70 results about "Drug permeability" patented technology

The present invention is directed to polymeric materials made of biodegradable, bioabsorbable triblock copolymers and implantable devices (e.g., drug-delivery stents) containing such polymeric materials. The polymeric materials may also contain at least one therapeutic substance. The polymeric materials are formulated so as to improve the mechanical and adhesion properties, degradation, biocompatibility and drug permeability of such materials and, thus, implantable devices formed of such materials.

The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.

The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and / or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and / or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.

The present invention provides a drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption / adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule (10) according to the present invention includes a container body (11), a fusion-bonded portion (13) which seals a mouth (12) of the container body, and a wrench-off holder tab (14) connected to the fusion-bonded portion. The ampoule (10) is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption / adsorption preventing capability. That is, the parison is extruded from a multilayer blow forming die, and then held between lower split mold pieces to be formed into the container body (11). After a drug solution (15) is filled in the container body (11), the mouth (12) is held between upper split mold pieces to form the fusion-bonded portion (13) and the holder tab (14). Thus, the plastic ampoule is provided.

Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

The invention relates to a micro-fluidic chip, which is applicable to researches on blood brain barrier drug permeability and high-throughput screening. The chip is prepared from elastic polydimethylsiloxane by virtue of a molding method. The chip, which is of a three-layer structure, comprises an array of nine groups of parallel micro-reaction units, wherein each of the micro-reaction units is composed of an upper cell culture chamber layer, a lower cell culture chamber layer and a microporous membrane layer, and each of the micro-reaction units comprises a chip micro-electrode and a fluid circulating pipeline. By continuously injecting a culture solution to the cell culture chambers, a fluid state in blood vessels can be simulated, so that a fluid environment is closer to a real internal environment of human body. By virtue of the chip micro-electrodes, electrical impedance signals are collected, and the physiological activity situations of the cell layers in the chip are monitored in real time. Drug molecules, which penetrate through the microporous membranes and the cell layers, deposit in the fluid circulating pipeline on the lower part of the chip and are eluted by virtue of the pipeline, and then membrane-permeable drugs can be collected for subsequent analysis. The micro-fluidic chip disclosed by the invention, compared with an existing method, can reflect blood brain barrier permeability of drugs, and the micro-fluidic chip can conduct high-throughput screening on nine drugs in a targeted mode in one time.

The invention discloses a compound pour point-depressing viscosity reducer for high pour-point crude oil and a preparation method thereof. Through multiple dissolution compounding of xylene, EVA, dodecylbenzene sulfonic acid, triethanolamine, polyether BCH-11, a lignin ampholytic surfactant and polyether TEF3232, the light brown compound pour point-depressing viscosity reducer is obtained. The compound pour point-depressing viscosity reducer has good drug permeability, large magnitude of pour point depression and a high pour point depression rate, realizes ideal paraffin inhibition effects on different water-containing oil wells, produces multiple effects, prolongs a paraffin removal period, has good adaptability, guarantees normal production of an oil well under various working conditions and well solves the problem that the oil well produced oil has a high pour-point and large viscosity and is conveyed difficultly. At an agent use concentration of 100mg / L, before agent addition, crude oil viscosity is 15836mpa. s at a temperature of 18 DEG C and after agent addition, crude oil viscosity is reduced to 120-208mpa. s at a temperature of 18 DEG C.

A process for preparing antalgic thermotherapeutic medicine includes preparing ointment, preparing heat-generating bag, and shaping. Its advantages are durable and stable heating (42-55 deg.C for 15 hr), small size, high medicine osmosis and high curative effect.

The invention relates to the technical field of sewage purification treatment, in particular to a sewage purification tank. The sewage purification box includes a box body, a water inlet pipe arranged on the top of the box body, a water outlet pipe arranged on the lower side of the box body, and a recovery box located outside the box body. It is characterized in that: the inside of the box body is provided with a guide , the deflector is evenly provided with a number of tapered diversion holes, the box is also provided with a drug injection pipeline and a drug infiltration pipeline connected with the injection pipeline, and the drug infiltration pipeline is arranged at In the inside of the box, the drug seepage pipeline is provided with a plurality of drug outlet holes, which are located between the deflector and the drug seepage pipeline. On the side wall of the box body, there are sewage outlet I and sewage outlet II, which are connected with the sewage outlet. The first pipeline communicating with I and the second pipeline communicating with sewage outlet II are respectively connected to the recovery box, and a filtering device is also provided on the box body between the deflector and the drug seeping pipeline. The sewage purification box designed by the invention has a simple structure, does not need to be disassembled when cleaning the filter screen, and is convenient to use.

The present invention is directed to polymeric materials made of biodegradable, bioabsorbable triblock copolymers and implantable devices (e.g., drug-delivery stents) containing such polymeric materials. The polymeric materials may also contain at least one therapeutic substance. The polymeric materials are formulated so as to improve the mechanical and adhesion properties, degradation, biocompatibility and drug permeability of such materials and, thus, implantable devices formed of such materials.

The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption / by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and / or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and / or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.

The invention discloses a grinding and decocting device for quick decoction of traditional Chinese medicine. The grinding and decocting device for quick decoction of the traditional Chinese medicine comprises a box body, a grinding barrel, a filtering box and a medicine storage box. The grinding barrel is arranged in the box body, a grinding plate is arranged at the bottom of an inner cavity of the grinding barrel, and a plurality of medicine-percolating holes are uniformly arranged on the grinding plate. A plurality of protrusions are uniformly arranged on the top end of the grinding plate, agrinding disk matched with the protrusions is arranged above the grinding plate, the top end of the grinding disk is fixedly connected with a rotating shaft, and the top end of the rotating shaft sequentially passes through the top wall of the grinding barrel and the top wall of the box body and is fixedly connected with a medicine adding hopper. A plurality of supporting legs are evenly arrangedat the bottom end of the box body; the bottom ends of the supporting legs are fixedly connected with a supporting plate and the medicine storage box is arranged on the supporting plate. According tothe grinding and decocting device for quick decoction of the traditional Chinese medicine, the grinding plate and the grinding disk are cooperated with each other, so that the traditional Chinese medicine material is completely ground into medicine powder, most of the medicine effect is exerted in the decocting process of the medicine and the utilization efficiency of the medicine is greatly improved. The medicine residue in the liquid medicine is completely filtered out by the double-layer filtration of a filtering cartridge and a filtering cloth layer, and patients are convenient to take themedicine.

The invention discloses a traditional Chinese medicine ointment for treating hyperosteogeny and a preparation method of the traditional Chinese medicine ointment and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine ointment for treating hyperosteogeny is prepared from the following raw materials in parts by weight: 1-2 parts of musk, 5-10 parts of dragon blood, 5-10 parts of saffron crocus and 10-20 parts of chicken oil. The preparation method comprises the following steps of: (1) preparing materials; (2) grinding and crushing; respectively grinding and crushing the three raw materials, i.e., the musk, the dragon blood and the saffron crocus, wherein the musk, the dragon blood and the saffron crocus are weighted according to weights, and the thickness is smaller than or equal to 60 meshes; and (3) preparing: heating the chicken oil to be in a boiling state, adding the ground musk, dragon blood and saffron crocus, uniformly stirring the musk, the dragon blood and the saffron crocus to form paste, and then, holding fire and naturally cooling. According to the formula, the muskone is used as a guiding medicine and matched with the other three traditional Chinese medicines to prepare the traditional Chinese medicine ointment which is strong in permeability and capable of rapidly penetrating bone joint barriers and deep tissues, softening and eliminating spurs, eliminating aseptic inflammation, preventing hyperosteogeny from developing and worsening, maintaining bone and dredging the channel as well as solving the problem that a common medicine is slow in taking effects and cures the symptoms but not the diseases.

An in vitro high-throughput screening method that models the absorption of drugs across the epithelial mucosa is provided. The invention discloses an in vitro mucin immobilized chromatography model to estimate drug permeability coefficients. The invention describes compositions for mucin immobilized chromatography media and methods to prepare this media. The invention also discloses a method to estimate in vitro drug permeability coefficients using mucin immobilized chromatography media. The invention also discloses methods to determine absorption processes in the digestive system and discloses methods of use for mucin chromatography media in column, batch, assay, diagnostic, or high-throughput screening analyses.

The invention relates to a healthcare thermal therapy instrument. The healthcare thermal therapy instrument comprises a handle and a thermal therapy device installed at one end of the handle; the thermal therapy device comprises a liquid medicine installing chamber, a power driving chamber, a massage head installing seat and a massage head. Different from the prior art, the thermal therapy instrument is composed of the handle and the thermal therapy device and is simple in structure, low in cost, and convenient to carry and operate in a handheld mode; liquid medicine is sprayed out of liquid spray holes of the massage head in the form of spray after being heated by a constant temperature thermal radiation element and heating tubes and cooperates with vibration therapy, magnet therapy and constant temperature thermal radiation of the massage head, so that the medicine permeability is obviously improved to achieve a better healthcare therapy effect.

Disclosed is drug delivery system for effectively administering a drug into a human or animal body tissue. The microjet drug delivery system includes (a) a microjet injector including: a pressure chamber partially sealed by an elastic membrane and containing a pressure-inducing liquid fluid-tightly filled therein; and a drug chamber adjacent to the pressure chamber, wherein the elastic membrane is disposed between the pressure and drug chambers, wherein the drug solution is contained in the drug chamber, wherein the drug chamber has a micro-nozzle partially defined in a wall thereof for ejecting the drug solution out of the drug chamber; (b) a laser generator for generating a laser beam and emitting the laser beam out of the laser generator, wherein the laser generator is configured by irradiating the laser beam into the pressure-inducing liquid in the microjet injector, thereby generating a bubble in the pressure-inducing liquid; and (c) a fractional laser filter module configured for splitting the laser beam incident from the laser generator into a plurality of fractional laser beams, each beam has a reduced diameter, and for irradiating the fractional laser beams. According to the microjet drug delivery system, the pre-ablating of the skin with the fractional laser beams to partially remove the stratum corneum may enable the drug microjet based injection to allow the drug to be effectively invaded into a skin tissue at the portion where the stratum corneum is partially removed and relatively softened.

The invention relates to a novel method for inducing Chinese mitten crab triploids. The method includes the following steps of seawater domestication of parent crabs, marking of the parent crabs, determination of a drug-induced start moment based on morphological markers, determination and application of KCI inducing optimal parameters and taking of drug permeability increasing measures. By the adoption of the steps of limitation of seawater domestication time, marking of the parent crabs, determination of the drug-induced start moment based on the morphological markers, taking of the drug permeability increasing measures and the like, stability and effectiveness of inducing the Chinese mitten crab triploids are obviously improved, and a technical support is provided for Chinese mitten crab triploid seed large-scale cultivation.

There is provided an assembly and process for its preparation for predicting the permeability of chemical compounds, comprising a donor compartment for adding a composition comprising the compound; a barrier based on a support and a phospholipid layer adhering to the support; and an acceptor compartment for accepting the compound upon permeation of the barrier.

The invention discloses a reagent for preventing and curing apple-tree valsa canker. The reagent is prepared from, by weight, 6-8 parts of dandelion extract, 8-15 parts of radix aconiti kusnezoffii, 8-12 parts of perilla frutescens leaves, 28-35 parts of cortex magnoliae officinalis, 2-4 parts of tuba roots, 12-18 parts of wrinkled gianthyssop herbs and 25-30 parts of pine needles. Compared with the prior art, the reagent has the advantages that the raw materials are all plant materials, antibiotics are not contained, the reagent is applied directly in the injection mode or the fertilization mode, and medicine losses caused by poor medicine permeability can be avoided; the medicine acts inside a trunk, pathogenic bacteria of apple-tree valsa canker can be killed, and fungi diseases such as apple valsa canker are prevented.

The present invention provides a method for determining drug permeability, wherein the method comprises, for each reference drug of at least two reference drugs having (i) the same ionization state at a given pH and (ii) a known drug permeability determined by the same drug permeability testing technique, the calculation of a metric related to retention time of each reference compound eluted from a liquid chromatography column having an immobilized artificial membrane functional group. Then, based on each metric and each known drug permeability, drug permeability is expressed as a function of the metric. The method may further comprise the calculation of the metric related to retention time for a further drug eluted from the liquid chromatography column, the further drug having the same ionization state at the given pH and an unknown drug permeability, and an assessment of drug permeability for the further drug, based on the metric for the further drug and the function.

The invention belongs to the technical field of medicines and relates to a liniment for treating vitiligo and a preparation method of the liniment. The liniment is prepared from betamethasone acetate,low molecular sodium hyaluronate, dimethyl sulfoxide, a penetrant aid, a coloring agent and a solvent. According to the liniment, good drug permeability and pigment retention are realized through a special penetration promoter, treatment of vitiligo and white spot covering of skin damage parts are completed simultaneously, betamethasone acetate and tacrolimus are used together, and the synergistic interaction function is realized. The preparation process of the liniment is simple, the liniment is easy to produce and operate and convenient to use and has small side effects, and the drug compliance of patients is notably improved.

Disclosed is a solventless silicone pressure sensitive adhesive, comprising: 100 parts by mass of a polydimethylsiloxane having an alkenyl group as an end group; 1 to 300 parts by mass of a polydimethylsiloxane having a hydroxyl group as an end group; 1 to 50 parts by mass of MQ resin; 1 to 30 parts by mass of polyisobutylene, 20 to 200 parts by mass of a diluent; 0.1 to 5 parts by mass of a crosslinking agent and a platinum catalyst capable of solidifying the silicone pressure sensitive adhesive. Also disclosed is a preparation method for the silicone pressure sensitive adhesive. The silicone pressure sensitive adhesive disclosed has the characteristics of good initial tackiness, long effectiveness, suitable peel-off strength and good drug permeability, is non-toxic and environmentally-friendly, is capable of repeated use, can be made into pressure sensitive adhesive tapes, pressure sensitive adhesive strips for medical use, as well as other functional materials where such pressure sensitive properties are required.

The invention discloses a size-variable intelligent drug-loading nano-cluster system and a preparation method and application thereof. The drug-loaded nano-cluster is composed of an outer-layer reticular host carrier with good biocompatibility and an inner small-size parasitic carrier. The nano-cluster has good safety and long circulation characteristics, after being efficiently accumulated at a tumor part, the nano-cluster intelligently adjusts the size under the stimulation of a tumor microenvironment, and releases small-size drug-loaded micelles to penetrate through a compact tumor matrix to realize deep drug delivery, so that the permeability and lethality of the drug are enhanced, and the toxic and side effects are reduced. The nano-cluster is a flexible drug loading platform, and has great practical value in the field of nano-drug treatment of solid tumors.

The invention discloses an environment-friendly chemical for preventing and treating plant rot and application thereof and belongs to the technical field of plant protection chemicals. The chemical is formed by mixing 70 parts of chloroisobromine cyanuric acid active compounds with the concentration being 98% and above and 30 parts of orange peel oil, and the following measures are taken based on different focuses: blending the 70 parts of chloroisobromine cyanuric acid active compounds with the concentration being 98% and above and the 30 parts of orange peel oil with water to obtain a liquid chemical with the weight being 50-600 times, and applying the liquid chemical to disease positions; blending the 70 parts of chloroisobromine cyanuric acid active compounds with the concentration being 98% and above and the 30 parts of orange peel oil with water to obtain a liquid chemical with the weight being 600-3000 times, and spraying the liquid chemical. The environment-friendly chemical is quick in degradation and small in environmental pollution. About one month later since the chemical is sprayed, the chemical cannot be detected in water, soil and plants of a rice field. The chemical is great in penetrability and can raise the hit rate for targets.

The invention discloses a resin type matrix and its preparation method wherein the resin type matrix comprises medical hot melt pressure-sensitive glue, rosin, zinc oxide, crystallite wax, ortho-phthalic acid dimethyl esters, and sorbic acid.

An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.

The invention discloses a medicament for treating hard turgescence caused by phlebitis and injection, wherein the medicament comprises Anisodamine Hydrobromide, carbomer-940, glycerin, Laurocapram and water. The medicament is in gel form and can be coated directly onto human skin.

The invention provides a traditional Chinese medicine hot-compress ointment. The traditional Chinese medicine is prepared by selecting and combining the following materials: folium artemisiae argyi, cinnamon, radix aconiti sinensis, rhizoma zingiberis, radix angelicae, camphor, red paeony root, radix clematidis, garden balsam stem, semen brassicae, kusnezoff monkshood root, frankincense, myrrh, nux vomica, fructus cnidii, parasitic loranthus, eucommia ulmoides, radix angelicae pubescentis, lycopodium clavatum, kadsura pepper stem, philippine flemingia root, dragon's blood, rhizoma cyperi, safflower, ephedra herb, ligusticum wallichii, medicinal cyathula root, cassia twig, pawpaw, caulis spatholobi, corydalis tuber, mirabilite, castor bean, pepper and clove. The preparation method comprises the steps of processing and ointment preparing. The hot-compress ointment combined by the traditional Chinese medicines in the invention has obvious effects of treating bone and blood stasis symptoms, does not have any toxic and / or side effects and is simple and convenient in treatment and high in drug permeability. According to actual application, the effective rate reaches 90%, the efficacy rate reaches 80%, and the cure rate reaches 70%. The hot-compress ointment is suitable to serve as a traditional Chinese medicine hot-compress ointment for disease treatment.

The invention discloses a traditional Chinese herb pillow for treating rhinitis, comprising following materials by weight: Carthamus tinctorius 12-15 parts, Herba Menthae 20-35 parts, Herba Ephedrae 4-6 parts, Fructus Viticis Negundo 25-33 parts, Radix Platycodonis 16-19 parts, Radix Puerariae 8-12 parts, Flos Magnoliae Liliflorae 8-12 parts, Herba Andrographitis 5-9 parts, Radix Glehniae 10-20 parts, Herba Houttuyniae 10-18 parts, camphor 2-5 parts, Calculus Bovis 2-4 parts, borneol 3-7 parts, Radix Rehmanniae Preparatae 4-10 parts, Radix Geutianae 6-12 parts, Radix Polygoni Multiflori 2-4 parts, and Cortex Phellodendri 7-9 parts. The traditional Chinese herb pillow for treating headache provided by the invention is simple and feasible, acts fast, causes no discomfort in long-term administration, has higher drug permeability, allows ease of absorption and low side effect and is effective in treating rhinitis and sinusitis.