84results about How to "Inhibit hypertrophy" patented technology

The production method of tea melon seed uses melon seed as raw material and uses the tea as main auxiliary material, and includes the following steps: boiling melon seed and tea together, after the tea juice is infiltrated into the melon seed kernel, removing tea and excess water and stir-frying to get the invented tea melon seed with several health-care functions of allaying thirst, relieving restless ness, eliminating fatigue, relaxing muscles and tendons, cleaning oral cavity and refreshing, etc. and with patatable taste.

The invention discloses a method for preparing a propolis, bee pollen and royal jelly nutritive mixture, which is characterized by comprising the following steps: adding high-purity propolis into 75 percent alcohol for heating and melting to prepare propolis liquid; mixing and stirring the propolis liquid and broken wall bee pollen uniformly, putting the mixture into a 50 DEG C low blowing dry box for full drying, taking the mixture out, mixing the mixture with freeze-dried powder of royal jelly, grinding the mixture into fine powder with 200 meshes by a fluid jet mill and packaging the fine powder. The method has the advantages of solving the difficult problems of difficult decomposition of the propolis, sterilization of the bee pollen and no high-temperature resistance of the royal jelly, simultaneously obtaining the nutrition and health care functions of three bee products, improving the absorptivity of the propolis, preventing nutrition of the three natural bee products from being damaged, having good synergism on the medical care function of the mixture of the three, and even improving the efficacy by 3 to 5 times. The preparation method is scientific, simple and convenient, and has low cost, and safety and reliability; and the mixture is convenient to take.

The invention discloses circRNA CHIF nucleotide and a pharmaceutical composition comprising the circRNA CHIF nucleotide. The pharmaceutical composition comprises the circRNA CHIF nucleotide, an auxiliary, and a viral vector or an embedding vector, the embedding vector is cholesterol, nanoparticles or lipidosome, preferably lipidosome, the viral vector is one or more of adenovirus vector, lentiviral vector and retroviral vector, preferably adenovirus vector, and the auxiliary is one or more of mannitol, phosphate buffer solution and normal saline, preferably phosphate buffer solution, the circRNA MNCR viral vector is 1016 PFU in infectivity titer, and a mass ratio of the circRNA CHIF nucleotide to the lipidosome is 1:1.25; a mass ratio of the viral vector or embedding vector to the auxiliaries is 1:200. The pharmaceutical composition is used for preventing and treating cardiac hypertrophy, cardiac fibrosis, coronary heart disease and heart failure, has reasonable formula, is simple to manufacture, has significant therapeutic effect, is widely applicable and is friendly to service environments.

The invention discloses a massage clothes comprising massage blocks corresponding with the human points and a controller for controlling the action of the massage blocks. The massage clothes can be worn on the body with good massaging effect and saved labor and very convenience. The massage blocks are corresponding with the neck, shoulder, back, waist, abdomen and perineum. The test shows that: the massage clothes can ease pain, resolve phlegm, increase sexual function, prevent menopause symptom. Splitting headache and chronic constipation, prostatic hyperplasia or urinary incontinence, and stimulate the qi and blood of the perineum and promote metabolism.

The invention belongs to the field of traditional Chinese medicines and relates to an uncaria extract and new application thereof in preparing medicines for reducing blood fat and resisting cardiac hypertrophy. Proved by the animal experiment, the uncaria ethanol extract has the functions of reducing blood fat and resisting cardiac hypertrophy, and especially can reduce the triglyceride level in blood, the weight ratio of the left ventricle to the whole heart, and the weight ratio of the left ventricle to the right ventricle. The uncaria ethanol extract can be used as the raw material for pharmaceutical preparations to further prepare the medicines for reducing blood fat and resisting cardiac hypertrophy, so that the medicines can be used for treating disturbance of lipid metabolism and metabolic syndromes, and preventing and curing atherosclerosis, and hypertensive cardiopathy caused by hypertension and cardiac hypertrophy, including myocardial ischemia, myocardial damage, myocardial infarction and heart failure.

The invention relates to technology for cultivating three-stem cotton. The technology is characterized by comprising the following steps: shooting growing points on the main stem of a cotton plant after 5 to 6 main leaves growing on the cotton plant are spread; and reshaping the cotton plant when three vegetative shoots over 5cm grow from the axil of the main leaves, removing other residual vegetative shoots, and keeping the three vegetative shoots with similar sizes to become three main stems, secondarily shooting tops of the three main stems and local conventionally cultured spring cotton which is subject to top shooting in the same term. The technology has the advantages of saving man power for management, increasing photosynthesis of the plant, improving the fiber quality, reducing amount of boll rot, increasing the amount of canicular boll, and improving the cotton yield.

The present invention relates to a pharmaceutical composition for preventing or treating a heart failure and a method for screening a therapeutic agent for preventing or treating a heart failure. The pharmaceutical composition of the present disclosure comprises the CCN5 or CCN2ΔCT protein, or a genetic carrier comprising a nucleotide sequence encoding the CCN5 or the CCN2ΔCT protein, exhibiting dramatic prevention or treatment efficacies on a heart failure even without surgical treatments accompanied with transplanting a donor heart.

The invention discloses a furocoumarin compound with a hypertension activity reducing function and preparation method thereof; the furocoumarin compound has similar nature to imperatorin, shows the activity of dilating blood vessels in isolated vascular ring tension research, and can be applied to the preparation of antihypertensive drugs. The preparation method of the furocoumarin compound has the advantages of easily available raw material sources, mild reaction conditions, simple reaction process operation, and inexpensive and easily available reagent.

The invention discloses a function and application of activin receptor-like kinase7 (ALK7) in treatment of a cardiac hypertrophy disease. According to the invention, the relationship between an ALK7 gene and the cardiac hypertrophy is determined: when the cardiac hypertrophy occurs, the expression of ALK7 is obviously reduced; the interference of ALK7 and over-expressed adenovirus are respectively used for promoting and inhibiting cardiomyocyte hypertrophy; ALK7 gene knockout has the effect of remarkably enhancing the activation of MEK1/2/ERK1/2 and Smad2/Samd3 signal channels so that the cardiac hypertrophy and fibrosis are promoted and the heart function is worsened; over-expression of the ALK7 gene has the effect of remarkably reducing the activation of MEK1/2/ERK1/2 and Smad2/Samd3 signal channels so that the cardiac hypertrophy and fibrosis are inhibited and the heart function is improved. Therefore, the ALK7 gene can be used as a target gene in gene therapy and can be used for preparing a medicine for protecting the heart function and/or preventing, relieving and/or treating the cardiac hypertrophy, thus providing a new way for treating the cardiac hypertrophy.

The invention provides application of 3-hydroxyphenylacetic acid (3-HPA) in preparation of a drug for improving ventricular pathological reconstruction and/heart failure after myocardial infarction, and belongs to the technical field of biomedicine. The 3-HPA can improve cardiac functions after myocardial infarction, reduce heart fibrosis after myocardial infarction and improve the size of cardiacmuscle cells after myocardial infarction. Mouse animal model experiments show that the 3-HPA can improve cardiac functions of mice after rejection of intestinal florae from myocardial infarction miceby antibiotic treatment, reduce heart fibrosis after rejection of intestinal florae from myocardial infarction mice by antibiotic treatment and inhibit myocardial hypertrophy after rejection of intestinal florae from myocardial infarction mice by antibiotic treatment.

The invention relates to the application of CP-1 siRNA in treating AngII induced cardiac hypertrophy. Experimental study proves that the CP-1 siRNA can inhibit cardiac hypertrophy in mice induced by AngII, weakens the degree of ventricular dilatation and the thickness of a ventricular wall, inhibits the expression of marker protein ANF, beta-MHC of the cardiac hypertrophy, inhibits cardiac fibrosis, and is an effective novel cardiac hypertrophy treatment drug.

The invention discloses application of leukocyte immunoglobulin like receptor B4 (LILRB4) to preparation of medicine for preventing, alleviating and/or treating cardiac hypertrophy. Cardiovascular-specific Cre mice and cardiovascular-specific LILRB4 gene knockout mice are selected, a surgery of coarctation of aorta is carried out by an operation group, determination of cardiac hypertrophy, fibrosis and cardiac functions on various groups of mice can be carried out, and a result proves that the cardiac hypertrophy, the fibrosis and the cardiac functions are obviously worsened because of LILRB4defects caused by knockout LILRB4 genes. Through recombination of adenovirus, AdshLILRB4 and AdLILRB4 infected SD primary myocardial cells of suckling mice are built, and a cardiomyocyte hypertrophy model is built through Ang II stimulation; due to LILRB4 over-expression viruses, the cardiomyocyte hypertrophy is obviously inhibited, the surface area of cardiomyocyte is reduced, and a result of LILRB4 interference virus is opposite. LILRB4 has effects of inhibiting the cardiac hypertrophy and the fibrosis and improving the cardiac functions.

The invention relates to a compound recipe kidney-strengthening tablet for enlivening the spleen and strengthening kidney in the traditional technique field. The preparing method comprises the following steps: disintegrating rhubarb horsetails into the powder; collating after immersing; collecting the collation liquid; disintegrating radix salvia miltiorrhiza, astragalus root, extractum glycyrrhizae liquidum and hirudo into the powder; extracting with alcohol reflux; filtering; merging the filtering liquid and the collation liquid; mixing uniformly; concentrating into the dense plaster; getting the extract of five tastes medicine; adding fermenting Cordyceps sinensis bacterial powder, crystalline cellulose, sodium carboxymethylstarch, starch and dolomol; mixing uniformly; getting the product by pelleting. The invention can reduce BUN and SCr level, which improves plasma protein content, improves the nutrient state, accelerates the renovation and the reactivation of nephric tubule epithelial cell, corrects the metabolic disorder of amino acid, protein and lipid, adjusts the cell immunity, improves the immunity, protects and recovers the kidney function, and prevents secondary infection.

The present invention relates to applications of 8-hydroxyquinoline (8-OH-quinoline) compounds or salts thereof in preparation of drugs for treatment of diseases associated with BRD4, wherein the diseases associated with BRD4 comprise NUT-midline carcinoma, acute lymphatic leukemia, mixed lineage leukemia, multiple myeloma, Burkitt's lymphoma, hepatocellular carcinoma, triple negative breast cancer, non-small cell lung cancer, prostate cancer, pancreatic cancer, neuroblastoma and other tumor types, and heart failures such as cardiac hypertrophy and cardiomyocyte hypertrophy.

Provided are an administrable aqueous solution to a living body and a method for manufacturing the same, the administrable aqueous solution having a function of supplying sufficient oxygen to peripheral cells, causing less damage and injury of cells under a hypoxic or anaerobic stimulation, and continuously exhibiting a sufficiently high and stable effect to protect cells. The administrable aqueous solution to a living body according to the present invention contains oxygen nanobubbles having a mean particle size of 30 nm or less and a density of 10¹⁶ bubbles per ml, preferably a mean particle size of 1 to 10 nm and a density 10¹⁷ bubbles or more per ml, respectively, as determined by a measurement with a cryo-transmission electron microscope by an ice-embedding method. The administrable aqueous solution to a living body according to the present invention contains oxygen nanobubbles which are generated by jetting an aqueous solution containing dissolved oxygen from the outside of a cylinder, the cylinder being provided with 2 or more small through holes formed in the circumferential direction, via the small through-holes under atmospheric pressure or higher and thus bringing the jetted solution into collision in such a manner that water hammer is concentrated at the center of the cylinder on the same plane parallel to a cross-section in a radial direction of the cylinder.

The invention discloses a method of raising the egg laying rate of ducks. The method includes the following steps: step (1) driving the ducks do the circle movement in the duck shed so as to promote the ducks' bone and muscle development, step (2) keeping low light lighting whole night in the duck shed, step (3) strengthening the prevention of infectious diseases, step (4) increasing the 10g shrimp clam per feather per day when the egg laying rate reaches to 50% in pre-laying period and increasing the amount of shrimp clam with the raising of the egg laying rate, step (5) adding 22g shrimp clam per feather per day in the middle of the egg laying period and meanwhile, adding 1 to 2 percent parts of shell powder, and keeping the temperature at 5 to 10 DE G, step (6) increasing or decreasing the feed based on the weight and the egg laying rate of ducks in the late of the egg laying period. Adding animal feed such as fish meal, silkworm chrysalis powder and the like when the egg production rate is still above 80% while the egg weight is loss, but if the weight is gained, the feed intake should be appropriately reduced. The method of raising the egg laying rate of ducks has the advantage that the egg laying rate is highly improved.

The 10-23 deoxyribozyme constructed in the invention utilizes in-vitro-transcription ET-1 full-length RNA as s substrate to filter the 10-23 deoxyribozyme with cut ET-1 mRNA, and can reduce the expression of an ET-1 gene of myocardial cells through transfection, inhibit hypertrophy of serum induced myocardial cells, and reduce the damage of hypoxic myocardial cells; the ET-1 10-23 deoxyribozyme can obviously reduce the occurrence of arrhythmia of isolated rat hearts after acute ischemia and improve heart functions. The invention provides tools for further clearing the functions of endogenous ET-1 in acute ischemic arrhythmia, and also provides theoretical basis and new ways of thinking for explaining the mechanism and prevention of and development of new medicaments for the acute ischemic arrhythmia.

The invention discloses a drug for curing and preventing cardiorenal failure and a preparation method thereof, which is prepared by the following materials by weight percent: 200-300 of prepared rhizome of rehmannia, 150-250 of dioscorea opposita thunb, 150-250 of sweet potato, 150-250 of radix achyranthis bidentatae, 150-250 of eucommia bark, 150-250 of morinda officinalis, 150-250 of polygala root, 150-250 of schisandra chinensis, 150-250 of semen cuscutae, 100-200 of rhizoma acori graminei, 200-300 of medlar, 150-250 of tuckahoe, 150-250 of herba cistanche, 150-250 of fructus broussonetiae, 100-200 of magnolia officinalis, 50-150 of dried orange peel, 30-80 of fructus aurantii, 30-80 of fennel, 30-80 of liquorices, 50-150 of salvia miltiorrhiza and 30-80 of angelica. The drug mainly cures cardiorenal failure, curves diseases and strengths bodies, prolongs lives, and is also helpful to give birth to babies.

The present invention relates to a height-adjustable dual plant cultivation management apparatus for root zone environment improvement, which removes the aged portion of the root zone so as to keep, from becoming bulky, the root zone of an edible (various kinds of wrapping vegetables, leaf vegetables, and root vegetables) or ornamental plant which is planted in a plant cultivation management apparatus, and forms a new root zone, thereby increasing yield and shortening harvest time through activation of growth and development. The present dual plant cultivation management apparatus comprises: a perforated suspension flowerpot having a plurality of perforations for securing air permeability and water drainage arranged in a matrix shape on the side surface and lower surface thereof and having an edible or ornamental plant planted therein; a water tank flowerpot for receiving water and enabling the lower portion of the perforated suspension flowerpot to be dipped into the water; a supporter supportably positioned at a certain height from the bottom of the water tank flowerpot so as to form a space separated from the perforated suspension flowerpot and support harvests (bulbs) of the root vegetables penetrating through the perforated suspension flowerpot; a stopper hole formed at a certain portion of the side surface of the water tank flowerpot and penetrated to be capable of confronting any one of the perforations; and a height-adjusting stopper pin combined to the stopper hole penetrable to confront the perforation so as to fix the perforated suspension flowerpot at a suspension position.