182 results about "Topical preparation" patented technology

The invention belongs to the technical field of external preparations, and provides compound itching-relieving cream as well as a preparation method and application thereof. The compound itching-relieving ointment is prepared from the following components in parts by weight: 3 to 6 parts of rhizoma coptidis, 9 to 15 parts of radix scutellariae, 9 to 15 parts of radix et rhizoma rhei, 3 to 6 parts of herba schizonepetae, 3 to 6 parts of herba menthae, 1 to 3 parts of cortex moutan, 1 to 3 parts of sandalwood and 0.5 to 1 part of borneol. The compound antipruritic ointment has the effects of cooling, relieving itching, detoxifying and diminishing swelling, and is used for treating itching and eczema dermatitis itching caused by biting of various small insects such as mosquitoes and the like. According to the compound antipruritic ointment disclosed by the invention, a plurality of components are in synergistic interaction, so that a multi-target and multi-layer treatment effect is realized. The traditional Chinese medicine composition can be used for cooling, relieving itching, detoxifying and diminishing swelling from the source while quickly relieving itching, and a comprehensive and effective solution is provided for itching.

The invention discloses a colchicine external preparation with high intradermal residual quantity and percutaneous transmittance as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The invention provides a colchicine external preparation with high intradermal residue and transdermal transmittance. The colchicine external preparation comprises: a) colchicine or a pharmaceutically acceptable salt thereof; b) a penetration enhancer; c) pharmaceutically acceptable excipients and / or excipients; the penetration enhancer is at least one of polyglycerol oleate or isosorbide dimethyl ether. The drug loading capacity and the percutaneous transmittance of the colchicine external preparation disclosed by the invention are remarkably improved. When polyglycerol oleate is selected as a penetration enhancer to prepare colchicine gel, the intradermal retention volume can reach 358.08 micrograms within 20 hours. When isosorbide monomethyl ether is selected as a penetration enhancer to prepare ethosome gel, the accumulated penetration amount can reach 106.87 mu g / cm < 2 >, and the intradermal residual amount can reach 90.58 mu g or above.

The invention discloses a compound fluralana external preparation for dogs, a preparation method and application, belongs to the technical field of veterinary drugs, and solves the problems that an existing preparation is poor in skin surface permeability, a solvent is easy to volatilize, and use experience and drug effect exertion are influenced. The preparation is prepared from the following raw materials: fluralana, moxidectin, ethyl butylacetamidopropionate and N, N-dimethylformamide. The preparation method comprises the following steps: adding N, N-dimethylacetamide, acetone, an auxiliary adjuvant, a transdermal penetration enhancer, an antioxidant and a surface film-forming agent; according to the invention, the combination of the fluralab and the moxidectin can play a synergistic effect and expand an anti-parasitic spectrum so as to achieve an internal and external driving effect; both the fluralab and the moxidectin belong to high-fat-soluble substances, parasites can be quickly repelled and killed by adding novel adjuvant natural parasite expelling ingredients, and meanwhile, the skin permeability can be improved by adding the efficient transdermal penetration enhancer, and the risk that medicine residues are licked by pets is reduced.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a marine small molecule peptide and an active variant thereof in preparation of a medicine for treating skin diseases, the marine small molecule peptide and the active variant thereof can effectively inhibit keratinocyte pan apoptosis induced by TNF-alpha and IFN-gamma, the formation of a PANoptosome complex is blocked through a multi-target synergistic effect, and the effect of treating the skin diseases is achieved. The oxidative stress is reduced, and mitochondria is stabilized, so that a skin inflammatory cell death network is inhibited from the source. The variant has the same high sequence as the peptide, retains the activity of inhibiting cell pan-apoptosis, and has enhanced stability, skin permeability, in vivo half-life or efficacy. Based on the action mechanism, the peptide and the variant thereof can be used for preparing medicines for preventing and treating intractable skin diseases such as epidermis necrolysis, psoriasis, atopic dermatitis, skin lupus erythematosus and lichen planus. The invention also provides a composition containing the peptide or the variant thereof, and dosage forms comprise an external preparation and an injection.

The invention discloses a short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis, and relates to the technical field of external preparations and scalp care, the short-contact washing agent comprises the following components by weight: an active component combination: 0.01-0.05 wt% of halcinonide; 0.5 to 1.0 wt% of piroctone ethanolamine; 0.1 to 0.3 wt% of total alkaloids of sophora flavescens; 0.05 to 0.1 wt% of berberine; standardized traditional Chinese medicine effective part extracts are compounded with modern active ingredients, and the problem that the quality difference between batches of traditional Chinese medicine lotion is large is solved. The combination of a plurality of active components aims to synergistically act on a plurality of targets such as anti-inflammation, antibiosis and oil control, so as to comprehensively improve the scalp condition. In addition, the specific semi-solid colloid dosage form improves the staying performance of the product on the scalp, and aims to improve the refreshing feeling after use while ensuring the cleaning effect. The lotion provides a hormone-containing and hormone-free double-version design, and provides choices for requirements of different severity degrees and different use stages.

The invention belongs to the field of traditional Chinese medicine compositions, and relates to an external traditional Chinese medicine composition and preparation for treating demodex blepharitis, the traditional Chinese medicine composition comprises the following raw materials by weight: 3-10 parts of coptis chinensis, 3-10 parts of sophora flavescens, and 7.5-10 parts of saposhnicovia divaricata. According to the formula, coptis chinensis and radix sophorae flavescentis are used as monarch drugs for clearing away heat and drying dampness and killing parasites to relieve itching, and the pathogenesis core of demodex infection and damp-heat interweaving is adopted; divaricate saposhnikovia root is used as a ministerial drug to dispel wind and eliminate dampness, eliminate swelling and relieve itching and help the monarch drug to relieve wind pathogen symptoms such as red, swollen, itching and pain of eyelids. In addition, the radix saposhnikoviae is slightly warm in nature and flavor, has the function of adjuvant drugs in the formula, and moderately restricts the bitter and cold nature of the coptis chinensis and the radix sophorae flavescentis; the traditional Chinese medicine composition is an external preparation, no conductant drug is independently arranged in the whole formula, and the formula is further simplified on the premise that the curative effect is guaranteed. The whole formula directly aims at the pathological core of vermiform mite infection and inflammatory response through triple action mechanisms of clearing away heat and toxic materials, dispelling wind and eliminating dampness and killing parasites to relieve itching. The total effective rate of the traditional Chinese medicine composition for demodex blepharitis reaches 94%, and the traditional Chinese medicine composition has the advantages of stable curative effect, high total effective rate, low recurrence rate, small side effect and the like.

The present invention relates to the process for the preparation of topical formulations of anthraquinone compound. The present invention specifically relates to the process for the preparation of topical formulations of Rhein or Diacerein in the form of ointment, cream, gel and transferosomal gel. The present invention more specifically relates to the process for the preparation of topical formulations of Rhein or Diacerein in the form of ointment, cream, gel comprising the steps of heating, adding, stirring, dissolving and mixing. The present invention also relates to the process for the preparation of topical formulations of Rhein or Diacerein in the form of transferosomal gel comprising the steps of thin film formation, hydration of thin film and transferosomal gel formation. The present invention also relates to the process for the preparation of topical formulations of Rhein or Diacerein in the form of transferosomal gel comprising the steps of dissolving, adding and mixing.

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a preparation method of a traditional Chinese medicine external preparation for arthralgia based on blood circulation promoting and blood stasis removing, which comprises the following steps: extracting ferulic acid from angelica sinensis and ligusticum wallichii by adopting a supercritical CO2 fluid extraction process; extracting safflower, frankincense and other medicinal materials to obtain a synergistic active ingredient extract; the ferulic acid is used as a first hydrogen bond donor to react with lauric acid used as a temperature-sensitive phase change hydrogen bond donor and choline chloride used as a hydrogen bond acceptor, and the temperature-sensitive bioactive ternary eutectic solvent is prepared; loading the synergistic active ingredient extract in the solvent at low temperature to form a medicine mother solution; and finally, mixing the medicine mother liquor with auxiliary materials to prepare the external preparation. Ferulic acid in medicinal materials serves as a structural unit of a functional solvent, the solvent prepared under the mild condition has biological activity and temperature-sensitive phase change characteristics, a medicine storage cavern can be formed on the skin surface in situ, long-acting slow release and efficient transdermal absorption of active ingredients are achieved, and the curative effect and safety of a preparation are improved.

The invention discloses a wind-dispelling, pain-relieving, blood-activating and blood-stasis-removing black plaster formula and a preparation process, and belongs to the field of traditional Chinese medicine external preparations. According to the formula, pseudo-ginseng and angelica sinensis are used as monarch drugs, ligusticum wallichii, radix angelicae pubescentis and the like are used as ministers, frankincense, myrrh and the like are used as assistants, musk and borneol are used as guides, sesame oil and fried yellow lead are matched as matrixes, and the compatibility of the monarch, the ministers, the assistants and the guides is rigorous. The preparation method comprises the following steps: performing targeted processing (stir-frying with wine, stir-frying with vinegar and the like) on each medicinal material, extracting medicinal oil, refining oil into paste, removing fire toxin, blending fine materials at low temperature, spreading, forming and the like, and performing standardized control on key process parameters. The traditional Chinese medicine composition integrates the holism concept of traditional Chinese medicine and the modern processing technology, aims at wind-cold-dampness arthralgia and blood stasis collateral obstruction syndromes in a targeted mode, and is high in effective component transdermal absorption efficiency, lasting in medicine effect and good in safety. Clinical verification shows that the total effective rate reaches 92.5%, the black plaster can be used for diseases such as neck-shoulder and lumbocrural pain and rheumatism arthralgia, the problems that a traditional black plaster is unstable in medicine effect and high in toxicity risk are solved, and the black plaster has remarkable clinical application and industrialization value.

The present application belongs to the technical field of traditional Chinese medicine composition, and relates to a traditional Chinese medicine transdermal external preparation for treating vulvar hypopigmentation disease. The preparation is a paste prepared by mixing traditional Chinese medicine powder and horse oil. The traditional Chinese medicine powder is composed of the following raw materials by weight: Xuchangqing 10-12, Pugongying 10-15, Difusiduo 12-15, Tuzifuding 12-15, Baiji 10-15, Huzhang 9-12, Quansie 6-10, Diyu 10-12, Xuezhi 10-12, Danggui 6-10, Rushang 6-10, Miedu 6-10, Bingpian 1-3. The traditional Chinese medicine transdermal external preparation has definite and significant effects on vulvar hypopigmentation disease, especially in relieving intractable pruritus, promoting pigment recovery and improving skin sclerosis / atrophy. The traditional Chinese medicine transdermal external preparation has high safety, few adverse reactions and low recurrence rate.

The invention provides a traditional Chinese medicine composition for regulating scalp micro-ecology, an external preparation containing the traditional Chinese medicine composition and application of the external preparation, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition for regulating and controlling scalp micro-ecology is prepared from cacumen biotae, rhizoma cyperi, fructus cnidii, cortex dictamni, radix sanguisorbae, herba ecliptae and herba menthae. Based on the compatibility principle of monarch, minister, assistant and guide, the composition takes fructus cnidii for eliminating dampness and killing parasites as monarch, cortex dictamni and cacumen biotae for removing heat to cool blood as minister, garden burnet, eclipta and rhizoma cyperi for astringing, detoxifying, nourishing yin and regulating qi as assistant, and mint for guiding the medicine to move upwards and transdermal permeation as guide, so that multiple effects of inhibiting bacteria, resisting inflammation, repairing a barrier, regulating sebum secretion and the like are synergistically realized. Modern pharmacological studies show that the active ingredients can inhibit malassezia proliferation, regulate and control inflammatory pathways of NF-kB, TLR4 and the like, reduce expression of proinflammatory factors of IL-6, TNF-alpha and the like, and promote skin barrier repair. Clinical observation shows that the composition can significantly improve the scalp seborrheic dermatitis symptom.

There is provided a resident-skin-flora-improving agent that is useful in keeping the skin in excellent condition. Specifically, there is provided a resident-skin-flora-improving agent in which sophorose is used. Sophorose is provided with functionality by which it is possible to promote proliferation of helpful bacteria that beneficially affect skin while suppressing growth of bacteria that could adversely affect the skin. The resident-skin-flora-improving agent can suitably be used for the object of maintaining balance of the resident skin flora and keeping the skin in excellent condition.

The invention discloses a traditional Chinese medicine composition for treating skin nodules and application thereof. The invention provides a novel traditional Chinese medicine formula for treating skin nodules and an external preparation prepared on the basis of the traditional Chinese medicine formula, which has a remarkable nodule dispersing effect, reduces the number of skin nodules, reduces the size of the skin nodules, improves the red and swollen skin, improves the microcirculation of the skin, reduces the inflammatory response of the skin, improves the oxidative stress of the skin, and has a remarkable anti-inflammatory effect. The collagen synthesis of the skin is promoted, the use is convenient, and a new technical choice is provided for the development of clinical medicines and cosmetics.

This invention discloses a pharmaceutical composition, a topical formulation, a method for producing the same, and its use. The pharmaceutical composition of this invention comprises the drug-active ingredient, diethylene glycol monoethyl ether, and polyethylene glycol 400, wherein the pharmaceutical composition does not contain water, and the mass ratio of diethylene glycol monoethyl ether to polyethylene glycol 400 is 1:(0.5~4.0), and the drug-active ingredient has structural formula (I). Topical formulations produced from the pharmaceutical composition provided by this invention have stable properties and do not crystallize, have a good feel, promote rapid penetration of the drug into the stratum corneum, have excellent epidermal and dermal retention ability, deliver the drug to the target on the skin, reduce systemic side effects, can achieve high local concentrations, have excellent therapeutic effects and stability, and can reduce safety risks. JPEG2026518290000036.jpg65142

The invention discloses a traditional Chinese medicine composition for treating anxiety insomnia. The traditional Chinese medicine composition is prepared from, by weight, 3-5 parts of rhizoma coptidis, 3-6 parts of cortex cinnamomi, 5-8 parts of fructus aurantii immaturus, 5-10 parts of radix curcumae, 5-8 parts of radix polygalae, 5-10 parts of fructus schizandrae, 5-8 parts of rhizoma chuanxiong and 1-3 parts of borneol. The traditional Chinese medicine composition can be used for preparing an external preparation navel patch, and the navel patch can be absorbed through the Shenque acupoint to play a whole regulation role. The navel patch disclosed by the invention has a remarkable curative effect on anxiety emotion caused by heart-kidney disharmony and qi stagnation and secondary anxiety insomnia symptoms such as difficulty in falling asleep, vexation, insomnia, dreaminess and easy awakening, is safe and convenient to use, provides a new solution for an external treatment method of anxiety insomnia, and has relatively high application and popularization values.

The invention discloses a pharmaceutical composition for bone diseases and bone fractures. The pharmaceutical composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of calcined native copper, 10-20 parts of vinegar myrrh, 10-20 parts of vinegar frankincense, 3-10 parts of cornu cervi degelatinatum, 3-10 parts of white dipsacus, 3-10 parts of safflower carthamus, 15-25 parts of ground beetles, 3-10 parts of white mulberry root-bark and 3-10 parts of dragon's blood. The fine powder of the pharmaceutical composition and pharmaceutically acceptable auxiliary materials or auxiliary components are prepared into an external preparation. The patch has good biocompatibility with skin, and the hydrophilic polymer matrix has air permeability, perspiration resistance, no sensitization and no irritation; the drug release performance is good, the affinity with the skin is strong, the hydration effect of the cuticle can be improved, and the transdermal absorption of the drug is facilitated; a transdermal absorption controlled release technology is applied, so that the blood concentration is stable, and the drug effect is lasting.

The invention belongs to the technical field of medicine preparation, and provides an ophthalmic external preparation and a preparation method thereof. According to the ophthalmic external preparation, curcumin included by hydroxypropyl-beta-cyclodextrin loaded on exosome modified by polylysine is adopted as an effective component. The preparation can improve the drug concentration of cornea tissues and realize accurate delivery of ocular surfaces; meanwhile, the exosome and curcumin form a synergistic effect, so that the release of proinflammatory factors such as IL-1beta and TNF-alpha can be inhibited, the secretion of goblet cell mucoprotein and the proliferation of corneal epithelial cells can be promoted, and the tear film rupture time is prolonged; in addition, the preparation is excellent in biocompatibility, free of ocular surface stimulation reaction and high in safety.

The invention belongs to the technical field of biological medicines, and particularly relates to a flavone-copper complex for promoting healing of diabetic foot ulcer, an external preparation of the flavone-copper complex, and a preparation method and application of the flavone-copper complex. According to the flavone-copper complex disclosed by the invention, a flavone compound and copper ions form the complex, so that the healing of the diabetic foot can be effectively promoted; meanwhile, after the flavonoid compound and the copper ions are compounded, slow release of the copper ions and the flavonoid components can be achieved, the medicine effect is improved, meanwhile, the potential toxicity of the copper ions is reduced, and the flavonoid compound can be directly used as a medicine for relieving ulcer of the diabetic foot.

The invention discloses external preparation full-automatic slitting and packaging integrated equipment and a using method thereof.The external preparation full-automatic slitting and packaging integrated equipment comprises a workbench, a side supporting plate and a control system, the side supporting plate is fixed to the upper portion of the workbench, an unwinding drum is arranged on one side of the workbench, and a winding drum is arranged on the other side of the workbench; two conveying assemblies and a recognition assembly are arranged above the workbench, a belt gear driving device is arranged in the workbench, and the gear driving device is connected with the conveying assemblies through a gear belt. A plurality of conveying supporting shafts, a limiting barrel, a first vision unit, a second vision unit and two sets of slitting assemblies are connected to the side supporting plate through bearings, the slitting assemblies are arranged in the front and back sets, the conveying supporting shafts are arranged on the side supporting plate according to the use condition, and the device has the beneficial effects of being high in practicability and slitting precision.

It relates to a composition, the use of the composition for preparing a topical external formulation or a cosmetic, and a method for preparing the composition. The composition comprises a linear saturated dicarboxylic acid and a polyaspartic acid or derivatives thereof, wherein the content of the polyaspartic acid or derivatives thereof is greater than or equal to 0.01% based on the total weight of the composition. The solubility of the linear saturated dicarboxylic acid (e.g., azelaic acid) in aqueous solutions can be increased by using the linear saturated dicarboxylic acid (e.g., azelaic acid) in combination with the polyaspartic acid or derivatives thereof. It can thus have improved skin permeability, for example when used in a cosmetic, thereby exerting its efficacy to a greater extent.

The invention belongs to the field of external medicines for pets, and provides a macromolecular medicine carrier for treating cat tinea, which is prepared by adopting a collaborative design of core-shell nanogel particles and a double-state antibacterial component and through stepwise reaction of hexamethylene diisocyanate, polyethylene glycol, polyethylene glycol diamine and a silane coupling agent. A core-shell structure with the particle size of 100-350 nm and the shell thickness of 5-30 nm is formed through water dispersion emulsification and silane hydrolytic condensation, and a Si-O-Si bond fixed state and non-covalent releasable state antibacterial mechanism is constructed by combining polyhexamethylene biguanide hydrochloride. According to the invention, the powerful antibacterial property of the minimal inhibitory concentration of 0.2-3.00 mg / mL to pathogenic dermatophyte is realized, a low-viscosity processing window and skin-friendly pH value are kept at 5.5-7.5, the coupling problem of high load, long-acting washing resistance, rapid effect and continuous inhibition and film-forming adhesion durability of an external preparation is solved, and the preparation has wide application value.

A collagen production promoter contains at least one pyrimidine nucleotide or precursor thereof as an active ingredient.

The invention discloses a pharmaceutical composition for treating eczema, application of the pharmaceutical composition and an external preparation based on the pharmaceutical composition, and belongs to the technical field of traditional Chinese medicines. Three medicinal materials including dandelion, polygonum aviculare and polygonum flaccidum are taken as raw materials, water and ethanol with different concentrations are taken as extraction solvents, the extracted extracts are taken as active ingredients of external preparations such as lotion, cream, gel and cream, the itching relieving effect can be quickly and effectively achieved through combination of the active ingredients, and the traditional Chinese medicine composition is suitable for treating eczema and has a wide application prospect. The symptoms of eczema scabbing, redness and swelling and pruritus are remarkably improved, and eczema is not prone to And the preparation is simple in process and suitable for industrial production.

This invention discloses a topical traditional Chinese medicine powder for eliminating effusions in cavities and its preparation method, belonging to the technical field of topical traditional Chinese medicine preparations. The powder is composed of Angelica sinensis, frankincense, myrrh, dragon's blood, catechu, Notopterygium incisum, Angelica dahurica, Saposhnikovia divaricata, Daphne genkwa, Paeonia lactiflora, Evodia rutaecarpa, and cinnamon in a specific weight ratio, prepared into a dark reddish-brown powder through a purely physical crushing process. This powder is specifically designed to eliminate various types of effusions in cavities. It can effectively improve symptoms within 1-7 days after use. The formula strictly adheres to traditional Chinese medicine compatibility principles, with each component working synergistically. The topical application method avoids the gastrointestinal irritation and other adverse reactions that may occur with oral medications. The preparation process is simple and environmentally friendly, requiring no complex equipment or chemical processing steps, and retains the original activity of each herbal component, demonstrating significant practical value and promising prospects for promotion.

The application discloses a hot compress plaster for promoting blood circulation and removing blood stasis and a preparation method thereof, and belongs to the technical field of external preparations of traditional Chinese medicines. The hot compress plaster is prepared from Prunella vulgaris, Gastrodia elata, Cyperus rotundus and other Chinese medicines and beeswax. The preparation method comprises the steps of raw material screening and pretreatment, medicine powder preparation, base preparation, mixing and forming, cooling and shaping and packaging and storage. The application is based on the pathogenesis of Qi stagnation and blood stasis and phlegm and blood stasis intermingling, follows the principles of promoting blood circulation, removing phlegm and resolving stasis, strengthening healthy energy and eliminating pathogenic factors, and can effectively improve the blood circulation of the body and dissipate tumor nodules in combination with the warm action of hot compress. The hot compress plaster is flexible in proportioning and can be personalized, is simple in preparation, safe in use, small in side effect, suitable for the auxiliary treatment of tumor nodules, and has high clinical application value and popularization prospect.

The invention relates to an external preparation for treating skin itch of a patient with jaundice and a preparation method of the external preparation, and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 25-35 parts of humulus lupulus, 10-20 parts of chionanthus retusus leaves and 10-20 parts of rhizoma tupistrae chinensis. A proper amount of humulus lupulus, chionanthus retusus leaves and rhizoma tupistrae chinensis are matched and used as functional components, and the humulus lupulus, the chionanthus retusus leaves and the rhizoma tupistrae Meanwhile, by combining a gradient decompression reflux extraction mode, effective components are efficiently extracted and fully reserved, so that the improvement effect of the obtained traditional Chinese medicine composition on the skin itch symptom of the jaundice patient is remarkably improved, the treatment effect is superior to that of an existing conventional medicine, a new means is provided for treating the skin itch disease of the jaundice patient, and the application prospect is wide.

The invention relates to an alkaloid liposome, a preparation process thereof and an application of the alkaloid liposome in an external preparation, and belongs to the technical field of external preparations. The technical problem to be solved is to provide an alkaloid liposome technology which is higher in stability, safe and non-irritating. According to the scheme, the alkaloid liposome technology is characterized in that raw materials comprise alkaloid, hydrogenated lecithin, grease, polyhydric alcohols and water; the alkaloid is selected from at least three of piperine, tetrahydropiperine, tetrahydropalmatine, dihydrooat alkaloid D, caffeine and leonurine; the hydrogenated lecithin is selected from at least one of PHOSPHOLIPON80H or PhoslipTM HPC (Hydroxyethyl Propyl Phosphatidylcholine). The liposome is good in stability and low in irritation, and has the effects of promoting local tissue microcirculation, reducing choked flow rate, increasing local body temperature, enhancing tissue metabolism and improving local inflammation when being externally applied to skin.

The invention discloses an externally-applied liniment containing saussurea involucrata and perilla oil for herpes zoster and a preparation method of the externally-applied liniment, and relates to the technical field of externally-applied traditional Chinese medicine preparations, the liniment is prepared from the following components in parts by weight: 30-40 parts of fresh stem and leaf extract of saussurea involucrata, 15-20 parts of perilla oil, 0.5-1 part of forsythin, 0.1-0.3 part of vitamin B12, 0.3-0.5 part of vitamin E and 40-50 parts of mountain spring water; according to the preparation method disclosed by the invention, the extract of the fresh stems and leaves of the herba ecliptae and the perilla oil are adopted as cores and compounded with the forsythin, the vitamin B12 and the vitamin E to form a synergistic effect system, and the optimized processes of ultrasonic extraction, reflux concentration, low-temperature squeezing, centrifugal purification and ultraviolet sterilization are combined, so that the active ingredients of all the components are fully released; the active ingredients of the saussurea involucrata and the forsythin synergistically inhibit virus replication and relieve inflammation, the perilla oil and the vitamin B12 jointly repair damaged nerves, the vitamin E protects skin barriers and improves the stability of the preparation, and the raw materials of the preparation are all natural ingredients or natural active factors, so that the safety is high, and the risk of skin irritation is avoided.