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Lamiophlomis rotata total iridoid glycoside extract, and extracting method and application of lamiophlomis rotata total iridoid glycoside extract

A technology of total iridoid glycosides and extracts, which is applied in the unique total iridoid glycosides extract, extraction and application fields, can solve problems such as complex extraction methods, and achieve the purpose of promoting wound healing, improving expression, promoting The effect of new capillary formation

Active Publication Date: 2018-06-15
甘南百草生物科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The application number is 200410011679.0, which discloses the extraction method of total iridoid glycosides in Duyiwei, but the extraction method is complicated
However, there is no report on the use of iridoid glycosides as active ingredients in Duyiwei to rapidly promote wound healing.

Method used

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  • Lamiophlomis rotata total iridoid glycoside extract, and extracting method and application of lamiophlomis rotata total iridoid glycoside extract
  • Lamiophlomis rotata total iridoid glycoside extract, and extracting method and application of lamiophlomis rotata total iridoid glycoside extract
  • Lamiophlomis rotata total iridoid glycoside extract, and extracting method and application of lamiophlomis rotata total iridoid glycoside extract

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0023] Weigh 5KG of unique medicinal material, crush it, add water 10 times the volume of the medicinal material, decoct twice, 2 hours each time, filter and combine the filtrate, let it stand for 12 hours, take the supernatant and pass it through the treated D101 macroporous adsorption resin Adsorption, first eluted with 5 times the amount of water of the adsorption resin bed, then eluted with 40% ethanol for analysis, collected the analysis solution, recovered the solvent, concentrated at 90°C, and dried to obtain the unique total iridoid glycosides Extract.

[0024] The obtained extract takes shanzhiside methyl ester as a standard substance, and the content of total iridoid glycosides in the obtained extract is 70%-90% as determined by ultraviolet spectrophotometry.

[0025] The extract was subjected to high performance liquid chromatography (chromatographic conditions: American Agilent 1200 high performance liquid chromatography; chromatography column: RP-18; flow rate: 1....

experiment example 2

[0027] Weigh 5KG of the unique medicinal material, crush it, add 15% ethanol (V / V) 10 times the volume of the medicinal material, reflux extraction twice, each time for 2 hours, filter and combine the filtrate, recover until there is no alcohol smell, add water to the weight of the medicinal material 3 times the volume, put it aside for 12 hours, take the supernatant and absorb it through the treated HPD100 macroporous adsorption resin, first elute with 5 times the amount of water of the adsorption resin bed, and then use 45% ethanol to elute and analyze, collect the analysis solution, and recover The solvent is concentrated at a temperature of 90° C., and then dried to obtain the total cycloentheroside extract of unique taste.

[0028] The obtained extract takes shanzhiside methyl ester as a standard substance, and the content of total iridoid glycosides in the obtained extract is 70%-90% as determined by ultraviolet spectrophotometry.

[0029] The extract was detected by hig...

Embodiment 1

[0055] Example 1: Preparation of Duyiwei total iridoid glycosides tablet

[0056] Duyiwei total iridoid glycosides extract 200g, add 0.05 times that is 10g of sodium carboxymethyl starch, 0.01 times that is 2g of microcrystalline cellulose, mix well, add stearic acid that is 0.01 times the weight of the obtained mixture after drying Magnesium, and then use a punching device to compress the granules into tablets to obtain 986 tablets of unique total iridoid glycosides, each containing about 0.2 g of total iridoid glycosides extract.

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PUM

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Abstract

The invention provides a lamiophlomis rotata total iridoid glycoside extract, a pharmaceutical composition comprising the extract, and a preparation method and application of the extract. The contentof a total iridoid glycoside compound in the extract is more than or equal to 70%, wherein the contents of Phlorigidoside C, sesamoside, caryptoside methyl ester and 8-O-acetyl caryptoside methyl ester are respectively more than or equal to 10%, more than or equal to 7%, more than or equal to 10%, and more than or equal to 15%; the preparation method of the lamiophlomis rotata total iridoid glycoside extract is simple, the ingredient of the general flavone is removed without the adsorption of polyamide, the total iridoid glycoside compound is obtained by optimizing the concentration of a polarorganic solvent eluted by a macroporous resin, and the content is high. The lamiophlomis rotata total iridoid glycoside extract promotes the healing of a wound, and can be used to prepare a medicinefor promoting healing of the wound as an effective active ingredient for treating the diseases like surgical injury and accident trauma.

Description

technical field [0001] The present invention relates to an active ingredient extracted from traditional Chinese medicine and its preparation method and application, in particular to a total iridoid glycoside extract which has the effect of promoting wound healing as a raw material, and a pharmaceutical composition containing the extract As well as the preparation method and application of the extract. Background technique [0002] Trauma is a relatively common accidental injury in people's daily life. Traffic accidents, factory and mine accidents, natural disasters and surgical injuries will all bring different degrees of injury to people. At present, the methods of clinical treatment of trauma are mainly suture, debridement and anti-infection treatment measures, but there is still a lack of effective methods to accelerate wound healing and active substances that can safely and effectively stimulate wound repair. It can promote wound healing, but these substances are expens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P17/02
CPCA61K36/53A61K2236/331A61K2236/333A61K2236/55
Inventor 潘正
Owner 甘南百草生物科技开发有限公司
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