The invention discloses a medicine for preventing and treating livestock blast diseases, which is made from Melastoma dodecandrum, dandelion, Herba Lobeliae Chinensis, honeysuckle, radix isatidis, rhizoma anemarrhenae, Bupleurum, pomegranate rind, plantain, cornu saigae Tataricae, terramycin, sulfamethoxazole compound, and chloromycetin. The medicine has the efficacies of clearing heat, purging fire, sterilizing, detoxifying, dissipating swollen symptom as well as lump, stopping blooding as well as relieving diarrhea, inducing diuresis for treating stranguria, calming liver-wind, treating diarrhea with astringents, evacuating and reducing fever, producing fluid as well as moisturizing dryness, and removing heat from the blood as well as relieving sore throat. The medicine has better effects of preventing and treating the blast diseases of a plurality of domestic animals and fowls such as pigs, chickens, ducks, gooses, etc., and further has certain curative effects on the blast diseases of cattle, sheep and dogs and the diseases such as bird flu, aftosa, etc.