15 results about "Sulfadiazine" patented technology

The application discloses a method for removing trace sulfonamidochrysoidine in water by activating peracetic acid through complexation of manganese sulfate and 2-picolinic acid, wherein, (1) a homogeneous Mn(II)-PICA complex solution is prepared by mixing and stirring a manganese sulfate solution and a 2-picolinic acid solution; (2) peracetic acid solution and the homogeneous Mn(II)-PICA complex solution are added into water containing sulfonamidochrysoidine, and the mixture is fully stirred, and in the reaction process, high-valence manganese active species Mn(V)=O is generated; the system mainly adopts a non-radical oxidation path, has high selectivity to sulfonamidochrysoidine, and realizes degradation of the sulfonamidochrysoidine. The method has high activation efficiency and fast degradation speed, and the complex system significantly improves the activation efficiency of PAA, and the removal rate of sulfonamidochrysoidine can reach more than 90 % within 10 min, which is much higher than that of a single activation system.

This invention discloses a continuous production equipment for solid combination herbicides, relating to the technical field of glyphosate and sulfadiazine production equipment. The continuous production equipment for solid combination herbicides includes a reactor, with a top cover fixedly connected to the top of the reactor. A first drive motor is fixedly connected to the top of the top cover, and a rotating shaft is rotatably connected inside the first drive motor. By setting a rotating collection block, a second drive motor is activated to drive spiral blades and first blades to rotate, thereby guiding agglomerated particles deposited at the bottom of the reactor through the spiral blades. Finally, the rotation of the first blades blows the agglomerated particles directly upwards and disperses them, accelerating particle dissolution. In conjunction with an extrusion block, the particles blown by the first blades pass through a rectangular box and ultimately enter the interior of an arc-shaped pipe. A corrugated plate continuously drives the extrusion block to vibrate during the rotation of the rotating shaft, further dispersing the agglomerated particles.

The utility model relates to a sulfadiazine wastewater treatment system which comprises a wastewater storage tank used for storing wastewater to be treated; the resin towers are communicated with the wastewater storage tank and are used for carrying out decoloration treatment on the wastewater and adsorbing sulfadiazine in the wastewater; the centrifugal pump is communicated with the resin tower through a three-way valve; the anaerobic tank is communicated with the centrifugal pump, and a stirrer is arranged in the anaerobic tank; the ozone reaction tank is communicated with the anaerobic tank, and an aeration structure is arranged in the ozone reaction tank; the ozone generation assembly is communicated with the aeration structure and is used for conveying generated ozone to the aeration structure; the flocculation tank is communicated with the ozone reaction tank; and the sedimentation tank is communicated with the flocculation tank. The sulfadiazine wastewater can be subjected to decoloration, adsorption, anaerobic treatment and ozone decomposition, and qualified discharge of the wastewater is realized.

This invention provides a strain of *Lactobacillus plantarum*, and discloses the fermentation product of *Eucommia ulmoides* leaves, *Rehmannia glutinosa*, dried ginger, and *Dendrobium officinale* obtained by fermenting these herbs, along with its preparation method and applications. This fermentation product can directionally activate the phenylpropane biosynthetic pathway, inducing the generation of characteristic small molecule metabolites of polyphenols, particularly sanguranyl sulfadiazine (SSA). Moreover, compared to the raw materials, the fermentation product contains more active small molecule metabolites. Finally, experiments on zebrafish modeled with prednisone demonstrated that the fermentation product can significantly promote bone formation. The fermentation product mainly restores the expression levels of related genes to normal zebrafish gene expression levels by regulating these genes. Therefore, the fermentation product can be used to prepare foods or medicines that improve bone health.

The invention belongs to the technical field of materials and advanced oxidation, and particularly relates to a phenanthroline-containing pyrenyl 2D covalent organic framework material as well as a preparation method and application thereof, and the covalent organic framework material is synthesized by taking 1, 3, 6, 8-tetra-(p-aminophenyl)-pyrene and 4, 4 '-(1, 10-phenanthroline-3, 8-diyl) dibenzaldehyde as precursors through Schiff base condensation reaction. According to the COFs material synthesized by the invention, on the basis of containing phenanthroline, by increasing benzene rings, regulation and control on covalent organic framework electron delocalization on the molecular level are realized, so that the capability of activating PMS to degrade organic pollutants is enhanced, and the COFs material is suitable for not only the organic pollutant bisphenol A, but also the organic pollutant PMS. The COFs prepared by the method also has an excellent degradation effect on other organic pollutants such as sulfadiazine and atrazine, and in addition, the COFs also has good cycle stability and does not generate secondary pollution.

This invention discloses the application of the WAT1 gene in regulating the absorption and accumulation of sulfonylurea herbicides in plants. The invention found that knocking out the OsWAT1 gene in rice reduces the absorption and accumulation of bensulfuron-methyl, lowers the bensulfuron-methyl content in rice, and increases resistance to bensulfuron-methyl. Rice with the OsWAT1 gene knocked out also developed resistance to ethoxysulfuron and sulfadiazine. Furthermore, knocking out the NtWAT1 homolog of flue-cured tobacco K326, indoor resistance verification experiments showed that the tobacco mutant also acquired bensulfuron-methyl resistance, also achieved by reducing herbicide absorption and accumulation. This indicates that the WAT1 gene plays a role in regulating the absorption and accumulation of sulfonylurea herbicides in plants and can be used to create new plant varieties with resistance to sulfonylurea herbicides.

The invention discloses a portable meat product sulfadiazine ZnO-Au nano colorimetric detector, and relates to the technical field of detection equipment. The portable meat product sulfadiazine ZnO-Au nano colorimetric detector comprises a detection box mechanism, and the detection box mechanism comprises a bottom plate; the upper surface of the bottom plate is fixedly connected with a first base; a bottle rack mechanism is arranged on the bottom plate, the bottle rack mechanism comprises a bottle rack for inversely filling a meat solution bottle, and the bottle rack is opposite to the first base; a colorimetric assembly is assembled between the bottle rack and the first base and comprises an upper cylinder assembly and a lower cylinder assembly; the upper cylinder assembly comprises an outer cylinder mechanism, an inner core mechanism and a top block mechanism; the lower tube assembly comprises a tube inserting mechanism and a needle tube mechanism located in the tube inserting mechanism. The outer cylinder mechanism comprises an outer cylinder, windows are uniformly embedded in the side of the outer cylinder at equal intervals, and a bottom block is fixedly connected to the lower end of the outer cylinder; the contact path of the two nano materials before storage, transportation and detection is completely blocked, and the material activity and the detection basis are guaranteed.

The invention discloses a preparation method and application of a spherical nucleic acid-based nanoprobe and a paper-based chip thereof. The preparation method is characterized by comprising the following steps: preparing the spherical nucleic acid nanoprobe based on a sulfadiazine aptamer by adopting a microwave method; the paper-based chip is prepared by constructing a hydrophobic barrier by adopting a laser printing and high-temperature heating method, a to-be-detected water sample is dropwise added into a sample adding area of the paper-based chip, and the sample firstly reaches a detection area 1 through capillary action and is gathered after acting with a nano probe for detecting aminoglycoside antibiotics, so that the color of the paper-based chip is changed; after the sample continuously flows to a detection area 2 and reacts with the prepared spherical nucleic acid nanoprobe based on the sulfadiazine aptamer, a sodium chloride solution is dropwise added into the area to trigger a particle aggregation reaction, so that the color of the paper-based chip is changed, and simultaneous detection of aminoglycoside and sulfonamide antibiotics is realized. Compared with the prior art, the method has the characteristics of rapidness, convenience, economy and practicability, and is of great significance to environmental risk assessment, pollutant control and public health.

This invention discloses the application of sulfadimidine in the preparation of drugs for treating osteoarthritis. This invention is the first to demonstrate the significant efficacy of intra-articular injection of sulfadimidine in the treatment of osteoarthritis (OA); the results show that sulfadimidine can not only significantly relieve the symptoms of osteoarthritis but also improve the metabolic function of chondrocytes, thereby slowing the progression of arthritis. Traditional treatment methods mainly include intra-articular injection of anesthetic drugs, joint lubricants (such as sodium hyaluronate), glucocorticoids, and platelet-rich plasma (PRP). However, these methods each have limitations, such as significant short-term effects but potential long-term side effects. Sulfamidine, as a novel treatment method, not only has good efficacy but also fewer side effects, providing a new approach to the drug treatment of osteoarthritis.

This invention belongs to the field of modified biochar technology, specifically disclosing an iron-manganese-nitrogen co-doped modified biochar, its preparation method, and its application. The invention first mixes corn stalk biochar with urea and performs a pyrolysis reaction to obtain nitrogen-doped biochar. Then, the nitrogen-doped biochar is mixed with an iron source, a manganese source, and water for impregnation. Finally, the iron / manganese-loaded nitrogen-doped biochar undergoes a pyrolysis reaction in a nitrogen atmosphere (temperature ≥650℃) to obtain iron-manganese-nitrogen co-doped modified biochar. This invention, through iron-manganese-nitrogen co-doping modification of biochar, can precisely control its microstructure and surface physicochemical properties, significantly improving its catalytic degradation and adsorption-synergistic removal capabilities for organic pollutants. It exhibits high removal efficiency for sulfadiazine without the addition of additional oxidants or chemical reagents.

This invention discloses a method for the synergistic treatment of hexavalent chromium and sulfadiazine complex wastewater. The method utilizes a bimetallic node coupled with a metal-organic framework derivative electrode for the synergistic treatment of hexavalent chromium and sulfadiazine complex wastewater. The electrode includes a conductive substrate coupled with ZrO2 and ZnO. In this invention, the bimetallic node coupled with a metal-organic framework derivative electrode is used as the working electrode. The resulting photoelectrocatalytic system has advantages such as strong light utilization, fast electron transfer efficiency, and strong conversion effect between complex free radical chemistry and different active substances. It can not only achieve the synergistic degradation of hexavalent chromium and sulfadiazine in wastewater, but also simultaneously and efficiently remove both hexavalent chromium and sulfadiazine from the wastewater. It has advantages such as good recyclability, high removal efficiency, good cycle performance, and strong practical application, making it a widely applicable photoelectrocatalytic method with high practical value and application prospects.

This invention provides a sulfadiazine amide compound having the structure shown in Formula (I), or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and its use in the preparation of GPX4 inhibitors, as well as its use in drugs for the prevention and / or treatment of tumors. The sulfadiazine amide compound provided by this invention can act on targets including GPX4, exhibits strong inhibitory activity against GPX4, exerts antitumor effects through the ferroptosis pathway, and has strong inhibitory and therapeutic effects on various tumors, including pancreatic cancer.

The invention belongs to the technical field of biological medicines, and discloses a toxoplasma gondii biomarker and an application thereof in order to solve the technical problem of relatively less research on TgAP2IX-5 regulation of toxoplasma gondii at present, and particularly, a G-quadruplex nucleic acid sequence is formed in a TgAP2IX-5 gene promoter region, and the TgAP2IX-5 gene promoter region is constructed to obtain the toxoplasma gondii biomarker. And screening of toxoplasma gondii-resistant drugs is carried out by taking the synthesized G-quadruplex as a target spot. The screened small molecular ligands sanguinarine and TMPyP4 have obvious effects of inhibiting transcription of the TgAP2IX-5 gene and proliferation of toxoplasma gondii, and the action effect is superior to that of a clinically common therapeutic drug sulfadiazine; and a good treatment effect can be achieved at a relatively low concentration.

This invention discloses a herbicidal composition containing ethyl 5-phenyl-4,5-dihydroisoxaazole-3-carboxylate and component B. Component B is selected from one or more of nicosulfuron, sulfadiazine, formamide sulfur, quizalofop-p-ethyl, cyclosulfonamide, isoxaflutole, dicamba, benzoxazine, 2,4-D and its salts, 2,4-D and its salts, 2,4-D isooctyl ester, and mesosulfuron-methyl. The composition of this invention exhibits good synergistic effects, good crop safety, and broad application prospects.

This invention belongs to the field of organic synthesis technology, specifically disclosing a bromoisoxazole compound and its synthesis and application. Compared with existing technologies that require the use of precious metal catalysts, additional oxidants, and high temperatures of 100°C, this process is the first to use trifluoroacetic acid (TFA) as a promoter, achieving efficient conversion in a mild air atmosphere of 28-60°C. This not only avoids the use of expensive metals and the risk of environmental pollution, but also has the advantages of inexpensive and readily available raw materials, short reaction time of only 4-12 hours, and a yield of up to 94%, showing significant industrialization advantages. Experimental data confirm that this series of compounds exhibits excellent biological activity, and its inhibitory effect on Staphylococcus aureus and Vibrio parahaemolyticus is significantly better than that of commercially available drugs sulfadiazine and sulfaguanidine. It has outstanding technological progress and broad market application prospects in the fields of developing new antibacterial drugs and food preservation.