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Surface enhanced raman spectroscopy detection method for sulfanilamide medicines

A technology of surface-enhanced Raman and sulfa drugs, applied in Raman scattering, material excitation analysis, etc., can solve the problems of inconvenient use, poor selectivity, and high cost, and achieve simple processing methods, high sensitivity, and mild detection conditions Effect

Inactive Publication Date: 2012-02-15
SHANGHAI OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in practical applications, the above technologies are usually affected by factors such as high cost, complicated sample processing methods, poor selectivity, and long detection cycle, resulting in inconvenient use

Method used

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  • Surface enhanced raman spectroscopy detection method for sulfanilamide medicines
  • Surface enhanced raman spectroscopy detection method for sulfanilamide medicines
  • Surface enhanced raman spectroscopy detection method for sulfanilamide medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Surface Enhanced Raman Spectroscopy Detection of Sulfamethazine Samples

[0019] Accurately take by weighing 0.01000g sulfamethazine standard substance and put it into a 100ml beaker, dissolve completely with ethanol (chromatographically pure) of 95% with a certain volume weight percentage concentration, and finally settle in a 100ml volumetric flask, and the concentration of this solution is 100mg / kg, and then diluted with a mixed solvent composed of 95% ethanol and water in a volume ratio of 1:1 to form different concentrations of sulfamethazine standard detection solutions, and pipettes were used to draw 1 microliter of different The concentration of sulfamethazine standard detection solution was dropped on the gold nanoparticle-modified substrate with SERS activity, and after the solution was naturally evaporated to dryness, it was put into a Raman detector for detection. Wherein the detection wavelength of the Raman spectrometer is 780nm.

[0020] fig...

Embodiment 2

[0022] Example 2: Surface Enhanced Raman Spectroscopy Detection of Sulfamethazine Samples

[0023] Accurately weigh 0.01000g sulfamethazine standard substance and put it into a 100ml beaker, completely dissolve it with ethanol (chromatographically pure) with a certain volume weight percentage concentration of 95%, and finally set the volume in a 100ml volumetric flask. The concentration of this solution is 100mg / kg, and then diluted with a mixed solvent composed of 95% ethanol and water with a volume ratio of 1:1 to form a standard detection solution of sulfamethazine with different concentrations, and draw 1 microliter of sulfamethazine with a pipette Standard detection solutions of sulfamethazine in different concentrations were dropped on the SERS-active substrate modified with gold nanoparticles, and after the solution was naturally evaporated to dryness, it was put into a Raman detector for detection. Wherein the detection wavelength of the Raman spectrometer is 780nm. ...

Embodiment 3

[0026] Example 3: Surface Enhanced Raman Spectroscopy Detection of Sulfamethoxazole Samples

[0027] Accurately take by weighing 0.01000g sulfamethoxazole standard substance and put it into a 100ml beaker, dissolve completely with ethanol (chromatographically pure) of 95% with a certain volume weight percentage concentration, and finally settle in a 100ml volumetric flask, and the concentration of this solution is 100mg / kg, then dilute the sulfamethoxazole standard detection solution of different concentrations with the mixed solvent formed after mixing 95% ethanol and water with a volume ratio of 1:1, and draw them respectively with a pipette 1 microliter of standard detection solution of sulfamethoxazole with different concentrations was dropped on the SERS-active substrate modified with gold nanoparticles, and after the solution was naturally evaporated to dryness, it was put into a Raman detector for detection. Wherein the detection wavelength of the Raman spectrometer is ...

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Abstract

The invention relates to a surface enhanced raman spectroscopy detection method for sulfanilamide medicines, which comprises the following steps: (1) dissolving a sulfanilamide medicine by ethanol with 95% of weight percentage concentration, then diluting by using a mixed solvent of ethanol with 95% of weight percentage concentration and water, preparing a standard detection solution with certain concentration for the sulfanilamide medicine; (2) dropping the standard detection solution for sulfanilamide medicine from a step (1) on a substrate possessing SERS activity which is modified by nano-gold particles, naturally volatilizing the solution to dry to obtain the substrate carried with the sulfanilamide medicine; (3) placing the substrate carried with the sulfanilamide medicine in a step (2) into a raman spectroscopy detector for detecting, wherein the detection wavelength of the raman spectroscopy detector is 780nm. The detection method has high sensitivity and short detection period, and realizes the nondestructive test to the substance.

Description

technical field [0001] The invention relates to the detection field of sulfa drugs, in particular to a method for detecting sulfa drug residues by using surface-enhanced Raman spectroscopy. Background technique [0002] With the development of society and the improvement of people's living standards, environmental protection, food safety and human health have become common concerns of the society. The hazards of veterinary drug residues in food safety are particularly prominent. Sulfonamide drugs are commonly used in clinical veterinary medicine. They are widely used and used in large quantities. They are likely to cause drug residues in animal tissues, and the residues enter the human body and ecosystem through the food chain, endangering human health and causing environmental pollution. It also seriously affects animal products in my country. exports and cause huge economic losses. Therefore, it is of great significance to strengthen the monitoring of sulfa drug residues....

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 黄轶群李春颖赖克强张衍亮
Owner SHANGHAI OCEAN UNIV
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