The invention provides anti-cancer and cancer-preventing health-care medicated wine. The anti-cancer and cancer-preventing health-care medicated wine is prepared from the following raw materials in parts by weight: 10 to 16 parts of glossy privet fruit, 13 to 17 parts of Chinese date, 12 to 18 parts of medulla tetrapanacis, 8 to 12 parts of asparagus, 2 to 4 parts of herba epimedii, 16 to 20 partsof radix celastri orbiculati, 14 to 18 parts of herba hedyotidis diffusae, 18 to 22 parts of lucid ganoderma, 3 to 5 parts of longan aril, 12 to 16 parts of herba cistanche, 15 to 17 parts of herba sculellariae barbatae, 4 to 8 parts of Chinese euroleon, 2 to 4 parts of smelly shell worm, 16 to 20 parts of herba rhodiolae, 2 to 6 parts of radix ginseng, 17 to 23 parts of manis pentadactyla, 11 to15 parts of sea horse and 100 to 160 parts of high-alcohol-content rice wine. The anti-cancer and cancer-preventing health-care medicated wine adopts pure natural plant materials, does not have any side effect, is reasonable to take, has remarkable curative effect on laryngeal cancer, breast cancer, rectal cancer, gastric cancer, liver cancer, bladder cancer, prostatic cancer, uterine cancer andthe like, effectively inhibits the deterioration speed of the disease state, alleviates symptoms, can effectively reduce surgical injury to patients subjected to surgery as well as radiotherapy and chemotherapy, and can improve the immune cell activity inhibited by radiotherapy and chemotherapy.