8 results about "Sarcomere" patented technology

The invention discloses application of functional protein STEAP3 in preparation of drugs for preventing, diagnosing and / or treating heart failure and medical inspection products, and belongs to the technical field of medicines. The invention discloses application of targeted regulation of STEAP3 in preparation of drugs for prevention, diagnosis and / or treatment of heart failure and medical inspection products. Experiments prove that targeted regulation of the protein can significantly improve the activity of cardiac muscle cells and enhance the ability of the protein to resist stress injury, and the protein also has the following five significant activities in DOX-induced heart failure model mouse in-vivo experiments: 1) improving cardiac dysfunction; the traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, reversing myocardial tissue fibrosis, improving myocardial tissue sarcoma disorder, relieving myocardial cell apoptosis and reducing myocardial cell mitochondria damage.

The present disclosure relates to the treatment and prevention of diseases and conditions (e.g., cardiomyopathy) by LINC complex inhibition. LINC complex inhibitors are provided for use in methods of treating or preventing a disease or condition characterized by microtubule dysfunction and / or a disease or condition characterized by sarcomere defects or dysfunction.

Disclosed are an apparatus and method for the joint imaging of high-frequency mechanical stimulation conjugated with sarcomere contraction and sarcoplasmic reticulum calcium activity, and an application. The method for the joint imaging of high-frequency mechanical stimulation conjugated with sarcomere contraction and sarcoplasmic reticulum calcium activity comprises: providing muscle cells; performing calcium ion staining on the muscle cells; and applying, to the muscle cells, which have been subjected to calcium ion staining, mechanical stimulation conjugated with the sarcomere contraction length of the muscle cells and oriented perpendicular to a sarcomere direction, and using a high-speed spinning disk confocal microscope to perform observation.

Compounds of formula (i) are provided: formula (i) or a pharmaceutically acceptable salt thereof, wherein a, z, b, r1, r2, r3, g1, g2 and g3 are as defined herein. A pharmaceutically acceptable composition comprising a compound of formula (i), or a pharmaceutically acceptable salt thereof, is also provided. Methods for using a compound of formula (i), or a pharmaceutically acceptable salt thereof, for use in methods of treating heart disease by inhibiting the cardiac sarcomere are also provided.

The application discloses a kind of based on sarcomere's bionic flexible driver, belong to soft robot technical field.The driver includes external pneumatic artificial muscle driving unit group, internal bionic tension integral framework and upper and lower connecting disc buckle group.External pneumatic artificial muscle driving unit group is made of four external pneumatic artificial muscle driving units distributed in cross shape, as active driving source;Internal tension integral framework realizes self-balancing and self-stabilization by prestress.By differentiating pressure to each external pneumatic artificial muscle driving unit, control its generation non-uniform axial contraction, to drive the whole realization controllable bending movement.The application fuses sarcomere bionic principle and tension integral structure, while maintaining good compliance, significantly improves stiffness and stability, effectively solves the problem of weak rigidity, slow response and insufficient deformation control precision of traditional flexible driver, and is suitable for robot operation scene needing high flexibility and environmental adaptability.

The invention discloses a differentiation method of hiPSCs-derived myocardial cells based on 3D suspension culture, belongs to the technical field of differentiation culture of human induced pluripotent stem cells, and realizes the effects of improvement of cell differentiation efficiency, improvement of cell function maturity, enrichment of cell purity, enhancement of clinical application suitability and the like by adopting staged directional induction based on 3D suspension culture. The problems that a two-dimensional adherent culture method is low in differentiation efficiency, poor in repeatability, difficult to scale and insufficient in physiological correlation of obtained myocardial cells are solved. Meanwhile, the 3D environment can induce cytoskeleton reconstruction, promote orderly arrangement of sarcoglyphs and improve the contraction strength, rhythm stability and cell sphere size uniformity of the myocardial cells, and the problems that the myocardial cells obtained through existing three-dimensional suspension culture are uneven in cell sphere size, low in purity and difficult to meet the requirements are solved.

Provided herein are compounds of formula (I):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein.Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing.Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Methods for treating heart failure are described herein. Treatment methods include administering a cardiac sarcomere activator (e.g., omecamtiv mecarbil, or a pharmaceutically acceptable salt and / or hydrate thereof) to a subject in need thereof.