42 results about "Skin flora" patented technology

The invention discloses an application of a milk peptide fermentation product in regulating skin micro-ecological balance, and belongs to the technical field of biological fermentation application, and the milk peptide fermentation product selectively regulates and controls the growth of staphylococcus epidermidis and inhibits the growth of staphylococcus aureus and escherichia coli. The milk peptide leavening is found to have a selective bacteriostatic effect on skin microorganisms for the first time, experimental results show that the milk peptide leavening has an inhibiting effect on escherichia coli and staphylococcus aureus, but has no influence on normal growth of epidermis grape germs, and the characteristic is obviously different from that of a common broad-spectrum chemical bacteriostatic agent; the milk peptide leavening is more beneficial to maintenance of skin flora balance.

The invention provides a composition for protecting micro-ecological balance of skin and a preparation method of the composition. Comprising the following components in percentage by weight: 84.12%-92.47% of a solvent, 5%-10% of a bifidus yeast fermentation product lysate, 0.1%-0.5% of tetrahydromethylpyrimidine carboxylic acid, 0.5%-1% of panthenol, 0.5%-1% of lactobacillus / soybean milk fermentation product filtrate, 0.5%-1% of arginine / lysine polypeptide, 0.5%-1% of 1, 2-hexanediol, 0.1%-0.5% of a pH regulator, 0.03%-0.08% of a chelating agent and 0.3%-0.8% of an antioxidant. According to the scheme, probiotic strains which are carefully screened are selected as powerful cell protection factors, an ideal environment for skin flora survival is kept, and the skin health level is improved.

There is provided a resident-skin-flora-improving agent that is useful in keeping the skin in excellent condition. Specifically, there is provided a resident-skin-flora-improving agent in which sophorose is used. Sophorose is provided with functionality by which it is possible to promote proliferation of helpful bacteria that beneficially affect skin while suppressing growth of bacteria that could adversely affect the skin. The resident-skin-flora-improving agent can suitably be used for the object of maintaining balance of the resident skin flora and keeping the skin in excellent condition.

The present invention relates to a cosmetic composition in which lipid fermentation metabolites are produced by fermenting vegetable oil with skin flora, and a method for producing the same. According to the present invention, lipid fermentation metabolites similar to skin lipids can be produced by fermenting vegetable oil with skin flora. Further, thereby, the skin affinity and skin barrier-protecting effect of the fermented vegetable oil can be maximized.

The application discloses a low-irritation borage oil nano-liposome, a diaper-care preparation and application of the diaper-care preparation in diaper rash of infants and young children, and belongs to the field of infant skin-care preparations. The nano-liposome is composed of the following components in percentage by weight: 0.5-2.0% of biodecolorized borage oil, 1.0-3.0% of chitosan oligosaccharide-ceramide binary membrane material, 0.3-1.0% of prebiotic skin flora regulator, 0.8-1.5% of pH 5.5 weak acid buffer system, 0.05-0.2% of edible-grade microencapsulated menthol, and the balance of sterile water for injection. The application also provides a diaper-care preparation containing the low-irritation borage oil nano-liposome, which is suitable for daily prevention and acute-phase intervention of infants and young children aged 0-36 months, has the characteristics of high bioavailability, low irritation, rapid repair and easy carrying, and has important clinical application value.

The present invention relates to a skin prebiotics composition comprising glycerol and disaccharides. The composition optimizes the content of glycerol and disaccharides to induce the balance of skin microbiota, thereby having an excellent skin improvement effect.

The invention discloses an atopic dermatitis repairing preparation based on skin micro-ecological regulation and control, which belongs to the field of medical moisturizing cream and is prepared from the following components in percentage by mass: 38.5 to 70.95 percent of phase A, 22.21 to 46.2 percent of phase B, 2.1 to 2.5 percent of phase C, 3 to 7.4 percent of phase D, 1.53 to 3.7 percent of phase E and 0.21 to 1.7 percent of phase F, the materials are prepared and discharged through a traditional preparation method; the repairing preparation provided by the invention can be combined with prebiotics, and can repair the micro-ecological environment together with other components, so that the micro-ecological balance of skin flora is promoted; a 4D moisturizing system is formed and is combined with sodium hyaluronate with different molecular weights to replenish water at different levels of the skin; multiple itching relieving mechanisms including physical itching relieving and bionic barrier repairing are achieved; meanwhile, the facial cleanser has the characteristics of safety and mildness, does not use irritating components, and is suitable for thin, tender, weak and sensitive atopic dermatitis skin.

The present application relates to the daily chemical technology field, especially to a composition with multiple anti-aging effects and application thereof.The composition comprises retinol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, lactobacillus / soybean milk fermentation product filtrate and resveratrol.The present application is a composition with a mild triple anti-aging system for promoting collagen regeneration and a preparation method thereof, which contains retinol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, lactobacillus / soybean milk fermentation product filtrate and resveratrol, has obvious effects on skin epidermis and dermis aging, up-regulates skin flora balance, enhances the water-locking ability of the stratum corneum, improves the penetration rate of active ingredients, and increases cell vitality on the epidermis;in the epidermis+dermis, it has antioxidant and anti-inflammatory properties, the components are mild and have good absorption effect, and there is no need to establish tolerance, so that the skin resistance is consolidated, and it is especially suitable for sensitive skin.

The invention relates to the field of microorganism application, in particular to lactobacillus kefiranofaciens W182, W182 lysate and application of the lactobacillus kefiranofaciens W182 and the W182 lysate in the anti-aging aspect. The preservation number of the W182 strain is CGMCC (China General Microbiological Culture Collection Center) No.27058. The research finds that the lactobacillus kefiranofaciens W182 lysate has very good tyrosinase inhibition capability, can inhibit melanin generation, has very good removal capability on DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radicals, can increase the activity of superoxide dismutase, glutathione peroxidase and the like in the skin of an aged mouse, and can be used for preparing the lactobacillus kefiranofaciens W182 lysate. The skin care product has a strong anti-oxidation function and an anti-aging function, can improve the contents of collagen and ceramide in skin and maintain the structural integrity of skin tissues, and has the effects of supplementing water, resisting aging, regulating skin flora, improving the micro-ecology of skin and the like; the compound can be applied to preparation of antioxidants, free radical scavengers, whitening products / cosmetics, food and / or drugs and products with an anti-aging function.

To provide a liquid cosmetic composition comprising chitosan and having beneficial properties for topical application to the skin, and to provide uses of the liquid cosmetic composition.SOLUTION: The present invention relates to liquid compositions as well as the use of liquid compositions for differentially promoting the growth of the microbiome. The liquid composition forms a membrane of the invention when applied to the skin of a subject. The liquid composition as well as the membrane comprise chitosan or a salt thereof with a degree of acetylation of 20% or less and at least one further agent. The present invention further relates to pharmaceutical compositions for the treatment of dysbiosis.SELECTED DRAWING: None

The present invention aims to provide a microbiota improving agent for improving at least one of mucosal microbiota, skin microbiota, or nail microbiota, the microbiota improving agent exhibiting a high pathogenic bacteria inhibitory effect while maintaining resident non-pathogenic bacteria, thus persistently improving the microbiota balance. The present invention relates to a microbiota improving agent for improving at least one of mucosal microbiota, skin microbiota, or nail microbiota, the microbiota improving agent containing: a substance (X); and a base (Y) containing a non-volatile component, the substance (X) including at least one selected from the group consisting of a compound (X1) having two or more hydroxy groups contained in at least one oxoacid group and a salt of the compound (X1), a compound (X2) having one hydroxy group contained in an oxoacid group and a salt of the compound (X2), a heterocyclic compound (X3) having no oxoacid group and a salt of the compound (X3), and a ketone (X4) having no oxoacid group. In the compound (X1), a total mass percentage of the at least one oxoacid group, a hydroxy group not contained in the oxoacid group, a carbonyl group not contained in the oxoacid group, carbon atoms contained in an imidazole skeleton and a pyridine skeleton, and nitrogen atoms contained in the imidazole skeleton and the pyridine skeleton is 45% by mass or more based on a molecular weight of the compound (X1). The compound (X2) has an atom having an unshared electron pair, the atom excluding atoms contained in the oxoacid group and atoms contained in an amino group not constituting an imidazole skeleton and in an amino group not constituting a pyridine skeleton. In the compound (X2), a total mass percentage of the oxoacid group, a hydroxy group not contained in the oxoacid group, a carbonyl group not contained in the oxoacid group, carbon atoms contained in an imidazole skeleton and a pyridine skeleton, and nitrogen atoms contained in the imidazole skeleton and the pyridine skeleton is 55% by mass or more based on a molecular weight of the compound (X2). The heterocyclic compound (X3) has an imidazole skeleton or a pyridine skeleton and at least one of a hydroxy group or a carbonyl group, or has two or more skeletons selected from the group consisting of an imidazole skeleton and a pyridine skeleton. The ketone (X4) has a linear β-diketone structure. The substance (X) has a molecular weight of 550 or less. The non-volatile component has an HLB value of 7 or more. The microbiota improving agent satisfies the following conditions (i) and (ii): (i) the microbiota improving agent has a worked penetration of 100 to 400 as measured in accordance with JIS K 2220; and (ii) the microbiota improving agent has a viscosity at 37° C. of 1 to 4,000 Pa·s as measured with a cone-and-plate rheometer.

The present invention relates to the technical field of skin flora sampling, and in particular to a skin flora sampling device. The device includes a liquid supply mechanism, a rotating mechanism and a sampling mechanism; the liquid supply mechanism includes a liquid supply cylinder and a pressure relief tank; a driving force is transmitted to the liquid supply cylinder so that the sampling mechanism applies pressure to the skin, and when the sampling pressure applied by the sampling mechanism to the skin exceeds a threshold value, the medium partially enters the pressure relief tank. When the skin flora sampling device provided by the present invention is in use, a driving force is transmitted to the liquid supply cylinder so that the sampling mechanism applies pressure to the skin, and when the driving force exceeds the threshold value, the medium in the liquid supply cylinder is input to the rotating mechanism, and the rotating mechanism drives the sampling mechanism to sample the skin flora; when the sampling mechanism applies a sampling pressure to the skin that exceeds the threshold value, the medium partially enters the pressure relief tank to control the sampling pressure applied to the skin, thereby solving the problem of easy damage to the skin during flora sampling.

The invention discloses torreya grandis seed oil and application thereof, and belongs to the field of plant extracts. The torreya grandis seed oil is prepared by adopting a supercritical CO2 extraction method, the expression level of a macrophage RAW264.7 inflammatory factor IL-6 caused by LPS can be remarkably reduced, and the torreya grandis seed oil has a good anti-inflammatory effect. The traditional Chinese medicine composition disclosed by the invention can effectively inhibit the growth of propionibacterium acnes, also can effectively regulate the skin flora balance of people with acnes, has no obvious influence on the growth of staphylococcus epidermidis while remarkably inhibiting the growth of propionibacterium acnes, is an excellent acne-removing cosmetic raw material, and has a wide application prospect in the development of nursing products for people with acnes.

The invention relates to cosmetic and dermatological preparations comprising a combination of levulinic acid and anisic acid. The preparations according to the invention are particularly suitable for application to the skin. These preparations exhibit selective antibacterial action on the skin, specifically targeting anaerobic bacteria of the skin flora, while having little or no bactericidal action against aerobic bacteria. The compositions according to the invention are therefore suitable for cosmetic skin care as well as for the dermatological treatment of certain skin conditions, such as acne.

To provide a novel agent for regulating skin-resident microbiota, not being limited in use form to topical skin agents and enabling adjustment of the balance of skin resident microbiota in other forms.SOLUTION: Provided is an agent comprising essential oil and / or extract of tea tree.SELECTED DRAWING: Figure 1

The invention relates to a cosmetic and / or dermo-cosmetic application method for the skin, comprising the application of a natural extract to the skin surface to induce biosynthesis in the skin microbiota. This biosynthesis induces the production of one or more metabolites of interest by the skin microbiota. The metabolite(s) of interest, associated with the applied natural extract, induce a beneficial effect on the skin. FIGURE: 3

The invention relates to a screening method and application of cosmetic preservatives, and belongs to the technical field of application of preservatives. The invention relates to a method for screening cosmetic preservatives, in particular to a method for screening cosmetic preservatives which can inhibit pathogenic bacteria and are friendly to skin bacteria by taking SVS values and / or CVS values as screening indexes. Wherein the SVS value is equal to the MIC value of the staphylococcus epidermidis / the MIC value of the staphylococcus aureus, and the CVS value is equal to the MIC value of the propionibacterium acnes / the MIC value of the staphylococcus aureus. The preservative composition constructed by the method has a good preservative effect, and has certain micro-ecological friendliness to the growth of resident skin flora (namely skin bacteria).

The invention designs a mild and skin-friendly compound preservative composition for cosmetics, and in the cosmetics containing the preservative composition, the growth of pathogenic microorganisms (such as staphylococcus aureus, pseudomonas aeruginosa and the like) in the cosmetics can be effectively inhibited; the skin care product is mild, does not cause harm to skin and is suitable for sensitive skin, and human healthy skin florae (such as staphylococcus epidermidis, staphylococcus capitis, propionibacterium acnes, micrococcus luteus, bacillus firmus, acinetobacter lwoffii and the like) are not inhibited, and the skin care product is mild, does not injure skin and is suitable for sensitive skin.

The invention discloses staphylococcus epidermidis NCU-07, a probiotic metagen and application, and relates to the technical field of biological medicine. The staphylococcus epidermidis NCU-07 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on January 18, 2023, and the preservation number is CGMCC NO.26493. The staphylococcus epidermidis NCU-07 is preserved in the China General Microbiological Culture Collection The bacterial strain is prepared into the probiotic metagen, and the application of the probiotic metagen, sulfadiazine silver cream and a compound coptis chinensis oil liniment in a medicine composition for treating skin burn wounds is provided in a combined mode of the probiotic metagen, the sulfadiazine silver cream and the compound coptis chinensis oil liniment. The probiotic metagen disclosed by the invention is beneficial to promoting the healing of the II-degree burn wound of a patient, can enhance the treatment effect when being combined with the sulfadiazine silver cream and the compound coptis oil liniment, relieves the itching symptom of the II-degree burn wound of the patient, has no obvious influence on the pain symptom of the wound, increases the diversity of skin florae, and can be used for treating the II-degree burn wound of the patient. Colonization and proliferation of pathogenic microorganisms can be inhibited, and proliferation of skin symbiotic bacteria is promoted.

Provided is an agent for improving permanent skin microflora, which is useful for satisfactorily maintaining the state of the skin. The present invention is an agent for improving permanent skin flora using sophorose. The sophorose has the functions of inhibiting the growth of bacteria which may cause adverse effects on the skin in the resident bacteria of the skin and promoting the proliferation of beneficial bacteria which cause good effects on the skin in the resident bacteria of the skin. This agent for improving skin resident microflora can be suitably used for the purpose of maintaining the balance of skin resident microflora and maintaining the state of skin satisfactorily.

The present invention relates to a composition and non-therapeutic use of a combination for targeted alteration of skin flora, said composition comprising levulinic acid and anisic acid. The formulations according to the invention are particularly suitable for use on the skin. The preparation shows a selective antibacterial effect on skin by specifically resisting anaerobic bacteria of skin flora, and almost has no or no bactericidal effect on aerobic bacteria. Thus, the compositions according to the invention are suitable for non-therapeutic uses of compositions and combinations for targeted alteration of skin flora.

The invention discloses a prebiotic composition for regulating skin flora and its preparation method and use, relates to the field of biomedical technology, including inulin, α-glucan oligosaccharide, white willow bark extract, honeysuckle extract; the preparation method is: after white willow bark extract and honeysuckle extract are mixed, inulin is added to stir and mix, and finally α-glucan oligosaccharide is added to mix to obtain a prebiotic composition; it can be used for the preparation of male and female private parts washing liquid. The formula of the prebiotic composition is used in external products, can play an effective antibacterial effect, inhibit Staphylococcus aureus, Candida albicans, Escherichia coli, competitively provide energy for private parts beneficial bacteria, protect private parts beneficial lactobacillus, and can produce the effect of reducing sensitivity and improving private parts discomfort to male and female private parts respectively.

The present invention relates to the field of microbial applications, and more specifically, to a kvass-producing Lactobacillus W182 strain, a W182 lysate, and their applications in anti-aging. The W182 strain has a deposit number of CGMCC No. 27058. Studies have shown that the kvass-producing Lactobacillus W182 lysate has excellent tyrosinase inhibition, can inhibit melanin production, has excellent DPPH free radical scavenging ability, can increase the activities of superoxide dismutase and glutathione peroxidase in the skin of aging mice, has strong antioxidant and anti-aging functions, can increase the content of collagen and ceramide in the skin, maintain the integrity of skin tissue structure, has hydrating, anti-aging, regulates skin flora, improves skin microecology, and can be used to prepare antioxidants, free radical scavengers, whitening products / cosmetics, foods and / or medicines, and products with anti-aging functions.

The invention provides rhizoma polygonati fermentation liquor, essence, a preparation method and application, and particularly belongs to the technical field of skin care cosmetics. The preparation method comprises the following steps: mixing rhizoma polygonati powder with water to obtain wet-based rhizoma polygonati powder; inoculating aspergillus oryzae into the wet-based rhizoma polygonati powder for solid-state fermentation, and drying to obtain a rhizoma polygonati solid-state fermentation product; mixing the rhizoma polygonati solid-state fermentation product with water, extracting with hot water, and performing suction filtration to obtain rhizoma polygonati fermentation filtrate; and sterilizing, filtering and centrifuging the polygonatum sibiricum fermentation filtrate to obtain polygonatum sibiricum fermentation liquor (fermentation liquor for short). The prepared fermentation liquor has the effects of accelerating skin injury repair, resisting oxidation, preserving moisture, diminishing inflammation and regulating skin flora.

The present invention relates to a phospholipid-based surfactant prepared using skin flora in an environmentally friendly and human-friendly manner, and to a method for preparing the same. The present invention can provide an environmentally friendly and human friendly composition that can replace synthetic surfactants. In addition, the surfactant disclosed by the invention can be widely applied to the fields of foods, detergents, cosmetics and the like.

To provide a method for finding bacteria having a high correlation with skin conditions from among the constituent bacteria of skin microbiome and predicting the skin conditions based on the abundance ratio of the bacteria.SOLUTION: The present invention provides a method for predicting a trans epidermal water loss (TEWL) using an abundance ratio of Malassezia fungi or a difference in the abundance ratio in skin mycoflora as an index.SELECTED DRAWING: None

The application discloses application of a Portulaca oleracea extracellular vesicle in resisting acne and regulating acne microecological flora. The Portulaca oleracea extracellular vesicle PDEVs provided by the application can significantly inhibit growth of Propionibacterium acnes, and has obvious bactericidal effect under a lower MIC condition, has less influence on skin beneficial bacteria, is helpful to maintaining or regulating skin microecological balance, and has the advantage of selectively regulating skin flora. Meanwhile, the PDEVs can significantly reduce mRNA expression levels of inflammatory factors IL-6, IL-8, IL-1beta and TNF-alpha of HaCaT cells under stimulation of inactivated Propionibacterium acnes and intracellular reactive oxygen species ROS levels, thereby reducing inflammatory reaction and oxidative stress reaction; the PDEVs have a synergistic effect in regulating skin microecology, inhibiting inflammatory reaction and relieving oxidative stress, have good biocompatibility and safety, and provide more choices for developing natural source active ingredients for preventing or improving acne.

The present invention can provide a method for preparing a fermented nano-emulsifier composition comprising a product obtained by fermenting an oil with a skin flora, and a skin-friendly composition by minimizing the contents of synthetic raw materials according to such a method. Further, it is possible to improve an emulsification power by forming a nano-emulsion in a size of nm, to be adopted to various formulations by enhancing stability of the composition, and to be easily applied to various formulations requiring a function of hypoallergenic skin due to minimization of the skin irritation.

The invention discloses a composition for relieving acne symptoms and fading acne marks as well as a preparation method and application of the composition, and belongs to the field of fine chemical engineering. The composition is prepared from the following components in parts by weight: 1 to 20 parts of quaternary ammonium salt-73, 1 to 30 parts of inonotus obliquus extract and 10 to 95 parts of glycyrrhiza inflate extract. The composition can relieve red, swollen and swelling pain when acnes occur, condition skin flora, relieve inflammation, fade pigmentation caused by inflammation and promote rapid healing of the acnes. The components of the composition can effectively cooperate, and the composition is mild and non-irritant and has excellent effects of relieving acne symptoms and fading acne marks.

The invention discloses an acne mask and a preparation process thereof, and belongs to the field of dressings, the acne mask comprises 5-15 g of magnolia flower, 10-20 g of bighead atractylodes rhizome, 10-20 g of honeysuckle, 10-20 g of bletilla striata, 10-20 g of scutellaria baicalensis, 10-20 g of dandelion, 5-10 g of asarum, 5-10 g of mint, 10-20 g of rheum officinale, 10-20 g of golden cypress, 10-20 g of coptis chinensis, 10-20 g of fructus forsythiae, 10-20 g of radix angelicae and 3-8 g of borneol. The problems that existing western medicines have large irritation to skin mucous membranes, skin dryness and water shortage are easily caused, and skin flora distribution is disordered are solved.