46 results about "Myofibrosis" patented technology

The present invention is concerned with composition and methods for treatment of certain cardiovascular conditions. In particular it is concerned with prophylactic or therapeutic treatment of myocardial fibrosis or associated conditions by administering compositions comprising vasoactive intestinal peptide (VIP) and / or active fragments) thereof.

The invention discloses an application of mesaconine. The application is the application of mesaconine or pharmaceutically acceptable salts, esters or solvates of mesaconine in preparation of drugs orhealth care products for preventing and / or treating myocardial fibrosis. Mesaconine can effectively prevent and / or treat myocardial fibrosis and chronic heart failure or cardiac remodeling caused bymyocardial fibrosis.

The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.

The invention discloses application of a substance for improving activity and / or expression quantity of liver SIRT5 protein in treatment of acute myocardial infarction. Experiments prove that compared with a C57BL / 6 mouse, the myocardial infarction area and the myocardial fibrosis area of the C57BL / 6 mouse of which a liver specifically overexpresses the SIRT5 protein are remarkably reduced, and the cardiac function is improved to a certain extent. Therefore, the substance for improving the activity and / or expression quantity of the liver SIRT5 protein can reduce the myocardial infarction area, reduce the myocardial fibrosis area and improve the cardiac function, and acute myocardial infarction is further prevented and / or treated. The application of the substance for improving the activity and / or expression quantity of the liver SIRT5 protein in treatment of acute myocardial infarction has an important application value.

The present invention discloses a myocardial infarction treating cell preparation, a preparation method and applications thereof, wherein the main components in the cell preparation are CTs and BMSCs. According to the present invention, with the direct intracardiac injection or the interventional intracardiac injection of the cell preparation, by performing cell preparation transplantation on the ischemic area and ischemic margin area of the heart of acute myocardial infarction, the severely damaged cell network formed from CTs in the ischemic myocardium ischemic area can be effectively repaired and regenerated so as to repair the cell structure microenvironment beneficial for the regeneration of the infarcted myocardium, such that the regeneration of the infarcted myocardium is easily achieved; and after the transplantation treatment on the acute myocardial infarction, the effects in the fields of infarction area reducing, myocardial infarction heart cardiac function improving, ischemic myocardium fibrosis improving, ischemic area angiogenesis and marginal area angiogenesis promotion, infarcted heart pathological reconstruction improving and after-myocardial-infarction heart failure incidence reducing are superior to the effect of the current commonly-used separate BMSCs treatment.

The present invention relates to a medical use of Cellular Repressor of E1A-stimulated Genes (CREG), in particular to a use of CREG protein or active fragment thereof in manufacture of a medicament for preventing and / or treating myocardial infarction, a use in manufacture of a medicament for preventing and / or treating ventricular remodeling after myocardial infarction and heart failure after myocardial infarction, a use in manufacture of a medicament for prevention and / or treatment of myocardial ischemia-reperfusion injury, a use in manufacture of a medicament for prevention and / or treatment of salt-sensitive hypertensive myocardial fibrosis.

The present inventors have found that an HMGB1 fragment peptide having a specific amino acid sequence exhibits an effect to improve the function of the heart, prevent cardiomyocyte hypertrophy, prevent myocardial fibrosis and promote angiogenesis in an animal model with dilated cardiomyopathy, the specific HMGB1 fragment peptide also exhibits an effect to improve the function of the heart, preventauxocardia, prevent cardiomyocyte hypertrophy, prevent myocardial fibrosis and promote angiogenesis in an animal model with ischemic cardiomyopathy associated with old myocardial infarction, and thespecific HMGB1 fragment peptide exhibits an effect to prevent cardiomyocyte hypertrophy and prevent myocardial fibrosis in an animal model with hypertensive cardiomyopathy. On the basis of this finding, a pharmaceutical composition for preventing and / or treating cardiomyopathy, old myocardial infarction, and chronic heart failure associated with these diseases is provided, which contains an HMGB1fragment peptide having a specific amino acid sequence.

The invention relates to a PK (Pyruvate Kinase) M2 mutant and application thereof to cardiovascular diseases. The nucleotide sequence of the PKM2 mutant is shown as SEQ ID NO. 2. The activity of the PKM2 in cells is recovered by using a specific PKM2 agonist or transfecting and modifying site mutation plasmids into cardiac muscle cells, so that the occurrence of myocardial fibrosis and congestiveheart failure can be effectively inhibited.

The invention relates to the technical field of medical treatment, and in particular, relates to an intelligent myocardial fibrosis analysis method and system. The intelligent myocardial fibrosis analysis system comprises a control terminal, a detection hardware, a data acquisition module, an input module, an analysis module and a memory bank; the control terminal is a main control terminal of the detection hardware and controls the detection hardware to execute and send out a command; the detection hardware is used for detecting the myocardial fibrosis condition of the target heart; the input module is used for inputting target parameters; the data acquisition module is used for acquiring target myocardial detection data detected by the detection hardware; the analysis module is used for analyzing and detecting target myocardial data, generating myocardial data parameters and forming a data summary file; and the memory bank is used for storing healthy myocardial data for a user and is a comparison basis of the comparison module. Aiming at the defects embodied in an existing myocardial fibrosis detection technology, the invention provides the intelligent myocardial fibrosis analysis system, when the system is used, accurate diagnosis reference opinions can be provided for doctors, and the doctors can compare and push the reference opinions with own diagnosis results, so that a more accurate and objective diagnosis result can be made for a patient.

The invention discloses application of CAND1 in preparation of a medicine for inhibiting myocardial cell hypertrophy, heart failure and myocardial fibrosis. The NCBI registration number of mRNA of CAND1 is NM _ 027994.1. The prepared medicine can only contain CAND1 and can also be prepared into a medicine compound which contains an effective dose of CAND1 and a pharmaceutically acceptable carrier,wherein the carrier can be virus, cholesterol, nanoparticles, chitosan, lipidosome and the like; the CAND1 is synthesized and wrapped by the carrier to prepare an injection preparation; and the injection preparation is used for treating myocardial hypertrophy, heart failure and myocardial fibrosis in an intravenous or intramuscular injection manner.

The disclosure concerns antibodies that bind fibronectin-EDA. These antibodies are particularly useful for use in treatment, prevention, or prevention of progression of fibrosis, adverse cardiac remodeling and conditions resulting from or relating to myocardial infarction and pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury.

The invention discloses application of doxycycline in preparation of a medicine for treating and / or preventing and / or relieving and / or improving cardiomyopathy. According to the invention, doxycycline is applied to treatment of cardiomyopathy, so that the diastolic function of the heart can be recovered, myocardial cell apoptosis can be reduced, and / or myocardial fibrosis and cardiomyopathy can be relieved, e.g. restricted cardiomyopathy.

The invention discloses an application of songlin in a medicine for resisting doxorubicin cardiotoxicity, and particularly relates to an application of songlin in a medicine for resisting doxorubicin cardiotoxicity, resisting heart failure, increasing cardiac ejection fraction and protecting myocardial mitochondrial functions. According to the application disclosed by the invention, the songorine is applied to the medicine for resisting doxorubicin cardiotoxicity and heart failure, so that the cardiac ejection fraction is effectively increased, the myocardial cell apoptosis is prevented, the myocardial mitochondrial function is protected, the myocardial fibrosis is reduced, the tumor cell proliferation inhibition effect of doxorubicin is not reduced while the myocardial cell activity is increased, and the application treatment effect is remarkable; the traditional Chinese medicine composition has no obvious side effect and has a good medicinal prospect.

The invention provides application of a beta-catenin specific inhibitor in preparation of a medicine for treating heart diseases. The beta-catenin specific inhibitor has the effect of treating the heart diseases such as dilated heart disease and myocardial fibrosis. Great clinical significance is realized on further development of related treatment medicines.

The purpose of the present invention is to provide: a composition for inhibiting myofibrosis, which contains, as an active ingredient, a component that can be safely ingested over a prolonged period of time; and a method for safely inhibiting myofibrosis. The present invention provides a composition for inhibiting myofibrosis, which contains quercetin or a glycoside thereof as an active ingredient.

The invention discloses an application of stevioside to prepare a health food and medicine for preventing or treating myocardial fibrosis. A new medicine for preventing myocardial fibrosis is provided. Since stevioside is sweet and is good in thermal stability and low in toxicity, stevioside can be used for preparing a health food.

The invention discloses a method for screening anti-myocardial fibrosis drugs, specifically: obtaining known marker genes of myocardial fibrosis; using the known marker genes to catch biological relationship with the known marker genes in biological big data Other genes or proteins, and limited to the genes that can be expressed in cardiac tissue, construct a specific myocardial fibrosis pathological gene module; construct a drug data set with transcriptomics data, and obtain drug transcription profile data; use gene expression deduction method according to drug The transcriptional profile data of the corresponding drug predicts the anti-myocardial fibrosis ability of the corresponding drug, and screens the desired drug according to the anti-myocardial fibrosis ability of the drug. Based on the different interactions between myocardial fibrosis marker genes and other genes, the present invention constructs a tissue-specific myocardial fibrosis module, screens potential anti-myocardial fibrosis drugs by computer, screens in batches, improves accuracy, high efficiency, and low cost .

The invention relates to applications of epicatechin in preparation of drugs for preventing or treating myocardial fibrosis, and belongs to the technical field of crude drugs. In order to provide a novel application of the epicatechin, the applications of the epicatechin in preparation of the drugs for preventing or treating myocardial fibrosis is disclosed. The using amount of the epicatechin is0.001-15 mg / Kg (weight / day). The drugs contain effective amount of epicatechin and pharmaceutically acceptable carriers and / or excipient. Through the verification of mouse experiments, the epicatechincan improve the cardiac functions of mice, protect mouse heart structures and relieve AngII induced myofibroblast transformation and collagen synthesis, so that the epicatechin is shown to have the effects of inhibiting myocardial fibrosis and has great application prospects on preventing and treating the myocardial fibrosis; and based on this, the novel applications of the epicatechin in preparation of the drugs for preventing or treating myocardial fibrosis is firstly provided.

The invention belongs to the field of biopharmaceutical research, and particularly relates to application of a human RAB22A gene as a target to preparation of a myocardial infarction treatment product. It is the first time for the invention to discover that the RAB22A can be applied as a potential target site to preparation of a medicine for treating myocardial infarction. The myocardial infarction can be effectively treated after the expression of the RAB22A gene is inhibited. A nucleic acid molecule or a nucleic acid construct including the nucleic acid molecule provided by the invention canspecifically inhibit and relieve myocardial cell inflammatory infiltration, reduce myocardial cell loss, inhibit myocardial cell apoptosis, inhibit myocardial fibrosis, inhibit reactive oxygen species (ROS) up-regulation,and treat ventricular remodeling after myocardial infarction. A new direction is opened up for myocardial infarction treatment.