37results about How to "Increased release rate" patented technology

The invention discloses a drug-loaded rod core, a raw material composition thereof, an implant, preparation and application. The raw material composition of the drug-loaded rod core comprises the following components in parts by weight: 1-1000 parts of active pharmaceutical ingredients; 100 parts of R-vinyl silicone rubber; 0.45 to 20 parts of hydrogen-containing silicone oil; the content of a catalyst is greater than or equal to 0.000002 part, preferably 0.000002-1 part; wherein the average particle size of the active pharmaceutical ingredients is 1-1000 nm. According to the invention, the drug active ingredients with the average particle size of 1-1000nm are adopted, so that the solubility of the drug can be obviously improved; the compatibility with silicon rubber is better, the release speed of the obtained skeleton type implant and storage type implant is obviously improved, and the drug release behavior is stable; meanwhile, the application range is wide, the preparation method is suitable for various drugs, and large-dose stable release is achieved.

According to the method for promoting the fragrance release of the Phalaenopsis amabilis in the flowering stage, the influence of flowering days, different light intensities and different temperatures on the fragrance release in the full-bloom stage is compared, and the light and temperature adaptability of the fragrance of potted Phalaenopsis amabilis in the full-bloom stage is proved; and a basic basis can be provided for breeding aromatic phalaenopsis varieties and researching the action mechanism of the flower fragrance of important economic ornamental flowers. Meanwhile, the optimal culture medium formula of each link of tissue culture and rapid propagation of the phalaenopsis purpurascens is further deeply researched, discussed and screened, so that the phalaenopsis purpurascens can be developed and applied on an industrial scale.

The invention discloses a mechanically activated kaolin modified fly ash phosphoric acid-based geopolymer and a preparation method thereof. The geopolymer is prepared from the following raw materials in parts by weight: 30-75 parts of fly ash, 15-60 parts of mechanically activated kaolin, 8-40 parts of red mud, 0.5-2 parts of a surface modifier, 10-35 parts of an acid activator and 10-35 parts of a solvent. The performance of the geopolymer is optimized, the early and final compressive strength of the geopolymer is improved, through the synergistic effect of the red mud and the mechanically activated kaolin, the preparation cost is reduced, the energy consumption and the environmental influence are reduced, and meanwhile, a new way is provided for resource utilization of the fly ash and other industrial byproducts. The geopolymer disclosed by the invention is suitable for various civil engineering projects such as road construction, foundation reinforcement, environment restoration and the like due to excellent mechanical properties, excellent durability and excellent environmental adaptability, and meets the requirements of sustainable development.

The invention relates to the technical field of sustained-release capsules, and particularly discloses a tamsulosin sustained-release capsule based on an instant coating and a preparation method of the tamsulosin sustained-release capsule. Comprising the following steps: S1, taking microcrystalline cellulose and talcum powder, and mixing to obtain a dry material; adding tamsulosin hydrochloride into water to prepare a liquid medicine; taking the methacrylic acid-ethyl acrylate copolymer dispersion liquid, adding glycerol triacetate and sodium carboxymethyl cellulose, and uniformly stirring to obtain a granulation dispersion liquid; s2, preparing pellets from the liquid medicine, the dry material and the granulation dispersion liquid; s3, taking the methacrylic acid-ethyl acrylate copolymer dispersion liquid, adding water, glycerol triacetate and the modified polyacrylate emulsion, and uniformly stirring; adding talcum powder, and uniformly stirring to obtain a coating solution; coating the pellets with a coating solution to obtain coated pellets; and S4, mixing talcum powder, calcium stearate and the coated pellets, and filling capsules with the mixture to obtain the tamsulosin sustained-release capsules.

The invention discloses a levonorgestrel tablet and a preparation method thereof. The levonorgestrel tablet is prepared from the following components: 0.75 part of levonorgestrel, 20 to 30 parts of lactose, 20 to 25 parts of corn starch, 0.8 to 1.0 part of corn starch slurry, 1 to 2 parts of colloidal silicon dioxide, 1 to 2 parts of talcum powder and 1 to 2 parts of magnesium stearate. The colloidal silicon dioxide provided by the invention can cooperate with the corn starch to help the tablet to be disintegrated more quickly in vivo, so that the release rate of the medicine is accelerated. The dissolution rate of the prepared levonorgestrel tablet reaches 65.6%-70.7% in 30 minutes, and the dissolution rate of the prepared levonorgestrel tablet reaches up to 86.0% in 60 minutes.

This invention belongs to the field of biomedical technology, specifically relating to a pharmaceutical composition formulation containing ertapenem and its preparation method. The ertapenem-containing pharmaceutical composition formulation comprises the following raw materials: 10-20 parts ertapenem, 40-60 parts choline-leucine ionic liquid, 30-50 parts polyethylene glycol-polylactic acid-glycolic acid copolymer, 2-5 parts gluconolactone, 2-3 parts antioxidant, 40-50 parts deionized water, 3-5 parts surfactant, and 20-30 parts mannitol. This invention utilizes choline-leucine ionic liquid to enhance the solubility and stability of the polyethylene glycol-polylactic acid-glycolic acid copolymer with ertapenem, forming uniform micelles to protect the drug from hydrolysis. Liquid nitrogen freezing technology is used to improve preparation efficiency and product quality, ensuring biocompatibility.

The application discloses a coated controlled-release fertilizer based on magnetic response intervention nutrient precise control release and a preparation method thereof, and belongs to the technical field of controlled-release fertilizers.The coated controlled-release fertilizer is prepared by using a magnetic response type biological base coating material as a film material, and the magnetic response type biological base coating material raw material comprises, by weight, 30-40 parts of vegetable oil polyol, 15-25 parts of a curing agent, 1-5 parts of a covalent network crosslinking agent, 2-6 parts of a hydrophobic crosslinking agent and 5-20 parts of a magnetic substance.The application can artificially control the film shell pores to realize precise release of nutrients, greatly improve the nutrient utilization rate, and meanwhile, after the nutrient release is completed, the film shell remaining in the soil can be recycled by physical magnetic attraction, which is efficient and environmentally friendly.The application realizes magnetic response precise control of nutrient release by hydrophobic modification, crosslinking degree enhancement technology and introduction of magnetic substances, can artificially intervene in dynamic matching of crop fertilizer requirement rules with the help of an external magnetic field, realizes efficient recycling of the film shell, and eliminates soil plastic residue pollution from the source.

The invention provides zinc acrylate resin, a tin-free self-polishing antifouling coating containing the zinc acrylate resin and a preparation method of the zinc acrylate resin, and belongs to the technical field of coatings. The preparation method comprises the following steps: mixing the zinc acrylate resin, the rosin, the antifouling agent, the iron oxide red, the talcum powder, the auxiliary agent and the xylene according to the formula ratio, stirring for 2-4 hours at the speed of 1000-1200 r / min, and grinding until the fineness is 1t; the thickness is 100 microns, so that the tin-free self-polishing antifouling paint is prepared. The tin-free self-polishing antifouling paint prepared by the invention has good mechanical properties, flexibility, oxidation resistance, aging resistance, antifouling effect, stable bactericide release and excellent self-polishing effect, has excellent antifouling effect in the advancing process of a ship and in still water, has small harm to the environment, has stable antifouling agent release rate, and can be widely applied to the fields of ships, ships and the like. And the antifouling period is prolonged.

The invention relates to a preparation method of a magnesium alloy stent composite coating, and belongs to the technical field of biomedical materials. The composite coating with the piezoelectric-pH synergistic protection function is provided for solving the technical problems that an existing polyester coating is degraded to produce acid, and corrosion of a magnesium alloy stent is accelerated. The coating comprises a PVDF (Polyvinylidene Fluoride)-g-APTES ( The pH regulation and control middle layer is composed of PVDF, PDLLA and alkaline nanoparticles; and a drug-loaded PDLLA outer coating layer. The pH value of the interface is actively increased to a passivation region through on-demand release of the alkaline nanoparticles, and a positive feedback mechanism that protection is achieved when stress is increased is achieved through the piezoelectric effect. Compared with the prior art, the dynamic corrosion resistance is enhanced by 40% or above, the protection effect is improved by 60% or above through the synergistic effect, piezoelectric and alkaline synergistic protection is achieved, and a comprehensive solution with long-acting corrosion resistance and intelligent response is provided for a degradable magnesium alloy implantation instrument.

This invention relates to the field of biomedical technology, specifically disclosing an anti-inflammatory and bone-promoting rhodioloside composite hydrogel and its preparation method. The thermosensitive carrier is a triple-response system, which enhances the drug release rate only in a specific microenvironment at 37°C, with a pH of 5.5-6.5 at the site of inflammation, and in which MMPs are overexpressed. MMPs are highly expressed at the implant periodontitis site, and MMP-sensitive peptides can be specifically degraded by this enzyme. This process can trigger the precise release of rhodioloside and quercetin active ingredients in the gel, avoiding systemic drug diffusion that could lead to drug waste or side effects at other sites. Rhodioloside and quercetin synergistically downregulate the expression levels of inflammatory factors such as IL-6 and TNF-α, while nisin and chitosan-ε-polylysine grafts inhibit the growth of Porphyromonas gingivalis. Runx2 / CON expression is increased, achieving a closed-loop treatment of anti-inflammatory, antibacterial, and bone-promoting effects.

This invention proposes an electrochemical method for rapidly removing scale-forming ions from water, belonging to the field of electrochemical technology. The method includes the following steps: A pulsed power supply is used; at least one anode plate is located inside the reactor; at least one cathode plate is located inside the reactor; and a dosing device is used; the pulsed power supply provides a pulsed voltage to the anode plate; after an appropriate time for the electrocoagulation reaction, the power supply is turned off, and an appropriate amount of sodium carbonate is added to the reactor. This invention utilizes an intermittent pulsed discharge mode, stopping the power supply after a suitable amount of metal flocs is generated, and cleverly utilizes the heterogeneous nucleation characteristics of calcium and magnesium ions on the floc surface, significantly reducing energy consumption and total reaction time, demonstrating significant advantages in the field of high-hardness water softening.

The invention belongs to the technical field of coal bed gas exploitation, relates to a self-energizing activated drainage gas recovery process, and introduces a self-energizing technology and a fracturing exploitation technology. In other words, before the self-energizing activator is injected, the fracturing technology is adopted to exploit the coal seam, high-pressure liquid or gas is injected into the coal seam, the coal seam is fractured, cracks are opened, and new cracks and channels are created. The self-energizing activator can increase the permeability of the coal bed, improve the pore connectivity, increase the release rate and collection efficiency of the coal bed gas, increase the quantity of the collected coal bed gas and reduce the waste of coal bed gas resources.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a sustained release preparation containing empagliflozin and metformin hydrochloride and a preparation method of the sustained release preparation. The method comprises the following steps: (1) preparing a sustained-release bulk drug, a sustained-release skeleton auxiliary material A, a sustained-release skeleton auxiliary material B, a lubricant and purified water into a tablet core; (2) preparing a coating spacer fluid from a film-forming agent, a thickening agent, a plasticizer, an opacifying agent and purified water; (3) preparing a coating liquid medicine from the quick-release bulk drug, a film-forming agent, a thickening agent, a plasticizer, an opacifying agent and purified water; (4) preparing a sealing solution from a film-forming agent, a plasticizer, an opacifying agent, a color lake and purified water; and (5) sequentially treating the tablet core with a spacer fluid, a coating liquid medicine and a sealing fluid to prepare the empagliflozin and metformin hydrochloride sustained release tablet. Under the condition of ensuring similar dissolution curves, polyoxyethylene is replaced, and the risk of high-temperature burst release of a large amount of metformin hydrochloride is avoided; and the coating process and the process flow are simplified, and the material consumption is reduced.

The invention provides solid chlorine dioxide and an application of the solid chlorine dioxide on a plate. The solid chlorine dioxide comprises 2.5-10% of sodium chlorite; 2.5%-10% of potassium chlorite; 50 to 90 percent of modified medical stone; 1-10% of tartaric acid; 1-10% of a stabilizer; and 0-5% of sodium dichloroisocyanurate. The preparation method has the beneficial effects that the adsorption capacity of the medical stone can be enhanced by activating the medical stone, the release rate can be well controlled by adding a certain amount of magnesium sulfate, calcium chloride and sodium dichloroisocyanurate, and the smaller the relative humidity is, the smoother the release of chlorine dioxide is.

The application relates to a multiple emulsion with high-precision gas-sensitive fracturing tracing capability and a preparation method and application thereof, and belongs to the technical field of functional materials. In view of the fact that, in the prior art, there are few reports on the gas-phase tracer in unconventional reservoir fracturing effect evaluation, and there is no W / O / W emulsion with sensitive response characteristics of hydrocarbon gas in a formation reservoir to realize efficient monitoring of the three-phase output of oil, gas and water in a well, a W / O / W type multiple emulsion is prepared by taking a solution with small-molecule gaseous hydrocarbon sensitivity as an oil phase and using modified starch particles to replace traditional small-molecule surfactants as stabilizers to stabilize Pickering emulsion. The multiple emulsion can realize the release of small-molecule rare earth tracing materials in fracturing flowback fluid and underground oil and gas, and further realize efficient monitoring of the three-phase output of oil, gas and water in a well, analysis of the fracture network shape formed by fracturing construction and an oil and gas production layer profile.

The application provides a groove structure and a medical stent. The groove structure comprises a body, a groove and a drug coating. The groove is located on the body. A part of the outer surface of the body forms a shoulder, and the shoulder is located at at least one side of the opening of the groove. A part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. In this way, a part of the drug coating is accommodated in the groove, and another part of the drug coating covers at least a part of the shoulder. An operator can control the contact area of the drug coating with the vascular tissue by adjusting the drug loading of the shoulder and the thickness of the drug coating in the groove, thereby controlling the release rate of the drug coating.

The invention discloses a gelatin hollow capsule with an effect of resisting crosslinking of macrolide drugs and a preparation method, and belongs to the technical field of hollow capsule production, the gelatin hollow capsule comprises gelatin, an antioxidant, a humectant, a surfactant, a pH regulator, a coloring agent and other raw materials; the preparation method comprises the following steps: adding and dissolving gelatin and auxiliary materials to obtain a gelatin solution, vacuumizing and defoaming, automatically dipping the gelatin, pulling, cutting and sleeving a capsule product, inspecting and selecting appearance, packaging and the like, thereby obtaining the anti-crosslinking gelatin hollow capsule. The preparation method provided by the invention can improve the anti-crosslinking performance and stability of the gelatin hollow capsule.

The invention discloses a hydrogen-rich essence as well as a preparation method and application thereof. The hydrogen-rich essence is prepared from the following raw materials in parts by weight: 200 to 300 parts of hydrogen-rich micro powder, 400 to 600 parts of phospholipid, 200 to 300 parts of sodium carboxymethyl cellulose, 500 to 1000 parts of butenol, 500 to 1000 parts of hexenol, 50 to 100 parts of tremelic acid, 50 to 100 parts of montanic acid, 200 to 300 parts of roxburgh rose seed oil, 200 to 300 parts of Arrocco nut oil, 30 to 50 parts of a pH regulator, 30 to 50 parts of an anti-allergic agent, 50 to 100 parts of a thickening agent and 200 to 500 parts of deionized water. The technical problems that an existing hydrogen production cosmetic is poor in hydrogen production effect, high in irritation and complex in preparation can be solved.

The invention provides a sustained-release fluorocalcitriol tablet and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the preparation raw materials comprise a sustained-release skeleton layer prepared from a fluorocalcitriol-containing drug core particle and a controlled-release film coating solution containing a methacrylate copolymer, the preparation method comprises the following steps: preparing the medicine core, preparing the controlled-release film coating solution and coating, preparing the controlled-release skeleton layer, and drying and packaging.

The invention discloses a preparation method of a poly-citric-acid-based viscous composite coating, which comprises the following steps: step 1, dissolving citric acid, adding polyethylene glycol and 1, 8-octylene glycol, dropwise adding acrylic acid, stirring, and sequentially dissolving, dialyzing, purifying and vacuum freeze-drying to obtain a double-bond poly-citrate prepolymer; step 2, mixing polylysine with the double-bond polycitrate prepolymer to obtain a polycitrate composite solution; step 3, dropwise adding the poly-citrate composite solution to the surface of a matrix, and carrying out thermocuring to obtain a poly-citric acid-based viscous composite coating; the invention further discloses application of the poly-citric acid-based viscous composite coating. Acrylic acid is added into a prepared poly-citric acid prepolymer system to generate a double-bond poly-citrate prepolymer, polylysine is added to form a poly-citrate composite solution, the poly-citrate composite solution is thermally cured to form the poly-citric acid-based viscous composite coating with strong adhesive force, and the poly-citric acid-based viscous composite coating is suitable for the technical field of degradable biomedical materials.

The utility model discloses a multi-channel large-volume nucleic acid extractor, which belongs to the technical field of nucleic acid extraction and comprises a bottom plate, and two groups of placing mechanisms distributed in parallel from left to right are mounted at the top end of the bottom plate; an extraction assembly is mounted at the upper end of the bottom plate; the extraction assembly comprises a linear moving assembly and a curve moving assembly, the linear moving assembly is connected with the bottom plate, and the linear moving assembly is connected with the curve moving assembly. Through the mode, the sample box is subjected to water area heating through the first water area heating box, the second water area heating box and the heating piece, the heating is uniform, the heating effect is good, the heating temperature is convenient to control, the magnetic bar sleeve and the magnetic bar can be driven to do sinusoidal motion in a sample liquid area, and lysate, nucleic acid and magnetic beads are fully and uniformly mixed.

The invention discloses a traditional Chinese medicine massage cream with rapid drug release capability and a preparation method thereof. The traditional Chinese medicine massage cream comprises a traditional Chinese medicine extract and a matrix, the matrix comprises modified sodium polyacrylate, a thickening agent, a humectant, cetostearyl alcohol and deionized water; the modified sodium polyacrylate is prepared by copolymerizing acrylic acid, acrylamide and cationic lignin; the cationic lignin is prepared from alkali lignin, epoxy chloropropane and 3-chloro-2-hydroxypropyl trimethyl ammonium chloride through a reaction. The medicine carrying capacity and the medicine releasing capacity of a matrix can be effectively improved, the infiltration effect of the massage cream can be improved, and then the absorption effect of a human body on traditional Chinese medicine ingredients in the massage process is promoted; meanwhile, the compounded traditional Chinese medicine components can effectively relieve diseases such as rheumatoid arthritis, scapulohumeral periarthritis, bone tuberculosis, cervical vertebra pain, lumbar disc herniation and limb pain and numbness, and can be widely applied to the field of traditional Chinese medicine massage ointment.

The invention provides a hydroxymethylated lignin-based urea formaldehyde slow release fertilizer and a preparation method thereof, and the preparation method comprises the following steps: carrying out hydroxymethylation modification on lignin nanofiber (LCNF) to obtain hydroxymethylated lignin nanofiber (HLCNF), and then mixing urea, a formaldehyde solution and the HLCNF to prepare the hydroxymethylated lignin-based urea formaldehyde (HLCNF-UF). HLCNF is introduced into a urea formaldehyde molecular chain, so that hydroxymethylated lignin-based urea formaldehyde also has a long-acting slow-release effect, the effective utilization rate of nitrogen elements in urea formaldehyde by crops is improved, and the excessive loss of nutrients is reduced. The mechanical strength of the modified hydroxymethylated lignin-based urea formaldehyde is remarkably enhanced, so that the integrity of the fertilizer can be ensured in the processing, transportation and storage processes, and the method is a key factor for reducing loss and improving efficiency.

This invention belongs to the field of medical device technology. This invention discloses a drug-coated balloon catheter and its preparation method. On one hand, a drug-coated balloon catheter includes a catheter with a balloon; the outer wall of the balloon is provided with a drug coating comprising at least an inner coating and an outer coating, both the inner and outer coatings carrying active pharmaceutical ingredients and different carriers; when the balloon inflates, the inner coating, together with the outer coating, detaches from the balloon under the influence of the patient's body temperature and hydration through a state change caused by the temperature-sensitive carrier of the inner coating; the outer coating, upon detachment from the balloon, facilitates the transfer of the corresponding active pharmaceutical ingredient into the target tissue via its carrier. On the other hand, a method for preparing a drug-coated balloon catheter is provided. This invention has the advantages of effectively improving the adhesion of the drug coating to the balloon to reduce delivery loss and increasing the release rate of the drug coating on diseased tissue to enhance drug transfer capability.

The application relates to a preparation method of a magnesium alloy stent composite coating and belongs to the technical field of biomedical materials. In view of the technical problem that an existing polyester coating produces acid by degradation, and accelerates corrosion of a magnesium alloy stent, a composite coating with piezoelectric-pH synergistic protection function is provided. The coating comprises a PVDF-g-APTES primer layer, a pH regulating intermediate layer composed of PVDF, PDLLA and alkaline nanoparticles, and a drug-loaded PDLLA outer coating. The application actively increases the interface pH to the passivation zone by on-demand release of alkaline nanoparticles, and realizes the positive feedback mechanism of "the more stress, the more protection" by using the piezoelectric effect. Compared with the prior art, the dynamic corrosion resistance of the application is increased by more than 40%, the synergistic effect makes the protection effect increased by more than 60%, the piezoelectricity and alkalinity are synergistically protected, a long-acting corrosion-resistant and intelligent response comprehensive solution is provided for the degradable magnesium alloy implant device.

The invention provides a preparation method of an enrofloxacin suspension with high stability and release rate, and belongs to the technical field of medicine. The enrofloxacin suspension is prepared from sodium phenylpropionate, disodium ethylene diamine tetraacetate, Pluronic F68, sodium lactate, carboxymethyl cellulose, glycerol, propylene glycol, enrofloxacin and water. Through reasonable proportioning and synergistic effect of all the components, the suspension has excellent stability in a high-temperature environment, degradation of drugs can be remarkably reduced, and the stability of the drugs in high-temperature storage and transportation is improved. Moreover, the synergistic effect of different components not only improves the stability, but also accelerates the release rate of the medicine. Therefore, the enrofloxacin suspension disclosed by the invention is suitable for use and storage requirements of medicines in tropical, subtropical and other high-temperature environments.

The invention relates to the technical field of traditional Chinese medicine application and preparation, and provides a pretreatment method for improving the coriolus versicolor polysaccharide content, which comprises the following steps: carrying out hot-pressing treatment and rapid pressure relief on a thoroughly-moistened coriolus versicolor sporocarp, then carrying out ultrasonic treatment, and drying by adopting a microwave drying method to obtain the coriolus versicolor with high polysaccharide content. The invention also provides coriolus versicolor obtained by the method, wherein the polysaccharide content is not less than 6%. According to the method, the content of coriolus versicolor polysaccharide is remarkably increased through the combined technology of spraying moistening, hot-pressing steam heating, ultrasonic treatment and microwave drying on coriolus versicolor, the release rate and the release amount of the polysaccharide from the coriolus versicolor are increased, and the curative effect of the coriolus versicolor and the utilization rate of the medicinal material are improved.