54results about How to "Restore activity" patented technology

The invention discloses an air preheater anti-blocking method for reducing NH3 escape and SO3 content, and relates to the field of air preheater anti-blocking. Comprising the steps of step-by-step soot blowing optimization, dynamic soot blowing parameter adjustment, ammonia escape precise control, coal type bin-divided blending, combustion parameter optimization control and wall temperature increase treatment. According to the invention, step-by-step soot blowing strengthens removal of ash on the surface of the catalyst and reduces the ammonia escape concentration through fixed-point retention and dynamic adjustment; the ammonia escape detection system monitors and adjusts the ammonia spraying amount in real time to ensure that the ammonia escape concentration is lower than 3 ppm, and generation of NH4HSO4 is reduced; the SO3 generation amount is reduced through coal type bin-dividing blending and combustion parameter optimization control, and the blocking risk is restrained from the source; in the wall temperature increasing treatment, the wall temperature is increased to 210 DEG C or above in a circulating air bin heating and single-side temperature increasing mode, and coagulated materials are promoted to be gasified and fall off. According to the method, the problem of blockage of the air preheater is effectively solved, and the operation efficiency and stability of a boiler system are improved.

The invention relates to a tail gas treatment device for an industrial boiler, which is applied to the technical field of tail gas treatment devices and adopts a honeycomb ceramic-based hexagonal prism catalyst tube to improve the mass transfer efficiency; the composite anode plate integrates ICCP cathode protection and plasma electrochemical regeneration functions, inhibits catalyst corrosion and performs in-situ activation; the composite anode plate adopts a titanium-based porous framework, and a special material is arranged in the composite anode plate to generate micro-discharge plasma; the cathode collector plate adopts a stainless steel screen plate and a conductive carbon coating, so that the corrosion resistance is improved; the potential reference hole adopts a multi-stage branch structure, so that multi-point in-situ detection is realized; the regeneration liquid circulation system uses a sulfuric acid solution to dissolve and remove surface sediments; the intelligent control system integrates multiple functions, realizes full-life-cycle management of the catalyst, improves the denitration and desulfurization effects, prolongs the service life of the catalyst, and realizes intelligent and accurate control of the regeneration process.

The invention particularly relates to an in-situ regeneration method of a molecular sieve catalyst. The in-situ regeneration method comprises the following steps: charking regeneration preparation; setting a test group: acquiring related reaction parameter information of a test reactor and related state information of a catalyst; analyzing and processing: obtaining a device influence value and a regeneration evaluation value, and analyzing to obtain a preferred group; performing charking regeneration reaction; cooling and purging; and performing safety check. In the invention, a plurality of test groups are set, key parameters are systematically combined and tested, the most suitable regeneration condition can be accurately screened out, and the accurate parameter optimization avoids the problem of poor regeneration effect or damage to the catalyst structure caused by improper parameter selection in the traditional regeneration method. The activity and the selectivity of the catalyst can be effectively recovered after the catalyst is regenerated, so that the chemical reaction efficiency and the product quality are remarkably improved, the service life of the catalyst is prolonged, and the industrial production cost is reduced.

The invention mainly relates to composite hydrogel of a targeted cartilage end plate as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of biological medicines. The composite hydrogel of the targeting cartilage end plate comprises a cartilage targeting peptide modified drug-loaded exosome, calcium carbonate, chitosan and water, and the cartilage targeting peptide modified drug-loaded exosome comprises an exosome, a cartilage targeting peptide and salvianolic acid A. The composite hydrogel of the targeting cartilage end plate is prepared by the following steps: encapsulating salvianolic acid A by exosome derived from human mesenchymal stem cells, modifying by cartilage targeting peptide to obtain drug-loaded exosome modified by the cartilage targeting peptide, and mixing the drug-loaded exosome with calcium carbonate, chitosan and water. The compound can be used for accurately targeting cartilage endplate cells (CEPCs), remarkably relieving the inflammation of the CEPCs, changing the secretion phenotype of the CEPCs, delaying the senescence of nucleus pulposus cells (NPCs), relieving the inflammation of the NPCs and effectively treating intervertebral disc diseases.

The invention relates to the technical field of calcium carbonate manufacturing, in particular to a preparation method of high-whiteness light calcium carbonate. Comprising the following steps: efficiently leaching the calcium element in the carbide slag; preparing a microbial crystal form control agent; and carrying out electric dispersion treatment and precipitation on calcium ions. The microbial crystal form control agent is prepared by regulating and controlling the mixing ratio of the bacillus pumilus fermentation liquor to the pseudomonas fluorescens fermentation liquor, and it is avoided that in the full mixing process of the microbial crystal form control agent and the calcium-containing filtrate, Ca < 2 + > is mineralized to form large calcium carbonate particles; stearic acid and sodium polyacrylate in the microbial crystal form control agent can enable particles to be more stable, provide ion adsorption capacity, optimize the crystal form of calcium carbonate and form vaterite type crystals with smaller crystal form, and bacillus pumilus can assist generation of small-particle-size calcium carbonate along with time, so that high-whiteness small-particle-size light calcium carbonate is obtained.

The invention discloses application of 2-ME in preparation of a medicine for preventing or treating sepsis cardiomyopathy, low-dose 2-ME can recover the activity of myocardial cells damaged by sepsis, reduce the apoptosis rate of the myocardial cells and enhance the contractility of the myocardial cells, so that the heart function is improved; the 2-ME can significantly inhibit cell death, reduce accumulation of disulphide in cells and prevent occurrence of disulphide death, and has potential application prospects in myocardial protection and prevention and treatment of sepsis myocardial injury.

The present application belongs to the field of catalyst regeneration technology, and discloses a regeneration method of a supported bimetallic alloy catalyst in alkane dehydrogenation. After the supported bimetallic alloy catalyst is calcined by oxygen, the auxiliary metal oxide is physically blended with the supported bimetallic alloy catalyst, and then the reduction treatment is carried out under high temperature using hydrogen atmosphere, so as to restore the activity of the supported bimetallic alloy catalyst. The present application can solve the problems of metal loss and bimetallic alloy structure damage of the bimetallic catalyst in the long-time high-temperature reaction environment and the regeneration process. By adding the oxide of the auxiliary metal, the auxiliary metal atoms are reduced and diffused onto the metal alloy under high-temperature conditions, so as to restore the structure and activity of the bimetallic alloy in the catalyst. The method is simple and convenient to operate, and is suitable for the supported bimetallic alloy prepared by different methods.

This invention discloses a method for preparing and analyzing trans-4-aminocyclohexylacetic acid. The preparation method is as follows: 4-nitrophenylacetic acid undergoes catalytic hydrogenation in a solvent, followed by filtration. The filtrate is then treated with acid to obtain a 4-aminophenylacetic acid salt solution. The collected catalyst is activated. The 4-aminophenylacetic acid salt solution is mixed with isopropanol, barium hydroxide, tetrabutylammonium bromide, 18-crown ether-6, and dibutyl phthalate. The activated catalyst is then added to initiate a catalytic hydrogenation reaction. After the reaction, the reaction solution is cooled and filtered. The resulting solid is mixed with a preheated dilute sulfuric acid solution and stirred to form a slurry. The mixture is then filtered, and the filtrate is neutralized and filtered again. The collected filtrate is concentrated and crystallized. The crystallized precipitate is washed and dried to obtain trans-4-aminocyclohexylacetic acid. The method provided by this invention has high reaction efficiency, mild conditions, and is suitable for industrial production. It yields high product purity and reliability. Furthermore, the analytical method provided by this invention is accurate and reliable.

The present invention belongs to the field of bioengineering, and specifically relates to a biological agent and application for uranium pollution control in an alkaline environment. The present invention provides a biological agent composed of Burkholderia and Pseudomonas. The microorganisms provided by the present invention can significantly reduce the cost of remediation, while restoring the activity of microbial communities, and providing long-term environmental stability and environmental resistance.

The present application relates to the technical field of feed processing, and particularly relates to a preparation method of Maotai-flavor distiller's grains fermented feed, which comprises the following steps: drying treatment based on the moisture content of Maotai-flavor distiller's grains to obtain basic distiller's grains; determining the strain ratio of brewer's yeast, bacillus subtilis and aspergillus niger based on the tannin content of the basic distiller's grains to obtain a compound fermentation inoculant; inoculating and then fermenting; determining state evaluation parameters based on the total polyphenol accumulation rate, the dissolved oxygen consumption rate and the microbial activity index during the fermentation process, and performing qualified evaluation, and dynamically adjusting when unqualified; determining the fermentation end point based on the tannin degradation rate and the total polyphenol accumulation rate; and mixing the fermented distiller's grains with the basic feed at a mass ratio of 1% after low-temperature drying of the fermented distiller's grains. The present application realizes three-layer control of raw material evaluation, process control and end point determination, significantly improves the stability and content of functional active ingredients in the product, reduces the tannin and safety risk, and has a good intestinal health improvement effect on animals.

The invention belongs to the technical field of sugar alcohol catalyst utilization, and relates to a system and method for improving the recycling rate of a hydrogenation catalyst, and the system comprises a raw material metering tank, a hydrogenation reaction kettle, a hot water tank, a settling tank, a washing liquid tank, a dilute alkali tank, a filtering tank, a product tank, a catalyst regeneration tank and a catalyst metering tank, the settling tank is used for settling the cooled sugar alcohol hydrogenation liquid containing the hydrogenation catalyst so as to separate precipitates and supernate, the filtering tank is used for filtering the supernate so as to obtain the sugar alcohol hydrogenation liquid and filtrate, and the product tank is used for storing the filtered sugar alcohol hydrogenation liquid. And the catalyst regeneration tank is used for recovering the hydrogenation catalyst in the settling tank and the filtrate in the filtering tank, and regenerating the recovered hydrogenation catalyst. The catalyst metering tank is used for storing the regenerated hydrogenation catalyst and preparing a hydrogenation catalyst solution. Efficient recovery and regeneration of the hydrogenation catalyst in the maltose hydrogenation process are achieved, and the recovery rate of the hydrogenation catalyst is increased.

The invention discloses application of a PD-1 inhibitor combined with Peg-IFN-alpha in preparation of a medicine for treating CHB which is not clinically cured, and belongs to the technical field of biological medicine. The PD-1 inhibitor is combined with Peg-IFN-alpha to treat a CHB patient which is not clinically cured, it is found that the PD-1 inhibitor can block a PD-1 / PD-L1 signal channel, relieve immunosuppression which is not clinically cured through Peg-IFN-alpha treatment, recover T cell activity and improve the HBV removing capacity of an immune system, and in the CHB treatment process, the good curative effect and safety are shown. By monitoring the expression level of target molecules related to nine interferon pathways in peripheral blood of a patient, it is found that the expression of ISG15 may be induced by adding a PD-1 inhibitor, and high expression of OAS1 may be a favorable factor for good treatment response of the combination of the PD-1 inhibitor and Peg-IFN-alpha.

The invention discloses a low-temperature self-adhesive high-modulus polyimide adhesive film for a filter and application of the low-temperature self-adhesive high-modulus polyimide adhesive film. The polyimide film material provided by the invention is prepared from the following raw materials: a polyamide acid solution, a low-temperature curing agent, a curing agent modifier and an adhesion promoter, the polyamide acid solution is obtained by reacting aromatic diamine with a dianhydride compound. The non-photosensitive filler-free PI membrane material provided by the invention can simultaneously meet the characteristics of high modulus, high tensile strength, excellent adhesion performance, low-temperature curing and the like, and can meet the standards that the surface is flat after a dry etching process and the surface is free of residual substances after being cleaned.

The invention relates to a water purification equipment control method and device, water purification equipment, computer equipment, a computer readable storage medium and a computer program product, and the method comprises the steps: obtaining the purified water amount of the water purification equipment, and controlling water at a first temperature to flush a filter element of the water purification equipment for a preset flushing duration when the purified water amount reaches a preset water passing threshold value, the water at the second temperature is controlled to wash the filter element for the preset cleaning time based on the purified water amount. Wherein the first temperature is higher than the second temperature. The filter element is washed, soaked and cleaned by using water with higher temperature, so that the activity of the filter element can be recovered in a heat regeneration manner, the service life of the filter element is prolonged, the frequency of replacing the filter element by a user is reduced, and the convenience of the water purification equipment is improved.

The invention belongs to the technical field of biological medicines, and particularly relates to an anti-alopecia pharmaceutical composition, anti-alopecia cream and a preparation method of the anti-alopecia cream. The invention discloses an anti-hair loss pharmaceutical composition which comprises dimethyl curcumin, eriochin and vitamin E, wherein the mass ratio of the dimethyl curcumin to the eriochin to the vitamin E is (0.5-2): 1: (1-2). The pharmaceutical composition provided by the invention can enhance hair follicle cell viability, restore hair follicle activity and skin state, improve hair regeneration capacity and slow down the alopecia process through dual effects of degrading scalp hair follicle androgen receptors and promoting scalp blood circulation. Meanwhile, the treatment target of the pharmaceutical composition provided by the invention is an androgen receptor instead of androgen, so that the adverse reaction caused by influence of 5 alpha-reductase inhibitors such as finasteride on the androgen level is overcome, and the pharmaceutical composition has higher biological safety.

The utility model discloses a catalytic cracking device, which relates to the technical field of petroleum processing and comprises a settling tank, a gas collecting chamber arranged at the exhaust end of the upper end of the settling tank, and a reactor arranged at the lower end of the settling tank and fixedly connected with a regenerated catalyst inclined pipe and one end of a regenerated catalyst guide pipe. The regeneration tank is fixedly connected with the regenerated catalyst inclined pipe and the other end of the regenerated catalyst guide pipe; the lower end of the regeneration tank is fixedly connected with the charring tank; a heating structure is arranged at the bottom of the charring tank, a regeneration structure is arranged in the regeneration tank, a waste gas collecting structure is arranged at the top end of the regeneration tank, the charring tank is heated through the heating structure, the combustion chamber and the outer heating chamber, the internal temperature of the charring tank is increased, and catalytic petroleum cracking of a catalyst is accelerated; through the regeneration structure, coke on the coking catalyst is burnt off by using the first regenerator and the second regenerator so as to recover the activity of the catalyst, and the catalyst is recycled; through a waste gas collecting structure, waste gas generated during catalyst recovery is sucked into a waste gas tank through a waste gas pipe, and environmental pollution is avoided.

This invention belongs to the field of microbial fermentation and functional food technology, specifically relating to a postbiotic composition derived from *Lactobacillus helveticus* CICC6024, its preparation method, and its applications. The postbiotic composition of this invention achieves multi-target synergistic regulation of blood glucose through three pathways: inhibiting α-amylase and α-glucosidase, significantly improving glucose consumption in insulin-resistant cells, and restoring the activity of key enzymes in glucose metabolism. Using LC-MS / MS peptidomics technology, the components of the postbiotic were systematically analyzed, and 27 fermentation-specific differentially produced peptides were identified, providing a clear material basis for its efficacy and achieving a leap from a "black box" to a "clear map."

This invention discloses a fluidized bed hydrotreating catalyst, its preparation method, and its application. The hydrotreating catalyst includes a hydrotreating active metal component, a support, and optional auxiliary phosphorus. The support is a carbon-containing alumina composite support. The preparation method includes the following steps: (1) spheroidizing a first pseudoboehmite powder to obtain a first support precursor; (2) treating an aqueous solution of the first support precursor, an additive, and an organic polymer B to obtain a second support precursor; (3) treating the second support precursor, the second pseudoboehmite powder, and an acidic solution to obtain a third support precursor; (4) subjecting the third support precursor to low-temperature heat treatment to obtain a fourth support precursor; (5) mixing the fourth support precursor with an auxiliary solution, drying, and calcining to obtain an auxiliary-modified carbon-containing alumina composite support; (6) introducing a hydrotreating active metal component onto the composite support, followed by drying and calcining to obtain the fluidized bed hydrotreating catalyst.

The utility model provides an ion adsorption device. The ion adsorption device comprises an adsorption box; the preheating box is mounted at the top of the adsorption box; the liquid storage tank is mounted at the top of the preheating tank and is used for storing eluent; the liquid inlet pipe is mounted on the adsorption box; the multi-way pipe is mounted at one end of the liquid inlet pipe; the liquid injection pipe is mounted on the preheating box; the rectangular insertion openings are formed in the two sides of the adsorption box respectively; the plurality of resin ion adsorption mechanisms are respectively mounted on the plurality of rectangular sockets and are used for adsorbing ions in the wastewater; and the positioning mechanism is arranged on the adsorption box and is used for positioning the plurality of resin ion adsorption mechanisms. The ion adsorption device provided by the utility model has the advantages that the resin bed can be conveniently assembled, disassembled and separated, the resin bed can be conveniently replaced, and the adsorption effect is better.

The present invention discloses a washing water physical optimization processor, filler and preparation method thereof, which is a filtering device for being arranged on a water pipe and manually operated, comprising: a filtering part, having an inlet end and an outlet end, connected in series on the water pipe so that water flows through a filtering channel provided in the filtering part, wherein filler is provided in the filtering channel so as to contact with the water flow; a backwashing part, which is rotatably connected with the filtering part and rotates relatively around their common rotation axis, and has a backwashing channel, wherein a backwashing detergent is provided in the backwashing channel; and a water inlet diverting part, which has a diverting valve and a water dividing plate, wherein the diverting valve is linked to the backwashing part and drives the diverting valve to rotate when the backwashing part rotates relative to the filtering part, wherein the water dividing plate has two groups of openings respectively connected to the filtering channel and the backwashing channel, and the diverting valve rotates so that water flows through the diverting channel provided in the diverting valve to introduce water into the corresponding opening.

The invention relates to the technical field of cosmetics, in particular to cellulite tightening cream and a preparation method thereof. The invention relates to a cellulite compacting cream, which comprises a water phase, an oil phase and an additive phase, the water phase comprises the following preparation raw materials: carbomer 980, chlorphenesin, a preservative A and deionized water; the oil phase is prepared from the following raw materials: stearic acid, monoglyceride, an emulsifier, 1618 alcohol and 26 # white oil; the additive phase is prepared from the following raw materials: an anti-allergy agent, a moisturizing anti-aging agent, a sodium hydroxide aqueous solution with the mass concentration of 20%, a thermal sensitizer, a preservative B and essence. Through scientific formula design, the cellulite tightening cream is mild, free of irritation, high in stability, excellent in moisturizing effect and remarkable in tightening and anti-wrinkle effect, skin elasticity can be effectively improved, and the skin is tighter and younger.

A method for catalytically producing hydrogen from hydrocarbon raw materials and enriching CO2, wherein petroleum hydrocarbons are fed into a fluidized reactor, contacted with a catalyst containing a metal oxide to undergo a carbon-hydrogen bond decomposition reaction to generate hydrogen, and the reaction oil gas and the carbon-bearing catalyst obtained by the reaction are separated; the reaction oil gas is further separated into products containing hydrogen, CO, CO2, methane and other hydrocarbons; the carbon-bearing catalyst is first fed to a gasifier, contacted with water vapor for a high-temperature gasification reaction to generate hydrogen and carbon dioxide; the deactivated catalyst with a small amount of coke after gasification is fed to a regenerator to contact with water vapor and an oxygen-containing gas for a high-temperature gasification and carbonization reaction to be regenerated, the regenerated catalyst with the carbon burned off is returned to the fluidized reactor for recycling, and the regenerated flue gas is separated to obtain products containing hydrogen, CO and CO2. The present invention converts low-value hydrocarbon raw materials into hydrogen, realizes the high-value utilization of petroleum resources, and simultaneously realizes CO2 enrichment in the gasification and regeneration process, which is beneficial to carbon recovery and capture.

The utility model relates to the technical field of electrochemical circulating water descaling, and discloses an electrochemistry-based circulating water descaling device which comprises a box body, a fixing block is fixedly connected to the middle of the inner top wall of the box body, connecting plates are fixedly connected to the two sides of the inner top wall of the box body, a double-shaft motor is fixedly connected to the bottom of the fixing block, and the double-shaft motor is fixedly connected to the bottom of the box body. Connecting rods are fixedly connected to two output ends of the double-shaft motor, eccentric wheels are fixedly connected to the other ends of the connecting rods, connecting rods are rotatably connected to eccentric shaft pins of the eccentric wheels, mounting blocks are rotatably connected to the bottoms of the connecting rods, and mounting shells are fixedly connected to the bottoms of the mounting blocks. According to the utility model, under the cooperation of the eccentric wheel, the double-shaft motor, the brush and other structures, dirt on the electrode plate can be removed, the activity of the electrode can be recovered, the descaling efficiency is improved, pollutants in water can be more easily removed, and the stability and the improvement of the water quality purification effect can be ensured.

The application provides a method for in-situ regeneration of Tl-poisoned SCR catalyst and recovery of Tl resources, and belongs to the field of waste SCR catalyst recovery; the Tl-poisoned SCR catalyst is placed in a glycine solution, and after solid-liquid separation, a thallium leaching solution and a regenerated SCR catalyst are obtained; then, the thallium leaching solution is subjected to thallium precipitation treatment, and after solid-liquid separation, a thallium-containing precipitate is obtained. The application utilizes the specific coordination of glycine and Tl to selectively extract Tl from the catalyst, restores the activity of the SCR catalyst, recovers the extracted Tl, realizes the resource utilization of waste, and reduces the environmental risk.

The utility model discloses a movable SCR (Selective Catalytic Reduction) catalyst offline thermal regeneration device which comprises a thermal regeneration box A, a thermal regeneration box B, a hot air circulating fan A and a hot air circulating fan B, wherein the hot air circulating fan A and the hot air circulating fan B are correspondingly arranged; the hot air circulating fan A and the hot air circulating fan B are respectively connected with the electric heater through a first three-way valve; the other end of the electric heater is respectively connected with the heat regeneration box A and the heat regeneration box B through a second three-way valve; an air supplement valve is arranged between the electric heater and the heat regeneration box A, and an air supplement valve is arranged between the electric heater and the heat regeneration box B. The two sides of the first three-way valve are respectively provided with an exhaust valve.

This invention provides a bisphenol A anion regeneration system, comprising an anion bed. The inlet pipes of the anion bed are connected to a demineralized water inlet pipe, a phenol inlet pipe, and a caustic soda inlet pipe. The anion bed is equipped with a top vent pipe and a bottom vent pipe, and a reverse flow pipe connects the inlet pipe and the bottom vent pipe. The upper inlet of the bottom vent pipe is higher than the upper surface of the anion bed. The advantages of this invention are: it extends the service life of the expensive anion catalyst, and through cyclic regeneration, avoids the huge cost of frequent catalyst replacement. The phenol solution used in the regeneration process can be recycled, and the waste alkali solution can be centrally treated or partially recovered, further reducing material consumption and waste disposal costs. Furthermore, during the regeneration operation, the material is introduced into the crystallization system through valve switching, avoiding shutdown of the entire production system, ensuring production continuity, and improving equipment utilization and overall economic efficiency.

The utility model relates to the technical field of quantitative adding instruments, and discloses a raw material quantitative adding instrument which comprises an equipment frame, a fixed concave block is fixedly connected to one side of the top of the inner surface of the equipment frame, a movable plate is movably connected to the inner surface of the fixed concave block, and a connecting plate is fixedly connected to the middle of the bottom of the movable plate. A connecting seat is fixedly connected to the middle of the top of the fixed concave block, a storage barrel is arranged at the top of the connecting seat, a scraper is movably connected to the inner surface of the storage barrel, and a motor is arranged at the top of the storage barrel, so that the operation steps of the quantitative adding instrument are simplified, the production efficiency is improved, and the maintenance cost of the equipment is reduced; the product quality and reliability are improved, the original uniformity, purity and activity of the raw materials can be recovered, and the raw materials are closer to the original state, so that the use effect is improved, meanwhile, the problem of pipeline blockage can be reduced, and the production efficiency is improved.

The catalytic oxidation furnace comprises a catalytic furnace body, a middle catalytic box is arranged in the middle of the catalytic furnace body, a pretreatment unit is arranged on the right side of the middle catalytic box, and a strengthening treatment unit is arranged on the left side of the middle catalytic box; a first flow equalizing plate, an upper-layer catalyst, a second flow equalizing plate and a lower-layer catalyst are sequentially arranged in the middle catalysis box from top to bottom and are used for filtering and adsorbing. According to the invention, through the arrangement of an active carbon adsorption layer, a medium-efficiency filter and a primary-efficiency filter in the middle catalysis box and the pre-treatment unit, impurities and toxicants in waste gas are effectively removed, and the poisoning risk of a catalyst is reduced; the working environment of the catalyst is optimized, the deactivation possibility of the catalyst is reduced, the activity of the deactivated catalyst can be recovered in time in cooperation with a catalyst regeneration system, and the service life of the catalyst is further prolonged.

This invention relates to the field of medical device technology, and discloses a 3D-printed humeral prosthesis that preserves the shoulder joint. The prosthesis includes a prosthesis body, with a proximal end for connecting to the humeral head of the patient's own shoulder joint. The proximal end of the prosthesis body is ball-shaped, and a connection area is provided at the top of the proximal end, with multiple nail-like protrusions. The proximal end of the prosthesis body also has through-holes perpendicular to the connection area. The ball-shaped proximal end of the prosthesis body of this invention, with its connection area, connects to the humeral head of the patient's own shoulder joint, preserving the patient's own shoulder joint, maintaining the patient's natural range of motion and function, reducing damage to surrounding tissues, facilitating more natural movement and recovery of daily activities, and improving postoperative function. The ball-shaped connection has a large contact area, and the nail-like protrusion structure in the connection area of ​​the proximal end of the prosthesis body further increases the contact area, making the connection more stable; this contributes to the initial and long-term stability of the prosthesis implantation.

The invention relates to the modulation of pyruvate kinase and to novel chemical compounds of formula (i) useful as PKR activators, as well as various uses of these compounds. The PKR-activating compounds of the invention are useful in the treatment of diseases and disorders associated with PKR and / or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.