The present application belongs to the technical field of
solid phase extraction, and particularly relates to a
solid phase extraction membrane based on a defective MOF as well as a preparation method and application thereof. The
solid phase extraction membrane based on the defective MOF comprises a carrier and a
coating layer loaded on the surface of the carrier; the composition of the
coating layer comprises a defective amino MOF material; the defective amino MOF material is prepared by taking a
metal as a center, taking 3,5-dibromo-4-hydroxybenzaldehyde as a template molecule, and reacting with an amino organic ligand. By adopting a specific template molecule, the defective MOF structure has pores that are matched with the shape and size of the template molecule, has strong adsorption capacity for structural analogues of the template molecule, has strong selectivity for target analytes, can highly selectively enrich
chlorophenol, and makes the
solid phase extraction membrane have excellent
adsorption effect on
chlorophenol, high enrichment multiple and good reproducibility.