55 results about "Pressure overload" patented technology

The invention relates to a slow release dosing pump which is buried in a human body and pressed through the deformation of an elastic membrane, comprising a pump body, a puncture membrane, a sieving plate, an elastic membrane, an internal duct, a diverting valve and an overload valve. The invention is characterized in that: the pump body and the puncture membrane form an inner cavity by a fixing sealing ring through embedded pressing or adhering, the inner cavity is divided into two parts, namely an upper chamber and a lower chamber, by the sieving plate; the lower chamber is provided with the elastic membrane which is coated on the sieving plate completely and can swell in the lower chamber, and after being injected into the upper chamber, the liquid medicine flows into the lower chamber through the sieving pores of the sieving plate and causes the elastic membrane to deform and swell until fully filling the lower chamber; in addition, the upper chamber is communicated with the exterior of the pump by the internal duct which is provided with the diverting valve and the overload valve, the flow speed of the liquid medicine in the upper chamber and the lower chamber to the exterior of the pump can be controlled by using the resiliency produced by the deformation of the elastic membrane and adjusting the diverting valve and the overload valve. The slow release dosing pump can precisely control the flow speed of the liquid medicine, has the function of pressure overload washing and the characteristics of simple structure, durable using and convenient maintenance. The medicine can be repeatedly filled through the skin, being convenient for patients to use.

The invention discloses a remote-controllable medical oxygen generation system. The remote-controllable medical oxygen generation system comprises an air compressor, a cool dryer, an air tank, an oxygen generator, a detection tank, an oxygen tank and a central control system, wherein the air compressor, the cool dryer, the air tank, the oxygen generator, the detection tank and the oxygen tank areall sequentially connected through pipelines, filters are separately arranged on the pipeline between the air compressor and the cool dryer and the pipeline between the cool dryer and the air tank, anair detecting device is mounted at an air inlet of the oxygen generator, pressure sensors and air pressure overload protecting valves are separately mounted in the air compressor, the air tank, the detection tank and the oxygen tank, an oxygen concentration analyzer is further arranged in the detection tank, an air flowmeter and an oxygen flowmeter are separately arranged at an air inlet of the air tank and a gas outlet of the oxygen tank, the air detecting device, the pressure sensors, the oxygen concentration analyzer, the air flowmeter and the oxygen flowmeter are connected with the central control system on the basis of a communication network, and the central control system is connected with an upper computer.

The invention belongs to the technical field of biological pharmacy, and discloses a medicine for resisting pressure overload myocardial hypertrophy and ventricular remodeling and application. The application comprises the following steps of: establishing a pressure overload rat myocardial hypertrophy and ventricular remodeling animal model by adopting abdominal aorta constriction; constricting the abdominal aorta for 28d, and sequentially detecting the change of a hemodynamic index and the diameter of a myocardial cell; and transecting the left ventricular myocardial tissue of a rat, observing the form of the myocardial cell under an optical microscope after conventional HE staining, and observing the change effect of leonurine on the pathological form of the left ventricular myocardial tissue of the rat. The invention proves that high and low dosage groups of leonurine have a certain improvement effect on cardiac diastolic and systolic dysfunction of a myocardial hypertrophy rat induced after abdominal aorta constriction; the high and low dosage groups of leonurine can reduce the left ventricular hypertrophy index of the rat after AAC operation; and the high and low dosage groups of leonurine and a positive group can inhibit myocardial cell hypertrophy of the rat after AAC operation and inhibit ventricular remodeling.

The invention relates to determination of an angiotensin II-1 type receptor perception site. Different AT1R mutants are constructed through an amino acid residue point mutation method to find different pathologic perception sites of AT1R, and the results shows that an Lys199 site of the AT1R is an Ang II perception site, Leu 212 and Cys 289 sites are mechanical stress perception sites, and a Gln 257 site is a common perception site of the Ang II and overloading pressure. By means of determination of the angiotensin II-1 type receptor perception site, design of the new generation of ARB medicines aiming at mechanical stress or the Ang II activated amino acid residue site can be guided, clinical medication can be guided, selective targeting of diseases, such as hypertensively myocardial hypertrophy, mediated by the AT1R is improved, adaptation diseases of the ARB type medicines are evaluated and compared, and the fundamental research of occurrence and development mechanisms of relevant diseases is guided.

The present invention is concerned with immunoglobulin (Ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression of adverse cardiac remodelling and conditions resulting from or relating to pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury. The invention also provides nucleic acid molecules encoding said Ig-like molecules, vectors comprising same, and host cells comprising same.

The invention discloses a method for establishing a mouse model of cardiac volume overload. Under guidance of high-frequency ultrasounds, metal wires of a built-in metal wire cannula used for a right-side common carotid artery damage an aortic valve once or multiple times, thereby causing blood regurgitation of the aortic valve. During a model establishing process, doppler ultrasounds of blood regurgitations at arcus aortae are monitored any time till the regurgitation degree is satisfied. The method enjoys obvious advantages over a present model-establishing method for arterio-venous fistulas. The method can establish a mouse model for aortic regurgitation with convenient operation, good regurgitation and repetitiveness and provide a novel and model animal satisfactory to simulated clinical lesions for the study of translational medicine for cardiac volume overload reconstitution. The method and a model of pressure overload can also be used for differential expressions of cardiac remodeling, which lay a foundation for clarification of a molecular mechanism for two types of overload cardiac remodeling differences. The method can provide importance references for personalized diagnosis and treatment of different types of clinical cardiomegaly diseases.

The invention discloses a poultry pen cleaning device for the animal husbandry. The poultry pen cleaning device for the animal husbandry comprises a main hollow shell, wherein a current controller isinstalled on the side surface of the main hollow shell, and a supporting rod is installed at the center of the bottom of the main hollow shell. One motor can be used for achieving not only a liquid injection function on ground cleaning liquid but also a liquid high-pressure jetting function, so that several purposes are realized through the one device, and the utilization rate of the motor is increased. High-pressure water flow is jet to the ground, so that the ground of a poultry pen is cleaned efficiently and rapidly. In addition, the device is provided with an air-liquid raw material turbotype injection mechanism which can be used for achieving not only a liquid injection function but also an air injection function. Moreover, the device is provided with a pressure overloading preventing control mechanism which can not only play a role in protecting the motor but also prevent the phenomenon of overlarge air pressure. Furthermore, the device is provided with an air-liquid raw material injection control mechanism, so that either injected materials are liquid or air can be controlled according to practical situations, and the practicality is high.

The invention discloses application of ganoderma lucidum spore powder in preparing medicine for preventing and treating compensatory cardiac hypertrophic heart disease. The ganoderma lucidum spore powder is preferably the ganoderma lucidum spore powder obtained by an ultra-low temperature freeze-thawing breaking method. In the invention, a mouse model of cardiac hypertrophy is induced by pressureoverload, the morphological structure and function of the heart of the mouse are evaluated by the left ventricular wall thickness, the inner diameter, the ejection fraction, and the histopathology andother indexes, and results indicate that the ganoderma lucidum spore powder (150 mg / (kg.BW)) can correct the morphological structure and function of the heart of the mouse with myocardial hypertrophyinduced by pressure overload. At the same time, the gene sequencing technology and bioinformatics analysis are applied, and it is found that ganoderma lucidum spore powder can protect the heart fromheart injury caused by pressure overload by regulating the changes of mRNA expression profile and by the multi-target and multi-channel integration regulation, wherein endocytosis, insulin signaling pathway and focal adhesion signaling pathway may be important regulatory mechanisms thereof.

The invention relates to a lumbar spine rehabilitation training device, which effectively solves the problems of lack of reasonable transition between passive rehabilitation and active rehabilitation for patients with lumbar spine diseases, and poor curative effect of the massage device; the technical solution includes a bed body, and a through hole is opened in the middle of the bed board , a support unit that can move up and down is installed on the lower surface of the bed board. The support unit includes a shell, and a vertical blind hole is opened on the upper end of the shell. A support that fits with the inner wall and can move up and down is installed in the blind hole. Column, the blind hole below the supporting column is filled with water, the shell is provided with a cavity located above it, a pressure overload device is provided between the bottom of the blind hole and the cavity, and there is a connection between the cavity and the bottom of the blind hole The liquid return channel, the lower port of the liquid return channel is equipped with a tapered plug whose small end faces the liquid return channel; the invention can make the patient carry out the transition of the exercise intensity with the rehabilitation cycle well, and is helpful for the patient to recover.

The invention relates to a method for constructing a cardiac pressure overload / unloading mouse model. The invention proposes a new stable overload / unloading animal model construction method by carrying out animal experimental research. The conventional practice of constructing a pressure overload model is to directly knot the aortic arch when it is narrowed, which has poor stability. The improvement of the present invention is characterized in that two small PE10 catheters are used, and the two ends of a 7-0 surgical line firstly pass through a PE10 catheter simultaneously, and then one of theends separately passes through another PE10 catheter, and finally the two ends are subjected to knotting. The improved method solves the problem of difficulty finding the knotting position and difficultly unraveling when the aortic arch is reinstated, significantly reduces the phenomenon of large bleeding during the operation, improves the operability and reliability of the experiment, reduces the difficulty of model construction, and improves the stability and uniformity of the model. The method provides animal models that are more stable and more in line with clinical features for the studyof related diseases.

The invention discloses a multifunctional high-voltage equipment safety performance detection device. It includes gas power system, water injection exhaust system, pressure lifting system, measurement control system and safety protection system. During the high-pressure test, the pressure medium is quickly filled into the high-pressure equipment through the liquid pipeline by the water injection and exhaust system, and the gas in the equipment is discharged. The pressurization, pressure maintenance and pressure relief operations are completed by the pressure lifting system. The power required for the treatment process is provided by the gas power system. The measurement control system monitors and controls the entire testing process and outputs process data. When the pressure is overloaded, the safety protection system ensures safety. The device can test the safety performance of high-voltage equipment, including withstand voltage test, fatigue test, burst test and stress test analysis. It has the advantages of fast boosting, stable pressure, easy operation, safety and reliability.