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4 results about "Cardiac myosin" patented technology
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Cardiac myosin is the major antigen in the myocardium. Using affinity-purified anti-myosin antibodies, Cunningham et al. 64 identified an epitope of the N-terminal M5 and M6 proteins consisting of a five-amino acid residue (Gln-Lys-Ser-Lys-Gln) that cross-reacted with cardiac myosin.
Treatment of cardiomyopathy with AAV gene therapy vectors
PendingUS20260091139A1Peptide/protein ingredientsNucleic acid vectorCardiac myosinHypertrophic cardiomyopathy
Provided herein are gene therapy compositions and methods of treating reduced levels of functional cardiac myosin binding protein C in a subject having hypertrophic cardiomyopathy.
Owner:DINAQOR AG
Methods for treating hypertrophic cardiomyopathy
Methods for treating obstructive hypertrophic cardiomyopathy are described herein. The treatment methods include the administration of a cardiac myosin inhibitor (CK-3773274, also referred to as CK-274 or aficamten) and may include titrating an administrated daily dose based on one or more components of an echocardiogram. The daily dose may be increased, maintained, decreased, or terminated, based on the echocardiogram.
Owner:CYTOKINETICS INC
Cardiac myosin-binding protein c detection kit and use thereof
PCT designated stageWO2026091296A1Genetic material ingredientsImmunoglobulins against animals/humansCardiac myosinEpitope
Provided herein is a myosin binding protein C detection kit, comprising: 1) a magnetic bead coupled with a first antibody, and 2) a second antibody coupled with an acridinium ester, the first antibody and the second antibody both being human myosin binding protein C antibodies, but binding to different antigenic epitopes. By means of a double antibody sandwich method and the chemiluminescence characteristics of the acridinium ester, the myosin binding protein C detection kit detects the content of myosin binding protein C in serum with high sensitivity.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV
Monoclonal paired antibodies of cardiac myosin binding protein c and application thereof
This invention discloses a monoclonal paired antibody against cardiac myosin-binding protein C and its application. The specific antibody comprises a first antibody and / or a second antibody; the first antibody and the second antibody bind to different epitopes of cardiac myosin-binding protein C, and the similarity between the heavy chain CDR3 sequence of the first antibody and the heavy chain CDR3 sequence of the second antibody is <70%, and the similarity between the light chain CDR3 sequence of the first antibody and the light chain CDR3 sequence of the second antibody is <70%. The monoclonal paired antibody against cardiac myosin-binding protein C of this invention exhibits high specificity and high affinity, with a cross-reactivity rate of <1% with skeletal muscle myosin-binding protein. The kit of this invention has a detection sensitivity ≤5 pg / mL and a detection time of only 10-15 min, making it suitable for the ultra-early diagnosis of acute myocardial infarction.
