24 results about "Skin flora" patented technology

There is provided a resident-skin-flora-improving agent that is useful in keeping the skin in excellent condition. Specifically, there is provided a resident-skin-flora-improving agent in which sophorose is used. Sophorose is provided with functionality by which it is possible to promote proliferation of helpful bacteria that beneficially affect skin while suppressing growth of bacteria that could adversely affect the skin. The resident-skin-flora-improving agent can suitably be used for the object of maintaining balance of the resident skin flora and keeping the skin in excellent condition.

The application discloses a low-irritation borage oil nano-liposome, a diaper-care preparation and application of the diaper-care preparation in diaper rash of infants and young children, and belongs to the field of infant skin-care preparations. The nano-liposome is composed of the following components in percentage by weight: 0.5-2.0% of biodecolorized borage oil, 1.0-3.0% of chitosan oligosaccharide-ceramide binary membrane material, 0.3-1.0% of prebiotic skin flora regulator, 0.8-1.5% of pH 5.5 weak acid buffer system, 0.05-0.2% of edible-grade microencapsulated menthol, and the balance of sterile water for injection. The application also provides a diaper-care preparation containing the low-irritation borage oil nano-liposome, which is suitable for daily prevention and acute-phase intervention of infants and young children aged 0-36 months, has the characteristics of high bioavailability, low irritation, rapid repair and easy carrying, and has important clinical application value.

The present invention relates to a skin prebiotics composition comprising glycerol and disaccharides. The composition optimizes the content of glycerol and disaccharides to induce the balance of skin microbiota, thereby having an excellent skin improvement effect.

The invention discloses an atopic dermatitis repairing preparation based on skin micro-ecological regulation and control, which belongs to the field of medical moisturizing cream and is prepared from the following components in percentage by mass: 38.5 to 70.95 percent of phase A, 22.21 to 46.2 percent of phase B, 2.1 to 2.5 percent of phase C, 3 to 7.4 percent of phase D, 1.53 to 3.7 percent of phase E and 0.21 to 1.7 percent of phase F, the materials are prepared and discharged through a traditional preparation method; the repairing preparation provided by the invention can be combined with prebiotics, and can repair the micro-ecological environment together with other components, so that the micro-ecological balance of skin flora is promoted; a 4D moisturizing system is formed and is combined with sodium hyaluronate with different molecular weights to replenish water at different levels of the skin; multiple itching relieving mechanisms including physical itching relieving and bionic barrier repairing are achieved; meanwhile, the facial cleanser has the characteristics of safety and mildness, does not use irritating components, and is suitable for thin, tender, weak and sensitive atopic dermatitis skin.

The present application relates to the daily chemical technology field, especially to a composition with multiple anti-aging effects and application thereof.The composition comprises retinol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, lactobacillus / soybean milk fermentation product filtrate and resveratrol.The present application is a composition with a mild triple anti-aging system for promoting collagen regeneration and a preparation method thereof, which contains retinol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, lactobacillus / soybean milk fermentation product filtrate and resveratrol, has obvious effects on skin epidermis and dermis aging, up-regulates skin flora balance, enhances the water-locking ability of the stratum corneum, improves the penetration rate of active ingredients, and increases cell vitality on the epidermis;in the epidermis+dermis, it has antioxidant and anti-inflammatory properties, the components are mild and have good absorption effect, and there is no need to establish tolerance, so that the skin resistance is consolidated, and it is especially suitable for sensitive skin.

The present invention aims to provide a microbiota improving agent for improving at least one of mucosal microbiota, skin microbiota, or nail microbiota, the microbiota improving agent exhibiting a high pathogenic bacteria inhibitory effect while maintaining resident non-pathogenic bacteria, thus persistently improving the microbiota balance. The present invention relates to a microbiota improving agent for improving at least one of mucosal microbiota, skin microbiota, or nail microbiota, the microbiota improving agent containing: a substance (X); and a base (Y) containing a non-volatile component, the substance (X) including at least one selected from the group consisting of a compound (X1) having two or more hydroxy groups contained in at least one oxoacid group and a salt of the compound (X1), a compound (X2) having one hydroxy group contained in an oxoacid group and a salt of the compound (X2), a heterocyclic compound (X3) having no oxoacid group and a salt of the compound (X3), and a ketone (X4) having no oxoacid group. In the compound (X1), a total mass percentage of the at least one oxoacid group, a hydroxy group not contained in the oxoacid group, a carbonyl group not contained in the oxoacid group, carbon atoms contained in an imidazole skeleton and a pyridine skeleton, and nitrogen atoms contained in the imidazole skeleton and the pyridine skeleton is 45% by mass or more based on a molecular weight of the compound (X1). The compound (X2) has an atom having an unshared electron pair, the atom excluding atoms contained in the oxoacid group and atoms contained in an amino group not constituting an imidazole skeleton and in an amino group not constituting a pyridine skeleton. In the compound (X2), a total mass percentage of the oxoacid group, a hydroxy group not contained in the oxoacid group, a carbonyl group not contained in the oxoacid group, carbon atoms contained in an imidazole skeleton and a pyridine skeleton, and nitrogen atoms contained in the imidazole skeleton and the pyridine skeleton is 55% by mass or more based on a molecular weight of the compound (X2). The heterocyclic compound (X3) has an imidazole skeleton or a pyridine skeleton and at least one of a hydroxy group or a carbonyl group, or has two or more skeletons selected from the group consisting of an imidazole skeleton and a pyridine skeleton. The ketone (X4) has a linear β-diketone structure. The substance (X) has a molecular weight of 550 or less. The non-volatile component has an HLB value of 7 or more. The microbiota improving agent satisfies the following conditions (i) and (ii): (i) the microbiota improving agent has a worked penetration of 100 to 400 as measured in accordance with JIS K 2220; and (ii) the microbiota improving agent has a viscosity at 37° C. of 1 to 4,000 Pa·s as measured with a cone-and-plate rheometer.

The present invention relates to the technical field of skin flora sampling, and in particular to a skin flora sampling device. The device includes a liquid supply mechanism, a rotating mechanism and a sampling mechanism; the liquid supply mechanism includes a liquid supply cylinder and a pressure relief tank; a driving force is transmitted to the liquid supply cylinder so that the sampling mechanism applies pressure to the skin, and when the sampling pressure applied by the sampling mechanism to the skin exceeds a threshold value, the medium partially enters the pressure relief tank. When the skin flora sampling device provided by the present invention is in use, a driving force is transmitted to the liquid supply cylinder so that the sampling mechanism applies pressure to the skin, and when the driving force exceeds the threshold value, the medium in the liquid supply cylinder is input to the rotating mechanism, and the rotating mechanism drives the sampling mechanism to sample the skin flora; when the sampling mechanism applies a sampling pressure to the skin that exceeds the threshold value, the medium partially enters the pressure relief tank to control the sampling pressure applied to the skin, thereby solving the problem of easy damage to the skin during flora sampling.

The invention discloses torreya grandis seed oil and application thereof, and belongs to the field of plant extracts. The torreya grandis seed oil is prepared by adopting a supercritical CO2 extraction method, the expression level of a macrophage RAW264.7 inflammatory factor IL-6 caused by LPS can be remarkably reduced, and the torreya grandis seed oil has a good anti-inflammatory effect. The traditional Chinese medicine composition disclosed by the invention can effectively inhibit the growth of propionibacterium acnes, also can effectively regulate the skin flora balance of people with acnes, has no obvious influence on the growth of staphylococcus epidermidis while remarkably inhibiting the growth of propionibacterium acnes, is an excellent acne-removing cosmetic raw material, and has a wide application prospect in the development of nursing products for people with acnes.

The invention relates to cosmetic and dermatological preparations comprising a combination of levulinic acid and anisic acid. The preparations according to the invention are particularly suitable for application to the skin. These preparations exhibit selective antibacterial action on the skin, specifically targeting anaerobic bacteria of the skin flora, while having little or no bactericidal action against aerobic bacteria. The compositions according to the invention are therefore suitable for cosmetic skin care as well as for the dermatological treatment of certain skin conditions, such as acne.

The present invention relates to the field of microbial applications, and more specifically, to a kvass-producing Lactobacillus W182 strain, a W182 lysate, and their applications in anti-aging. The W182 strain has a deposit number of CGMCC No. 27058. Studies have shown that the kvass-producing Lactobacillus W182 lysate has excellent tyrosinase inhibition, can inhibit melanin production, has excellent DPPH free radical scavenging ability, can increase the activities of superoxide dismutase and glutathione peroxidase in the skin of aging mice, has strong antioxidant and anti-aging functions, can increase the content of collagen and ceramide in the skin, maintain the integrity of skin tissue structure, has hydrating, anti-aging, regulates skin flora, improves skin microecology, and can be used to prepare antioxidants, free radical scavengers, whitening products / cosmetics, foods and / or medicines, and products with anti-aging functions.

The present invention relates to a phospholipid-based surfactant prepared using skin flora in an environmentally friendly and human-friendly manner, and to a method for preparing the same. The present invention can provide an environmentally friendly and human friendly composition that can replace synthetic surfactants. In addition, the surfactant disclosed by the invention can be widely applied to the fields of foods, detergents, cosmetics and the like.

To provide a method for finding bacteria having a high correlation with skin conditions from among the constituent bacteria of skin microbiome and predicting the skin conditions based on the abundance ratio of the bacteria.SOLUTION: The present invention provides a method for predicting a trans epidermal water loss (TEWL) using an abundance ratio of Malassezia fungi or a difference in the abundance ratio in skin mycoflora as an index.SELECTED DRAWING: None

The application discloses application of a Portulaca oleracea extracellular vesicle in resisting acne and regulating acne microecological flora. The Portulaca oleracea extracellular vesicle PDEVs provided by the application can significantly inhibit growth of Propionibacterium acnes, and has obvious bactericidal effect under a lower MIC condition, has less influence on skin beneficial bacteria, is helpful to maintaining or regulating skin microecological balance, and has the advantage of selectively regulating skin flora. Meanwhile, the PDEVs can significantly reduce mRNA expression levels of inflammatory factors IL-6, IL-8, IL-1beta and TNF-alpha of HaCaT cells under stimulation of inactivated Propionibacterium acnes and intracellular reactive oxygen species ROS levels, thereby reducing inflammatory reaction and oxidative stress reaction; the PDEVs have a synergistic effect in regulating skin microecology, inhibiting inflammatory reaction and relieving oxidative stress, have good biocompatibility and safety, and provide more choices for developing natural source active ingredients for preventing or improving acne.

The present invention can provide a method for preparing a fermented nano-emulsifier composition comprising a product obtained by fermenting an oil with a skin flora, and a skin-friendly composition by minimizing the contents of synthetic raw materials according to such a method. Further, it is possible to improve an emulsification power by forming a nano-emulsion in a size of nm, to be adopted to various formulations by enhancing stability of the composition, and to be easily applied to various formulations requiring a function of hypoallergenic skin due to minimization of the skin irritation.

The invention discloses an acne mask and a preparation process thereof, and belongs to the field of dressings, the acne mask comprises 5-15 g of magnolia flower, 10-20 g of bighead atractylodes rhizome, 10-20 g of honeysuckle, 10-20 g of bletilla striata, 10-20 g of scutellaria baicalensis, 10-20 g of dandelion, 5-10 g of asarum, 5-10 g of mint, 10-20 g of rheum officinale, 10-20 g of golden cypress, 10-20 g of coptis chinensis, 10-20 g of fructus forsythiae, 10-20 g of radix angelicae and 3-8 g of borneol. The problems that existing western medicines have large irritation to skin mucous membranes, skin dryness and water shortage are easily caused, and skin flora distribution is disordered are solved.

The application belongs to the technical field of cosmetics, and particularly relates to a composition for improving oily skin and application thereof in skin care. The composition for improving oily skin comprises 0.1%-2% sodium acrylate / sodium acryloyldimethyl taurate copolymer, 1%-3% evening primrose oil, 1%-3% isononyl isononanoate, 1%-3% dimethicone, 0.05%-0.2% sodium hyaluronate, 0.5%-1% D-mannitol, 1%-3% fucoidan, 0.01%-0.03% oligoisomaltose, and the rest is water. The application firstly studies the physiological characteristics and skin flora characteristics of the oily skin population, and on this basis, the raw materials are screened based on the proliferation law of the raw materials for the large abundance of bacteria of the oily skin, the safety of the formula is further verified, and the skin improvement after the population uses the formula, so that the application has a wide application prospect.

The present invention relates to a fermented oil in which the content of a lipid fermentation metabolite having an amine group is increased by fermenting caviar and vegetable oil with skin flora, and a cosmetic composition comprising same. The cosmetic composition according to the present invention can improve anti-aging, barrier strengthening, moisturizing, and differentiation effects, thereby maximizing beneficial effects on the skin.

The invention relates to the technical field of daily chemicals, in particular to a composition with a multi-effect anti-aging effect and application of the composition. The composition is prepared from retinol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, lactobacillus / soybean milk fermentation product filtrate and resveratrol. The invention relates to a composition with a triple anti-aging system capable of mildly promoting collagen regeneration and a preparation method of the composition, the composition comprises retinol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, lactobacillus / soybean milk fermentation product filtrate and resveratrol, and the composition has an obvious effect on skin epidermis aging and dermis aging; the skin flora balance is regulated on the epidermis, the water locking capacity of the cuticle is enhanced, the permeability of active ingredients is improved, and the activity of cells is improved; in epidermis and dermis, the composition has anti-oxidation and anti-inflammatory characteristics, is mild in components and good in absorption effect, does not need to establish tolerance and consolidate skin resistance, and is particularly suitable for sensitive skin.

The present invention relates to a method for providing a lipid fermentation product having high polarity using skin flora. The lipid fermentation product of the present invention contains glycolipids with high polarity, and thus can easily form emulsified self-assembled particles and liquid crystal emulsions to improve emulsification properties.

An ostomy barrier, skin adhesive, accessory or a peristomal skin treatment comprises a population of non-pathogenic bacteria, fungi, algae, yeast or their lysates configured to limit proliferation of pathogenic organisms in or on peristomal skin or skin at other body sites and / or maintain healthy skin flora. The ostomy barrier, adhesive, accessory or peristomal skin treatment can also be configured to alter the peristomal or other skin environment to promote growth of a desirable or commensal population while discouraging growth of the pathogenic organisms.

The invention discloses a composition with effects of whitening skin and improving micro-ecological health and a preparation method of the composition. The composition provided by the invention comprises stearyl glycyrrhetinate, colloidal oat powder, a citrus peel extract and a yeast fermentation product extract. The composition can inhibit generation of pigments in melanocytes, promote skin pigment metabolism and improve the diversity of skin flora. The composition has the effects of reducing the melanin content of the skin, improving the brightness and fineness of the skin and enhancing the micro-ecological health of the skin.

The invention belongs to the technical field of cosmetics, and particularly relates to a composition for adjusting a skin micro-ecological flora structure and application of the composition in improving red skin. Specifically, aiming at the problem of skin flora unbalance, skin physiological characteristics and skin flora characteristics of the red crowd are selected for research, key bacteria which influence flora composition of the red crowd are screened, and common cosmetic raw materials are screened by using characteristic bacteria propionibacterium acnes. On the basis, formula matching is carried out based on the proliferation rule of the raw materials on skin characteristic bacteria, the formula is further applied to the formula, the safety of the formula and the skin redness improvement condition after people use the formula are verified, and a product suitable for the skin characteristics of the redness people is obtained. Tests prove that the composition can remarkably improve the diversity of florae of the reddish skin, reduce the sebum content, the percutaneous moisture loss rate and the a value, recover the skin barrier function and improve the reddish symptom, so that the composition has good practical application value.

The present application belongs to the technical field of cosmetics, and particularly relates to an oil-controlling and repairing microemulsion for regulating the flora of oily sensitive skin as well as a preparation method and application thereof. Specifically, the oil-controlling and repairing microemulsion is directed against the flora of oily sensitive skin and the physiological characteristics of the skin, regulates propionibacterium which is prone to cause skin problems of the oily sensitive skin, thereby regulating the skin flora structure, and simultaneously improves the oil secretion and skin barrier of the oily sensitive skin, so as to achieve the effect of oil control and repair. It is also unexpectedly found in the present application that the formed oil-controlling and repairing emulsion can promote the proliferation of functional skin bacteria Staphylococcus epidermidis, and has a synergistic effect on relieving the flora imbalance caused by the proliferation of propionibacterium of oily skin acne, thus having good practical application value.

The application discloses a staphylococcus epidermidis NCU-07, probiotic postbiotic and application, relates to the field of biological medicine technology. The staphylococcus epidermidis NCU-07 is preserved in the China General Microbiological Culture Collection Center on January 18, 2023, and the preservation number is CGMCC NO.26493. The strain is prepared into probiotic postbiotic, and the application of the probiotic postbiotic in combination with silver sulfadiazine cream and compound coptis oil ointment in a drug combination for treating skin burn wounds is provided. The probiotic postbiotic disclosed by the application is helpful to promote the healing of the Ⅱ degree burn wound of a patient, can enhance the therapeutic effect when being used in combination with silver sulfadiazine cream and compound coptis oil ointment, relieve the itching symptoms of the Ⅱ degree burn wound of the patient, has no obvious influence on the pain symptoms of the wound, increases the diversity of skin flora, can inhibit the colonization and proliferation of pathogenic microorganisms, and promote the proliferation of skin symbiotic bacteria.