Anti-wrinkle agent and adam inhibitor

An anti-wrinkle and inhibitor technology, which is applied in the field of new ADAM inhibitors and anti-wrinkle agents for fine wrinkles, can solve the problems of not being able to fully prevent/improve fine wrinkles, and achieve the goal of inhibiting hypertrophy, improving wrinkles, and preventing or improving wrinkles Effect

Inactive Publication Date: 2009-11-25
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, prevention / improvement of fine wrinkles cannot be sufficiently prevented or improved only by using a moisturizer or the like to prevent dryness of the skin, and therefore, more effective prevention / improvement of fine wrinkles is strongly desired

Method used

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  • Anti-wrinkle agent and adam inhibitor
  • Anti-wrinkle agent and adam inhibitor
  • Anti-wrinkle agent and adam inhibitor

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0045] Alkyl glucosides and salts thereof can be produced according to known production methods.

[0046] In addition, the anti-wrinkle agent of the present invention basically consists of an alkyl glucoside or a salt thereof, but may contain other components. By blending this anti-wrinkle agent with a skin external preparation base, a skin external preparation can be provided.

[0047] The compounding amount of the alkyl glucoside or its salt in the above-mentioned skin external preparation varies depending on the form of use, the form of the product, etc., and is not particularly limited. For example, based on the total amount of the skin external preparation, the compounding amount is preferably 0.001 to 10 mass %, more preferably 0.005 to 5% by mass, still more preferably 0.01 to 1% by mass.

[0048] In this specification, the "external skin preparation" includes cosmetics, pharmaceuticals, quasi-drugs, and the like. Similarly, its dosage forms include aqueous solution, ...

Embodiment

[0073] The present invention will be further described in detail below through examples. The present invention is not limited to these Examples. The compounding quantity here is mass %.

[0074] 1. Exploration of new ADAM inhibitors

[0075] The inhibitory effect of ADAM activity was evaluated as follows: TNF-α excised and released from the membrane of human lymphoma-derived U937 cells under the action of ADAM was used as an index to evaluate the inhibitory effect of TNF-α released by the drug. Use this method to screen various compounds to find new ADAM inhibitors.

[0076] The U937 cells derived from human lymphoma were inoculated into 48-well plates, and the number of cells was adjusted to 1×10 5 cells / 0.25ml and cultured overnight at 37°C. A medium containing 30 μm / ml of alkyl glucoside was added and incubated at 37° C. for 30 minutes for pretreatment. Thereafter, 10 nM PMA (phorbol ester: 12-O-tetradecanoylphorbol acetate; Sigma P8139) was added, and cultured at 37° ...

preparation example 1

[0102] Formulation Example 1: Emulsion

[0103] (formula) mass%

[0104] Stearic acid 2.5

[0105] Cetyl Alcohol 1.5

[0106] Vaseline 5.0

[0107] Liquid Paraffin 5.0

[0108] Polyoxyethylene (10mol) monooleate 2.0

[0109] Polyethylene glycol 1500 3.0

[0110] Triethanolamine 1.0

[0111] Carboxyvinyl polymer 0.05

[0112] Decyl beta-D-glucoside 2.0

[0113] Sodium bisulfite 0.01

[0114] Ethyl p-hydroxybenzoate 0.2

[0115] Appropriate amount of spices

[0116] Purified water balance

[0117] (preparation method)

[0118] The carboxyvinyl polymer was dissolved in a small amount of purified water (Phase A). Add polyethylene glycol 1500, triethanolamine, and decyl β-D-glucoside to the remaining purified water, heat to dissolve, and keep at 70°C (aqueous phase). The other ingredients were mixed, heated and melted, and kept at 70°C (oil phase). Add the oil phase to the water phase for pre-emulsification, add phase A, uniformly emulsify with a homomixer, and cool ...

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Abstract

Disclosed is an anti-wrinkle agent for ameliorating a wrinkle (particularly a fine wrinkle) developed when the barrier function is decreased by dryness or the like. Also disclosed is an ADAM inhibitor. The anti-wrinkle agent or the ADAM inhibitor comprises an alkyl glucoside represented by the general formula: (1) [wherein R represents a linear or branched alkyl group having 1 to 18 carbon atoms] or a salt thereof.

Description

technical field [0001] The present invention relates to an anti-wrinkle agent, and more particularly to an anti-wrinkle agent for suppressing skin hypertrophy caused by a decrease in barrier function due to dryness, and preventing and improving wrinkles, especially fine wrinkles, caused by the decrease in barrier function. In addition, the present invention also relates to novel ADAM inhibitors. Background technique [0002] In recent years, as middle-aged and elderly women pay more attention to beauty, attention has increased on the fine wrinkles formed around the corners of the eyes and mouth. Such fine wrinkles become more pronounced due to the decrease in the water retention capacity of the stratum corneum of the epidermis and Sebum reduction due to decreased secretion of epidermal lipids. Fine wrinkles are considered to be caused by skin dryness, and it is considered that the mechanism of their occurrence and morphological, histological or biochemical changes, etc. are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61K31/7028A61Q19/00A61Q19/08
CPCA61K8/604A61K2800/782A61Q19/08A61K31/7028A61P17/00A61P43/00A61K8/49A61K31/70
Inventor 松永由纪子天野聪蛭间卓也福西宏忠末继胜柴田道男
Owner SHISEIDO CO LTD
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