Preparation method and application of hydrophilic magnetic molecule imprinted material for sulfonamides veterinary drugs

A technology of magnetic molecular imprinting and sulfonamides, which is applied in the preparation of molecular imprinting materials of sulfonamide drugs, the application field of polymers of molecular imprinting materials of sulfonamide drugs in the detection of sulfonamide veterinary drugs, which can solve the problems of limited application and poor adsorption

Inactive Publication Date: 2017-06-09
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the molecularly imprinted material prepared by the above method has the advantages of large adsorption capacity, good selectivity, fast response and good chemical stability, but because the molecularly imprinted material has the characteristics of biological antibodies, it can only be used for specific targets (multiple traces) Steroids and phenolic environmental endocrine disruptors) have selective adsorption properties, while other substances (such as sulfonamide veterinary drugs) have poor adsorption properties
At the same time, this method is based on the preparation of molecularly imprinted polymers by organic polymerization of methacrylic acid and 2-vinylpyridine, which limits its application in aqueous phase sample matrices (such as animal-derived foods).

Method used

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  • Preparation method and application of hydrophilic magnetic molecule imprinted material for sulfonamides veterinary drugs
  • Preparation method and application of hydrophilic magnetic molecule imprinted material for sulfonamides veterinary drugs
  • Preparation method and application of hydrophilic magnetic molecule imprinted material for sulfonamides veterinary drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Preparation of Hydrophilic Magnetic Sulfonamide Molecularly Imprinted Polymer

[0088] 1) Synthesis of Fe by co-precipitation method 3 o 4 particle

[0089] 2.5g FeSO 4 .7H 2 O with 4.0g FeCl 3 .6H 2O was placed in a Erlenmeyer flask, added 200mL of deionized, mechanically stirred to dissolve, then heated to 60°C under nitrogen protection, 5mL of ammonia water was added at one time, and continued to heat and stir for 1 hour; Apply an external magnetic field to separate the black product from the supernatant, and repeatedly wash with deionized water and absolute ethanol until the washing liquid is neutral; place the composite in a vacuum drying oven at 60°C to dry to constant weight, and grind the obtained black product for future use. use;

[0090] 2) Preparation of silanized Fe by stober method 3 o 4

[0091] Accurately weigh the Fe obtained in step 1) 3 o 4 Pour 0.625g of particles into a round-bottomed flask filled with 2.5mL of water and 8mL of absolute ...

Embodiment 2

[0103] Characterize the imprinted polymer obtained in Example 1 to determine the presence of imprinted binding sites;

[0104] The characterization methods include dynamic adsorption, static adsorption and selectivity experiments.

[0105] Characterization of Magnetic Molecularly Imprinted Polymers

[0106] (1) Adsorption kinetics experiment

[0107] Accurately weigh 50 mg of magnetic molecularly imprinted polymer, place it in a 25 mL volumetric flask, pipette accurately 5 mL of 30 mg / L SMZ-water solution, shake at room temperature for 5 min, 10 min, 20 min, 40 min, 80 min, and 120 min respectively , the material is separated under the adsorption of an external magnet;

[0108] Under the condition of wavelength 270nm, the concentration of sulfamethazine in the supernatant was measured by ultraviolet-visible spectrophotometer; the adsorption kinetics experiment was to determine the adsorption efficiency of the synthesized magnetic molecularly imprinted polymer, and this paten...

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Abstract

The invention discloses a preparation method and application of hydrophilic magnetic molecule imprinted material for sulfonamides veterinary drugs, belongs to the field of organic matter inspection, and particularly relates to a preparation method and application of the sulfonamides drug molecule imprinted material. The method includes the steps of 1), preparing Fe3O4 particles with a coprecipitation method; 2), preparing Fe3O4 for silylation by adopting a stober method to obtain SiO2 coated magnetic microspheres; 3), synthesizing sulfonamides molecule printed polymer particles. The magnetic molecule imprinted materials is fast in adsorption capacity in water phase, high in adsorption function, strong in specificity, high in recovery rate and low in preparation cost; meanwhile, the shortcoming that large amount of solvent required in pretreatment technology of traditional samples is overcome.

Description

technical field [0001] The invention belongs to the field of organic matter detection, and specifically relates to a preparation method of a sulfonamide drug molecularly imprinted material, and also relates to the application of the above-mentioned polymer of the sulfonamide drug molecularly imprinted material in the detection of sulfonamide veterinary drugs. Background technique [0002] Sulfa drugs are the earliest antibiotic drugs applied to the nervous system of the whole body. Its birth paves the way for the development of antibiotic drugs in the field of medicine. Because sulfa drugs have the advantages of low cost and high efficiency, they are widely used in medicine, animal husbandry, food and other fields. However, with the wide application of sulfonamides in many fields, its abuse also appears, and its potential carcinogenicity and drug resistance are also gradually emerging. endangered by misuse. At the same time, once sulfonamides are released into the environm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/06C08F220/28C08F222/14C08F230/08C08F2/44C08K9/10C08K3/22C08J9/26G01N30/06G01N30/02B01J20/26B01J20/28B01J20/30C02F1/28C02F101/30
CPCB01J20/268B01J20/28009B01J20/28019C02F1/285C02F2101/30C08F2/44C08F220/06C08F220/28C08F220/281C08F222/10C08F222/102C08F230/08C08J9/26C08J2201/0424C08J2333/02C08J2333/14C08J2335/02C08J2343/04C08K3/22C08K9/10C08K2003/2275G01N30/02G01N30/06G01N2030/062
Inventor 何金兴崔一笑梁金玲
Owner QILU UNIV OF TECH
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