4 results about "Sulfa drug" patented technology

The invention provides a micro-fluidic chip for detecting the content of sulfonamides in dairy products and a method for detecting the content of sulfonamides in dairy products, and relates to the technical field of food detection. The micro-fluidic chip comprises a chip body, a sample inlet and a sample outlet are formed in the chip body, and a sample pretreatment channel communicated with the sample inlet, a filtering, buffering and mixing channel communicated with the sample pretreatment channel and a filtering and buffering channel communicated with the filtering, buffering and mixing channel are formed in the chip body. The reaction tank and the waste liquid tank are communicated with the filtering buffer channel, and the sample outlet is communicated with the reaction tank and the waste liquid tank; wherein the sample pretreatment channel is filled with a filter filler, the filter buffer mixing channel is used for full pretreatment reaction, a filter membrane is arranged between the filter buffer mixing channel and the filter buffer channel, and the reaction tank is filled with a biological composite material; the content of the sulfonamides in the dairy product can be effectively detected.

The present invention discloses a compound solution of a sulfonamide and an antimicrobial synergist, its preparation method, and application. The compound solution further comprises a solvent, a pH buffer system, and a diluent; the solvent is N-methylpyrrolidone, and the pH buffer system is triethanolamine and an organic acid. The present invention discloses a stable, clear compound solution of a sulfonamide and an antimicrobial synergist, and its preparation method. The compound solution can be mixed with water for administration, exhibits excellent stability and lacks a distinctive odor after mixing with water, and eliminates problems such as uneven mixing of existing premixes and low intake of sick animals when their appetite decreases.

The invention discloses a method for detecting sulfonamides residues in milk, which comprises the following steps: firstly, mixing to-be-detected milk containing sulfonamides with a deproteinization reagent, performing deproteinization treatment on the to-be-detected milk, then removing solids in the formed deproteinized mixture, and adjusting the obtained clear liquid to be acidic, obtaining a pretreated sample; then uniformly mixing the pretreated sample and a color developing agent to form a mixed sample; then, applying a medium-frequency oscillation electric field to the mixed sample, enabling the mixed sample to fully react to form a to-be-detected sample, continuously applying the medium-frequency oscillation electric field, and measuring the light absorption value of the to-be-detected sample at the ultraviolet wavelength; and finally, calculating the content of the sulfonamides in the milk to be detected according to the measured light absorption value and a pre-established standard curve relational expression. Compared with the prior art, the detection method is high in precision, sensitivity and accuracy and short in detection time.

This invention discloses a mixed broad-spectrum nucleic acid aptamer for the simultaneous detection of nine sulfonamide drugs and its applications. The mixed broad-spectrum nucleic acid aptamer is composed of nucleic acid aptamer sequences Sul-01 and Sul-04, which can be used as probes to construct a ratiometric fluorescence method for the simultaneous detection of nine sulfonamide drugs. The mixed broad-spectrum nucleic acid aptamer provided by this invention exhibits high specificity and high binding affinity for multiple sulfonamide drugs. The detection method established using it can achieve rapid, low-cost, and highly sensitive simultaneous detection of nine sulfonamide drug residues in aquatic environments and seafood.