58 results about "Sarcomere" patented technology

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, are useful in the treatment of systolic heart failure including congestive heart failure.

A meat or fish composition which retains moisture during cooking is provided. A concentrated aqueous acidic protein solution derived from animal muscle tissue is added to the meat or fish prior to cooking. The concentrated aqueous acidic protein solution comprises myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres.

A meat or fish composition which retains moisture during cooking is provided. A dry protein mixture or an aqueous acidic protein solution derived from animal muscle tissue is added to the meat or fish prior to cooking. The dry protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres.

A peptide composition derived from a protein composition when added to uncooked food effects moisture retention during cooking of the food. The peptide composition is derived from a dry protein mixture or an aqueous acidic protein solution which, in turn, is derived from animal muscle tissue. The peptide composition is added to uncooked poultry, meat or fish prior to cooking. The dry protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres.

A method and apparatus generate resonant sequences having pulses optimally spaced and configured to realize uniform contractions in a musculature. Namely, each subsequent pulse maintains tension within sarcomeres of the musculature as the resonant sequence propagates inwardly to progressively stimulate the entirety of the musculature. Variation in the width, spacing, polarity and / or amplitude of the pulses comprising the resonant sequence further overcomes accommodation and nutritional depletion while minimizing discomfort.

The invention relates to a preparation method of a nanofiber scaffold for heart tissue engineering. The preparation method comprises the steps of preparing the nanofiber scaffold from poly(glyceroi sebacate) (PGS) / a gelatin nanofiber scaffold material with different components through electrostatic spinning, and crosslinking the nanofiber scaffold in a mixed solution of hydrochlorinated N,N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to obtain the nanofiber scaffold. The nanofiber scaffold related by the invention can be used for promoting the formation of sarcomere and has wide prospects on the aspect of being used as a material for cardiac muscle cell regeneration and repair.

A muscle biopsy clamp device may be used to measure sarcomere lengths in vivo where laser diffraction may not be possible. The clamp device includes a jaw having serrated markings for securing a muscle bundle in the clamp device as well as to provide markings for the muscle biopsy as reference for the sarcomere length measurement.

Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

The invention relates to a method for improving beef quality by gradually cooling beef carcasses. The method includes the steps that the carcasses of killed cattle are pushed into a cooling chamber immediately to be rapidly cooled for 2 hours, wherein the air temperature is minus 11 + / -1 DEG C, and the air flow velocity is 0.5 m / s, cooling is stopped, the air flow velocity is maintained at 0 m / s, the center temperature of the cattle back longissimus is maintained at 12-18 DEG C till ten hours pass after the cattle are killed, and then the beef carcasses are pushed into a conventional cooling chamber to be cooled till 48 hours pass after the cattle are killed; then the beef carcasses are packaged and cooked according to a conventional technology. By means of the method, cold shrinkage can be avoided, beef quality can be improved, the beef shear force value is remarkably lowered compared with conventional cooling, the cooking time is shortened, the MFI value and the sarcomere length are increased, and meanwhile the water-retaining property and color of beef can also be improved in the cooking process.

The invention discloses a modeling method of excitation and contraction processes of fast muscle fibers of skeletal muscle. The method includes the steps of (1) adopting half sarcomere as a unit and building an electrophysiologic mathematic model of fast muscle sarcolemma of the skeletal muscle; (2) adopting the half sarcomere as a unit and building a geometric model of calcium ions circulation; (3) building a mathematic model of a release process of calcium ions from a RyR channel on terminal pond; (4) building a mathematic model of combining calcium ions and magnesium ions with ATP and parvalbumin separately; (5) building a methematic model of cross-bridge power and a mathematic model of combination of the calcium ions and troponin; (6) building a sarcolemma fatigue model and a metabolism fatigue model during the excitation and contraction processes of the fast muscle fibers of the skeletal muscle. The modeling method of the excitation and contraction processes of the fast muscle fibers of the skeletal muscle is based on the biologic structure of the skeletal muscle, and can achieve building of mathematic models in each link, more precise analysis, simulation and prediction of the excitation and contraction processes of the sarcolemma of the skeletal muscle, and provide theoretical guidance for disease diagnoses and rehabilitation therapies of the skeletal muscle.

The invention provides an electromagnetic bionic muscle fiber and an electromagnetic bionic muscle group. The electromagnetic bionic muscle fiber comprises multiple magnetic sarcomeres which are connected in series, at least one insulation casing pipe, a muscle fiber control unit and at least one bionic muscle tedon, the magnetic sarcomeres are elastically connected together through at least one elastic connecting part, each magnetic sarcomere comprises a magnet body and a wire wound around the magnet body to form a magnetic field, the multiple series-connection magnetic sarcomeres are sleevedwith the insulation casing pipes, the muscle fiber control unit is electrically connected with a wire winding around each magnetic sarcomere, and the first ends of the bionic muscle tedons are connected with the multiple series-connection magnetic sarcomeres. The human body muscle fiber and the muscle group principle can be simulated to achieve the motion control , the structure is simple, the raw material cost is low, and the popularization is easy.

The invention provides a schizothorax waltoni fertilized egg incubating method. Before reaching the sarcomere appearing stage, fertilized eggs are placed in an incubating frame to be incubated in flowing water; after the fertilized eggs grow to the sarcomere appearing stage, dead eggs are removed, and the fertilized eggs are moved into a fish egg incubator to be incubated. In combination with thecharacteristics of the schizothorax waltoni fertilized eggs in the sensitive period, incubating is conducted in different stages, labor input is effectively reduced, and the method is suitable for large-scale artificial propagation of schizothorax waltoni.

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

A method and system of predicting a muscle characteristic using ultrasound. The characteristic may include a tenderness characteristic and / or a strength characteristic. An analysis of muscle structure is performed for a sample using ultrasound data of the sample. The analysis may include determining a relative number of bundles, fascicles, sarcomeres, fibers, and / or sheath thickness from the ultrasound data. Thereafter, the muscle characteristic is predicted for the sample based on the analysis.

The invention relates to a pelvis hanging type cooking method capable of improving beef tenderness. The method comprises the following steps of: hanging cattle by stabbing the obturator of cattle pelvis by a hook immediately after the cattle is slaughtered, and cooking the cattle in a cooking workshop for 14 days, wherein the cooking temperature is 0-4 DEG C, the air speed is 0.5m / s and the relative air humidity is 90%. The pelvis hanging procedure aims to restrict the contraction of muscles during a carcass rigidity process by the stretching effect of self weight of carcasses so as to increase the sarcomere length and reduce the diameter of muscle fibers, thus playing an important role in improving beef tenderness and reducing the loss of beef juice. The beef sirloin cooked by the method is characterized that the sarcomere length increases by 32%, the shear force is reduced by 12%, the tenderness of the beef sirloin hung and cooked for 14 days is better than that of sirloin obtained from tendon hung and cooked for 21 days, and the juice loss is reduced by 22.5%.

Certain embodiments of the invention provide a polypeptide comprising:(a) an amino acid sequence encoding a first chromophore;(b) a first linker;(c) an amino acid sequence having at least about 80% sequence identity to an amino acid sequence encoding a troponin C;(d) a second linker; and(e) an amino acid sequence encoding a second chromophore;wherein the first and second chromophores are a Förster resonance energy transfer (FRET) donor-acceptor pair; wherein the first chromophore is a donor chromophore and the second chromophore is an acceptor chromophore, or wherein the first chromophore is an acceptor chromophore and the second chromophore is a donor chromophore; and wherein the polypeptide is capable of integrating into a sarcomere. Certain embodiments of the invention also provide methods of using such polypeptides.

The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its role molecular events that lead to or contribute to cardiac hypertrophy and / or dilated cardiomyopathy. In particular, inhibition of MEK5 activity will lead to decrease signalling of the pathways and reduce or eliminate the effects on sarcomere assembly, which in turn result or contribute to cardiac dysfunction. Also provided are transgenic animals and methods of screening for inhibitors of MEK5.

A meat or fish composition which retains moisture during cooking is provided. A dry protein mixture or an aqueous acidic protein solution derived from animal muscle tissue is added to the meat or fish prior to cooking. The dry protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres.

A process for cooking a potato in oil and / or fat is provided. An acidic dry protein mixture, an alkaline dry protein mixture, an aqueous alkaline protein mixture or an aqueous acidic protein or peptide derived therefrom is added to a food prior to cooking. The acidic dry protein mixture, alkaline dry protein mixture, aqueous alkaline protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres. The uncooked potato and protein and / or peptide is frozen and then cooked in a fat or oil. The amount of oil and / or fat absorbed by the food during cooking is substantially reduced.

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

A process is provided for isolating a protein component of animal muscle tissue by mixing a particulate form of the tissue with an acidic aqueous liquid having a pH below about 3.5 to produce a protein rich solution substantially free of myofibrils and sarcomere tissue structure. The protein rich aqueous solution can be treated to effect protein precipitation, followed by protein recovery.

A homogeneous cooked roux is formed by heating a mixture of (a) a starchy food and (b) a dry protein mixture, an aqueous alkaline protein mixture or an aqueous acidic protein. The dry protein mixture, aqueous alkaline protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic protein derived from animal muscle tissue and are substantially free of myofibrils and sarcomeres.