358 results about "Topical preparation" patented technology

The invention relates to the technical field of medicines, in particular to application of an active ingredient xanthohumol (XAN) derived from a traditional Chinese medicine humulus lupulus in preparation of medicines for reducing uric acid and resisting gout, and the xanthohumol (XAN) can be prepared into various oral preparations, injection preparations and external preparations with the assistance of pharmaceutically acceptable auxiliary materials and has good development and application prospects. The inventor finds that the xanthohumol has relatively strong effects of reducing blood uric acid, resisting inflammation, resisting bone damage and the like, and the mechanism of the effect of reducing the blood uric acid is that the activity of xanthine oxidase is inhibited so as to reduce the generation of uric acid, and the renal function of an organism is improved so as to enhance uric acid excretion; according to the anti-inflammatory effect, the inflammatory reaction is relieved mainly by down-regulating the levels of inflammatory factors such as IL-1beta, IL-6, TNF alpha and PEG2; the mechanism for resisting gout bone damage is realized through the fact that RANKL / OPG / RANK signal pathway participates in bone metabolism regulation.

The invention discloses a plant extract composition with Nrf2 excitation as well as a preparation method and application of the plant extract composition. Belongs to the technical field of skin care products. The traditional Chinese medicine composition is prepared from the following components in percentage by weight: 0.1 to 1.0 percent of ginger root extract, 0.1 to 1.0 percent of ormosia henryi bark extract and 0.1 to 1.0 percent of saffron crocus extract. The plant extract composition with the Nrf2 excitation can obviously activate an Nrf2 target spot, scavenge free radicals, reduce ROS (reactive oxygen species) and realize oxidation resistance; the composition also has the effects of remarkably reducing the melanin content and improving the skin brightness. The core active components of the three plant extracts are all natural fat-soluble molecules, and have the advantages of being high in safety, free of irritation and high in efficiency, so that the plant extracts are easily applied to external local preparations of oil skin care products.

The invention relates to the technical field of biomedical materials and tissue engineering, in particular to a bionic skin model for drug transdermal release research. The hydrogel has skin-like epidermis and dermis structures, the epidermis structure is composed of an electrostatic spinning high-molecular polymer, and the dermis structure is composed of an interpenetrating hydrogel skeleton formed by interweaving polysaccharide, protein and lipid. By adjusting the thickness and composition of the bionic skin, the bionic skin can show a transdermal drug release behavior similar to that of traditional in-vitro skin (such as pigskin, human skin and rat skin) in drug transdermal penetration research, so that the bionic skin is suitable for research on transdermal penetration and absorption behaviors of drugs in external preparations such as ointment, patches and skin care products; and an alternative scheme which is more consistent with ethics, stable, economic and good in reproducibility is provided for prescription screening, quality evaluation and the like.

The invention relates to a traditional Chinese medicine composition for treating pressure sores, a preparation method and application of the traditional Chinese medicine composition and pressure sore ointment, and relates to the technical field of traditional Chinese medicine compositions.The traditional Chinese medicine composition for treating pressure sores is prepared from, by weight, 35-55 parts of derris eriocarpa, 20-30 parts of gerbera piloselloides, 10-18 parts of dandelion, 7-15 parts of astragalus membranaceus, 5-10 parts of rhizoma bletillae and 5-10 parts of borneol. The traditional Chinese medicine composition for treating the pressure sores is prepared by taking the derris eriocarpa and the gerbera piloselloides as monarch drugs, giving full play to the synergistic effect of the derris eriocarpa and the gerbera piloselloides, and matching with a proper amount of dandelion, astragalus membranaceus, rhizoma bletillae and borneol as minister, assistant and guide drugs. Animal experiments show that the traditional Chinese medicine composition is high in healing rate on the surface of pressure sores and quick in curative effect, can be further applied to preparation of external preparations such as pressure sore cream and the like, provides a new means for treatment of the pressure sores, and has a wide application prospect.

The invention provides a tubulin-SRC double-target inhibitor in a crystal form as well as a preparation method and application thereof, and particularly discloses 13 crystal forms of two free crystal forms and 10 salts of a compound as shown in a formula I as well as a preparation method and application thereof. The compound, the salt form and the crystal form can be used as a tubulin and Src kinase double-target inhibitor, and can also be used as a single tubulin or Src kinase inhibitor; the compound, the salt form and the crystal form can also obviously inhibit polymerization of tubulin monomers and inhibit cell proliferation; the compound has good pharmacokinetic properties of skin local administration and good druggability, can be used for preparing skin external preparations, and has the advantages of fast metabolism and small side effects. # imgabs0 #

The invention belongs to the technical field of external preparations, and provides compound itching-relieving cream as well as a preparation method and application thereof. The compound itching-relieving ointment is prepared from the following components in parts by weight: 3 to 6 parts of rhizoma coptidis, 9 to 15 parts of radix scutellariae, 9 to 15 parts of radix et rhizoma rhei, 3 to 6 parts of herba schizonepetae, 3 to 6 parts of herba menthae, 1 to 3 parts of cortex moutan, 1 to 3 parts of sandalwood and 0.5 to 1 part of borneol. The compound antipruritic ointment has the effects of cooling, relieving itching, detoxifying and diminishing swelling, and is used for treating itching and eczema dermatitis itching caused by biting of various small insects such as mosquitoes and the like. According to the compound antipruritic ointment disclosed by the invention, a plurality of components are in synergistic interaction, so that a multi-target and multi-layer treatment effect is realized. The traditional Chinese medicine composition can be used for cooling, relieving itching, detoxifying and diminishing swelling from the source while quickly relieving itching, and a comprehensive and effective solution is provided for itching.

The invention discloses a colchicine external preparation with high intradermal residual quantity and percutaneous transmittance as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The invention provides a colchicine external preparation with high intradermal residue and transdermal transmittance. The colchicine external preparation comprises: a) colchicine or a pharmaceutically acceptable salt thereof; b) a penetration enhancer; c) pharmaceutically acceptable excipients and / or excipients; the penetration enhancer is at least one of polyglycerol oleate or isosorbide dimethyl ether. The drug loading capacity and the percutaneous transmittance of the colchicine external preparation disclosed by the invention are remarkably improved. When polyglycerol oleate is selected as a penetration enhancer to prepare colchicine gel, the intradermal retention volume can reach 358.08 micrograms within 20 hours. When isosorbide monomethyl ether is selected as a penetration enhancer to prepare ethosome gel, the accumulated penetration amount can reach 106.87 mu g / cm < 2 >, and the intradermal residual amount can reach 90.58 mu g or above.

The invention belongs to the technical field of anhydrous emulsions, and discloses an anhydrous self-emulsifying drug-loaded emulsion based on a deep eutectic solvent and a preparation method thereof.The preparation method comprises the following steps that 1, betaine and a hydrogen bond donor are mixed, the deep eutectic solvent is prepared through a mixed heating method, a drug is dissolved in the deep eutectic solvent, and a drug solution is prepared; the hydrogen bond donor is levulinic acid or lactic acid; (2) mixing Tween 80 and Span 80 according to a mass ratio of (1-2): 1 to obtain a surfactant, adding absolute ethyl alcohol as a co-emulsifier, adding isopropyl myristate, and uniformly stirring and mixing to obtain a dispersion liquid; and (3) dropwise adding the drug solution in the step (1) into the dispersion liquid in the step (2), and stirring at the same time to finally form the anhydrous self-emulsifying drug-loaded emulsion. According to the invention, the loading capacity, the stability and the bioavailability of the medicine can be obviously improved; in addition, the efficiency of transdermal drug delivery of the emulsion is high, and the emulsion can be applied to skin external preparations.

The invention relates to the technical field of external preparations, in particular to a soluble microneedle patch, a microneedle mask, a microneedle smoking cessation patch and a preparation method thereof.The soluble microneedle patch comprises a microneedle layer and a backing layer, the microneedle layer is prepared from a microneedle matrix solution, the backing layer is prepared from a backing matrix solution, and the backing matrix solution comprises hyaluronic acid and povidone K30; the mass ratio of the hyaluronic acid to the povidone K30 is (3-4): 1, and the concentration of the backing matrix solution is 1.2-1.8 g / ml. The problems that a soluble microneedle is insufficient in mechanical strength, cannot penetrate into the skin for administration, is prone to fragmentation during administration, and is high in pain feeling and poor in comfort can be solved.

The invention discloses an external preparation of a microsphere-loaded medicine for treating chloasma and a preparation method of the external preparation. The preparation method comprises the following steps: preparing polyvinyl alcohol acrylate microspheres, loading a tranexamic acid medicine and adding a matrix to prepare the external preparation of the microsphere-loaded medicine. By means of oleophylic and hydrophilic segments on the polyvinyl alcohol acrylate microspheres, fusion with skin lipid components is increased, permeability of the medicine is improved, meanwhile, due to the large specific surface area of the microspheres, the medicine can be more evenly loaded on the microspheres, and due to the hydrophilicity of the microspheres, moisture can be kept for a longer time; and the problem of crystallization of tranexamic acid caused by moisture volatilization is well solved. The ointment or gel external preparation prepared by the invention is relatively good in character and stability, good in in-vitro permeation and in-vitro release performance and remarkable in treatment effect on chloasma of mice.

To provide a topical composition with excellent adhesiveness to the skin.SOLUTION: A topical composition according to the present invention comprises (A) at least one polyhydric alcohol having a molecular weight of 100 to 200, and (B) at least one non-polymerizable cationic compound. The component (B) may be a compound containing a metal to be a divalent or higher cation in an aqueous solution, a basic amino acid, alkanol amine, or alkyl amine, and the component (A) may be glucose, sorbitol, fructose, xylitol, or erythritol.SELECTED DRAWING: None

The invention discloses a compound fluralana external preparation for dogs, a preparation method and application, belongs to the technical field of veterinary drugs, and solves the problems that an existing preparation is poor in skin surface permeability, a solvent is easy to volatilize, and use experience and drug effect exertion are influenced. The preparation is prepared from the following raw materials: fluralana, moxidectin, ethyl butylacetamidopropionate and N, N-dimethylformamide. The preparation method comprises the following steps: adding N, N-dimethylacetamide, acetone, an auxiliary adjuvant, a transdermal penetration enhancer, an antioxidant and a surface film-forming agent; according to the invention, the combination of the fluralab and the moxidectin can play a synergistic effect and expand an anti-parasitic spectrum so as to achieve an internal and external driving effect; both the fluralab and the moxidectin belong to high-fat-soluble substances, parasites can be quickly repelled and killed by adding novel adjuvant natural parasite expelling ingredients, and meanwhile, the skin permeability can be improved by adding the efficient transdermal penetration enhancer, and the risk that medicine residues are licked by pets is reduced.

The present invention provides a biopolysaccharide that synergistically promotes the expression of ceramide synthase and / or hyaluronic acid synthase and its application, belonging to the technical field of traditional Chinese medicine. The biopolysaccharide is prepared from polygonatum and yam as raw materials through alternating enzymatic hydrolysis, extraction, impurity removal, molecular interception, compounding and other processes to promote the expression of ceramide synthase. The polysaccharide also promotes the expression of hyaluronic acid synthase and can be used in external preparations for the treatment and prevention of dryness, itching and skin barrier defects caused by weakened expression of ceramide synthase and hyaluronic acid synthase.

To provide external skin compositions for bacteria or virus killing, which have a good bacteria or virus killing effect and persistence thereof, and have low skin irritation and high safety to the human body.SOLUTION: Provided is an external skin composition for bacteria or virus killing that contains: (A) one or more acids selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid, or salts thereof; and (B) acids other than component (A) whose pKa is 3.0 or more and 5.0 or less, or salts thereof, the content of component (A) being 0.1 mass% or more and 10 mass% or less, the content of component (B) being 0.1 mass% or more and 10 mass% or less, and the pH being 3.5 or more and 5.0 or less.SELECTED DRAWING: None

To provide an external preparation that contains 3-10 w / v% of minoxidil, pantothenic acid or a derivative thereof or a salt thereof, and an alcohol, wherein the precipitation of the external preparation is suppressed.SOLUTION: An external composition has a container, and an external composition stored in the container. The external composition contains 3-10 w / v% of minoxidil, pantothenic acid or a derivative thereof or a salt thereof, and an alcohol. Of the container, the portion to be contact the external composition is at least partially composed of polyester.SELECTED DRAWING: None

The invention belongs to the technical field of biological medicines, and particularly relates to application of a marine small molecule peptide and an active variant thereof in preparation of a medicine for treating skin diseases, the marine small molecule peptide and the active variant thereof can effectively inhibit keratinocyte pan apoptosis induced by TNF-alpha and IFN-gamma, the formation of a PANoptosome complex is blocked through a multi-target synergistic effect, and the effect of treating the skin diseases is achieved. The oxidative stress is reduced, and mitochondria is stabilized, so that a skin inflammatory cell death network is inhibited from the source. The variant has the same high sequence as the peptide, retains the activity of inhibiting cell pan-apoptosis, and has enhanced stability, skin permeability, in vivo half-life or efficacy. Based on the action mechanism, the peptide and the variant thereof can be used for preparing medicines for preventing and treating intractable skin diseases such as epidermis necrolysis, psoriasis, atopic dermatitis, skin lupus erythematosus and lichen planus. The invention also provides a composition containing the peptide or the variant thereof, and dosage forms comprise an external preparation and an injection.

The invention discloses a short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis, and relates to the technical field of external preparations and scalp care, the short-contact washing agent comprises the following components by weight: an active component combination: 0.01-0.05 wt% of halcinonide; 0.5 to 1.0 wt% of piroctone ethanolamine; 0.1 to 0.3 wt% of total alkaloids of sophora flavescens; 0.05 to 0.1 wt% of berberine; standardized traditional Chinese medicine effective part extracts are compounded with modern active ingredients, and the problem that the quality difference between batches of traditional Chinese medicine lotion is large is solved. The combination of a plurality of active components aims to synergistically act on a plurality of targets such as anti-inflammation, antibiosis and oil control, so as to comprehensively improve the scalp condition. In addition, the specific semi-solid colloid dosage form improves the staying performance of the product on the scalp, and aims to improve the refreshing feeling after use while ensuring the cleaning effect. The lotion provides a hormone-containing and hormone-free double-version design, and provides choices for requirements of different severity degrees and different use stages.

The invention belongs to the field of traditional Chinese medicine compositions, and relates to an external traditional Chinese medicine composition and preparation for treating demodex blepharitis, the traditional Chinese medicine composition comprises the following raw materials by weight: 3-10 parts of coptis chinensis, 3-10 parts of sophora flavescens, and 7.5-10 parts of saposhnicovia divaricata. According to the formula, coptis chinensis and radix sophorae flavescentis are used as monarch drugs for clearing away heat and drying dampness and killing parasites to relieve itching, and the pathogenesis core of demodex infection and damp-heat interweaving is adopted; divaricate saposhnikovia root is used as a ministerial drug to dispel wind and eliminate dampness, eliminate swelling and relieve itching and help the monarch drug to relieve wind pathogen symptoms such as red, swollen, itching and pain of eyelids. In addition, the radix saposhnikoviae is slightly warm in nature and flavor, has the function of adjuvant drugs in the formula, and moderately restricts the bitter and cold nature of the coptis chinensis and the radix sophorae flavescentis; the traditional Chinese medicine composition is an external preparation, no conductant drug is independently arranged in the whole formula, and the formula is further simplified on the premise that the curative effect is guaranteed. The whole formula directly aims at the pathological core of vermiform mite infection and inflammatory response through triple action mechanisms of clearing away heat and toxic materials, dispelling wind and eliminating dampness and killing parasites to relieve itching. The total effective rate of the traditional Chinese medicine composition for demodex blepharitis reaches 94%, and the traditional Chinese medicine composition has the advantages of stable curative effect, high total effective rate, low recurrence rate, small side effect and the like.

The invention relates to the technical field of external preparations, in particular to a preparation process and equipment of a traditional Chinese medicine external preparation compound safflower tincture for treating alopecia, and the preparation process comprises the following steps: S1, grinding a plurality of raw materials into powder, and mixing the powder into a dry material; s2, extracting extracts of a plurality of materials to obtain a mixed extract; s3, mixing the dry material and the mixed extract in water at a preset temperature for a preset time to obtain a mixed solution; s4, heating the mixed solution to a preset extraction temperature, maintaining preset extraction time, and mixing the mixed solution with ethanol to obtain an extract; s5, determining the qualification of the extract liquor based on the color evaluation value of the extract liquor; s6, determining the qualification of the adjusted extraction liquid based on the light transmittance of the adjusted extraction liquid; and step S7, mixing the optimized extract with olive oil to obtain the safflower tincture. The preparation efficiency of the safflower tincture is improved.

The present invention relates to the process for the preparation of topical formulations of anthraquinone compound. The present invention specifically relates to the process for the preparation of topical formulations of Rhein or Diacerein in the form of ointment, cream, gel and transferosomal gel. The present invention more specifically relates to the process for the preparation of topical formulations of Rhein or Diacerein in the form of ointment, cream, gel comprising the steps of heating, adding, stirring, dissolving and mixing. The present invention also relates to the process for the preparation of topical formulations of Rhein or Diacerein in the form of transferosomal gel comprising the steps of thin film formation, hydration of thin film and transferosomal gel formation. The present invention also relates to the process for the preparation of topical formulations of Rhein or Diacerein in the form of transferosomal gel comprising the steps of dissolving, adding and mixing.

A formulation of an mTOR inhibitor for topical administration with a longer shelf life. The formulation includes an mTOR inhibitor and a solvent capable of dissolving and stabilizing the inhibitor. The document also discloses the use of the formulation for the treatment of skin lesions and other diseases for topical administration.

The invention discloses a formula of a Chinese herbal medicine patch for activating blood and dredging meridians and collaterals. According to the invention, a distinct-level efficacy system is formed through a monarch, minister, assistant and guide compatibility theory of traditional Chinese medicines and a modern preparation technology. The monarch drug group is used for promoting blood circulation to remove blood stasis as a core and is matched with the channel-clearing and collateral-activating components of the ministerial drug group, so that local qi-blood circulation can be effectively promoted, and the meridian blocking state is improved. The traditional transdermal limitation is broken through by an intelligent permeation enhancing technology adopted by the adjuvant drug group, so that the drug components rapidly permeate into deep tissues and are continuously released, the advantage of overall regulation of traditional Chinese medicines is reserved, and the problem of low bioavailability of an external preparation is solved. The precise design of each component in spatial distribution and time release realizes quick-acting and long-acting dynamic balance, is particularly suitable for the requirements of different pathological stages such as chronic strain or acute sprain, forms multi-target intervention in the aspects of improving microcirculation, relieving pain, eliminating swelling and the like, and has a wide application prospect. And compared with the traditional plaster, the plaster better meets the requirement of modern clinic on precise treatment.

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a preparation method of a traditional Chinese medicine external preparation for arthralgia based on blood circulation promoting and blood stasis removing, which comprises the following steps: extracting ferulic acid from angelica sinensis and ligusticum wallichii by adopting a supercritical CO2 fluid extraction process; extracting safflower, frankincense and other medicinal materials to obtain a synergistic active ingredient extract; the ferulic acid is used as a first hydrogen bond donor to react with lauric acid used as a temperature-sensitive phase change hydrogen bond donor and choline chloride used as a hydrogen bond acceptor, and the temperature-sensitive bioactive ternary eutectic solvent is prepared; loading the synergistic active ingredient extract in the solvent at low temperature to form a medicine mother solution; and finally, mixing the medicine mother liquor with auxiliary materials to prepare the external preparation. Ferulic acid in medicinal materials serves as a structural unit of a functional solvent, the solvent prepared under the mild condition has biological activity and temperature-sensitive phase change characteristics, a medicine storage cavern can be formed on the skin surface in situ, long-acting slow release and efficient transdermal absorption of active ingredients are achieved, and the curative effect and safety of a preparation are improved.

The invention discloses a wind-dispelling, pain-relieving, blood-activating and blood-stasis-removing black plaster formula and a preparation process, and belongs to the field of traditional Chinese medicine external preparations. According to the formula, pseudo-ginseng and angelica sinensis are used as monarch drugs, ligusticum wallichii, radix angelicae pubescentis and the like are used as ministers, frankincense, myrrh and the like are used as assistants, musk and borneol are used as guides, sesame oil and fried yellow lead are matched as matrixes, and the compatibility of the monarch, the ministers, the assistants and the guides is rigorous. The preparation method comprises the following steps: performing targeted processing (stir-frying with wine, stir-frying with vinegar and the like) on each medicinal material, extracting medicinal oil, refining oil into paste, removing fire toxin, blending fine materials at low temperature, spreading, forming and the like, and performing standardized control on key process parameters. The traditional Chinese medicine composition integrates the holism concept of traditional Chinese medicine and the modern processing technology, aims at wind-cold-dampness arthralgia and blood stasis collateral obstruction syndromes in a targeted mode, and is high in effective component transdermal absorption efficiency, lasting in medicine effect and good in safety. Clinical verification shows that the total effective rate reaches 92.5%, the black plaster can be used for diseases such as neck-shoulder and lumbocrural pain and rheumatism arthralgia, the problems that a traditional black plaster is unstable in medicine effect and high in toxicity risk are solved, and the black plaster has remarkable clinical application and industrialization value.

The present application belongs to the technical field of traditional Chinese medicine composition, and relates to a traditional Chinese medicine transdermal external preparation for treating vulvar hypopigmentation disease. The preparation is a paste prepared by mixing traditional Chinese medicine powder and horse oil. The traditional Chinese medicine powder is composed of the following raw materials by weight: Xuchangqing 10-12, Pugongying 10-15, Difusiduo 12-15, Tuzifuding 12-15, Baiji 10-15, Huzhang 9-12, Quansie 6-10, Diyu 10-12, Xuezhi 10-12, Danggui 6-10, Rushang 6-10, Miedu 6-10, Bingpian 1-3. The traditional Chinese medicine transdermal external preparation has definite and significant effects on vulvar hypopigmentation disease, especially in relieving intractable pruritus, promoting pigment recovery and improving skin sclerosis / atrophy. The traditional Chinese medicine transdermal external preparation has high safety, few adverse reactions and low recurrence rate.

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation process of crotamiton and an external preparation applied by the crotamiton. Comprising the following steps: step 1, slowly dropwise adding 2-butenoyl chloride into N-ethyl-o-toluidine, and controlling the reaction temperature at 10-30 DEG C; after the reaction is finished, heating to 45-55 DEG C, and reacting for 2-4 hours to obtain a product A; adding purified water for dilution, adding a demulsifier, and adding ethyl acetate for extraction to obtain an organic phase; 2, washing the organic phase with a hydrochloric acid solution and a sodium hydroxide solution in sequence, performing liquid separation, performing reduced pressure distillation, collecting fractions at the temperature of 152-155 DEG C and the pressure of-0.096 to-0.1 Mpa, performing refined filtration with a 0.2-0.24 [mu] m filter element in sequence, performing filling, performing capping, and performing packaging; and thus, the crotamiton is obtained. And preparing a medicine solution from crotamiton and other substances, and combining the medicine solution with the pre-gel solution to obtain the external preparation of crotamiton.

This invention relates to pharmaceutical formulations for topical skin application comprising (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, or a pharmaceutically acceptable salt thereof, and use in the treatment of skin disorders.

The invention provides a traditional Chinese medicine composition for regulating scalp micro-ecology, an external preparation containing the traditional Chinese medicine composition and application of the external preparation, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition for regulating and controlling scalp micro-ecology is prepared from cacumen biotae, rhizoma cyperi, fructus cnidii, cortex dictamni, radix sanguisorbae, herba ecliptae and herba menthae. Based on the compatibility principle of monarch, minister, assistant and guide, the composition takes fructus cnidii for eliminating dampness and killing parasites as monarch, cortex dictamni and cacumen biotae for removing heat to cool blood as minister, garden burnet, eclipta and rhizoma cyperi for astringing, detoxifying, nourishing yin and regulating qi as assistant, and mint for guiding the medicine to move upwards and transdermal permeation as guide, so that multiple effects of inhibiting bacteria, resisting inflammation, repairing a barrier, regulating sebum secretion and the like are synergistically realized. Modern pharmacological studies show that the active ingredients can inhibit malassezia proliferation, regulate and control inflammatory pathways of NF-kB, TLR4 and the like, reduce expression of proinflammatory factors of IL-6, TNF-alpha and the like, and promote skin barrier repair. Clinical observation shows that the composition can significantly improve the scalp seborrheic dermatitis symptom.

The invention provides a healthy, safe and effective new raw material for cosmetics, namely flavone piperil ester or a salt compound thereof. The flavonoid piperazine ester can well inhibit the activity of hyaluronidase and increase the content of collagen in cells, so that the flavonoid piperazine ester has the effects of relieving, moisturizing and resisting wrinkles, meanwhile, the flavonoid piperazine ester shows remarkable DPPH free radical scavenging capacity, and the flavonoid piperazine ester is a good antioxidant. The composition can be used for preparing skin external preparations and is a good cosmetic raw material.