Application of ganoderma lucidum spore powder in preparing medicine for preventing and treating compensatory cardiac hypertrophic heart disease

Abstract

The invention discloses application of ganoderma lucidum spore powder in preparing medicine for preventing and treating compensatory cardiac hypertrophic heart disease. The ganoderma lucidum spore powder is preferably the ganoderma lucidum spore powder obtained by an ultra-low temperature freeze-thawing breaking method. In the invention, a mouse model of cardiac hypertrophy is induced by pressureoverload, the morphological structure and function of the heart of the mouse are evaluated by the left ventricular wall thickness, the inner diameter, the ejection fraction, and the histopathology andother indexes, and results indicate that the ganoderma lucidum spore powder (150 mg / (kg.BW)) can correct the morphological structure and function of the heart of the mouse with myocardial hypertrophyinduced by pressure overload. At the same time, the gene sequencing technology and bioinformatics analysis are applied, and it is found that ganoderma lucidum spore powder can protect the heart fromheart injury caused by pressure overload by regulating the changes of mRNA expression profile and by the multi-target and multi-channel integration regulation, wherein endocytosis, insulin signaling pathway and focal adhesion signaling pathway may be important regulatory mechanisms thereof.

Description

technical field [0001] The invention belongs to the technical field of ganoderma lucidum spore powder, and in particular relates to the application of ganoderma lucidum spore powder in the preparation of medicines capable of preventing and treating compensatory myocardial hypertrophy heart disease. Background technique [0002] Cardiac hypertrophy, whether intrinsic (such as hereditary hypertension) or extrinsic (such as arterial hypertension and valvular disease), is a stress response of cardiomyocytes to increased biomechanics, characterized by increased cardiomyocyte volume and increased protein synthesis (such as Structural and contractile proteins), changes in the intercellular matrix, and reexpression of fetal genes are the main features, which are not only an adaptive response required to maintain cardiac output and restore the normalization of cardiac wall tension, but also induce myocardial infarction, cardiac rhythm, etc. An independent risk factor for heart failur...

AI Technical Summary

Problems solved by technology

However, so far, there have been no reports on the effect of Ganoderma lucidum spore powder on pressure overload-induced compensatory myocardial hypertrophy in mice and the regulation of gene expression profiles in cardiac tissue.

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