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Cardiac myosin is the major antigen in the myocardium. Using affinity-purified anti-myosin antibodies, Cunningham et al. 64 identified an epitope of the N-terminal M5 and M6 proteins consisting of a five-amino acid residue (Gln-Lys-Ser-Lys-Gln) that cross-reacted with cardiac myosin.
Monoclonal paired antibodies of cardiac myosin binding protein c and application thereof
This invention discloses a monoclonal paired antibody against cardiac myosin-binding protein C and its application. The specific antibody comprises a first antibody and / or a second antibody; the first antibody and the second antibody bind to different epitopes of cardiac myosin-binding protein C, and the similarity between the heavy chain CDR3 sequence of the first antibody and the heavy chain CDR3 sequence of the second antibody is <70%, and the similarity between the light chain CDR3 sequence of the first antibody and the light chain CDR3 sequence of the second antibody is <70%. The monoclonal paired antibody against cardiac myosin-binding protein C of this invention exhibits high specificity and high affinity, with a cross-reactivity rate of <1% with skeletal muscle myosin-binding protein. The kit of this invention has a detection sensitivity ≤5 pg / mL and a detection time of only 10-15 min, making it suitable for the ultra-early diagnosis of acute myocardial infarction.
