9results about How to "Increased release rate" patented technology

The application discloses a coated controlled-release fertilizer based on magnetic response intervention nutrient precise control release and a preparation method thereof, and belongs to the technical field of controlled-release fertilizers.The coated controlled-release fertilizer is prepared by using a magnetic response type biological base coating material as a film material, and the magnetic response type biological base coating material raw material comprises, by weight, 30-40 parts of vegetable oil polyol, 15-25 parts of a curing agent, 1-5 parts of a covalent network crosslinking agent, 2-6 parts of a hydrophobic crosslinking agent and 5-20 parts of a magnetic substance.The application can artificially control the film shell pores to realize precise release of nutrients, greatly improve the nutrient utilization rate, and meanwhile, after the nutrient release is completed, the film shell remaining in the soil can be recycled by physical magnetic attraction, which is efficient and environmentally friendly.The application realizes magnetic response precise control of nutrient release by hydrophobic modification, crosslinking degree enhancement technology and introduction of magnetic substances, can artificially intervene in dynamic matching of crop fertilizer requirement rules with the help of an external magnetic field, realizes efficient recycling of the film shell, and eliminates soil plastic residue pollution from the source.

The invention relates to a preparation method of a magnesium alloy stent composite coating, and belongs to the technical field of biomedical materials. The composite coating with the piezoelectric-pH synergistic protection function is provided for solving the technical problems that an existing polyester coating is degraded to produce acid, and corrosion of a magnesium alloy stent is accelerated. The coating comprises a PVDF (Polyvinylidene Fluoride)-g-APTES ( The pH regulation and control middle layer is composed of PVDF, PDLLA and alkaline nanoparticles; and a drug-loaded PDLLA outer coating layer. The pH value of the interface is actively increased to a passivation region through on-demand release of the alkaline nanoparticles, and a positive feedback mechanism that protection is achieved when stress is increased is achieved through the piezoelectric effect. Compared with the prior art, the dynamic corrosion resistance is enhanced by 40% or above, the protection effect is improved by 60% or above through the synergistic effect, piezoelectric and alkaline synergistic protection is achieved, and a comprehensive solution with long-acting corrosion resistance and intelligent response is provided for a degradable magnesium alloy implantation instrument.

This invention relates to the field of biomedical technology, specifically disclosing an anti-inflammatory and bone-promoting rhodioloside composite hydrogel and its preparation method. The thermosensitive carrier is a triple-response system, which enhances the drug release rate only in a specific microenvironment at 37°C, with a pH of 5.5-6.5 at the site of inflammation, and in which MMPs are overexpressed. MMPs are highly expressed at the implant periodontitis site, and MMP-sensitive peptides can be specifically degraded by this enzyme. This process can trigger the precise release of rhodioloside and quercetin active ingredients in the gel, avoiding systemic drug diffusion that could lead to drug waste or side effects at other sites. Rhodioloside and quercetin synergistically downregulate the expression levels of inflammatory factors such as IL-6 and TNF-α, while nisin and chitosan-ε-polylysine grafts inhibit the growth of Porphyromonas gingivalis. Runx2 / CON expression is increased, achieving a closed-loop treatment of anti-inflammatory, antibacterial, and bone-promoting effects.

The invention belongs to the technical field of coal bed gas exploitation, relates to a self-energizing activated drainage gas recovery process, and introduces a self-energizing technology and a fracturing exploitation technology. In other words, before the self-energizing activator is injected, the fracturing technology is adopted to exploit the coal seam, high-pressure liquid or gas is injected into the coal seam, the coal seam is fractured, cracks are opened, and new cracks and channels are created. The self-energizing activator can increase the permeability of the coal bed, improve the pore connectivity, increase the release rate and collection efficiency of the coal bed gas, increase the quantity of the collected coal bed gas and reduce the waste of coal bed gas resources.

The application relates to a multiple emulsion with high-precision gas-sensitive fracturing tracing capability and a preparation method and application thereof, and belongs to the technical field of functional materials. In view of the fact that, in the prior art, there are few reports on the gas-phase tracer in unconventional reservoir fracturing effect evaluation, and there is no W / O / W emulsion with sensitive response characteristics of hydrocarbon gas in a formation reservoir to realize efficient monitoring of the three-phase output of oil, gas and water in a well, a W / O / W type multiple emulsion is prepared by taking a solution with small-molecule gaseous hydrocarbon sensitivity as an oil phase and using modified starch particles to replace traditional small-molecule surfactants as stabilizers to stabilize Pickering emulsion. The multiple emulsion can realize the release of small-molecule rare earth tracing materials in fracturing flowback fluid and underground oil and gas, and further realize efficient monitoring of the three-phase output of oil, gas and water in a well, analysis of the fracture network shape formed by fracturing construction and an oil and gas production layer profile.

The application provides a groove structure and a medical stent. The groove structure comprises a body, a groove and a drug coating. The groove is located on the body. A part of the outer surface of the body forms a shoulder, and the shoulder is located at at least one side of the opening of the groove. A part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. In this way, a part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. An operator can control the contact area of the drug coating with the vascular tissue by adjusting the drug loading of the shoulder and the thickness of the drug coating in the groove, thereby controlling the release rate of the drug coating.

This invention belongs to the field of medical device technology. This invention discloses a drug-coated balloon catheter and its preparation method. On one hand, a drug-coated balloon catheter includes a catheter with a balloon; the outer wall of the balloon is provided with a drug coating comprising at least an inner coating and an outer coating, both the inner and outer coatings carrying active pharmaceutical ingredients and different carriers; when the balloon inflates, the inner coating, together with the outer coating, detaches from the balloon under the influence of the patient's body temperature and hydration through a state change caused by the temperature-sensitive carrier of the inner coating; the outer coating, upon detachment from the balloon, facilitates the transfer of the corresponding active pharmaceutical ingredient into the target tissue via its carrier. On the other hand, a method for preparing a drug-coated balloon catheter is provided. This invention has the advantages of effectively improving the adhesion of the drug coating to the balloon to reduce delivery loss and increasing the release rate of the drug coating on diseased tissue to enhance drug transfer capability.

The application relates to a preparation method of a magnesium alloy stent composite coating and belongs to the technical field of biomedical materials. In view of the technical problem that an existing polyester coating produces acid by degradation, and accelerates corrosion of a magnesium alloy stent, a composite coating with piezoelectric-pH synergistic protection function is provided. The coating comprises a PVDF-g-APTES primer layer, a pH regulating intermediate layer composed of PVDF, PDLLA and alkaline nanoparticles, and a drug-loaded PDLLA outer coating. The application actively increases the interface pH to the passivation zone by on-demand release of alkaline nanoparticles, and realizes the positive feedback mechanism of "the more stress, the more protection" by using the piezoelectric effect. Compared with the prior art, the dynamic corrosion resistance of the application is increased by more than 40%, the synergistic effect makes the protection effect increased by more than 60%, the piezoelectricity and alkalinity are synergistically protected, a long-acting corrosion-resistant and intelligent response comprehensive solution is provided for the degradable magnesium alloy implant device.

The present application relates to a kind of chlorine dioxide solid sustained-release agent and its preparation method, the preparation method includes: S1, zeolite, activated carbon fiber and water are mixed, stirring and then filtering dry, obtain activated carbon fiber modified zeolite;S2, the above activated carbon fiber modified zeolite is contacted with fluorine gas, and activated carbon fiber-fluorine gas modified zeolite is obtained;S3, the above activated carbon fiber-fluorine gas modified zeolite is soaked in chlorite solution, filter dry, and the chlorine dioxide solid sustained-release agent is obtained, the chlorine dioxide solid sustained-release agent obtained by the method has the advantages of large chlorite loading, chlorine dioxide release rate is fast, sustained-release period is long etc..