Separation method and application of isoliquiritin apioside

A technology of apigenin and a separation method, which is applied in the field of separation of apigenin and preparation of angiotensin-converting enzyme inhibitors, and can solve the problem of no cardiovascular disease research report and research on pharmacological effects of apigenin. Less problems such as delaying or reversing ventricular and vascular remodeling, simple and efficient separation methods, and improving compliance

Active Publication Date: 2020-04-03
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there are relatively few studies on the pharmacological effects of apiloliquiritin, and there are no relevant research reports on the treatment of cardiovascular diseases.

Method used

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  • Separation method and application of isoliquiritin apioside
  • Separation method and application of isoliquiritin apioside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: Separation of celery isoliquiritin

[0041] The crushed licorice was extracted twice with water under reflux, each time for 1 hour, the medicinal residue was filtered off, the filtrate was combined, and concentrated to obtain the extract concentrate; after the extract concentrate was suspended in water, it passed through the macroporous adsorption resin column at a flow rate of 2BV / h Wash with 4BV of water at a flow rate of 2BV / h; wash with 5BV of 20% (volume fraction) ethanol at a flow rate of 2BV / h; wash with 4BV of 40% ethanol at a flow rate of 2BV / h; wash with 4BV of 95% Rinse with ethanol at a flow rate of 2BV / h; collect 40% ethanol eluate, concentrate and dry, then use preparative liquid chromatography to separate and collect the chromatographic peaks for 52 minutes, and recover the solvent under reduced pressure to obtain apiloisoliquiritin with a purity greater than 95%.

[0042] Wherein, the preparative liquid chromatography separation condition i...

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PUM

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Abstract

The present invention provides an application of isoliquiritin apioside as an angiotensin converting enzyme inhibitor. The isoliquiritin apioside has relatively strong angiotensin converting enzyme inhibitory activity and can be used to prevent and / or treat cardiovascular diseases, type 2 diabetes, diabetic nephropathy and other diseases that require inhibition of angiotensin converting enzyme activity. The present invention also provides a separation method of the isoliquiritin apioside. The separation method is very simple and highly efficient, simple and convenient to operate, and good in control and repeatability, and the separated isoliquiritin apioside has relatively high purity.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a separation method of apiloisoliquiritin and its application in the preparation of angiotensin-converting enzyme inhibitors. Background technique [0002] Licorice is a perennial herbaceous plant of the leguminous family. It is an indispensable traditional Chinese medicinal material commonly used in clinical practice. Licorice was first recorded in "Shen Nong's Materia Medica", and it is called beautiful grass and dense sweet. It is listed as the top grade. Licorice is mainly used to treat inflammation, cardiovascular and cerebrovascular diseases, oxidative aging, tumors, etc., which are inseparable from the pharmacological effects of active ingredients of licorice extract. [0003] The main active ingredients of licorice include glycyrrhizin, flavonoids, and polysaccharides, and the specific structure of isoliquiritin apioside (CAS number: 120926-46-7) is shown in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/08A61K31/7048A61P9/12A61P9/04A61P3/10A61P13/12
CPCA61P3/10A61P9/04A61P9/12A61P13/12C07H1/08C07H15/203
Inventor 王毅杨振中赵筱萍
Owner ZHEJIANG UNIV
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