58 results about "Sarcomere" patented technology

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

A meat or fish composition which retains moisture during cooking is provided. A concentrated aqueous acidic protein solution derived from animal muscle tissue is added to the meat or fish prior to cooking. The concentrated aqueous acidic protein solution comprises myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres.

A peptide composition derived from a protein composition when added to uncooked food effects moisture retention during cooking of the food. The peptide composition is derived from a dry protein mixture or an aqueous acidic protein solution which, in turn, is derived from animal muscle tissue. The peptide composition is added to uncooked poultry, meat or fish prior to cooking. The dry protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres.

A method and apparatus generate resonant sequences having pulses optimally spaced and configured to realize uniform contractions in a musculature. Namely, each subsequent pulse maintains tension within sarcomeres of the musculature as the resonant sequence propagates inwardly to progressively stimulate the entirety of the musculature. Variation in the width, spacing, polarity and/or amplitude of the pulses comprising the resonant sequence further overcomes accommodation and nutritional depletion while minimizing discomfort.

The invention relates to a preparation method of a nanofiber scaffold for heart tissue engineering. The preparation method comprises the steps of preparing the nanofiber scaffold from poly(glyceroi sebacate) (PGS)/a gelatin nanofiber scaffold material with different components through electrostatic spinning, and crosslinking the nanofiber scaffold in a mixed solution of hydrochlorinated N,N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to obtain the nanofiber scaffold. The nanofiber scaffold related by the invention can be used for promoting the formation of sarcomere and has wide prospects on the aspect of being used as a material for cardiac muscle cell regeneration and repair.

Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

The invention discloses a modeling method of excitation and contraction processes of fast muscle fibers of skeletal muscle. The method includes the steps of (1) adopting half sarcomere as a unit and building an electrophysiologic mathematic model of fast muscle sarcolemma of the skeletal muscle; (2) adopting the half sarcomere as a unit and building a geometric model of calcium ions circulation; (3) building a mathematic model of a release process of calcium ions from a RyR channel on terminal pond; (4) building a mathematic model of combining calcium ions and magnesium ions with ATP and parvalbumin separately; (5) building a methematic model of cross-bridge power and a mathematic model of combination of the calcium ions and troponin; (6) building a sarcolemma fatigue model and a metabolism fatigue model during the excitation and contraction processes of the fast muscle fibers of the skeletal muscle. The modeling method of the excitation and contraction processes of the fast muscle fibers of the skeletal muscle is based on the biologic structure of the skeletal muscle, and can achieve building of mathematic models in each link, more precise analysis, simulation and prediction of the excitation and contraction processes of the sarcolemma of the skeletal muscle, and provide theoretical guidance for disease diagnoses and rehabilitation therapies of the skeletal muscle.

The invention provides an electromagnetic bionic muscle fiber and an electromagnetic bionic muscle group. The electromagnetic bionic muscle fiber comprises multiple magnetic sarcomeres which are connected in series, at least one insulation casing pipe, a muscle fiber control unit and at least one bionic muscle tedon, the magnetic sarcomeres are elastically connected together through at least one elastic connecting part, each magnetic sarcomere comprises a magnet body and a wire wound around the magnet body to form a magnetic field, the multiple series-connection magnetic sarcomeres are sleevedwith the insulation casing pipes, the muscle fiber control unit is electrically connected with a wire winding around each magnetic sarcomere, and the first ends of the bionic muscle tedons are connected with the multiple series-connection magnetic sarcomeres. The human body muscle fiber and the muscle group principle can be simulated to achieve the motion control , the structure is simple, the raw material cost is low, and the popularization is easy.

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

The invention provides a schizothorax waltoni fertilized egg incubating method. Before reaching the sarcomere appearing stage, fertilized eggs are placed in an incubating frame to be incubated in flowing water; after the fertilized eggs grow to the sarcomere appearing stage, dead eggs are removed, and the fertilized eggs are moved into a fish egg incubator to be incubated. In combination with thecharacteristics of the schizothorax waltoni fertilized eggs in the sensitive period, incubating is conducted in different stages, labor input is effectively reduced, and the method is suitable for large-scale artificial propagation of schizothorax waltoni.

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

A method and system of predicting a muscle characteristic using ultrasound. The characteristic may include a tenderness characteristic and/or a strength characteristic. An analysis of muscle structure is performed for a sample using ultrasound data of the sample. The analysis may include determining a relative number of bundles, fascicles, sarcomeres, fibers, and/or sheath thickness from the ultrasound data. Thereafter, the muscle characteristic is predicted for the sample based on the analysis.

Certain embodiments of the invention provide a polypeptide comprising:

• • (a) an amino acid sequence encoding a first chromophore;
  • (b) a first linker;
  • (c) an amino acid sequence having at least about 80% sequence identity to an amino acid sequence encoding a troponin C;
  • (d) a second linker; and
  • (e) an amino acid sequence encoding a second chromophore;
  • wherein the first and second chromophores are a Förster resonance energy transfer (FRET) donor-acceptor pair; wherein the first chromophore is a donor chromophore and the second chromophore is an acceptor chromophore, or wherein the first chromophore is an acceptor chromophore and the second chromophore is a donor chromophore; and wherein the polypeptide is capable of integrating into a sarcomere. Certain embodiments of the invention also provide methods of using such polypeptides.

A meat or fish composition which retains moisture during cooking is provided. A dry protein mixture or an aqueous acidic protein solution derived from animal muscle tissue is added to the meat or fish prior to cooking. The dry protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres.

A process for cooking a potato in oil and/or fat is provided. An acidic dry protein mixture, an alkaline dry protein mixture, an aqueous alkaline protein mixture or an aqueous acidic protein or peptide derived therefrom is added to a food prior to cooking. The acidic dry protein mixture, alkaline dry protein mixture, aqueous alkaline protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres. The uncooked potato and protein and/or peptide is frozen and then cooked in a fat or oil. The amount of oil and/or fat absorbed by the food during cooking is substantially reduced.

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

A process is provided for isolating a protein component of animal muscle tissue by mixing a particulate form of the tissue with an acidic aqueous liquid having a pH below about 3.5 to produce a protein rich solution substantially free of myofibrils and sarcomere tissue structure. The protein rich aqueous solution can be treated to effect protein precipitation, followed by protein recovery.

A homogeneous cooked roux is formed by heating a mixture of (a) a starchy food and (b) a dry protein mixture, an aqueous alkaline protein mixture or an aqueous acidic protein. The dry protein mixture, aqueous alkaline protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic protein derived from animal muscle tissue and are substantially free of myofibrils and sarcomeres.