The invention provides a porous magnetic
hyaluronic acid microneedle for treating knee
osteoarthritis and a preparation method, and relates to the technical field of
biological materials. The porous magnetic
hyaluronic acid microneedle for treating knee
osteoarthritis comprises a needle body and a matrix layer, the needle body is a porous
drug-loading autolysis
hyaluronic acid microneedle body, and the matrix layer is a magnetic hyaluronic acid matrix. The invention has the following beneficial effects: 1, a soluble biocompatible microneedle structure is adopted, so that the injury caused by the breakage of a
metal microneedle is avoided, and the
medicine can directly reach the subcutaneous part; 2, a porous structure is constructed through ice
crystal recrystallization, and the
drug loading content is increased through a secondary
drying technology; 3, the
drug carrier is added through the nano magnetic particles, so that
diffusion and absorption of drug components are promoted; 4, the operation is simple, tedious steps such as injection in the
articular cavity are not needed, and the
infection risk in the
articular cavity is reduced; 5, batch mold production can be realized, and the production cost is reduced; 6, the administration amount is increased through microneedle perforation administration and matrix layer
permeation micropore administration.