126 results about "Glycoside Compound" patented technology

The invention discloses a plant-source nutritional supplement based on glycoside compounds and a preparation method thereof, and relates to the technical field of preparation of plant-source nutritional supplements.The preparation method comprises the steps that raw materials are prepared; the preparation method comprises the following steps: respectively carrying out ultrasonic-assisted extraction on flavonoid glycoside, saponin and geniposide raw materials to obtain an extracting solution; carrying out centrifugal separation on the extracting solution, taking supernate, and then purifying by adopting a macroporous resin adsorption method to obtain a purified glycoside compound solution; mixing the purified glycoside compound solution with lycium barbarum polysaccharide, Chinese yam starch, vitamin E and other auxiliaries in proportion, and uniformly stirring to form a mixed solution; carrying out spray drying on the mixed solution to obtain a powdery nutritional supplement; and screening the powdery nutritional supplement. The high-purity plant source glycoside compound and the functional auxiliary agent are scientifically compounded, and ultrasonic extraction, resin purification and precise process control are combined, so that the integrated improvement of activity synergy, quality stability and personalized scene adaptation of the nutritional supplement is realized.

The invention discloses glycosyltransferase in safflower and a related biological material and application thereof. The invention firstly discloses any one of the following proteins: A1) a protein consisting of an amino acid sequence as shown in a sequence 2; a2) a fusion protein obtained by connecting the N end or / and C end of the protein as shown in the sequence 2 with a protein tag. The invention further discloses the protein related biological material and application thereof. The HSYA biosynthesis key glycosyl transferase gene UGT708U5 is obtained from safflower for the first time, it is proved that the protein UGT708U5 coded by the gene can catalyze phloretin to form HSYA precursor compounds, namely phloretin-mono-C-glucoside and phloretin-di-C-glucoside, and the gene plays an important role in biosynthesis and heterologous production of HSYA; the method has important theoretical and practical significance for regulating and producing the quinonechalcone C-glycoside compounds of plants and cultivating high-quality safflower carthamus.

The present invention discloses a method for extracting effective active ingredients from Buddleja buddhist flower and its application. The method comprises the following steps: first subjecting the crushed Buddleja buddhist flower to ethanol reflux extraction and concentration, and then extracting the obtained Buddleja buddhist flower alcohol extract with petroleum ether, ethyl acetate, and n-butanol respectively. The remaining aqueous phase is concentrated under reduced pressure, purified by a D101 macroporous resin column, and the target product obtained after drying is structurally identified as a verbascoside monomer compound. The method of the present invention can better control the quality standards of Buddleja buddhist flower and pave the way for a more in-depth study of its pharmacological effects by effectively separating the verbascoside compounds from the Buddleja buddhist flower, thereby laying the foundation for the clinical development of new drugs with anti-tumor, antioxidant, and immunomodulatory activities.

The present invention discloses a sesquiterpene glycoside compound and its preparation method and application. A new sesquiterpene glycoside ligulariatinside A is isolated and identified from the n-butanol extraction part of 95% ethanol extract from the root of Ligularia glossata by multiple chromatographic methods such as macroporous resin column chromatography, positive and reverse phase silica gel column chromatography and high performance liquid chromatography, as well as spectral methods. The molecular formula of the new sesquiterpene glycoside ligulariatinside A is determined to be C 21 H 34 O7, the structure is (3 S ,4 R ,5 R ,7 R )‑11‑hydroxy‑11,12‑dihydronootkatone‑11‑ O ‑ β ‑D‑glucopyranoside enriches the chemical diversity of Ligularia officinalis. Bacterial inhibition experiments revealed that the new sesquiterpenoid glycoside exhibits inhibitory activity against Vibrio anguillarum, with a minimum inhibitory concentration (MIC) of 50 μg / mL, laying the foundation for the development of new antibacterial drugs.

This invention discloses a novel chalcone gypsum glycoside compound with the structure shown in Formula I. The chalcone gypsum glycoside compound of this invention has a novel and unique structure, and for the first time, it is disclosed that this compound possesses significant hepatoprotective activity and can be used in the preparation of hepatoprotective drugs. This invention also discloses the use of the aforementioned novel chalcone gypsum glycoside compound in the preparation of hepatoprotective drugs.

The invention belongs to the technical field of medicines, and discloses preparation of a glycoside compound and application of the glycoside compound in acute kidney injury, and the structural formula of the glycoside compound K30 is shown in the specification. The K30 compound is obtained by improving the chemical structure of the glycoside compound and the corresponding preparation method, and the K30 compound can be particularly used for treating acute kidney injury.

The invention relates to a sesquiterpenoid glycoside compound in Atractylodes lancea, and a preparation method and application thereof. The invention belongs to the technical field of medicines, and relates to a method for extracting and separating a sesquiterpenoid glycoside compound (1S, 5S, 7R, 10S)-10-hydroxy-deoxy split-ring atractylodes macrocephala delta-lactone-11-O-beta-D-glucopyranoside from rhizome of Atractylodes lancea by using normal phase silica gel, reverse phase silica gel, preparative high performance liquid chromatography and other technologies. In-vitro anti-tumor activity screening experiments show that the compound has good anti-tumor activity, including obvious inhibition effects on human lung cancer cells A549, human cervical cancer cells Hela and human liver cancer cells HepG-2. Therefore, the sesquiterpenoid glycoside compound has a prospect of being developed into antitumor drugs.

The invention relates to the technical field of medicines, in particular to glycoside compounds as well as a preparation method and application thereof. The glycoside compound is selected from compounds represented by formulas (1) to (4) or medicinal salts represented by formulas (1) to (4). The glycoside compound is used for preparing the anti-inflammatory medicine. The siraitia grosvenorii extracting solution is systematically separated and purified by adopting multiple chromatographic technologies, and is subjected to structural identification, so that the inhibition effect of the separated compound on LPS-induced RAW264.7 cell NO is evaluated, and a foundation is laid for developing a novel anti-inflammatory drug and promoting high-value utilization of the resource.

The invention provides a synthesis method of a quaternary cycloalkane modified O-glucoside compound shown in formula 3, in the presence of a catalyst, a sugar compound shown in formula 1 with exposed hydroxyl and a quaternary tension ring substrate compound shown in formula 2 are subjected to nucleophilic addition reaction in an organic solvent to prepare the quaternary cycloalkane modified O-glucoside compound shown in formula 3: X is H, CF3 or Cl; a is a dioxolane type compound or a pyran type compound; the catalyst is phosphazene base P4-t-Bu, and the specific structural formula is shown in the specification.

The invention discloses a benzofuran glycoside compound as well as a separation and extraction method, a pharmaceutical composition and application thereof. The compound 1 is separated from an eupatorium chinense extract. And separating and purifying chemical components of the n-butyl alcohol part of the eupatorium chinense root to obtain the benzofuran compound. The inhibition activity of target cyclooxygenase-2 of inflammatory related diseases of all the separated compounds 1 is tested, and the compounds 1 have good inhibition activity on COX-2 enzyme and have good binding energy with target protein. In addition, the compound also has a good NLRP3-related inhibition effect, can be independently used or combined with other medicines to regulate NLRP3-related proteins, and is used for treating NLRP3-related mediated diseases and / or diseases and preparing medicines for preventing or treating the diseases or diseases. The compound 1 also has a good inhibition effect on acetylcholin esterase, and can be used for treating Alzheimer's disease, myasthenia gravis, Parkinson's disease and other diseases.

The invention relates to the technical field of medicines, in particular to a novel triterpenoid glycoside compound extracted from rosa roxburghii tratt fruits and a preparation method and application of the novel triterpenoid glycoside compound. The novel triterpenoid glycoside compound is Roxbuterene E, the molecular formula of the novel triterpenoid glycoside compound is C41H66O13, the novel triterpenoid glycoside compound is obtained by separating and purifying a rosa roxburghii tratt fruit methanol extract by adopting normal-phase silica gel column chromatography, reversed-phase ODS column chromatography and HPLC (High Performance Liquid Chromatography), and a PTP1B enzyme inhibitory activity experiment proves that the novel triterpenoid glycoside compound has potential activity for treating diabetes. And technical support is provided for research and development of novel diabetes treatment drugs.

The invention discloses an application of a composition of isoliquiritigenin (glycoside), licochalcone and ethnic groups thereof in personal care products, and relates to the technical field of daily chemicals, and the composition is an anti-allergy soothing composition prepared based on a natural plant licorice extract isoliquiritigenin or a glycoside compound isoliquiritigenin thereof, licochalcone A and ethnic groups of licochalcone B, C, D, E and G. The traditional Chinese medicine composition has multiple functions of resisting allergy, relieving, resisting bacteria, diminishing inflammation, improving skin itch and stabbing pain and the like, does not contain hormones and antibiotics, has no toxic or side effect, is mild in effect and non-irritant to skin, can be used for treating skin allergy, red and swollen skin, itch and stabbing pain caused by various reasons, is applied to cosmetics and skin care products, such as gel, cream, masks and facial cleansers, and can be used for treating skin allergy, red and swollen skin, pruritus and stabbing pain caused by various reasons. The skin care product is mild to human bodies, safe and non-irritant, is suitable for sensitive skin, is suitable for people of all ages to use, has strong market competitiveness, and has relatively high economic and social benefits and the like.

The inventive technology described herein includes systems, methods, and compositions for the upregulation of Uridine diphosphate glucose (UDPG) recycling in a yeast cell, by expressing a heterologous nucleotide sequence, operably linked to a promoter, encoding a phosphoglucomutase enzyme which catalyzes the conversion from glucose-6-phosphate to glucose- 1 -phosphate, and a UDP-glucose pyrophosphorylase enzyme which catalyzes the formation of UDPG from glucose 1 -phosphate and UTP. The increased levels of UDPG substrate produced by the yeast cell may be used as a substrate for a co-expressed UDP -glycosyltransferases enzyme capable of generating cannabinoid glycoside compounds.

The invention belongs to the technical field of desulfurizer preparation and flue gas purification treatment, and particularly relates to a calcium-based desulfurizer, a preparation method thereof and application of the calcium-based desulfurizer in high-concentration carbon dioxide flue gas. The preparation method of the calcium-based desulfurizing agent comprises the following steps: mixing quick lime, a first modifier, a second modifier and water, performing digestion reaction in a reactor, and drying the obtained reaction mixture to obtain the calcium-based desulfurizing agent, the first modifier is N-acyl amino acid salt formed by amino acid and derivatives thereof and C8-C18 alkyl chains through amido bonds; the second modifier is an alkyl glycoside compound. The key point of the invention is that two specific modifiers, namely N-acylamino acid salt and alkyl glycoside compounds, are introduced in the process of preparing calcium hydroxide by adopting a digestion process, so that the prepared calcium-based desulfurizing agent has high desulfurization efficiency in desulfurization treatment of flue gas containing high-concentration carbon dioxide.

The invention provides a rehmannia pigment compound as shown in a formula (I), a stereoisomer thereof or pharmaceutically acceptable salt thereof, and particularly relates to the technical field of natural pharmaceutical chemistry and pharmaceutical compounds. The invention aims to solve the problems that the radix rehmanniae pigment is not clear in material basis and lacks a compound with a clear structure and excellent anti-inflammatory activity. The rehmannia pigment compound disclosed by the invention comprises a structure as shown in a formula (I). The invention also discloses a preparation method of the compound and application of the compound in medicines. The compound has a novel chemical structure and remarkable anti-inflammatory activity, release of nitric oxide can be effectively inhibited in a lipopolysaccharide induced macrophage model, the cytotoxicity is far lower than that of a positive control drug quercetin, and the compound shows huge potential as an anti-inflammatory drug lead compound.

The invention relates to a water-soluble composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products. The water-soluble composition disclosed by the invention is prepared from the following components in parts by weight: 2 to 6 parts of paeonol glycoside extract, 0.02 to 0.1 part of licochalcone A, 0.02 to 0.12 part of solubilizer and 0.94 to 4.87 parts of water. According to the water-soluble composition, solubilization is assisted by the paeonol glycoside compound, the addition amount of a solubilizer is greatly reduced, the irritation of the solubilizer is remarkably reduced, and the composition is safe and free of irritation. The water-soluble composition disclosed by the invention can be widely applied to cosmetics such as emulsion and face cream, is particularly suitable for a water agent formula, and can be used for remarkably improving the transparency of a product. Through the synergistic effect of the components, the composition disclosed by the invention has the effects of high transdermal property, efficient moisture retention, immediate soothing and red fading and tissue repair promotion. Meanwhile, the water-soluble composition disclosed by the invention is simple in preparation method, economical and feasible, and wide in market prospect.

The application discloses a selenoglycoside compound and a synthesis method, and aims at a series of technical defects in the existing selenoglycoside synthesis technology, such as high reagent toxicity, strong irritability, poor stability, harsh reaction conditions, complicated operation, insufficient stereoselectivity, poor substrate universality and difficulty in industrial application, and provides a green and efficient selenoglycoside compound synthesis method with strong universality, which has remarkable beneficial technical effects. The core reaction substrate adopted in the application is a glycosyl selenosulfonate and a (hetero) aryl boronic acid, both of which are conventional reagents easy to obtain, have no irritating odor, and have excellent chemical stability and environmental tolerance, thereby avoiding the use of high-toxicity, high-irritability and low-stability reagents such as diselenide, selenol and glycosyl stannane in the traditional synthesis process from the source, greatly reducing the safety control cost and three-waste treatment pressure in the synthesis process, and meeting the development requirements of green chemistry.

The application discloses a preparation method and application of a new glycoside component in Metaplexis japonica, and the compound is separated from a Metaplexis japonica extract. The Metaplexis japonica root extract is separated by using extraction, macroporous adsorption resin impurity removal, HW-40F gel column chromatography and high performance liquid chromatography, and a new glycoside compound is obtained. The inhibitory activity of the separated compound on diabetes related target alpha-glucosidase and protein tyrosine phosphatase 1B (PTP1B) is tested, and the experimental results show that the compound has good inhibitory activity on the two enzymes, and molecular docking experiments also show that the compound has good binding energy with the two target proteins alpha-glucosidase and protein tyrosine phosphatase 1B. Therefore, the compound can be used for preparing medicines for preventing, delaying or treating diseases mediated by alpha-glucosidase or PTP1B, in particular, type II diabetes and obesity, or as a lead compound of the medicines.

This invention discloses a self-thickening, moisturizing, and oil-controlling gentle facial cleanser and its preparation method, belonging to the field of cosmetic technology. The raw materials are composed of the following percentages by weight: rhamnolipin 2%~8%, alkyl glycoside 5%~15%, cationic polymer 0.1%~1.5%, moisturizer 2%~6%, plant extract 0.5%~3%, pH adjuster (the amount needed to adjust the system pH to 5.0~7.0), preservative 0.1%~1.0%, and water as the balance. Through the ternary system of rhamnolipin-alkyl glycoside-cationic polymer, self-thickening and foam stability are achieved through electrostatic interaction and steric hindrance synergy, without relying on traditional thickeners such as carbomer. Simultaneously, it possesses excellent moisturizing and oil-controlling properties, with an oil removal rate ≥89%, a skin moisture content increase of ≥15% after 4 hours of use, and an oil secretion inhibition rate of ≥20% after 4 hours, with extremely low irritation. This invention solves the technical problem of low viscosity and poor foam performance in the rhamnolipin and alkyl glycoside compound system.

The application discloses a coumarin tyramine glycoside compound and application thereof in preparation of PTP1B inhibitors and anti-diabetic drugs, and a structural formula of the compound is shown in the following formula: wherein R represents a fatty (aromatic) acyl or a monosaccharide substituent, and R' represents a hydrogen atom or an acetyl group; the compound is prepared by taking 4-methoxycoumarin tyramine 4'-acetyl-O-L-rhamnose as a starting material, introducing a fatty (aromatic) acyl or a monosaccharide substituent into a 2-position hydroxyl and a 3-position hydroxyl of L-rhamnose at the same time, and then removing a protecting group of a sugar group. Pharmacological activity tests show that the compound has good inhibitory activity on protein tyrosine phosphatase 1B, and it is indicated that the coumarin tyramine glycoside compound can be researched and utilized as a new type of PTP1B inhibitor and anti-diabetic drug.

The application discloses a composition containing sesame lignan compounds and application thereof, and selects at least one of sesame lignan or similar compounds, glycoside compounds as a main active ingredient, so that the obtained composition can significantly improve physiological activities in the aspects of controlling fat in vivo, regulating intestinal flora, maintaining blood fat, blood sugar, blood pressure, protecting liver, controlling appetite, antioxidation and anti-aging, etc. Compared with single components, two or more than two compound combinations have a better synergistic effect. Meanwhile, the components in the composition are pure natural plant food raw materials, and have no toxic side effects. Therefore, the composition has a good application prospect.

The present invention relates to the technical field of steviol glycoside compounds, and provides a steviol glycoside composition, a preparation method, and a food. The composition comprises component one and component two, wherein component one is Reb D or Reb M, and component two is Reb I; the mass concentration of Reb D is less than 1%, and the mass ratio of Reb D to Reb I is (1-40):(1-10); the mass concentration of Reb M is 0.038-1.5%, and the mass ratio of Reb M to Reb I is (0.75-19):1. The present invention does not require complex processes or the addition of other substances, but only utilizes the structural and solubility differences between steviol glycoside compounds to improve the solubility of Reb D or Reb M and maintain dissolution stability for a sufficiently long time, while also meeting taste requirements.

The invention discloses a benzylisoquinoline alkaloid glycoside compound as well as a preparation method and application thereof. The preparation method comprises the following steps: soaking tubers of rhizoma corydalis in a 6% acetic acid solution, crushing, soaking in water, and carrying out ultrasonic extraction to obtain a plant extract; after water dispersion, carrying out HPD100 type macroporous resin column chromatography separation, carrying out gradient elution by using ethanol aqueous solutions with different concentrations, and collecting a 50% ethanol elution part to obtain an elution part YH-D; carrying out MCI column chromatography separation, and carrying out gradient elution by using a 0-100% methanol-water solution to obtain four parts of eluents; the preparation method comprises the following steps: dissolving YH-D-2 in water, filtering, and carrying out medium-pressure ODS column chromatography separation, Sephadex LH-20 column chromatography separation, medium-pressure ODS column chromatography separation and semi-preparative C18 column HPLC (High Performance Liquid Chromatography) purification on the filtrate to obtain six new compounds 1-6. In-vitro experiments prove that the elution part YH-D-2 containing benzylisoquinoline alkaloid glycoside of the benzylisoquinoline alkaloid glycoside compounds 1-6 has NO generation inhibition activity, and has a good development prospect as an anti-inflammatory drug.

This invention belongs to the field of pharmaceutical technology and relates to eight glycoside compounds extracted and isolated from the dried leaves of *Picrasma quassioides* Benn, a plant belonging to the genus *Picrasma* in the family Simaroubaceae. The compounds were obtained using chromatographic methods including silica gel chromatography, HP20 column chromatography, ODS column chromatography, and HPLC. This invention also relates to the acetylcholinesterase inhibitory activity of compounds 1-8 and their pharmaceutical uses. The preparation method of this invention is simple, reproducible, and of high purity.

The present invention discloses an oleanane-type triazole glycoside compound and its application in the preparation of PTP1B inhibitors and anti-diabetic drugs. The structural formula of the compound is: wherein R represents a saccharide group, which is oleanolic acid C 28 The oleanane-type triazole glycoside is prepared by converting the 3-hydroxyl group of methyl n-aminohexanoate into a 4-pentynyl ester as the starting material, followed by a click reaction with an azidosugar compound to introduce different sugar units. Pharmacological activity tests have shown that the oleanane-type triazole glycoside has excellent inhibitory activity against protein tyrosine phosphatase 1B and can be studied and utilized as a novel PTP1B inhibitor and antidiabetic drug.

The application discloses sulfonated modified metal organic framework material and a preparation method thereof and application of the sulfonated modified metal organic framework material in yield increase of aryl glycoside compounds, wherein the sulfonated modified metal organic framework material is prepared by taking a zirconium-based MOF material Zr-BTB as a precursor and reacting with 1,2 ethanedithoic acid. The prepared sZr-BTB can be fixed on the surface of Yarrowia lipolytica by the principle of physical adsorption, so as to form a dense protective film, so that the relatively large molecular glycosidase is limited in the cell and cannot be secreted, the efflux of the small molecular aryl glycoside compound is not affected, the decomposition of the main biosynthesis product is avoided, meanwhile, the stable adsorption with Yarrowia lipolytica can be maintained under strong acidic conditions, the yield of the fermentation production of the aryl glycoside compound is improved, and the hindering of the non-model microorganism is solved, and the low-cost industrialization of the biosynthesis is promoted.

A purpose of the present invention is to provide a method for producing a glycoside compound having a high purity. The present invention provides a method for producing a glycoside compound represented by formula (3) (wherein Ba, i-Pr and n are the same as those defined below), which comprises reacting a glycoside compound of formula (1) (wherein Ba represents an adenine group which may be optionally substituted with an acyl group, and i-Pr represents an isopropyl group) with an ether compound of formula (2) (wherein R1 represents a C1-C6 alkyl group or a phenyl group, and n is 0 or 1) in one or more solvents selected from tetrahydropyran and 4-methyltetrahydropyran in the presence of one or more halogenated agents selected from halogen, N-halogenated succinimide, and N-halogenated hydantoin.

The present invention belongs to the technical field of extraction, separation and purification of plant components, and specifically relates to passion fruit megastigmane glycoside compounds, their preparation methods, and applications. The passion fruit megastigmane glycoside compounds provided by the present invention are derived from passion fruit juice and are natural plant secondary metabolites. These disaccharide compounds, formed by linking a C13 norsesquiterpene aglycone to glucose and rhamnose via an oxyglycosidic bond, represent a novel class of compounds with broad application prospects in anti-anxiety, sedative-hypnotic, or flavor-enhancing products.

A sesquiterpene acyl glycoside in rhizoma artemisiae japonicae and preparation method and application thereof. The present application belongs to the technical field of medicine, and relates to extraction and separation of a sesquiterpene acyl glycoside compound rhizoma artemisiae japonicae cembranoid I from rhizome of rhizoma artemisiae japonicae by using macroporous resin, silica gel and preparation chromatography and the like, and the preparation method is simple and easy to implement. 23 H 38 O 10 In vitro human cancer cell inhibition activity research shows that the compound has anticancer activity, including obvious inhibition on human colon cancer cells HT-29 and human breast cancer MCF-7 cells, and is expected to be developed into a new anticancer drug.

The invention relates to a high-absorptivity glycoside compound synergistic water-soluble fertilizer and a preparation method thereof. The water-soluble fertilizer comprises the following components in parts by weight: a nitrogen source, a phosphorus source, a potassium source, chelated trace elements, a water-soluble organic matter, an auxiliary agent, a structure stabilizer and an absorption promoting component, the absorption promoting component is composed of a cyclodextrin inclusion glycoside compound, sodium alginate oligosaccharide and sodium polyaspartate, and the structure stabilizer is chitosan quaternary ammonium salt. The glycoside compound is clathrated by cyclodextrin, so that the stability and the availability of the glycoside compound in a water-soluble system are improved, and the polysaccharide oligomer and the polyamino acid substance are combined to synergistically promote root system absorption and in-vivo transport. Through step-by-step preparation of the absorption promotion mother liquor and the nutritive salt mother liquor and compounding modulation, uniform dispersion of the components and stability of the system are realized. Test results show that the water-soluble fertilizer can improve the accumulation level of glycoside targets in plants and synchronously promote mineral nutrition absorption and yield and quality improvement, and is suitable for water-fertilizer integrated application of various crops.