The invention discloses a breviscapine-
panax notoginseng saponins double-pharmaceutical nano-composite particle and a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The nano-composite particle is of a nano-composite particle stable structure which takes a breviscapine
nanocrystal as a
nucleus and takes
panax notoginseng saponins with the pharmacological effect and the
natural surface activity attribute as a shell. The preparation method of the nano-composite particle mainly comprises the steps of pharmaceutical mixing, dispersing, high-pressure homogenizing,
drying and the like. The nano-composite particle has the advantages that the
solubility, the dissolving-out speed and the
bioavailability of breviscapine can be significantly increased, collaborative dosing of breviscapine and
panax notoginseng saponins is achieved, the pharmaceutical compatibility
treatment effect is achieved, the nano-composite particle is conveniently further processed into a preparation form containing the composite particle intermediate, and clinical application is convenient. According to the breviscapine-panax notoginseng saponins double-pharmaceutical nano-composite particle and the preparation method and application thereof, no toxic
solvent or
synthetic surfactant or macromolecular material is used, the safety is high, the preparation process is simple, industrialization is easy to achieve, and the very good application prospect is achieved.