81 results about "Glycoside Compound" patented technology

The invention belongs to the technical field of medicines, and discloses preparation of a glycoside compound and application of the glycoside compound in acute kidney injury, and the structural formula of the glycoside compound K30 is shown in the specification. The K30 compound is obtained by improving the chemical structure of the glycoside compound and the corresponding preparation method, and the K30 compound can be particularly used for treating acute kidney injury.

The invention relates to the technical field of medicines, in particular to glycoside compounds as well as a preparation method and application thereof. The glycoside compound is selected from compounds represented by formulas (1) to (4) or medicinal salts represented by formulas (1) to (4). The glycoside compound is used for preparing the anti-inflammatory medicine. The siraitia grosvenorii extracting solution is systematically separated and purified by adopting multiple chromatographic technologies, and is subjected to structural identification, so that the inhibition effect of the separated compound on LPS-induced RAW264.7 cell NO is evaluated, and a foundation is laid for developing a novel anti-inflammatory drug and promoting high-value utilization of the resource.

The invention provides a synthesis method of a quaternary cycloalkane modified O-glucoside compound shown in formula 3, in the presence of a catalyst, a sugar compound shown in formula 1 with exposed hydroxyl and a quaternary tension ring substrate compound shown in formula 2 are subjected to nucleophilic addition reaction in an organic solvent to prepare the quaternary cycloalkane modified O-glucoside compound shown in formula 3: X is H, CF3 or Cl; a is a dioxolane type compound or a pyran type compound; the catalyst is phosphazene base P4-t-Bu, and the specific structural formula is shown in the specification.

The invention discloses a benzofuran glycoside compound as well as a separation and extraction method, a pharmaceutical composition and application thereof. The compound 1 is separated from an eupatorium chinense extract. And separating and purifying chemical components of the n-butyl alcohol part of the eupatorium chinense root to obtain the benzofuran compound. The inhibition activity of target cyclooxygenase-2 of inflammatory related diseases of all the separated compounds 1 is tested, and the compounds 1 have good inhibition activity on COX-2 enzyme and have good binding energy with target protein. In addition, the compound also has a good NLRP3-related inhibition effect, can be independently used or combined with other medicines to regulate NLRP3-related proteins, and is used for treating NLRP3-related mediated diseases and / or diseases and preparing medicines for preventing or treating the diseases or diseases. The compound 1 also has a good inhibition effect on acetylcholin esterase, and can be used for treating Alzheimer's disease, myasthenia gravis, Parkinson's disease and other diseases.

The invention relates to the technical field of medicines, in particular to a novel triterpenoid glycoside compound extracted from rosa roxburghii tratt fruits and a preparation method and application of the novel triterpenoid glycoside compound. The novel triterpenoid glycoside compound is Roxbuterene E, the molecular formula of the novel triterpenoid glycoside compound is C41H66O13, the novel triterpenoid glycoside compound is obtained by separating and purifying a rosa roxburghii tratt fruit methanol extract by adopting normal-phase silica gel column chromatography, reversed-phase ODS column chromatography and HPLC (High Performance Liquid Chromatography), and a PTP1B enzyme inhibitory activity experiment proves that the novel triterpenoid glycoside compound has potential activity for treating diabetes. And technical support is provided for research and development of novel diabetes treatment drugs.

The inventive technology described herein includes systems, methods, and compositions for the upregulation of Uridine diphosphate glucose (UDPG) recycling in a yeast cell, by expressing a heterologous nucleotide sequence, operably linked to a promoter, encoding a phosphoglucomutase enzyme which catalyzes the conversion from glucose-6-phosphate to glucose- 1 -phosphate, and a UDP-glucose pyrophosphorylase enzyme which catalyzes the formation of UDPG from glucose 1 -phosphate and UTP. The increased levels of UDPG substrate produced by the yeast cell may be used as a substrate for a co-expressed UDP -glycosyltransferases enzyme capable of generating cannabinoid glycoside compounds.

The invention belongs to the technical field of desulfurizer preparation and flue gas purification treatment, and particularly relates to a calcium-based desulfurizer, a preparation method thereof and application of the calcium-based desulfurizer in high-concentration carbon dioxide flue gas. The preparation method of the calcium-based desulfurizing agent comprises the following steps: mixing quick lime, a first modifier, a second modifier and water, performing digestion reaction in a reactor, and drying the obtained reaction mixture to obtain the calcium-based desulfurizing agent, the first modifier is N-acyl amino acid salt formed by amino acid and derivatives thereof and C8-C18 alkyl chains through amido bonds; the second modifier is an alkyl glycoside compound. The key point of the invention is that two specific modifiers, namely N-acylamino acid salt and alkyl glycoside compounds, are introduced in the process of preparing calcium hydroxide by adopting a digestion process, so that the prepared calcium-based desulfurizing agent has high desulfurization efficiency in desulfurization treatment of flue gas containing high-concentration carbon dioxide.

The invention provides a rehmannia pigment compound as shown in a formula (I), a stereoisomer thereof or pharmaceutically acceptable salt thereof, and particularly relates to the technical field of natural pharmaceutical chemistry and pharmaceutical compounds. The invention aims to solve the problems that the radix rehmanniae pigment is not clear in material basis and lacks a compound with a clear structure and excellent anti-inflammatory activity. The rehmannia pigment compound disclosed by the invention comprises a structure as shown in a formula (I). The invention also discloses a preparation method of the compound and application of the compound in medicines. The compound has a novel chemical structure and remarkable anti-inflammatory activity, release of nitric oxide can be effectively inhibited in a lipopolysaccharide induced macrophage model, the cytotoxicity is far lower than that of a positive control drug quercetin, and the compound shows huge potential as an anti-inflammatory drug lead compound.

The application discloses a selenoglycoside compound and a synthesis method, and aims at a series of technical defects in the existing selenoglycoside synthesis technology, such as high reagent toxicity, strong irritability, poor stability, harsh reaction conditions, complicated operation, insufficient stereoselectivity, poor substrate universality and difficulty in industrial application, and provides a green and efficient selenoglycoside compound synthesis method with strong universality, which has remarkable beneficial technical effects. The core reaction substrate adopted in the application is a glycosyl selenosulfonate and a (hetero) aryl boronic acid, both of which are conventional reagents easy to obtain, have no irritating odor, and have excellent chemical stability and environmental tolerance, thereby avoiding the use of high-toxicity, high-irritability and low-stability reagents such as diselenide, selenol and glycosyl stannane in the traditional synthesis process from the source, greatly reducing the safety control cost and three-waste treatment pressure in the synthesis process, and meeting the development requirements of green chemistry.

The application discloses a preparation method and application of a new glycoside component in Metaplexis japonica, and the compound is separated from a Metaplexis japonica extract. The Metaplexis japonica root extract is separated by using extraction, macroporous adsorption resin impurity removal, HW-40F gel column chromatography and high performance liquid chromatography, and a new glycoside compound is obtained. The inhibitory activity of the separated compound on diabetes related target alpha-glucosidase and protein tyrosine phosphatase 1B (PTP1B) is tested, and the experimental results show that the compound has good inhibitory activity on the two enzymes, and molecular docking experiments also show that the compound has good binding energy with the two target proteins alpha-glucosidase and protein tyrosine phosphatase 1B. Therefore, the compound can be used for preparing medicines for preventing, delaying or treating diseases mediated by alpha-glucosidase or PTP1B, in particular, type II diabetes and obesity, or as a lead compound of the medicines.

This invention discloses a self-thickening, moisturizing, and oil-controlling gentle facial cleanser and its preparation method, belonging to the field of cosmetic technology. The raw materials are composed of the following percentages by weight: rhamnolipin 2%~8%, alkyl glycoside 5%~15%, cationic polymer 0.1%~1.5%, moisturizer 2%~6%, plant extract 0.5%~3%, pH adjuster (the amount needed to adjust the system pH to 5.0~7.0), preservative 0.1%~1.0%, and water as the balance. Through the ternary system of rhamnolipin-alkyl glycoside-cationic polymer, self-thickening and foam stability are achieved through electrostatic interaction and steric hindrance synergy, without relying on traditional thickeners such as carbomer. Simultaneously, it possesses excellent moisturizing and oil-controlling properties, with an oil removal rate ≥89%, a skin moisture content increase of ≥15% after 4 hours of use, and an oil secretion inhibition rate of ≥20% after 4 hours, with extremely low irritation. This invention solves the technical problem of low viscosity and poor foam performance in the rhamnolipin and alkyl glycoside compound system.

The application discloses a coumarin tyramine glycoside compound and application thereof in preparation of PTP1B inhibitors and anti-diabetic drugs, and a structural formula of the compound is shown in the following formula: wherein R represents a fatty (aromatic) acyl or a monosaccharide substituent, and R' represents a hydrogen atom or an acetyl group; the compound is prepared by taking 4-methoxycoumarin tyramine 4'-acetyl-O-L-rhamnose as a starting material, introducing a fatty (aromatic) acyl or a monosaccharide substituent into a 2-position hydroxyl and a 3-position hydroxyl of L-rhamnose at the same time, and then removing a protecting group of a sugar group. Pharmacological activity tests show that the compound has good inhibitory activity on protein tyrosine phosphatase 1B, and it is indicated that the coumarin tyramine glycoside compound can be researched and utilized as a new type of PTP1B inhibitor and anti-diabetic drug.

The application discloses a composition containing sesame lignan compounds and application thereof, and selects at least one of sesame lignan or similar compounds, glycoside compounds as a main active ingredient, so that the obtained composition can significantly improve physiological activities in the aspects of controlling fat in vivo, regulating intestinal flora, maintaining blood fat, blood sugar, blood pressure, protecting liver, controlling appetite, antioxidation and anti-aging, etc. Compared with single components, two or more than two compound combinations have a better synergistic effect. Meanwhile, the components in the composition are pure natural plant food raw materials, and have no toxic side effects. Therefore, the composition has a good application prospect.

The invention discloses a benzylisoquinoline alkaloid glycoside compound as well as a preparation method and application thereof. The preparation method comprises the following steps: soaking tubers of rhizoma corydalis in a 6% acetic acid solution, crushing, soaking in water, and carrying out ultrasonic extraction to obtain a plant extract; after water dispersion, carrying out HPD100 type macroporous resin column chromatography separation, carrying out gradient elution by using ethanol aqueous solutions with different concentrations, and collecting a 50% ethanol elution part to obtain an elution part YH-D; carrying out MCI column chromatography separation, and carrying out gradient elution by using a 0-100% methanol-water solution to obtain four parts of eluents; the preparation method comprises the following steps: dissolving YH-D-2 in water, filtering, and carrying out medium-pressure ODS column chromatography separation, Sephadex LH-20 column chromatography separation, medium-pressure ODS column chromatography separation and semi-preparative C18 column HPLC (High Performance Liquid Chromatography) purification on the filtrate to obtain six new compounds 1-6. In-vitro experiments prove that the elution part YH-D-2 containing benzylisoquinoline alkaloid glycoside of the benzylisoquinoline alkaloid glycoside compounds 1-6 has NO generation inhibition activity, and has a good development prospect as an anti-inflammatory drug.

This invention belongs to the field of pharmaceutical technology and relates to eight glycoside compounds extracted and isolated from the dried leaves of *Picrasma quassioides* Benn, a plant belonging to the genus *Picrasma* in the family Simaroubaceae. The compounds were obtained using chromatographic methods including silica gel chromatography, HP20 column chromatography, ODS column chromatography, and HPLC. This invention also relates to the acetylcholinesterase inhibitory activity of compounds 1-8 and their pharmaceutical uses. The preparation method of this invention is simple, reproducible, and of high purity.

A purpose of the present invention is to provide a method for producing a glycoside compound having a high purity. The present invention provides a method for producing a glycoside compound represented by formula (3) (wherein Ba, i-Pr and n are the same as those defined below), which comprises reacting a glycoside compound of formula (1) (wherein Ba represents an adenine group which may be optionally substituted with an acyl group, and i-Pr represents an isopropyl group) with an ether compound of formula (2) (wherein R1 represents a C1-C6 alkyl group or a phenyl group, and n is 0 or 1) in one or more solvents selected from tetrahydropyran and 4-methyltetrahydropyran in the presence of one or more halogenated agents selected from halogen, N-halogenated succinimide, and N-halogenated hydantoin.

A sesquiterpene acyl glycoside in rhizoma artemisiae japonicae and preparation method and application thereof. The present application belongs to the technical field of medicine, and relates to extraction and separation of a sesquiterpene acyl glycoside compound rhizoma artemisiae japonicae cembranoid I from rhizome of rhizoma artemisiae japonicae by using macroporous resin, silica gel and preparation chromatography and the like, and the preparation method is simple and easy to implement. 23 H 38 O 10 In vitro human cancer cell inhibition activity research shows that the compound has anticancer activity, including obvious inhibition on human colon cancer cells HT-29 and human breast cancer MCF-7 cells, and is expected to be developed into a new anticancer drug.

The invention relates to a high-absorptivity glycoside compound synergistic water-soluble fertilizer and a preparation method thereof. The water-soluble fertilizer comprises the following components in parts by weight: a nitrogen source, a phosphorus source, a potassium source, chelated trace elements, a water-soluble organic matter, an auxiliary agent, a structure stabilizer and an absorption promoting component, the absorption promoting component is composed of a cyclodextrin inclusion glycoside compound, sodium alginate oligosaccharide and sodium polyaspartate, and the structure stabilizer is chitosan quaternary ammonium salt. The glycoside compound is clathrated by cyclodextrin, so that the stability and the availability of the glycoside compound in a water-soluble system are improved, and the polysaccharide oligomer and the polyamino acid substance are combined to synergistically promote root system absorption and in-vivo transport. Through step-by-step preparation of the absorption promotion mother liquor and the nutritive salt mother liquor and compounding modulation, uniform dispersion of the components and stability of the system are realized. Test results show that the water-soluble fertilizer can improve the accumulation level of glycoside targets in plants and synchronously promote mineral nutrition absorption and yield and quality improvement, and is suitable for water-fertilizer integrated application of various crops.

The invention belongs to the technical field of medicinal chemistry and pharmacology, and discloses a diphyllin amide derivative as well as a preparation method and application thereof. The diphyllin thioether derivative has a structure as shown in the following formula, wherein R represents one of phenyl, 3-fluorophenyl, 2-thienyl, 2-pyrrolyl and tert-butyl. The diphyllin amide derivative disclosed by the invention is a diphyllin amide derivative with a non-glycoside structure, does not contain structures such as glycosidic bonds and double bonds which are easy to hydrolyze in vivo, has the metabolic stability superior to that of glycoside compounds, has relatively strong tumor cell proliferation inhibition activity, and can be applied to preparation of medicines for treating cancers such as liver cancer, colorectal adenocarcinoma and lung cancer.

The invention discloses a method for synthesizing C-alkyl glycoside from sugar ester through a one-pot method. According to the method, sugar ester is used as a raw material, a halogenated sugar intermediate is generated in situ under the condition of a catalytic amount of iodine and trimethyl halogenosilane, then separation is not needed, the halogenated sugar intermediate and active olefin are directly subjected to a free radical addition reaction in the presence of a reducing agent zinc-copper couple, and the C-alkyl glycoside compound is efficiently obtained with high stereoselectivity. The method realizes one-pot series synthesis from sugar ester to C-alkyl glycoside, and has the advantages of cheap and easily available raw materials, simple operation, good reaction yield, short reaction time, good stereoselectivity and the like.

The application belongs to the technical field of medicine, and relates to extraction and separation of a guaiane sesquiterpene glycoside compound guaiane sesquiterpene glycoside II from rhizome of rabdosia japonica by using macroporous resin, normal-phase silica gel, reverse-phase silica gel and dextran gel column chromatography and recrystallization and the like. 21 H 36 O8, in-vitro anti-tumor activity research shows that the compound has good anti-tumor activity, including obvious inhibition on human gastric cancer cells BGC-823, human hepatoma cells HepG-2 and human lung cancer cells A549. The application can provide a source of pharmacodynamic material basis for development of anti-tumor drugs, and has development and application prospects.

The application discloses a benzofuran glycoside compound, a separation and extraction method thereof, a pharmaceutical composition and application, and the compound 1 is separated from a macleaya cordata extract. A benzofuran compound is obtained by separating and purifying a n-butanol part chemical component of a macleaya cordata root. The inhibitory activity of all separated compounds 1 on a target point cyclooxygenase-2 of an inflammatory related disease is tested, the compound 1 has good inhibitory activity on COX-2 enzyme, and the compound 1 has better binding energy with the target point protein. The compound also has good NLRP3 related inhibitory effect, can be used alone or in combination with other drugs to regulate NLRP3 related proteins, is used for treating NLRP3 related mediated diseases and / or diseases, and is used for preparing drugs for preventing or treating the diseases. The compound 1 also has better inhibitory effect on acetylcholinesterase, and can be used for treating diseases such as Alzheimer's disease, myasthenia gravis and Parkinson's disease.

The invention discloses a coumarin and lignan glycoside compound separated from passiflora foetida and an anti-RA application of the coumarin and lignan glycoside compound. The structure of the coumarin-lignan glycoside compound is shown as a formula I in the specification. According to the invention, 75-95% ethanol is adopted to carry out heating reflux extraction on the phoenix tibetan, and a biological activity tracking separation method is utilized to carry out directional separation and purification on an anti-RA active part of the phoenix tibetan, so that the novel coumarin-lignan glycoside compound is separated from the anti-RA active part of the phoenix tibetan. The coumarin and lignan glycoside compound is novel and unique in structure, the preparation method is simple and easy to operate, and the coumarin and lignan glycoside compound has remarkable anti-RA activity and can be used for preparing anti-RA drugs. The invention also discloses an application of the coumarin and lignan glycoside compound in preparation of a medicine for treating rheumatoid arthritis.

The application discloses a kind of synergistic lycium barbarum polysaccharide-glycoside composite nutritional supplement and preparation method thereof, belong to food nutritional supplement preparation technical field.New fresh Ningxia wolfberry is used as raw material, high-activity lycium barbarum polysaccharide is obtained by enzyme hydrolysis-ultrasonic synergistic extraction, fractional ultrafiltration purification, and target group and crosslinking site are introduced by "click chemistry" strategy;Ginkgo biloba flavonoid glycoside, astragalus saponin and gardenia jasminoides glycoside with specific active conformation are selected, and after being directionally modified by enzyme method, site-specific coupling is carried out with modified lycium barbarum polysaccharide, forming "polysaccharide-glycoside" target coupling compound;After compounding intestinal adhesion type adjuvant and antioxidant protective agent, the finished product is prepared after low-temperature vacuum spray granulation and target modification.The application realizes the double breakthrough of targeted delivery and synergistic effect, the intestinal target enrichment rate is increased by more than 60%, the bioavailability of active ingredient is 90%, the activity retention rate is more than 98% after 6 months of storage, and the antioxidant and immunomodulatory functions are increased by about 2 times compared with traditional products.

Disclosed in the present invention are a sulfonation-modified metal organic framework material, a preparation method therefor, and the use thereof in the yield increase of aryl glycoside compounds. The sulfonation-modified metal organic framework material reacts with 1,2-ethanedisulfonic acid by taking a zirconium-based MOF material Zr-BTB as a precursor, so as to perform sulfonation modification. The sZr-BTB prepared in the present invention can enable a material to be fixed on the surface of Yarrowia lipolytica by means of a physical adsorption principle, so as to form a layer of a compact protective film, such that relatively macromolecular glycosidase is confined in cells and cannot be secreted, and the excretion of small-molecular aryl glycoside compounds is not influenced. The biosynthetic main product is prevented from being decomposed, and stable adsorption on Yarrowia lipolytica can also be maintained under strongly acidic conditions, which is beneficial for improving the yield of aryl glycoside compounds produced by means of fermentation, thereby breaking through non-pattern microorganism obstacles and advancing the low-cost industrialization of biosynthesis.

The invention discloses arecoline type triazole glycoside compounds and application thereof in preparation of weight-reducing drugs, the structural formula of the compounds is as follows: in the formula, R represents glycosyl, arecoline is used as a starting raw material, methyl is removed from carboxylic acid methyl ester group or N-methyl group, then the carboxylic acid methyl ester group or N-methyl group is converted into propyne, and the propyne is converted into propargyl; and carrying out a click reaction with an azido sugar compound to introduce different sugar units. Pharmacological activity tests show that the compound has good inhibitory activity on lipase, which indicates that the arecoline type triazole glycoside compound can be used as a novel weight-reducing drug for research and utilization.

The invention belongs to the technical field of medicines, and particularly relates to a naphthol glycoside compound walnut naphthol glycoside I extracted and separated from cortex juglandis mandshuricae as well as a preparation method and application thereof. The preparation method specifically comprises the following steps: firstly, taking juglans regia powder, adding 70% ethanol, heating, refluxing and extracting, filtering, adding 10% (W / V) CaCl2 powder into an extracting solution, fully stirring, standing, recovering ethanol from supernate to obtain a concentrated extract, dispersing with water, respectively extracting with dichloromethane and n-butyl alcohol for five times, respectively taking an n-butyl alcohol layer, and drying to obtain the juglans regia extract. According to the preparation method provided by the invention, efficient enrichment and separation of the target object are realized only through the processes of salting-out impurity removal, solvent extraction, reversed-phase column chromatography separation and recrystallization, the steps are simple, and the operation is easy; meanwhile, in-vitro activity experiment research shows that the juglans regia naphthol glycoside provided by the invention has good resistance to gastric ulcer injury caused by ethanol, provides a valuable drug effect substance for developing novel anti-gastric ulcer drugs in the future, and has a wide application prospect.

The application provides a sesquiterpene dimer compound, a preparation method and application, and belongs to the field of medical biotechnology. The sesquiterpene dimer compound is extracted and separated from a Lemnalia soft coral to obtain a sesquiterpene dimer compound lemnalinoid L. The sesquiterpene dimer compound lemnalinoid L has an antitumor effect, has inhibitory activity on a human breast cancer cell line MDA-MB-231, can be used for developing a candidate molecule for treating the disease, and can be used as a lead compound for chemical synthesis and structural modification of other drugs. The preparation method is simple and fast, and the extracted new diterpene glycoside compound has high purity.

This invention discloses a method for preparing microencapsulated glycoside compound nutritional supplements, belonging to the field of food nutritional supplement preparation technology. The invention first involves enzymatic hydrolysis-ultrasonic co-extraction of glycoside raw materials followed by purification with modified macroporous resin. Then, the purified glycoside solution is grafted onto a composite encapsulation material to prepare a modified composite encapsulation material emulsion. A core-shell microcapsule precursor emulsion is constructed using microfluidic homogenization, followed by low-temperature vacuum spray granulation to achieve microcapsule formation. Finally, crystal stabilization treatment is performed to obtain the finished product. The microencapsulated glycoside compound nutritional supplements prepared by this invention achieve a glycoside encapsulation rate of over 95%, an in vitro sustained-release period of over 8 hours, and an activity retention rate of over 92% after 6 months of storage. Furthermore, water solubility and intestinal absorption are improved by over 40%, solving the problems of easy inactivation, poor absorption, and lack of sustained-release properties in traditional glycoside nutritional supplements.

The invention belongs to the technical field of medicines, and discloses a diterpenoid glycoside compound as well as a preparation method and application thereof. According to the invention, the diterpenoid glycoside compound with a novel structure is obtained by taking the chrysosplenium nigrum seeds as a separation target and comprehensively applying various separation technologies and means. In-vitro experiments prove that the diterpenoid glycoside compound provided by the invention has remarkable alpha-glucosidase inhibitory activity, can be used as an active ingredient of an anti-diabetic drug, and has wide application.