13 results about "Hyperplastic scar" patented technology

The invention belongs to the technical field of biomedicine, and discloses a soluble microneedle for treating hyperplastic scars as well as a preparation method and application of the soluble microneedle. The preparation method comprises the following steps: modifying hyaluronic acid to obtain sulfonated hyaluronic acid, blending the sulfonated hyaluronic acid with a natural penetration enhancer d-borneol with anti-inflammatory activity, carrying out rotary evaporation and freeze-drying to obtain a sulfonated hyaluronic acid-d-borneol solid dispersion, and loading the solid dispersion into a microneedle to obtain the soluble microneedle with the hyperplastic scar treatment function. The preparation method is simple and easy to operate, and large-scale production can be realized. According to the preparation method, the sulfonated hyaluronic acid and the d-borneol are effectively combined, the bioavailability and biocompatibility of the d-borneol are improved, and the d-borneol is loaded into the microneedle, so that the anti-inflammatory and fibroblast migration inhibition capability of the solid dispersion is maximized, and meanwhile, the anti-inflammatory and fibroblast migration inhibition capability of the solid dispersion can be further improved under the dual permeation promotion of the microneedle and the d-borneol. And the aim of deeply delivering the medicine is fulfilled by penetrating dense scar tissues. The problems that in a traditional scar treatment method, medicine permeability is poor, and the treatment effect is limited are solved, a safe and efficient novel transdermal drug delivery system is provided for treating hyperplastic scars, and wide clinical application prospects and market value are achieved.

The application belongs to the technical field of biological medicine, and discloses soluble microneedles for treating hyperplastic scars, and a preparation method and application thereof. The hyaluronic acid is modified to obtain sulfonated hyaluronic acid, which is blended with natural penetration enhancer dextro-borneol having anti-inflammatory activity, rotary evaporated and freeze-dried to obtain a sulfonated hyaluronic acid-dextro-borneol solid dispersion, and then the solid dispersion is loaded into the microneedles to obtain the soluble microneedles having the function of treating hyperplastic scars. The method improves the bioavailability and biocompatibility of dextro-borneol, and the dextro-borneol is loaded into the microneedles, so that the anti-inflammatory and migration inhibition of fibroblasts of the solid dispersion can be maximized, and the microneedles and dextro-borneol can penetrate the dense scar tissue to achieve the purpose of deep drug delivery under the double penetration of the microneedles and dextro-borneol. The application provides a safe and efficient novel transdermal drug delivery system for treating hyperplastic scars, and has a wide clinical application prospect and market value.

This invention discloses a chitosan-based wound adhesive for promoting healing and inhibiting scarring, and its preparation method. The adhesive employs a time-controlled release structure: an outer layer is a chitosan-Imperata cylindrica inflammatory response coating, and an inner layer is a polylactic acid-egg membrane, loaded with tranexamic acid and onion extract liposomes. Upon contact with wound exudate, the outer layer can solidify in situ in response to salt, rapidly stopping bleeding and relieving pain; in the acidic inflammatory microenvironment, the inner layer gradually degrades, with the egg membrane and tranexamic acid synergistically promoting epithelial regeneration and improving scar quality; onion extract inhibits excessive fibroblast proliferation and regulates orderly collagen deposition, preventing hypertrophic scars and pigmentation from the source. This invention primarily uses natural biomaterials, exhibiting excellent biocompatibility, and simultaneously achieves hemostasis, anti-inflammation, healing promotion, and scar inhibition throughout the entire treatment cycle, overcoming the shortcomings of traditional dressings such as uncontrollable drug release and limited functionality.

The application discloses a microneedle, a preparation method, a microneedle patch and application. The microneedle comprises a shell of a cross-linked hydrophilic polymer, a negatively charged substance filled in a cavity surrounded by the shell, and verteporfin arranged on the outer surface of the shell and / or the shell layer. The cross-linked hydrophilic polymer comprises a plurality of inflammation-responsive linkers. The microneedle patch containing the microneedle is programmed to promote faster wound healing, repair normal skin function, prevent or reduce scar formation, and has a significant alleviating effect on the formed hyperplastic scar.

A skin patch is composed of a plurality of functional layers provided by a plurality of materials. The moisturizing layer is provided with through holes with a diameter of 1mm-5mm and a hole spacing of 1mm-5mm. The adsorbing layer is made of hydrocolloid material and is attached to the moisturizing layer. The water vapor and oil produced by skin metabolism enter the through holes and are captured by the adsorbing layer. The medical device made of the skin patch is used by removing the protective layer and attaching the moisturizing layer to the skin after injury. The skin epidermis is hydrated, the skin metabolism is promoted, and the skin is autolyzed. Finally, the effect of preventing scar hyperplasia and promoting the flattening of hyperplastic scars is achieved.

The invention discloses a pharmaceutical composition for treating hypertrophic scars and / or keloids. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 15-25 parts of gallnut, 15-25 parts of smoked plum, 15-25 parts of senecio scandens, 15-25 parts of fructus cnidii, 10-20 parts of radix angelicae, 10-20 parts of cortex lycii radicis, 170-230 parts of vinegar and 170-230 parts of honey. The composition disclosed by the invention has the effects of detoxifying, diminishing swelling, astringing dampness and relieving itching. The traditional Chinese medicine composition has obvious effects on hypertrophic scars and keloids formed after trauma, operation, burns and scalds, acne, folliculitis and other inflammations, and itching and pain caused by the hypertrophic scars and keloids.

The invention discloses application of hydrogel in preparation of an external preparation for treating wound scar infection risk, and belongs to the technical field of biomedical materials. The preparation method of the hydrogel comprises the following steps: preparing a copper ion solution with the mass fraction of 0.01%-0.05%, adding 0.1%-1% of sodium alginate into every 100 mL of the copper ion solution according to the mass fraction, adjusting the pH value to 4.5-5.5, and carrying out defoaming and sterile treatment to obtain the hydrogel capable of regulating and controlling the collagen proportion and reducing the risk of wound scar infection. According to the invention, a'regeneration type 'mode with a better healing guide structure and higher softness is adopted, so that the risks of hypertrophic scars, skin sclerosis and hardening after wound healing caused by fungal infection and the like are obviously reduced from the source. The application is suitable for high-quality repair of chronic wounds of human and pets.

The invention provides a construction method and application of an artificial scar-like organ based on a micro-fluidic chip, the artificial scar-like organ is constructed based on the micro-fluidic chip with multiple channels, the tissue microenvironment can be accurately controlled through a micro-fluidic technology, and the tissue microenvironment can be accurately controlled. And epidermis, dermis and vein endothelial cells from a human body can be subjected to differential culture through design of different channels, so that a humanized scar tissue model which is more simulated compared with a traditional method is constructed. The device has the advantages of being small in size, good in visibility, derived from a human body and capable of being stored for a long time. Therefore, the model can be prepared on a large scale for scar drug treatment effect research, and experimental materials and research bases can be provided for treatment prescriptions of pathological hypertrophic scars caused by wounds and burns.

The invention relates to the technical field of deep learning, in particular to an orthopaedic surgery postoperative scar recovery dynamic evaluation system based on deep learning, and the system comprises the steps: obtaining gray images of a dermoscope at different sampling moments, and dividing the gray images to obtain a scar region and a capillary region around the scar; determining a recovery state index according to the area change of the microvessel texture distribution characteristic scar region in the microvessel region; when the hypertrophic scar appears, determining the area and the gray scale of the hypertrophic scar in the scar region, and determining the hyperplasia degree of the hypertrophic scar according to the area characteristic and the gray scale characteristic; and adjusting the recovery state index according to the hyperplasia degrees in the images with different gray levels to obtain a recovery evaluation coefficient, and determining a recovery evaluation result according to the recovery evaluation coefficients at different sampling moments. According to the invention, timely evaluation can be carried out in combination with the overall recovery state and the hyperplasia condition of the pathological scar area, and the accuracy and reliability of the evaluation result of scar recovery are effectively improved.

The invention provides a stem cell exosome-loaded degradable scar patch. The stem cell exosome-loaded degradable scar patch comprises a scar patch main body, a degradable hydrogel matrix layer and a microneedle array layer, the degradable hydrogel matrix layer is arranged in the scar patch main body; the microneedle array layer is uniformly distributed on the surface of the degradable hydrogel matrix layer. According to the degradable scar patch loaded with the stem cell exosomes, the stem cell exosomes are combined with the microneedle array and the degradable hydrogel, transdermal absorption is enhanced through the microneedles, and the slow release characteristic of the hydrogel is combined, so that non-invasive treatment of hyperplastic scars is achieved; the hydrogel has the advantages of being high in transdermal efficiency, good in biocompatibility, degradable, free of residues and the like, and scars formed by burns and surgical incisions can be effectively repaired.

The invention relates to the technical field of surgical distraction devices, in particular to an angle-adjustable surgical distraction device which comprises a support, an adjusting seat is rotatably arranged at the lower end of the support, a threaded rod A is rotatably arranged in the adjusting seat, and two supporting frames driven by the threaded rod A are slidably arranged in the adjusting seat. According to the device, skin on the two sides of the neck is drawn to gather towards the center of an incision through the multiple sets of suction cups, the tension generated by opening of the edge of the incision is reduced, and therefore the skin on the two sides of the neck is drawn to gather towards the center of the incision, and the skin on the two sides of the neck is drawn to gather towards the center of the incision; the incision edge tissue tearing or microvascular injury caused by traction is prevented, the physiological structural integrity of the surgical incision is protected, meanwhile, traction of the opening device to the surgical incision is reduced, hyperplastic scars or wide scars caused by tissue injury are effectively reduced, collagenous fibers are arranged more regularly when the postoperative incision is healed, and the healing rate of the postoperative incision is increased. And the skin beauty of the patient after operation is improved.

The application discloses a kind of double-network hydrogel based on chlorogenic acid, preparation method and application, belong to the technical field of wound dressing.It is the first network that the double-network hydrogel based on chlorogenic acid is made of chlorogenic acid and Zn 2+ Coordination composition, can release CA and Zn 2+ Inflammation and proliferation stage, so as to play the role of antibacterial, antioxidant, anti-inflammatory and angiogenesis;The second network is made of heparin grafted gelatin and genipin covalent crosslinking, and gelatin and genipin crosslinking can enhance mechanical strength, and heparin is grafted into gelatin, can stabilize the added bFGF and prolong its release time in wound site, and bFGF is slowly released in proliferation and remodeling stage, so as to prevent the formation of scar;The in vivo study of MRSA infected diabetic mouse model and rabbit ear hyperplastic scar model shows that the double-network hydrogel can significantly promote the healing of scar-free wound.The program release function of the application CZGF hydrogel plays a key role in accelerating chronic wound healing and preventing scar formation.

The present application relates to the technical field of deep learning, and particularly relates to a kind of dynamic evaluation system of plastic surgery postoperative scar recovery based on deep learning, comprising: the gray image of dermoscope at different sampling moments is obtained, and scar area and microvessel area around scar are obtained by division;According to the area change of microvessel texture distribution feature in microvessel area scar area, determine recovery state index;When hyperplastic scar appears, determine the area and gray scale of hyperplastic scar in scar area, according to area feature and gray scale feature, determine the proliferation degree of hyperplastic scar;According to the proliferation degree in different gray images, adjust the recovery state index, obtain recovery evaluation coefficient, and determine recovery evaluation result according to recovery evaluation coefficient under different sampling moments.The present application can evaluate in time by combining overall recovery state and the proliferation of pathological scar area, effectively improve the accuracy and reliability of the evaluation result of scar recovery.