The invention relates to a multi-effect rectifying process of methanol, which belongs to the technical field of separation and purification of chemical products. In the process, a crude methanol raw material of coal-to-methanol is rectified by a pre-rectifying tower, a pressurizing tower I, a pressurizing tower II, an atmospheric tower and a recovery tower in turn at appropriate temperature and pressure so as to obtain a high-purity refined methanol product according with quality requirements. In the flow, methanol steam on the top of the pressurizing tower I is used for providing heat for a reboiler at the bottom of the pressurizing tower II, the methanol steam on the top of the pressurizing tower II is used for providing heat for a reboiler at the bottom of the atmospheric tower, and the pressurizing tower I, the pressurizing tower II and the atmospheric tower form multi-effect rectification; and simultaneously, the methanol steam on the top of the recovery tower is used for providing heat for a reboiler at the bottom of the pre-rectifying tower, and the recovery tower and the pre-rectifying tower form double-effect rectification. The invention provides an energy-saving methanol multi-effect rectifying process method which has the advantages of greatly reduced energy consumption, more stable production process, more easily controlled product quality, higher methanol recovery rate and basically equivalent investment compared with a three-tower rectifying process.