289 results about "Sulfur drug" patented technology

The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions.

Certain substituted sulfonamide derivatives of Formula I selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

A disclosed method for simultaneously analyzing and detecting residual veterinary drug compositions in animal tissue comprises: performing homogenate on an animal tissue sample by 50% acetonitrile and ethanol, performing ultrasonic extraction and hexane purifying, and performing further precipitation by acetonitrile and ethanol, concentrating, utilizing UPLC-MS / MS to perform multi-reaction monitoring (MRM) determination under the negative ion mode, and quantifying according to a standard curve and an external standard method, detecting and calculating to obtain the content of 46 residual veterinary drug compositions in animal tissue. The method is applicable to present commonly-used veterinary drugs such as 18 kinds of quinolone drugs, 22 kinds of sulfanilamide drugs, dapsone, phenylethanolamine A, amoxicillin, adamantanamine, rimantadine, ethoxyquin and the like, and is capable of performing one-step simultaneous rapid accurate detection, and the application scope of the method is enlarged.

The present invention belongs to the technical field of bioengineering, and relates to a method for purifying sulfanilamide by using a molecularly imprinted polymer of a sulfanilamide drug. The method comprises the following steps: (1) mixing and dissolving template molecules of a sulfanilamide drug mixture, a functional monomer of methacrylic acid and a cross-linking agent of ethylene glycol dimethacrylate in a pore forming agent (a ratio of methanol to acetonitrile is 2:3); adding an initiator, and sealing; (2) crushing the synthesized polymer, removing fine particles, removing the template molecules through extraction; (3) drying the template molecule-removed polymer overnight at a temperature of 60 DEG C to obtain the molecularly imprinted polymer of the sulfanilamide; (4) filling the molecularly imprinted polymer into a solid phase extraction column tube; (5) activating the solid phase extraction column, adding an animal tissue extraction solution or a water sample, wherein the animal tissue extraction solution is dissolved in 40% methanol; then leaching the solid phase extraction column to elute and purify the sulfanilamide. The method provided by the present invention has advantages of high selectivity, high specificity and adverse environment resistance, and has broad application potential.

The invention discloses a feed special for a low-fat meat chicken without antibiotic, which consists of the following by weight percentage: 10-25 of lactobacillus fermented material and 75-90 of main material, wherein the lactobacillus fermented material consists of the following raw materials: cotton dregs, rapeseed dregs, bran, peanut meal, maize and lactobacillus fermented liquid; and the main material consists of the following raw materials: bean dregs, maize protein powder, maize flour stone dust, calcium hydrophosphate, orexin and growth promotion agents, flavoring agents and trace elements. 10-25 percent of the obtained lactobacillus fermented material is taken according to the percentage of the total weight of the feed for bagging, and 75-90 percent of the obtained main material is taken according to the percentage of the total weight of the feed for packing after bagging, thus the feed special for the meat chicken is prepared. The chicken fed by the feed which is prepared by uniformly mixing the lactobacillus fermented material and the main material have pork type meat quality, abundant muscles, less fat and high protein content, are inspected to have no chloromycetin, terramycin, aureomycin and sulfanilamide medicaments by the national meat product supervision and inspection center and completely reach a non-antibiotic standard and meet the requirement of food security of the European Union.

The invention provides a superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA and a preparing method and application of the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA. According to the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA and the preparing method and application of the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA, silylanization is conducted on the surface of superparamagnetic nanoparticle Fe3O4, a silylating reagent with a PSA structure is bonded, and thus a PSA group is introduced. The superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA and the preparing method of the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA can be applied to the magnetic solid-phase extraction (M-SPE) field, and the superparamagnetic nanoparticle Fe3O4@SiO2@PSA modified by the PSA can serve as an adsorbent which is frequently used for magnetic solid-phase extraction, be applied to various pesticides such as carbamic acid ester, the organophosphorus pesticide and the herbicide and be used for absorption and extraction of target objects such as sulfonamides, organic acid and saccharides; meanwhile, the functional group of the PSA is a good binary ligand, in this way, the PSA is a good chelation material, can be used for extraction of metal ions and has high practical value and broad application prospect in the aspect of analytical investigation.

The invention discloses a method for detecting a sulfanilamide medicine and a special enzyme-linked immunoassay reagent kit thereof. The enzyme-linked immunoassay reagent kit comprises a sulfanilamide medicine monoclonal antibody and the sulfanilamide medicine. The sulfanilamide medicine monoclonal antibody is secreted by the hybridoma cell line SAs of a sulfanilamide monoclonal antibody, whose preservation number is CGMCC No. 3393. In the enzyme-linked immunoassay reagent kit of the invention, an indirect competition ELISA (Enzyme-Linked Immuno Sorbent Assembly) method is mainly used for qualitatively or quantitatively detecting the content of the sulfanilamide medicine in products (especially milk, pork, chicken, eggs, honey, fish, shrimp and the like) eaten by animals or people. The reagent kit and the detection method of the invention have low requirements on the pretreatment of samples and simple pretreatment process of the samples and can detect mass samples quickly at the same time. By using the sulfanilamide medicine monoclonal antibody with high specificity, the detection method is convenient and simple, and the invention has the characteristics of high specificity, high sensibility, high precision, high accuracy and the like.

Provided are methods of producing refined silane compounds comprising providing a starting composition comprising a silane ester and an acidic halide and contacting the starting composition with an alkali metal salt selected from the group consisting of alkali metal salts derived from amides, imides, oxazolidinones, amines, sulfonamides, and combinations of two or more thereof.

The invention provides an enzyme-linked immunosorbent kit for inspecting sulfa drugs, comprising an ELISA plate which is coated with coating antigen, an enzyme label, sulfa drug specific antibody working liquid (being contained when the antigen is coated on the ELISA plate and the enzyme label is enzyme labeling antibody or antibody is coated on the ELISA plate and the enzyme label is enzyme labeling antigen), sulfamethoxy-isoxazole standard product solution, substrate color development solution, stop solution, concentrated washing liquid and concentrated complex solution. The invention further discloses a method which applies the enzyme-linked immunosorbent kit for inspecting the sulfa drugs, and the method comprises the steps of firstly carrying out the pre-treatment on a sample, then using the kit for inspecting and finally analyzing the inspection result. The provided enzyme-linked immunosorbent kit can be used for inspecting the residual amount of the sulfa drugs in animal tissues(chicken, pork, fish and shrimp), honey, eggs, milk, feeds and other samples, the operation is simple, the cost is low, the sensitivity is high and the enzyme-linked immunosorbent kit can be monitore d on-site and is applicable in screening mass samples.

The present invention discloses a sulfanilamide drug chemiluminescence enzyme-linked immunodetection kit, which comprises a kit body, an enzyme label plate placed inside the kit body, and reagents placed inside the kit body, and is characterized in that every hole of the enzyme label plate is coated with coating antigen, the coating antigen is a sulfanilamide mother nucleus and carrier protein conjugate, and the reagents comprise sulfanilamide monoclonal antibody, horseradish peroxidase-labeled goat anti-mouse antibody, a series of sulfanilamide standard solutions, a concentrated phosphate buffer, a concentrated washing solution and a chemiluminescence solution. The sulfanilamide drug chemiluminescence enzyme-linked immunodetection kit has characteristics of high sensitivity, simple and rapid detection, high accuracy, and more drug detection types, provides a substantially reduced operation time compared to the conventional colorimetric ELISA method, and can be used for detection of residues of the 17 sulfanilamide drugs in animal tissues (pork, chicken, pork liver and chicken liver), aquatic products (fish and shrimp), eggs, milk and milk powder.

The invention relates to a determination method of residual quantity of five sulfonamides in animal foods, in particular to a liquid-phase chromatography method for determining the drug residual quantity in the animal foods, aiming to provide a determination method which has the advantages of simple operation, rapidness, high automation degree, high extraction efficiency, good recovery rate and good repeatability. The determination method of the residual quantity of the five sulfonamides in the animal foods comprises the following steps of sample preparation; sample pre-treatment: weighing a sample, uniformly mixing the sample with diatomite, transferring the mixture into an extraction pool, arranging the extraction pool on a rapid solvent extraction apparatus to extract, adding n-hexane in the obtained extract to remove lipid impurities, violently oscillating, standing for layering, removing an n-hexane layer, adding the n-hexane again to repeat the operation twice, transferring a solution at the lower layer into a concentration bottle, carrying out reduced pressure distillation on the solution in a rotary evaporimeter until dry, dissolving residual slags with a mobile phase, filtering the solution with a filter membrane, and analyzing with HPLC (High-Efficiency Liquid-Phase Chromatography); standard solution preparation; and high-efficiency liquid-phase chromatographic determination.

The present invention relates to 'method for examining solid-phase dispersion -high performance liquid chromatogram of residues substrate of sulfonamides in animal derived food' which belongs to the field of food safety-veterinary drug residues. The method comprises of chromatogram examining steps of substrate solid-phase dispersion and high performance liquid, wherein, the mobile phase of sodium dihydrogen phosphate-acetonitrile is 50mmol / L in high performance liquid chromatogram examining method, the volume ratio of sodium dihydrogen phosphate and acetonitrile is 70:30, because the sodium dihydrogen phosphate solution is buffer solution which has a certain PH buffer capability and makes the PH value stable, the stability of pH value of HPLC mobile phase is ensured, and repeatability and reproducibility of analysis result are ensured also, at the same time, the classical process of extraction, separation, concentration and purification are simplified, the operation is simple, the milk combination phenomenon is eliminated. The method of present invention has the merits of ideal precision and sensitivity, and environment protecting by using the less toxicity organic solvent eluting analyte employed.

The invention discloses a feed special for a low-fat meat duck without antibiotic and fishy smell, which consists of the following components by weight percentage: 10-25 of lactobacillus fermented material and 75-90 of main material, wherein the lactobacillus fermented material consists of the following raw materials: cotton dregs, rapeseed dregs, bran, peanut meal, maize and lactobacillus fermented liquid; and the main material consists of the following raw materials: bean dregs, maize protein powder, orexin and growth promotion agents, de-fishy agents, stone dust, calcium hydrophosphate, trace elements and maize flour. 10-25 percent of the obtained lactobacillus fermented material is taken according to the percentage of the total weight of the feed for bagging, and 75-90 percent of the obtained main material is taken according to the percentage of the total weight of the feed for packing after bagging, thus the feed special for the meat duck is prepared. The duck fed by the feed which is prepared by uniformly mixing the lactobacillus fermented material and the main material has pork type meat quality, abundant muscles, less fat and high protein content, is inspected to have no chloromycetin, terramycin, aureomycin and sulfanilamide medicaments by the national meat product supervision and inspection center and completely reaches a non-antibiotic standard and meets the requirement of food security of the European Union.

The invention discloses a method for detecting residual quantity of 18 sulfanilamide drugs in beef and mutton. The method comprises taking 5g of uniform beef and mutton, adding anhydrous magnesium sulfate, sodium acetate and acetonitrile acetate solutions into the beef and mutton, carrying out high-speed homogenized extraction, carrying out centrifugation, carrying out vortex mixing purification impurity-removal on the supernatant by an adsorbent containing a plurality of purification materials, carrying out pressure reduction or nitrogen blowing condensation on the supernatant subjected to re-centrifugation until drying, redissolving the residues, after shaking-up, filtering the solution by a microfiltration membrane with pore sizes of 0.22 micrometers to obtain a sample solution, carrying out separation by a reversed phase column filled with C18 as a filler, carrying out ultraviolet light on-line rapid derivation, carrying out detection by a fluorescence detector, carrying out qualitative analysis according chromatographic peak retention time, carrying out quantification by an external standard method and calculating residual quantity of 18 sulfanilamide drugs in beef and mutton. The method has simple processes, utilizes less amount of a reagent, has high detection sensitivity, releases simultaneous rapid detection of 18 sulfanilamide drugs by one step, greatly shortens analysis time and has a good application prospect.

The invention relates to a method for preparing molecularly imprinted sulfamethoxazole polymer with ionic liquid to be a pore-forming agent. The specific steps are as follows: functional monomers and template molecules are dissolved into the ionic liquid and crosslinker and initiator are added after oscillation. Nitrogen is added to eliminate oxygen after ultrasonic degasification, the liquid is sealed by vacuum-pumping, and the polymer is then obtained by thermal initiation reaction. The molecularly imprinted polymer is obtained by the steps of elution, desiccation and grinding etc. The molecularly imprinted sulfamethoxazole polymer prepared by the invention has evenly massive structure. Compared with traditional synthetic method, the method is characterized by taking ionic liquid as the pore-forming agent which has excellent catalytic effect for polymer reaction when in the synthesis process. The synthetic polymer has the advantages of excellent dispersity, easy grinding and good molecular recognition properties, which can be used as solid phase extracting agent and packing materials for liquid phase chromatography to realize dispersion, concentration and purification of sulfonamides and resolving the defect of serious impurity interference of the existing common chromatographic detection.

The invention relates to a sulfa drugs direct competition enzyme-linked immunity detection reagent box, which belongs to the enzyme-linked immunity and the veterinary drug residues detection technical fields. The invention comprises the preparation of an artificial immune antigen which can produce a sulfa drugs antibody, an enzyme label antigen, a sulfa drugs antibody, a standard liquor reagent, a bottom content liquor reagent, a display color liquor reagent, a termination liquor reagent, an enzyme label antigen diluent reagent, a packet sulfa drugs antibody porous polystyrene micro reaction board and a concentration washing liquid reagent. The invention mainly adopts the direct competition enzyme-linked immunity method to detect qualitatively or quantitatively the sulfa drugs residues quantity in the food and feed; the detection limit is larger than 2 Mug / kg, the detection time only need 2 hours; the average recovery is 70 percent to 120 percent, the errors in a batch are smaller than 10 percent, the errors between the batches are smaller than 20 percent, and the invention is characterized by simpleness, rapidness and accurateness, which can be directly used for the detection of the sulfa drugs residues quantity in the food and feed.

The invention provides an enzyme immune agent box for detecting sulpha drugs of animal organization, which uses enzyme immune method to detect the preprocessed animal organization, honey, urine, milk. The enzyme immune agent box comprises: enzyme mark plate which coats sulpha drugs antigen or antibody, sulpha drugs mouse monoclonal antibody working solution, enzyme mark antibody or sulpha drugs antigen solution, sulpha drugs standard solution, base material color developing solution, compression cleaning liquid, ending solution and compression extracting solution. The invention also discloses a method for applying the detecting method, which comprises: first doing sample front process, then using the agent box to detect, at last analyzing the detected result.

The invention discloses a dipstick used for testing sulfonamides and fluoroquinolones and test method thereof. The dipstick consists of a dipstick body and a microporous reagent, the said microporous reagent contains a freeze-dried sulfonamides monoclonal antibody-colloidal gold marker and a freeze-dried fluoroquinolones monoclonal antibody-colloidal gold marker; the said dipstick body consists of a sample absorption pad, a reaction film, an absorbent pad, a protective film and a bottom patch which are connected in sequence, the said reaction film includes two detection lines and a quality control line, the said two detection lines are respectively coated with sulfonamides hapten carrier protein conjugates and fluoroquinolones hapten carrier protein conjugates, the said quality control line is coated with goat-anti-mouse antibody. Using the dipstick introduced in this invention to test sulfonamides and fluoroquinolones is convenient, fast, intuitive, and accurate. The dipstick is convenient to carry, is wide in application range and low in cost and is easy to promote and use.

The invention discloses a preparation method and application of hydrophilic magnetic molecule imprinted material for sulfonamides veterinary drugs, belongs to the field of organic matter inspection, and particularly relates to a preparation method and application of the sulfonamides drug molecule imprinted material. The method includes the steps of 1), preparing Fe3O4 particles with a coprecipitation method; 2), preparing Fe3O4 for silylation by adopting a stober method to obtain SiO2 coated magnetic microspheres; 3), synthesizing sulfonamides molecule printed polymer particles. The magnetic molecule imprinted materials is fast in adsorption capacity in water phase, high in adsorption function, strong in specificity, high in recovery rate and low in preparation cost; meanwhile, the shortcoming that large amount of solvent required in pretreatment technology of traditional samples is overcome.

The invention discloses a rabbit monoclonal antibody based ciprofloxacin residue analysis enzyme-linked immune adsorption kit. In the ciprofloxacin detection, the IC50 value of the kit is 1.41ng / mL, the linear fitting equation of an inhibition ratio curve is y = 0.0239x - 1.3159, the detection range is between 0.19 and 10ng / mL, and the lowest detection limit is 0.095ng / mL. The ciprofloxacin antibody in the kit has higher specificity, and has lower crossing-over rate with other quinolone micromolecules; and the cross reaction rates between the ciprofloxacin antibody and enrofloxacin, ofloxacin, norfloxacin, fleroxacin or pefloxacin are 28.8 percent, 13.1 percent, 11 percent, 22.6 percent and 20.4 percent respectively. The ciprofloxacin antibody has no cross reaction with other antibiotics and sulfanilamide medicaments. The kit is suitable for detecting ciprofloxacin residue in samples of milk, urine and the like. The kit can detect samples on a large scale at the same time, is convenient and quick, has quite important realistic significance for on-site supervision and trace analysis, meanwhile greatly reduces the detection cost, and has potential economic value.

The invention discloses a method for detecting residual quantity of sulfonamide in milk and meat products. Sulfonamide antibiotic residues in the milk and meat products are measured by four steps of: pretreating a sample; performing chemical reaction on the sulfonamide antibiotic and an aldehyde reagent; extracting; and adopting fluorophotometry. In the technique, derivative substances emitted by strong fluorescence are generated through the derivative reaction of sulfanilamide; and the derivative substances are extracted, so that detection sensitivity is improved, interference is eliminated, a low residual quantity detection requirement is met, system stability is improved obviously, and the defect of low fluorescence detection stability is overcome. The method has the characteristics of simpleness and quickness in operation, high detection sensitivity and the like and is operable in actual detection application.

The invention belongs to the technical field of chemical detection, and particularly relates to a preparation method of a hydrophilic sulfa drug molecularly imprinted solid-phase extraction column. The preparation method of the hydrophilic sulfa drug molecularly imprinted solid-phase extraction column comprises the following steps: (1) synthesizing a hydrophilic sulfa molecularly imprinted polymer by a bulk polymerization method; (2) characterizing the imprinted polymer obtained in the step (1), and determining the presence of an imprinted binding site; and (3) filling in the polypropylene solid-phase extraction column. The prepared hydrophilic solid-phase extraction column has powerful adsorption function, relatively strong specificity, high recovery rate and relatively low preparation cost, besides, improves the disadvantage of large required solvent amount in a traditional sample pretreatment technology, can be directly used for detection of ten sulfa veterinary drugs in animal-derived foods, and has the characteristics of high selective adsorption and high-efficiency enrichment on the sulfa drugs; and moreover, the solid-phase extraction column can be used for detection of sulfa veterinary drugs in a completely aqueous phase.

The invention discloses a preparation method and application of sulphonamide molecular-imprinting solid-phase extraction columella. The preparation method comprises the following steps of: (1) mixing a template molecule, a functional monomer and a cross-linking agent; (2) representing molecular-imprinting polymer particles; (3) filling the molecular-imprinting polymer particles into a solid-phase extraction columella, wetting and washing by using methanol and acetone, sealing in vacuum, wherein the sulphonamide molecular-imprinting polymer is obtained by the following steps of: (a) dissolving the template molecule sulfanilamide and the functional monomer in pore-foaming agent acetonitrile to obtain a mixed solution; (b) carrying out ultrasonic treatment onto the mixed solution by an ultrasonic cleaner to obtain a pre-polymerization system; (c) transferring the pre-polymerized system to a quartz reaction test tube, adding cross-linking agent and imitator; (d) placing the pre-polymerization system under ultraviolet light; (e) directly grinding the imprinted polymer to obtain the imprinted polymer particles. The preparation method of the sulphonamide molecular-imprinting solid-phase extraction columella is high in recovery rate, simple to prepare, low in cost and capable of being directly used for selective adsorption and efficient enrichment of sulfadiazine, sulfamerazine and sulfadimidine in animal-origin food.

The invention relates to a surface enhanced raman spectroscopy detection method for sulfanilamide medicines, which comprises the following steps: (1) dissolving a sulfanilamide medicine by ethanol with 95% of weight percentage concentration, then diluting by using a mixed solvent of ethanol with 95% of weight percentage concentration and water, preparing a standard detection solution with certain concentration for the sulfanilamide medicine; (2) dropping the standard detection solution for sulfanilamide medicine from a step (1) on a substrate possessing SERS activity which is modified by nano-gold particles, naturally volatilizing the solution to dry to obtain the substrate carried with the sulfanilamide medicine; (3) placing the substrate carried with the sulfanilamide medicine in a step (2) into a raman spectroscopy detector for detecting, wherein the detection wavelength of the raman spectroscopy detector is 780nm. The detection method has high sensitivity and short detection period, and realizes the nondestructive test to the substance.

The sensitivity of a tumor cell to a sulfonamide compound or the anti-tumor effect of a sulfonamide compound can be examined by determining the expression level of EGFR1 in the tumor cell and employing the variation in the EGFR1 expression level as a measure. Thus, a method for determination of the sensitivity of a tumor cell to a sulfonamide compound; a method for determination of the anti-tumor effect of a sulfonamide compound; and a test kit for use in these methods are provided.

Belonging to the technical field of Chinese medicine preparation methods, the invention relates to a preparation method of a Chinese medicinal lotion treating dark urine-type cellulitis. Current treatment of dark urine-type cellulitis generally employs antibiotics and sulfonamides, and has the disadvantage of great side effect. A technical scheme adopted by the invention consists of: taking Polyporus, Rhizoma Dioscoreae Hypoglaueae, coix seeds, waxgourd peels, Phaseolus calcaratus, Zanthoxylum bungeanum Maxim, Corn Stigma, gourds, Commelina communis, Polygonum aviculare, Dianthus superbus, akebia stems, Ricepaperplant Pith, Juncus effusus, Patience Dock Roots, Ilex pubescens, Herba Patriniae, Changium smyrnioides, Hemsleya macrosperma, Anemarrhena asphodeloides, radix tinosporae, Trollius chinensis, honeysuckle, Bidens biternata, houttuynia cordata, Herba Lespedezae Cuneatae, hypericum perforatum, Sedum sarmentosum, Sagina subulata, convallaria majalis and licorice, and placing the 31 medicines into water for immersion, then conducting decocting with slow fire, and carrying out filtration to remove the residue, thus obtaining a liquid medicine, i.e. the Chinese medicinal lotion treating dark urine-type cellulitis. The prepared Chinese medicine has the advantages of simple preparation, small toxic and side effect, short treatment course, and high curative rate.

The invention discloses a method for removing sulfonamides in water by using modified zeolite to activate peracetic acid. The method comprises the following steps: S1, preparing a catalyst: grinding artificial zeolite into fine powder, acid pickling, washing, drying, soaking in a ferrous sulfate solution for a period of time, centrifugally separating, washing solids by using deionized water, and drying; S2, performing the oxidization reaction: adding a prepared peracetic acid solution into sulfamethoxazole waste water, adjusting initial pH of water water, adding an appropriate amount of catalyst, and performing the oxidization reaction under the normal temperature normal pressure stirring condition. The adopted catalytic material is simple in preparation, easy to store, high in activationefficiency and low in active component and low in active component dissolution rate; the activated peracetic acid system is high in oxidation performance, the treatment process also has the sterilizing function, the combination of the further treatment and disinfection treatment for the waste water can be realized, the compatibility with the modern water treatment factory process is high, the sulfamethoxazole degradation efficiency is high, the reaction condition is mild, the cost is low, and the method is suitable for the industrialized mass treatment of the waste water.

The application provides a kit for detecting drug residues in meat. The kit contains a hybrid cation exchange solid-phase extraction column, an extract of adamantanamine, quinolones and sulfanilamide medicines, a first leacheate, a second leacheate, an eluate and a reconstitution fluid. The invention also provides a drug residue detection method by the use of the kit. Pretreatment methods of the above three medicines are integrated to design a kit for simultaneous pretreatment of drug residues of adamantanamine, quinolones and sulfanilamide medicines. The kit can be used for pretreating the above three medicines simultaneously. After pretreatment, chromatography or mass spectrometry of a sample can be carried out by a conventional technology.