47 results about "Sulfadiazine" patented technology

The present invention discloses an anti-sulfadiazine nano-antibody and its application, belonging to the field of nano-antibody technology. In order to provide a nano-antibody for detecting sulfadiazine that has a small molecular weight, strong penetrating power, good stability, strong antigen binding ability, and can recognize antigen epitopes that are difficult for conventional antibodies to recognize. The present invention provides a nano-antibody for detecting sulfadiazine, the amino acid sequence of CDR1 of the variable region of the nano-antibody is shown as SEQ ID NO.6, the amino acid sequence of CDR2 of the variable region of the nano-antibody is shown as SEQ ID NO.7, and the amino acid sequence of CDR3 of the variable region of the nano-antibody is shown as SEQ ID NO.8. The indirect competitive ELISA method established by the present invention is a simple, rapid, sensitive, and low-cost immunoassay method, which has great application prospects in the detection of sulfadiazine residues in animal-derived foods.

The invention provides a preparation method of a compound sulfonamide medicinal preparation. The compound sulfonamide medicinal preparation contains a premix prepared from sulfadiazine, sulfamethoxazole, trimethoprim, sodium bicarbonate and a slow-release coating medium. Compared with sulfadiazine, sulfamethoxazole and trimethoprim preparations, the sodium bicarbonate coated compound is high in bioavailability, and after the sodium bicarbonate coated compound is added, caking in urine can be remarkably reduced, and the stability of the preparation is not affected.

The invention provides a weeding composition which comprises a component A and a component B. The component A is one of a compound 1, a compound 2 and a compound 3, the component B is selected from one of tembotrione, isoxaflutole, dicamba, foramsulfuron, nicosulfuron, rimsulfuron, topramezone, 2, 4-D isooctyl ester, fenoxaprop-p-ethyl and MCPA, and the component B is one of tembotrione, isoxaflutole, dicamba, foramsulfuron, nicosulfuron, rimsulfuron, topramezone, 2, 4-D isooctyl ester, fenoxaprop-p-ethyl and MCPA. The component A and the component B in the composition have a good synergistic effect, and the composition has a good application prospect.

The application discloses a method for removing trace sulfonamidochrysoidine in water by activating peracetic acid through complexation of manganese sulfate and 2-picolinic acid, wherein, (1) a homogeneous Mn(II)-PICA complex solution is prepared by mixing and stirring a manganese sulfate solution and a 2-picolinic acid solution; (2) peracetic acid solution and the homogeneous Mn(II)-PICA complex solution are added into water containing sulfonamidochrysoidine, and the mixture is fully stirred, and in the reaction process, high-valence manganese active species Mn(V)=O is generated; the system mainly adopts a non-radical oxidation path, has high selectivity to sulfonamidochrysoidine, and realizes degradation of the sulfonamidochrysoidine. The method has high activation efficiency and fast degradation speed, and the complex system significantly improves the activation efficiency of PAA, and the removal rate of sulfonamidochrysoidine can reach more than 90 % within 10 min, which is much higher than that of a single activation system.

The invention belongs to the technical field of antibiotic wastewater treatment, and particularly relates to a Z-type CdWO4 / Bi2WO6 catalyst as well as a preparation method and application thereof. The catalyst is formed by loading CdWO4 particles on a Bi2WO6 nanosheet unit. The Z-type CdWO4 / Bi2WO6 catalyst is prepared by adopting a hydrothermal process, the photo-generated charge separation efficiency and the sulfadiazine degradation rate of the catalyst are remarkably improved through energy band structure regulation and interface optimization, and meanwhile, the catalyst has excellent structural stability and recycling performance. The Z-type heterojunction is constructed by accurately controlling integration of CdWO4 and a Bi2WO6 substrate, and the Z-type CdWO4 / Bi2WO6 catalyst is high in light adsorption capacity, high in electron hole separation efficiency, stable in material structure, fast in photon-generated carrier transmission and capable of effectively inhibiting recombination of photon-generated carriers.

This invention discloses a continuous production equipment for solid combination herbicides, relating to the technical field of glyphosate and sulfadiazine production equipment. The continuous production equipment for solid combination herbicides includes a reactor, with a top cover fixedly connected to the top of the reactor. A first drive motor is fixedly connected to the top of the top cover, and a rotating shaft is rotatably connected inside the first drive motor. By setting a rotating collection block, a second drive motor is activated to drive spiral blades and first blades to rotate, thereby guiding agglomerated particles deposited at the bottom of the reactor through the spiral blades. Finally, the rotation of the first blades blows the agglomerated particles directly upwards and disperses them, accelerating particle dissolution. In conjunction with an extrusion block, the particles blown by the first blades pass through a rectangular box and ultimately enter the interior of an arc-shaped pipe. A corrugated plate continuously drives the extrusion block to vibrate during the rotation of the rotating shaft, further dispersing the agglomerated particles.

The invention discloses a bacteriostatic light cage for light-controlled rapid release of sulfadiazine, a preparation method and application thereof, and the bacteriostatic light cage is based on a light-controlled release system of a Sanger reagent, and realizes efficient space-time release and targeted antibiosis of SD. The light-operated bacteriostatic light cage capable of rapidly releasing sulfadiazine, disclosed by the invention, has sulfadiamidine-2, 4-dinitrobenzene derivative # imgabs0 # with a structure as shown in a formula SD-Py-N < + >

The utility model relates to a sulfadiazine wastewater treatment system which comprises a wastewater storage tank used for storing wastewater to be treated; the resin towers are communicated with the wastewater storage tank and are used for carrying out decoloration treatment on the wastewater and adsorbing sulfadiazine in the wastewater; the centrifugal pump is communicated with the resin tower through a three-way valve; the anaerobic tank is communicated with the centrifugal pump, and a stirrer is arranged in the anaerobic tank; the ozone reaction tank is communicated with the anaerobic tank, and an aeration structure is arranged in the ozone reaction tank; the ozone generation assembly is communicated with the aeration structure and is used for conveying generated ozone to the aeration structure; the flocculation tank is communicated with the ozone reaction tank; and the sedimentation tank is communicated with the flocculation tank. The sulfadiazine wastewater can be subjected to decoloration, adsorption, anaerobic treatment and ozone decomposition, and qualified discharge of the wastewater is realized.

The utility model relates to a sodium sulfadiazine dispersing stirrer which comprises a stirring mechanism and a lifting mechanism, the lifting mechanism is connected with the stirring mechanism, and the lifting mechanism is used for driving the stirring mechanism to lift up and down in the vertical direction while the stirring mechanism works; the stirring mechanism comprises a first driving motor, a rotating rod and a stirring rotating wheel, one end of the rotating rod and the stirring rotating wheel are fixedly installed together, and the first driving motor drives the rotating rod to rotate, so that the first driving motor drives the stirring rotating wheel to rotate.

This invention provides a strain of *Lactobacillus plantarum*, and discloses the fermentation product of *Eucommia ulmoides* leaves, *Rehmannia glutinosa*, dried ginger, and *Dendrobium officinale* obtained by fermenting these herbs, along with its preparation method and applications. This fermentation product can directionally activate the phenylpropane biosynthetic pathway, inducing the generation of characteristic small molecule metabolites of polyphenols, particularly sanguranyl sulfadiazine (SSA). Moreover, compared to the raw materials, the fermentation product contains more active small molecule metabolites. Finally, experiments on zebrafish modeled with prednisone demonstrated that the fermentation product can significantly promote bone formation. The fermentation product mainly restores the expression levels of related genes to normal zebrafish gene expression levels by regulating these genes. Therefore, the fermentation product can be used to prepare foods or medicines that improve bone health.

The invention belongs to the technical field of materials and advanced oxidation, and particularly relates to a phenanthroline-containing pyrenyl 2D covalent organic framework material as well as a preparation method and application thereof, and the covalent organic framework material is synthesized by taking 1, 3, 6, 8-tetra-(p-aminophenyl)-pyrene and 4, 4 '-(1, 10-phenanthroline-3, 8-diyl) dibenzaldehyde as precursors through Schiff base condensation reaction. According to the COFs material synthesized by the invention, on the basis of containing phenanthroline, by increasing benzene rings, regulation and control on covalent organic framework electron delocalization on the molecular level are realized, so that the capability of activating PMS to degrade organic pollutants is enhanced, and the COFs material is suitable for not only the organic pollutant bisphenol A, but also the organic pollutant PMS. The COFs prepared by the method also has an excellent degradation effect on other organic pollutants such as sulfadiazine and atrazine, and in addition, the COFs also has good cycle stability and does not generate secondary pollution.

This invention discloses the application of the WAT1 gene in regulating the absorption and accumulation of sulfonylurea herbicides in plants. The invention found that knocking out the OsWAT1 gene in rice reduces the absorption and accumulation of bensulfuron-methyl, lowers the bensulfuron-methyl content in rice, and increases resistance to bensulfuron-methyl. Rice with the OsWAT1 gene knocked out also developed resistance to ethoxysulfuron and sulfadiazine. Furthermore, knocking out the NtWAT1 homolog of flue-cured tobacco K326, indoor resistance verification experiments showed that the tobacco mutant also acquired bensulfuron-methyl resistance, also achieved by reducing herbicide absorption and accumulation. This indicates that the WAT1 gene plays a role in regulating the absorption and accumulation of sulfonylurea herbicides in plants and can be used to create new plant varieties with resistance to sulfonylurea herbicides.

The invention discloses a portable meat product sulfadiazine ZnO-Au nano colorimetric detector, and relates to the technical field of detection equipment. The portable meat product sulfadiazine ZnO-Au nano colorimetric detector comprises a detection box mechanism, and the detection box mechanism comprises a bottom plate; the upper surface of the bottom plate is fixedly connected with a first base; a bottle rack mechanism is arranged on the bottom plate, the bottle rack mechanism comprises a bottle rack for inversely filling a meat solution bottle, and the bottle rack is opposite to the first base; a colorimetric assembly is assembled between the bottle rack and the first base and comprises an upper cylinder assembly and a lower cylinder assembly; the upper cylinder assembly comprises an outer cylinder mechanism, an inner core mechanism and a top block mechanism; the lower tube assembly comprises a tube inserting mechanism and a needle tube mechanism located in the tube inserting mechanism. The outer cylinder mechanism comprises an outer cylinder, windows are uniformly embedded in the side of the outer cylinder at equal intervals, and a bottom block is fixedly connected to the lower end of the outer cylinder; the contact path of the two nano materials before storage, transportation and detection is completely blocked, and the material activity and the detection basis are guaranteed.

The utility model relates to the field of filtrate circulating devices, and discloses a sulfadiazine filtrate circulating device which comprises a bottom plate, a reaction tank is fixedly connected to the top end of the outer wall of the left side of the bottom plate, a liquid inlet pipe is fixedly connected to the outer wall of the reaction tank, and a filtrate box is detachably installed on the outer wall of the liquid inlet pipe through a flange. A circulating pump is detachably mounted on the outer wall of the filtrate tank through a flange, and the filter assembly comprises a rotating ring; a T-shaped rod is fixedly connected to the side wall of the inner side of the rotating ring, and a filter screen is fixedly connected to the inner wall of the right side of the circulating pump. According to the utility model, the filter screen in the filter assembly can effectively prevent large-particle materials from entering the circulating pump and avoid the abrasion of the impeller, and meanwhile, the dredging ball can automatically dredge the filter holes when the filter screen is blocked, so that the normal flow of filtrate is ensured, the filtering effect is improved, and the purity of the circularly applied filtrate is ensured; therefore, the product quality of sulfadiazine is improved.

The invention discloses a vinylether method-based sulfadiazine high-quality mother liquor recycling method, which comprises the following steps of: 1, mixing high-quality mother liquor with a decolorizing agent, heating to 80-100 DEG C, decolorizing, and filtering while hot to obtain decolorized mother liquor; step 2, adding sulfadiazine sodium into the decolorized mother liquor, maintaining the temperature at 80-95 DEG C, and stirring for reaction to obtain feed liquid A; step 3, adding an acidity regulator into the feed liquid A at 80-95 DEG C, cooling, filtering and washing to obtain crude product mother liquor and a sulfadiazine crude product; step 4, dissolving the sulfadiazine crude product in pharmaceutical process water, heating to 80-95 DEG C, adding an alkaline regulator, and adding a decolorizing agent for secondary decolorization to obtain feed liquid B; step 5, carrying out heat preservation and filtration on the feed liquid B, adding an acidic regulator, cooling, filtering, and washing with water to obtain recyclable fine mother liquor and a sulfadiazine fine wet product; and step 6, drying the fine wet sulfadiazine product to obtain a dry sulfadiazine product. The method has the beneficial effects that the high-quality mother liquor can be recycled and treated, and no adverse effect is caused on the final product.

The invention relates to the technical field of green chemical synthesis, in particular to a preparation method, a product and application of cetylamine functionalized sulfadiazine carbon quantum dots. The preparation method of the cetylamine functionalized sulfadiazine carbon quantum dots comprises the following steps: adding carbon quantum dots containing carboxyl groups on the surfaces, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide into a solvent, adjusting the pH value to be acidic, and then stirring and activating to obtain an activated solution; adding a cetylamine solution into the activated solution for reaction, and then filtering to obtain the cetylamine functionalized sulfadiazine carbon quantum dots. The cetylamine functionalized sulfadiazine carbon quantum dots are synthesized by adopting a surface functionalization method, and the cetylamine functionalized sulfadiazine carbon quantum dots have good light stability and adjustable photoluminescence characteristics, and have good selectivity and high sensitivity when being used for detecting p-nitrophenol; and trace detection of p-nitrophenol can be realized.

The application discloses a preparation method of a hydrogel immobilized composite enzyme, and a product and application thereof. Due to the protection of bacterial cell walls, the removal efficiency of resistant genes in traditional processes is low. The application utilizes polyacrylamide hydrogel to jointly immobilize laccase, hydrolase and nuclease, so that the enzymes are effectively coated inside the carrier, the problems of easy loss and easy reduction of activity of free enzymes are avoided, and the reusability is good, and no secondary pollution is generated. The laccase is used to reduce the concentration of sulfadiazine, the hydrolase is used to hydrolyze the bacterial cell walls to release intracellular ARG, and the nuclease is used to degrade the released intracellular ARG, so that the purpose of quickly eliminating ARG in water is achieved. The method has high removal efficiency on ARG and sulfadiazine, is simple, efficient and safe, is suitable for remediation treatment of aquaculture wastewater containing antibiotic and ARG pollution, and solves the problems of poor environmental stability of water-soluble enzymes and difficult recycling.

The present invention belongs to the field of functional material preparation, and is specifically related to a polyaniline-derived carbon-doped boron nitride material, a preparation method and its application. The present invention uses a very small amount of polyaniline as a carbon precursor, and calcines the carbon in situ with a boron nitride precursor at high temperature to form carbon-doped boron nitride in boron nitride, so that it has two active sites of B-N-C and pyridinic nitrogen, and its ultrathin porous structure further increases the number of active sites, so that the carbon-doped boron nitride material of the present invention can efficiently activate PMS to catalyze the degradation of pollutants. When the carbon-doped boron nitride material of the present invention activates PMS to degrade sulfadiazine, it can be completely degraded in 60min without additional energy input. The preparation process of the present invention is simple, and the carbon-doped boron nitride prepared at the same time has extremely high activation PMS catalytic degradation of pollutants performance, and has broad application prospects.

This invention relates to the field of immunology, and more particularly to a hybridoma cell line and its secreted monoclonal antibody against the metamizole residue marker 4-methylaminoantipyrine (MAA), and its applications. This invention uses 4-aminoantipyrine to react with methyl 4-bromomethylbenzoate, followed by alkaline hydrolysis to obtain a hapten (Formula I). ​​An immunogen is then synthesized and used to immunize mice. After cell fusion and screening, a hybridoma cell line capable of secreting a monoclonal antibody recognizing MAA is prepared, named Metamizole-6A4. This hybridoma cell line has a high efficiency in secreting monoclonal antibodies. The secreted monoclonal antibody can accurately detect MAA, IC50, and other markers. 50 The concentration is 4.06 ng / mL, with high specificity. Cross-reactivity with aminopyrine and its metabolites 4-aminoantipyrine, 4-formamidoantipyrine, 4-acetamidoantipyrine, sulfadiazine, norfloxacin, lincomycin, tylosin, penicillin G, streptomycin, and gentamicin is less than 5%. It can accurately detect MAA residues in food. Formula I.

The invention provides a bimetallic three-dimensional MOF (Metal Organic Framework) material based on a pyrazole ligand as well as a preparation method and application of the bimetallic three-dimensional MOF material, and belongs to the technical field of MOF materials. An organic ligand of the bimetallic three-dimensional MOF material based on the pyrazole ligand is a pyrazole organic monomer with a structure shown in a formula I, and coordination metals are two of Zn, Ni, Co and Mn; the bimetallic three-dimensional MOF material based on the pyrazole ligand is prepared by adopting a solvothermal method. According to the method, the molecular characteristics of specific organic pollutants (such as tetracycline, bisphenol A, sulfadiazine and methylene blue) are accurately matched by regulating and controlling the types of metal nodes, and efficient selective adsorption is realized. According to the invention, two metal ions are introduced to construct the bimetal MOF, and unique electron interaction and synergistic catalytic effect of bimetal centers are utilized to create more catalytic centers with higher activity, so that the redox degradation efficiency of target pollutants is fundamentally improved, and the effect of 1 + 1 > 2 can be realized.

The invention discloses a bio-based antibacterial spinning yarn, and relates to the technical field of spinning yarns. When the bio-based antibacterial spinning yarn is prepared, terephthalic acid, a vanillin-based silicon-containing flame-retardant monomer and 1, 3-propylene glycol are polymerized to prepare polyester; the preparation method comprises the following steps: reacting ethylbutyl-3-alkenyl sulfide with methyl iodide to prepare butenyl sulfonium salt; the preparation method comprises the following steps: reacting lignin, butenyl sulfonium salt and 3-butenyl diethyl phosphate to prepare modified lignin; the preparation method comprises the following steps: reacting zinc acetate, sulfadiazine and kaempferol to prepare an organic zinc complex; mixing polyester, the modified lignin and an organic zinc complex, and performing melt spinning to obtain the polyester fiber, and spinning the polyester fibers in spinning equipment to obtain the bio-based antibacterial spinning yarn. The bio-based antibacterial spinning yarn prepared by the invention has excellent antibacterial and flame-retardant properties.

The invention discloses a preparation method and application of a spherical nucleic acid-based nanoprobe and a paper-based chip thereof. The preparation method is characterized by comprising the following steps: preparing the spherical nucleic acid nanoprobe based on a sulfadiazine aptamer by adopting a microwave method; the paper-based chip is prepared by constructing a hydrophobic barrier by adopting a laser printing and high-temperature heating method, a to-be-detected water sample is dropwise added into a sample adding area of the paper-based chip, and the sample firstly reaches a detection area 1 through capillary action and is gathered after acting with a nano probe for detecting aminoglycoside antibiotics, so that the color of the paper-based chip is changed; after the sample continuously flows to a detection area 2 and reacts with the prepared spherical nucleic acid nanoprobe based on the sulfadiazine aptamer, a sodium chloride solution is dropwise added into the area to trigger a particle aggregation reaction, so that the color of the paper-based chip is changed, and simultaneous detection of aminoglycoside and sulfonamide antibiotics is realized. Compared with the prior art, the method has the characteristics of rapidness, convenience, economy and practicability, and is of great significance to environmental risk assessment, pollutant control and public health.

The invention discloses benzobicylon herbicide ionic liquid as well as a preparation method and application thereof, and belongs to the technical field of agricultural herbicide preparations. The benzobicylon herbicide ionic liquid has a molecular structure as shown in formula (I), in the formula (I), R1, R2 and R3 are respectively and independently selected from-CH3 and-H, and R4 is selected from-C8H17,-C10H21 and-C12H25. The benzobicylon herbicide ionic liquid disclosed by the invention is obtained by reacting tertiary amine or quaternary ammonium salt with a triketone structure in an active form of benzobicylon. The benzobicylon herbicide ionic liquid has good water solubility and does not need an auxiliary agent; the plant leaf surface wetting ability is strong, the bioavailability is high, and the weed killing ability is strong; the herbicide has the characteristics of low aquatic toxicity, good crop safety and the like, and can realize application reduction and synergism of benzobicylon. Formula (I).

This invention relates to the field of herbicide technology, specifically to a method for preparing a sulfadiazine intermediate, comprising: (1) reacting 3,4-dichloronitrobenzene, methyl cyanoacetate, and a first base in the presence of a first solvent to obtain a compound of formula (II); (2) reacting the compound of formula (II) with sodium methanethiol in the presence of a second solvent to obtain a compound of formula (III); and (3) reacting the compound of formula (III) with a second base and hydrogen peroxide in the presence of a third solvent to obtain the sulfadiazine intermediate of formula (I). This method has the advantages of mild reaction conditions, high reaction yield and purity, and low cost, making it suitable for industrial production.

This invention relates to the field of pesticide technology, specifically to a herbicidal composition containing dichloroisoxane and sulfadiazine and its application in controlling agricultural weeds, wherein the weight ratio of dichloroisoxane to sulfadiazine in the composition is 1:0.007-1.4. The composition can significantly reduce herbicide damage to crops and has a synergistic effect on weeds, making it an ideal herbicide.

The application discloses a preparation method of urchin spine globular iron-sulfur co-doped biochar and application thereof. The method uses biomass as a carbon source, and sulfur-containing compounds and iron salts as modification components, and through impregnation, freeze drying and carbonization by staged pyrolysis in a nitrogen atmosphere, urchin spine globular iron-sulfur co-doped biochar is prepared. In the obtained material, iron and sulfur elements are co-doped and uniformly distributed in the carbon skeleton, forming an active structure in which iron oxides and iron sulfides coexist, and the material has more exposed active sites and good electron transfer performance. The material can be used for activating persulfate to degrade antibiotics and dye organic pollutants in water, and the degradation rate of sulfadiazine can reach nearly 100%, and the material also shows high degradation efficiency for tetracycline, methylene blue and other pollutants, and still maintains good catalytic activity and stability after multiple cycles. The preparation method is simple, the raw materials are widely available, the cost is low, and the method is suitable for treatment of organic contaminated water.

The invention relates to a polyaniline / tin dioxide / carbon nanobelt-based electrochemical sensor as well as a preparation method and application thereof. The invention relates to a preparation method of a polyaniline / tin dioxide / carbon nanobelt-based electrochemical sensor. The preparation method comprises the following steps: preparing a carbon nanobelt; preparing a polyaniline / tin dioxide compound; preparing a polyaniline / tin dioxide / carbon nanobelt composite material; and preparing the polyaniline / tin dioxide / carbon nanobelt modified electrode. The electrochemical sensor is applied to simultaneous detection of acetaminophen, sulfadiazine and trimethoprim residues in commercially available milk and environmental water. The invention discloses an application method of a polyaniline / tin dioxide / carbon nanobelt-based electrochemical sensor. A detection method comprises the following steps: preparing a standard solution and an actual sample solution; detecting through cyclic voltammetry and differential pulse voltammetry; and determining the recovery rate. The polyaniline / tin dioxide / carbon nanobelt composite material is used for modifying the electrode, the surface area and the conductivity of the electrode are increased, the sensing performance of the electrode is effectively improved, the electrode is used for simultaneous determination of acetaminophen, sulfadiazine and trimethoprim drug residues, the detection limits are respectively as low as 0.18 mu mol / L, 0.13 mu mol / L and 2.67 mu mol / L (S / N = 3), and the sensitivity is high. The method has a wide linear range and good selectivity and anti-interference capability.

The invention belongs to the technical field of repair liquid detection, and provides a sulfonamide active molecule and a preparation method and application thereof.The active molecule tool is obtained based on natural product unsaturated aldehyde derivatives and sulfadiazine functional molecules through reconstruction, flexible conjugated single and double bonds capable of freely rotating exist in the molecular structure of the active molecule tool, and the flexible conjugated single and double bonds can be used for detecting the sulfonamide active molecule tool. The relatively flexible conjugated structure can freely rotate in a dilute solution, rotation in a thick solution is inhibited, and optical signals with different intensities are shown, so that control of the thickness of the epidermis repair liquid becomes visual, and real-time, in-situ and visual detection support can be provided for process development of the epidermis repair liquid. And the development of the chromogenic function of the microcell viscosity measuring agent cannot be influenced by common macromolecular proteins and auxiliaries (such as panthenol, ceramide, hyaluronic acid, vitamin C and derivatives thereof) contained in various epidermal repair liquids, so that the microcell viscosity measuring agent is particularly suitable for measuring the microcell viscosity of the epidermal repair liquid.

This invention discloses the application of sulfadimidine in the preparation of drugs for treating osteoarthritis. This invention is the first to demonstrate the significant efficacy of intra-articular injection of sulfadimidine in the treatment of osteoarthritis (OA); the results show that sulfadimidine can not only significantly relieve the symptoms of osteoarthritis but also improve the metabolic function of chondrocytes, thereby slowing the progression of arthritis. Traditional treatment methods mainly include intra-articular injection of anesthetic drugs, joint lubricants (such as sodium hyaluronate), glucocorticoids, and platelet-rich plasma (PRP). However, these methods each have limitations, such as significant short-term effects but potential long-term side effects. Sulfamidine, as a novel treatment method, not only has good efficacy but also fewer side effects, providing a new approach to the drug treatment of osteoarthritis.

This invention belongs to the field of modified biochar technology, specifically disclosing an iron-manganese-nitrogen co-doped modified biochar, its preparation method, and its application. The invention first mixes corn stalk biochar with urea and performs a pyrolysis reaction to obtain nitrogen-doped biochar. Then, the nitrogen-doped biochar is mixed with an iron source, a manganese source, and water for impregnation. Finally, the iron / manganese-loaded nitrogen-doped biochar undergoes a pyrolysis reaction in a nitrogen atmosphere (temperature ≥650℃) to obtain iron-manganese-nitrogen co-doped modified biochar. This invention, through iron-manganese-nitrogen co-doping modification of biochar, can precisely control its microstructure and surface physicochemical properties, significantly improving its catalytic degradation and adsorption-synergistic removal capabilities for organic pollutants. It exhibits high removal efficiency for sulfadiazine without the addition of additional oxidants or chemical reagents.