mucous membrane adhesion layer (HTSO hydrogel) and an anti-adhesion layer (GSC hydrogel), the mucous membrane adhesion layer is formed by dynamic Schiff base crosslinking of hyaluronic acid-spermidine conjugate and oxidized dextran loaded with lidocaine, and the anti-adhesion layer is composite hydrogel composed of carboxymethyl chitosan, gelatin and silk fibroin. The Janus hydrogel microneedle system provided by the invention can directly deliver a drug to mucous membrane tissues, so that the permeability of the drug is improved, the compliance of a patient is improved through painless local drug delivery, and the Janus hydrogel microneedle system shows lasting adhesion in an oral environment, effectively inhibits ferroptosis activity and active oxygen, remodels a local immune microenvironment and has a good application prospect. In-vivo angiogenesis and epithelium regeneration are promoted.

The utility model provides an alkaline soil improvement and remediation device, belongs to the technical field of soil improvement, and solves the technical problems that the existing medicine can only be simply discharged to the ground, so that the medicine permeability is poor, and the treatment effect is influenced. An alkaline soil improvement and remediation device comprises a remediation box, a pair of driving wheels are arranged at the bottom of the remediation box, a pair of servo motors are fixed in the bottom of the remediation box, an output shaft of each servo motor is coaxially and fixedly connected with the corresponding driving wheel, a liquid mixing cavity is formed in the remediation box, and a driving disc is rotationally installed in the liquid mixing cavity; a stirring rod is fixed to the disc face of the driving disc, a pair of transmission wheels is arranged at the bottom of the repairing box, and a transmission assembly is arranged in the repairing box. According to the device, the soil can be overturned and loosened in the improvement and remediation process, so that the granular structure of the soil is recovered, and the permeation effect of the soil on drugs and water and the air permeability of the soil are enhanced.

The invention discloses targeted nano-liposomes (SPL NPs) capable of releasing nitric oxide (NO) through ultrasonic triggering and application of the targeted nano-liposomes (SPL NPs) combined with a PD-L1 antibody in pancreatic cancer treatment. The nano-liposome is formed by self-assembly of DSPE-PEG2000-SNO (which is used as a NO prodrug), pyropheophorbide acid (PPAL (which is used as a sound-sensitive agent) and DSPE-PEG2000-LFC131 (which is used as a pancreatic cancer targeting ligand), and has good stability and targeting property. Under an ultrasonic irradiation condition, the nano system can generate active oxygen at a tumor part through the sonodynamic effect of PPAL, and can induce obvious immunogenic cell death. In addition, quick release of NO of an NO prodrug DSPE-PEG2000-SNO at a tumor site can be induced, and peroxynitrite with higher activity is generated through combined action of active oxygen and NO, so that an efficient tumor cell killing effect is realized. Meanwhile, the released NO can effectively release a pancreatic cancer compact matrix, improve the tumor microenvironment and enhance the permeability of drugs and the infiltration capacity of immune cells. The invention also discloses an application of the nano-liposome system in pancreatic cancer treatment.

The present invention relates to a nano-drug delivery system that targets cancer cells in the hypoxic region of tumor microenvironment and a method for preparing same. The novel nano-drug delivery system according to the present invention can capture an extracellular matrix-degrading enzyme and encapsulate an anticancer drug by binding SO3-PEG-amine as a bifunctional ligand to manganese dioxide nanoparticles, thereby significantly improving drug permeability. In addition, through such high drug permeability, cancer cells in the hypoxic region of tumor microenvironment can be effectively killed.

To provide a drug delivery device (1000) having a drug-permeable component and a method for producing and using the same.SOLUTION: A drug delivery device includes a housing (1002) having a first wall structure (1012) and a second wall structure (1014) that are adjacent to each other and together form a tube (1010) defining a drug reservoir lumen (1004). The second wall structure or both the first wall structure and the second wall structure is or are permeable to water, and the first wall structure is impermeable to a drug while the second wall structure is permeable to the drug, such that the drug is releasable in vivo by diffusion through the second wall structure.SELECTED DRAWING: Figure 10A

The invention belongs to the field of biological tissue engineering, and discloses a culture method for promoting testicular tissue structural maturation in vitro and application. The method comprises the following steps: cutting a testicular tissue into blocky fragments with the volume of 0.5-1 mm; a gas-liquid interface culture mode is adopted, the lower portion of a pre-balanced 1.5% sepharose gel cubic support is soaked in a basic culture medium, the upper portion of the pre-balanced 1.5% sepharose gel cubic support makes contact with air, and then tissue blocks are placed on the support; the method comprises the following steps: adding a WNT5A pathway agonist Foxy-5 with the final concentration of 200-400 [mu] M into a basic culture medium containing alpha MEM, 10% KSR and 1% P / S, and continuously culturing for 11 days under the conditions of 34 DEG C and 5% COs. According to the method, a WNT5A signal channel is continuously activated by using Foxy-5 through gas-liquid interface culture, so that the polarity of a supporting cell can be effectively maintained, and the integrity of a blood-testis barrier (BTB) and the morphology regularization of a seminiferous tubule are promoted. According to the invention, a standardized and repeatable testicular tissue in-vitro maturation platform is established, and the method can be used for research in fields related to reproductive toxicity evaluation, drug permeability test and spermatogenesis microenvironment.

The invention provides an umbilicus application suppository for treating dysmenorrhea and a preparation method thereof, and relates to the technical field of medicines.The umbilicus application suppository for treating dysmenorrhea comprises a suppository body, and the suppository body comprises a suppository matrix, an emulsified oil phase, an emulsified water phase, an emulsifier and a traditional Chinese medicine composition, the traditional Chinese medicine composition comprises astragalus membranaceus, ginseng, angelica sinensis, radix paeoniae alba, cassia twig, rhizoma zingiberis, fructus cnidii, herba epimedii, salvia miltiorrhiza, leonurus, ligusticum wallichii and curcuma zedoary. By designing the suppository containing the specific traditional Chinese medicine composition and the emulsification system, the medicine permeability and bioavailability can be effectively improved, so that acute pain attack is rapidly relieved, the skin allergy risk is reduced, long-acting conditioning is performed on dysmenorrhea roots such as cold in uterus and blood stasis, and the curative effect is good. The traditional Chinese medicine composition has the advantages of quickly relieving dysmenorrhea symptoms, improving medicine permeability, reducing skin irritation response and comprehensively conditioning dysmenorrhea pathogenesis.

The invention discloses a skin compatibility evaluation model of an acupoint application preparation and an allergy early warning method. An optical coherence tomography unit generates a skin depth reflection profile (d) (d is depth, and the unit is [mu] m); according to the multi-dimensional dynamic evaluation, comprehensive quantitative analysis of the skin barrier function, the drug permeability and the inflammation degree is achieved by integrating skin optical characteristics (such as reflectivity changes and epidermal structures) and biochemical indexes (such as inflammatory factors). Compared with a traditional method depending on single symptom observation (such as erythema and edema), the method has the advantage that the recognition sensitivity to early allergy signs is remarkably improved. Non-invasive real-time monitoring is achieved, the optical imaging technology is adopted, skin data can be obtained in real time in the application process, trauma of traditional biopsy or patch tests is avoided, and the device is particularly suitable for sensitive crowds such as children and the old.