37results about How to "Improve systolic function" patented technology

A ginger extract mainly containing the volatile oil of ginger and gingerol for preparing medicines to treat heart failure, myocardial ischemia, atherosclerosis, etc is prepared from the dried ginger through pulverizing, supercritical CO2 fluid extracting and separation.

The invention discloses an application of a traditional Chinese medicine composition in the preparation of a medicine for treating dilated cardiomyopathy. The traditional Chinese medicine composition of the invention achieves the aim of treating dilated cardiomyopathy by improving the heart function effectively and improving the ventricular remodeling to a certain extent.

The invention discloses a pure traditional Chinese medicine preparation for treating dilated cardiomyopathy, which is prepared from astragali, radix salviae miltiorrhizae, red peony root, root-bark of peony, radix rehmanniae and the like as raw materials by steps of decocting twice, decocting filtrate, concentrating, granulating and packing in composite membrane bags. Shown by pharmacodynamic experiments of animals and clinical statistical results of patients, the pure traditional Chinese medicine preparation for treating dilated cardiomyopathy has the efficacies of supplementing qi, activating blood circulation, detoxifying and tranquilizing mind, and can eliminate the symptoms of chest distress, short breath, palpitation, edema, vexation, dark red tongue, yellow fur of tongue, thready rapid pulse, intermittent pulse and the like caused by deficiency of qi, blood stasis, toxic heat and heart disturbance due to dilated cardiomyopathy. The pure traditional Chinese medicine preparation can effectively resist myocardial fibrosis, improves the anoxia tolerance ability of myocardial cells and can be safely taken for a long time without toxic or side effect, the total effective rate in treating the dilated cardiomyopathy is 96.6%, and the curative effect is obviously better than that of conventional simple treatment of Western medicine.

The invention discloses the application of a Chinese traditional medicinal combination in preparing the medicaments used for curing myocardial infarction. The Chinese traditional medicinal combination inhibits the activity of matrix metalloproteinase, the damage to the heart support structure, the progressive ventricular dilatation, and the change of gene phenotype of the heavy chain of myosin of the cardiac muscle during the reversion of the restructuring of the cardiac muscle, thus inhibiting the restructuring of the cardiac muscle after myocardial infarction, improving the function of heart after myocardial infarction so that sufferers of myocardial infarction benefit from the Chinese traditional medicinal combination clinically, or the prognoses of myocardial infarction is improved.

The invention belongs to the field of medicine, which relates to Deferiprone and a novel medicated purpose of a Deferiprone preparation, in particular to Deferiprone (1,2- dimethyl-3-hydroxide radical-4-pyridine, Deferiprone) and the application of the Deferiprone preparation in the prevention and curing of Anthracycline medicine heart toxicity. The invention researches the preventing and curing function of the Deferiprone to bandicoot heart toxicity caused by Adriamycin from the cell level, the tissue level and the whole level and prepares biodegradable type Deferiprone implant, Deferiprone troche, capsule, oral liquor and injection that can release medicine continuously. An experimental result proves that the Deferiprone and the Deferiprone preparation can not only improves the cardiac muscle shrinkage functions and protects the myocardial cell organ structure, but also complexes free iron ions directly, reduces the heart toxicity and other side and toxic effects caused by the Anthracycline medicine obviously and the mortality rate caused by the Anthracycline medicine.

The invention discloses a composition based on stem cells and application thereof in preparing preparation for the coronary heart disease. The composition based on the stem cells includes the stem cells prepared through an optimizing method and cell preserving liquid serving as a solvent. Firstly, proper stem cells are selected; secondly, the selected stem cells are further processed through the optimizing method; lastly, the stem cells are collected and resuspended in the cell preserving liquid. A various cell implanting method is adopted in the application of the composition based on the stem cells in preparing the preparation for the coronary heart disease, the time nodes before an operation, during the operation and after the operation are combined, and it is ensured that the transplanted stem cells can give the full play. The optimizing method is used for preparing the stem cells and the stem cell composition in the cell preserving liquid, the ventricle function can be extremely obviously enhanced after cell transplantation, and the left ventricle reconstitution is restrained. The optimal cell composition is provided for treating the coronary heart disease, the source is wide, preparation is simple, toxic and side effects are avoided, and the transplanting effect is good.

The invention discloses an application of a traditional Chinese medicine composition in preparation of a drug for treating transient ischemic attack, wherein the traditional Chinese medicine composition is prepared from 11 traditional Chinese medicines including astragalus membranaceus, ginseng, salviae miltiorrhizae and the like. A clinical experiment proves that the traditional Chinese medicine composition is significant in treatment effects on the transient ischemic attack.

The invention discloses an application of thrombin aPC in drugs for prevention and treatment of diabetic cardiomyopathy induced by streptozotocin. The thrombin aPC can stabilize the expression of YB1by inhibiting ubiquitination of a cardiac muscle cell YB1 in a hyperglycemic state, so as to alleviate cardiomyocyte hypertrophy and fibrosis. The therapeutic study results indicate that the thrombinaPC has significant curative effects of alleviating cardiomyocyte hypertrophy and fibrosis, improving myocardial contractile functions and increasing ejection fraction.

The invention discloses an anti-dropping biogen of dogs and cats, which is prepared by mixing blueberry extract, urtica urens extract, total matrines extract, Indian watercress extract, mint extract, ginger extract, pueraria mirifica extract, ginseng extract, saffron extract and pure water according to a certain proportion, stirring under normal temperature the filtering. The anti-dropping biogen can clean hairs comprehensively, kill insets and bacteria, remove acarus, relieve itching, comprehensively supply nutritive materials needed by the hair follicle, hairs and the skin by enhancing blood circulation of the skins of dogs and cats, improve the immunity of the skin, the hair follicle and the hair, reduce antianaphylaxis, strengthen the repairing function of the skin, the hair follicle and the hair, and achieve the purpose of treating abnormal hair-dropping of dogs and cats. Proved by experiments, the biogen has good inhibiting effect to the abnormal hair-dropping of dogs and cats, can lead the hair to be smooth and glazing and can not generate any side effect to the dogs and cats.

The invention relates to a traditional Chinese medicinal electuary, in particular to a traditional Chinese medicinal electuary for treating dilated cardiomyopathy and a preparation method of granules of the traditional Chinese medicinal electuary. The traditional Chinese medicinal electuary is prepared from the following raw materials in parts by weight: 10-15 parts of astragalus, 7-10 parts of ginsengs, 5-8 parts of radix ophiopogonis, 5-8 parts of the fruit of Chinese magnoliavine, 5-8 parts of rhizoma chuanxiong, 10-15 parts of peach seeds, 5-8 parts of leonurus, 10-15 parts of poria cocos, 3-5 parts of cassia twig, 5-8 parts of herba lycopi, 5-8 parts of white atractylodes rhizome, 8-10 parts of jujube dates and 8-10 parts of pseudo-ginseng. The preparation method comprises the steps of extracting effective components of the fruit of Chinese magnoliavine and the like by a vapor distillation method, smashing astragalus and the like into fine powder, screening by a 80-100-mesh sieve, adding astragalus powder and the like into the extracts of the fruit of Chinese magnoliavine and the like to prepare granules, screening by a 10-15-mesh sieve, then screening by a 60-mesh sieve, drying and sub-packaging, wherein each bag is filled with 15-20 grams of granules. The traditional Chinese medicinal electuary has the advantages that natural traditional Chinese medicines are used as raw materials and are non-toxic to and do not have side effects on a human body; furthermore, the cost is low, the treating effect is definite, and the aim of treating both the symptoms and root causes is achieved.

The invention relates to a traditional Chinese medicinal preparation, and in particular relates to a traditional Chinese medicinal preparation for treating dilated cardiomyopathy and a preparation method of a fluid extract thereof. The traditional Chinese medicinal granule is prepared from the following traditional Chinese medicinal raw materials: 5-8 parts of semen lepidii, 10-15 parts of astragalus membranaceus, 5-8 parts of rhizoma anemarrhenae, 7-10 parts of ginseng, 10-15 parts of selfheal, 5-8 parts of ligusticum wallichii, 5-8 parts of chrysanthemum, 5-8 parts of cassia twig, 5-8 parts of rehmannia root, 10-15 parts of poria cocos, 3-5 parts of angelica, 5-8 parts of radix curcumae, 8-10 parts of jujube, 5-8 parts of fritillaria cirrhosa and 5-8 parts of folium mori. The preparation method of the fluid extract comprises the following steps: grinding raw materials into fine powder; thinning the fine powder through 60% ethanol which serves as a solvent with addition of water, through a percolation method, collecting primary filtrate and storing the primary filtrate in a bottle A, and keeping percolating until the filtrate is observed by naked eyes to be colorless; collecting filtrate, concentrating at 40-60 DEG C under reduced pressure to obtain thick paste, and mixing with the primary filtrate in the bottle A to obtain mixed liquid; thinning the mixed liquid through 60% ethanol, keeping for 30h, and reserving supernatant liquid to obtain fluid extract of the traditional Chinese medicine. The traditional Chinese medicinal preparation disclosed by the invention has the advantages that the traditional Chinese medicinal composition, prepared from natural traditional Chinese medicines, can achieve a purpose of treating both symptoms and root causes.

The invention discloses a medicine for preventing and treating coronary heart disease and a preparation method and application thereof. The medicine is extract of ginseng and root of red-rooted salvia, the extract mainly comprises ginsenoside, saccharide, salvianolic acid, amino acid and protein ingredient, and the medicine can be prepared into tablets, capsules, granules, pills and inhalants. The medicine is especially suitable for application in treating coronary heart disease due to qi deficiency and blood stasis or coronary heart disease combined with lower cardiac function and can obviously improve lower cardiac function symptoms caused by the coronary heart disease; syndrome differentiation and treatment rules in theories of traditional Chinese medicine are adopted, nature of symptoms of the coronary heart disease is analyzed deeply, defects that medicine on the current market has are avoided, a novel treatment option is provided for the coronary heart disease, especially that combined with lower cardiac function, and market space is made up well.

The invention discloses the application of a composite containing polygonum orientale in preparing medicaments for preventing and treating diabetes and complication thereof. The composite is prepared from extracts of polygonum orientale, panax notoginseng, hawthorn leaves and Rhizoma Chuanxiong. The invention provides a novel medical application of the composite containing polygonum orientale anda new medicine selection for patients.

The invention discloses an application of anemoside B4 to preparation of medicines for reducing blood pressure. The anemoside B4 has treatment effects on high blood pressure, can reduce blood pressureof renal hypertension, can also reduce blood pressure of spontaneously hypertensive, has protection effects on high blood pressure and has the effects of improving cardiac functions.

The invention provides applications of drynaria fortune and drynaria fortune extract in prevention or treatment of heart failure. The drynaria fortune and the drynaria fortune extract can effectively reduce the heart weight index of a rat with heart failure, reduce levels of BNP (B-type natriuretic peptide), Ang II (Angiotensin II) and ALD (aldosterone) and remarkably improve the left ventricular systolic function of the rat with heart failure, thereby having the function of preventing or treating heart failure and having positive significance for development and utilization of Chinese herbal medicines, and a new scheme is provided for the treatment of the disease.

The invention discloses a pure traditional Chinese medicine preparation for treating dilated cardiomyopathy, which is prepared from astragali, radix salviae miltiorrhizae, red peony root, root-bark of peony, radix rehmanniae and the like as raw materials by steps of decocting twice, decocting filtrate, concentrating, granulating and packing in composite membrane bags. Shown by pharmacodynamic experiments of animals and clinical statistical results of patients, the pure traditional Chinese medicine preparation for treating dilated cardiomyopathy has the efficacies of supplementing qi, activating blood circulation, detoxifying and tranquilizing mind, and can eliminate the symptoms of chest distress, short breath, palpitation, edema, vexation, dark red tongue, yellow fur of tongue, thready rapid pulse, intermittent pulse and the like caused by deficiency of qi, blood stasis, toxic heat and heart disturbance due to dilated cardiomyopathy. The pure traditional Chinese medicine preparation can effectively resist myocardial fibrosis, improves the anoxia tolerance ability of myocardial cells and can be safely taken for a long time without toxic or side effect, the total effective rate in treating the dilated cardiomyopathy is 96.6%, and the curative effect is obviously better than that of conventional simple treatment of Western medicine.

The invention relates to application of sulfur and ferric oxide to preparing epilepsy medicament, and belongs to application of medicament. The application is characterized in that the sulfur and the ferric oxide are used for preparing the epilepsy medicament, and in the medicament for treating epilepsy, each of the sulfur and the ferric oxide accounts for 50 percent weight portions. The invention provides novel medical application of the sulfur and the ferric oxide, which can be used for preparing the medicament for treating the epilepsy, have good curative effect, and have no toxic and side effect.

The invention relates to the fields of medicine and health care, in particular to a composition for preventing and curing renal osteodystrophy and a preparation thereof. The composition is prepared from the following components in parts by weight: 2440 to 6910 parts of calcium aspartate, 1040 to 2360 parts of magnesium aspartate, 37 to 63 parts of zinc aspartate and 21 to 35 parts of manganese aspartate. The composition is prepared through reasonable compatibility of medicines and a scientific method, so that the product is stable in effect, convenient to use, quick to become effective and effective in treatment, has the effects of preventing and curing renal osteodystrophy and strengthening osteotrophy, and is free of toxic and / or side effects; through mutual effects of the effective active ingredients, the composition disclosed by the invention is high in bioavailability and reaches a synergistic interaction effect. The composition is safe, scientific, simple and effective.

The present invention provides an application of isoliquiritin apioside as an angiotensin converting enzyme inhibitor. The isoliquiritin apioside has relatively strong angiotensin converting enzyme inhibitory activity and can be used to prevent and / or treat cardiovascular diseases, type 2 diabetes, diabetic nephropathy and other diseases that require inhibition of angiotensin converting enzyme activity. The present invention also provides a separation method of the isoliquiritin apioside. The separation method is very simple and highly efficient, simple and convenient to operate, and good in control and repeatability, and the separated isoliquiritin apioside has relatively high purity.

The invention discloses an application of a recombinant adeno-associated virus of a target silent KLF4 gene, and primarily an application of a recombinant adeno-associated virus rAAV1-KLF4-shRNA of atarget silent KLF4 gene to preparation of medicines for preventing and treating pulmonary hypertension. According to the recombinant adeno-associated virus rAAV1-KLF4-shRNA of the target silent KLF4 gene, having GFP fluorescence labelling, disclosed by the invention, type 1 adeno-associated virus (AAV1) which can stably express target protein for a long term and is high in biological safety can beused as a transduction vector, the high tropism of AAV1 to vascular tissue is utilized, an administration mode of infusing medicines in air ducts is combined, and recombinant adeno-associated virusescan be stably expressed for a long term in lung vessels, so that the effects of enabling lung vessel KLF4 gene to be silent, restraining lung vessel remodeling and preventing and treating the pulmonary hypertension can be achieved.

The invention relates to application of a Chinese medicinal preparation, in particular to application of a compound polygonum orientale preparation in preparing medicaments for preventing and treating climacteric diseases and delaying senility, wherein the compound polygonum orientale preparation consists of polygonum orientale and erigeron breviscapus.

The invention discloses an anti-shedding lotion for dogs and cats, which is prepared by mixing blueberry extract, urtica urens extract, total matrines extract, Indian watercress extract, mint extract, ginger extract, pueraria mirifica extract, ginseng extract, saffron extract and pure water according to a certain proportion, stirring under normal temperature the filtering. The anti-shedding lotion can clean hairs comprehensively, kill insets and bacteria, remove acarus, relieve itching, comprehensively supply nutritive materials needed by the hair follicle, hairs and the skin by enhancing blood circulation of the skins of dogs and cats, improve the immunity of the skin, the hair follicle and the hair, reduce antianaphylaxis, strengthen the repairing function of the skin, the hair follicle and the hair, and achieve the purpose of treating abnormal hair shedding of dogs and cats. Proved by experiments, the anti-shedding lotion has good inhibiting effect on the abnormal hair shedding of dogs, making hair smooth and glazing, and can not generate any side effect to the dogs and cats.

The invention provides an application of licochalcone B as an angiotensin-converting enzyme inhibitor. Licochalcone B has extremely strong angiotensin-converting enzyme inhibitory activity, and the inhibition rate of angiotensin-converting enzyme is as high as 95%. It can be used to prevent and / or treat cardiovascular diseases, type 2 diabetes and diabetic nephropathy and other diseases that need to inhibit the activity of angiotensin converting enzyme. The invention also provides a separation method of licochalcone B, which is very simple and efficient, easy to operate, controllable and repeatable, and the separated licochalcone B has high purity.

The invention discloses the application of a composite containing polygonum orientale in preparing medicaments for preventing and treating diabetes and complication thereof. The composite is prepared from extracts of polygonum orientale, panax notoginseng, hawthorn leaves and Rhizoma Chuanxiong. The invention provides a novel medical application of the composite containing polygonum orientale and a new medicine selection for patients.

The invention provides an anti-fatigue traditional Chinese medicine composition. The composition contains the following components in parts by weight: 100-300 parts of asparagus, 100-150 parts of rose hips, 100-150 parts of rutae folium, 100-150 parts of jasmines, 100-150 parts of water fennels and 100-150 parts of pericarpium citri reticulatae. The invention further provides a honey-refined ointment. The composition and the honey-refined ointment provided by the invention are low in cost, good in treatment effect and suitable for being eaten for a long time.

The invention discloses an application of thrombin aPC in drugs for prevention and treatment of diabetic cardiomyopathy induced by streptozotocin. The thrombin aPC can stabilize the expression of YB1by inhibiting ubiquitination of a cardiac muscle cell YB1 in a hyperglycemic state, so as to alleviate cardiomyocyte hypertrophy and fibrosis. The therapeutic study results indicate that the thrombinaPC has significant curative effects of alleviating cardiomyocyte hypertrophy and fibrosis, improving myocardial contractile functions and increasing ejection fraction.

The invention relates to application of a Chinese medicinal preparation, in particular to application of a compound polygonum orientale preparation in preparing medicaments for preventing and treating climacteric diseases and delaying senility, wherein the compound polygonum orientale preparation consists of polygonum orientale and erigeron breviscapus.