53 results about "Articular cavity" patented technology

The invention provides a dynamic approach planning method and system for an acupotomy scope, and relates to the technical field of approach planning of the acupotomy scope, and the technical scheme is characterized in that real-time image data of an articular cavity is acquired; the real-time image data and the preoperative image data are subjected to registration analysis, and anatomical structure changes in the articular cavity are recognized; according to the recognized anatomical structure change in the joint cavity and a preset anatomical partition rule, anatomical partition information is dynamically updated, and updated anatomical partition information is obtained; according to the updated anatomical partition information, an approach path is set before an operation, real-time path adjustment is carried out, and an optimized needle knife mirror safe approach path is generated; and displaying the real-time image data, the updated anatomical partition information and the optimized safe approach path of the acupotomy mirror in an overlapping manner so as to guide a doctor to operate. The dynamic approach planning method and system for the acupotomy scope have the advantages that the dynamic change of an anatomical structure in an intra-operative joint cavity can be adapted, and safe operation of surgical instruments is ensured.

The gadolinium-based cationic polymer contrast agent is synthesized by chelating a cationic polymer and gadolinium ions, has high biological safety and can be used for cartilage imaging. The prepared contrast agent adopts an articular cavity direct injection method, so that the imaging effect is improved, and the contrast dosage is reduced. When the cartilage activity is normal, the content of glycosaminoglycan in the matrix is rich, and when the cartilage is inactivated or the activity is reduced, the content of glycosaminoglycan in the matrix is obviously reduced. The gadolinium-based cationic polymer contrast agent is combined with negatively charged glycosaminoglycan in a cartilage matrix through the charge effect. The gadolinium-based cationic polymer contrast agent can be used for noninvasive and quantitative evaluation of cartilage activity in nuclear magnetic resonance imaging, especially cartilage activity and stability in transplantation.

The invention relates to perfusion pump equipment applied to intra-articular flushing and a control method. The method comprises the steps that a liquid injection pump is driven by a liquid injection pump driving circuit to inject medical flushing liquid into an operation cavity; a pressure sensor is used for collecting real-time expansion pressure in the liquid injection process of the liquid injection pump; the difference value between the real-time expansion pressure and the set expansion pressure is calculated; calculating control parameters of the liquid injection pump by combining the difference value, the historical accumulated difference value and the difference value change trend; based on the control parameters, the flow speed of the liquid injection pump injected into the surgical cavity is adjusted through the liquid injection pump driving circuit. By dynamically regulating and controlling the liquid injection pump, the expansion pressure is kept stable, the problem of pressure fluctuation caused by intermittent liquid injection in the prior art is avoided, the surgical space and the surgical field definition can be effectively maintained, and the risk that air enters an articular cavity and causes embolism is reduced.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

The present invention provides an injectable magnesium-loaded lipid-based super-lubricating hydrogel microsphere, an articular cavity injection formulation, and a preparation method therefor. The method comprises the following steps: S1, preparing a magnesium-loaded multilamellar vesicular liposome suspension containing magnesium ions; S2, preparing an uncrosslinked magnesium-containing hydrogel; and S3, mixing the magnesium-loaded multilamellar vesicular liposome suspension with the magnesium-containing hydrogel to prepare hydrogel droplets, and carrying out crosslinking to form the magnesium-loaded lipid-based super-lubricating hydrogel microspheres. According to the present invention, the magnesium loading capacity of the lipid-based super-lubricating hydrogel microspheres can be greatly improved; on one hand, the biological function provided by the magnesium ions can be greatly prolonged, that is, the repair of cartilage by synovial liquid progenitor cells is continuously promoted; and on the other hand, the intrinsic lubricating effect of the lipid-based super-lubricating hydrogel microspheres can mitigate the further wear of newly formed cartilage; in addition, the magnesium ions can significantly promote the expression of PRG4 in chondrocytes, which not only facilitates the maintenance of chondrocyte homeostasis, but also further enhances articular lubrication.

The application provides a joint cavity puncture auxiliary positioning device, which comprises a base, a liftable lifting frame arranged on the base, a hinged mounting frame arranged at one end of the lifting frame, two groups of swingable supporting rods arranged on the mounting frame, a mounting frame arranged in the mounting frame, a movable frame slidably arranged in the mounting frame, a control assembly arranged on the mounting frame and used for driving the movable frame to slide, a first fixing assembly arranged on the movable frame and connected with the lifting frame, a second fixing assembly arranged on the movable frame and connected with the supporting rods, a hinged bracket arranged at one end of each of the two groups of supporting rods, and a third fixing assembly arranged on the bracket and used for fixing the bracket on the supporting rod. The device can realize the adjustment and position fixing of the two groups of brackets at any angle, and fix the limbs of a patient through the brackets, so that the joints of the patient at various positions are fixed at multiple angles, the displacement of the joints of the patient during the operation is avoided, and the joint cavity puncture work is more stable.

The present application relates to a kind of arthroscopic approach water leakage prevention device, including the elastic cover with dome structure, the sealing valve being arranged in the center position of cover and negative pressure suction mechanism, sealing valve has the conical hollow structure extending to base direction and gradually reducing outer diameter, reverse compensation sealing is realized using joint cavity infusion liquid pressure, cover base edge is equipped with flexible sealing skirt, by the negative pressure interface connection external negative pressure source, so that cover and skin form negative pressure sealing space, the device can be connected in series by negative pressure interface multiple occluder, and equipped with detachable guide rod auxiliary coaxial positioning.The present application uses non-insertion type surface adsorption occlusion, effectively solve the space interference and tissue damage problem in multiple tunnel operation, realize the dynamic water stop of pressure self-adaption, with the advantages of simple operation, sealing stable, strong dissection adaptability, can significantly improve the operation visual clarity and maintain joint cavity pressure stability.

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.

The invention belongs to the field of biological materials, and particularly discloses a multi-component microcapsule with multiple ultrasonic responses as well as a preparation method and application of the multi-component microcapsule with the multiple ultrasonic responses, and a hydrogel microcapsule with structural and functional design is prepared through a microfluidic double-emulsion technology on the basis of light-cured methacrylic anhydride gelatin hydrogel and liquid decafluoropentane. According to the prepared multi-ultrasonic-responsive multi-component microcapsule, ultrasonic-responsive oxygen release and controllable generation of reactive oxygen free radicals are realized on the basis of curcumin loaded in methacrylic anhydride gelatin and oxygen dissolved in decafluoropentane; the released oxygen provides an oxygen raw material for sonodynamic therapy while relieving a hypoxic environment in an articular cavity, so that generation of reactive oxygen free radicals is enhanced, apoptosis of pathological synovial fibroblasts is induced, and synovial proliferation in the pathological articular cavity is inhibited.

The invention relates to the technical field of biological materials, in particular to chitosan-mussel mucin bionic polypeptide-SVF composite hydrogel as well as a preparation method and application thereof. The mussel mucin bionic polypeptide endows the hydrogel with strong adhesion capacity, so that the hydrogel can be firmly adhered to the surface of cartilage, and SVF loss is prevented; as a carrier of the SVF, the hydrogel can be fixed in an articular cavity, the retention time of the hydrogel is prolonged, and the treatment effect is continuously achieved. Chitosan and mussel mucin bionic polypeptide have good biocompatibility and do not cause immunological rejection, an RGD sequence in the polypeptide can promote cell adhesion, chitosan provides a good cell growth microenvironment, and colonization, survival and function exertion of cells in SVF are facilitated. Chitosan has a certain cartilage repair promoting effect and has a synergistic effect with SVF, cartilage regeneration can be more effectively promoted, a hydrogel precursor solution has good fluidity, the hydrogel precursor solution can be injected into an articular cavity in a minimally invasive mode, and operation is easy and convenient.

The utility model relates to the technical field of medical instruments, in particular to a hip joint endoscope operation approach positioning device which is characterized by comprising a sheathing canal which is in a tubular shape matched with an arthroscope and allows the arthroscope to go in and out of an articular cavity; the arthroscope is arranged in the sheath tube; the left positioning arm is arranged on the sheathing canal, and one end of the left positioning arm is connected with the sheathing canal; the positioning sleeve is arranged on the side surface of the right positioning arm; the right positioning arm is arranged on the positioning sleeve, a connecting hole is formed in the right positioning arm, the circle center of the right positioning arm is the same as that of the left positioning arm, one end of the right positioning arm is connected with the positioning sleeve, the right positioning arm is movably connected with the left positioning arm, and any position of the positioning sleeve in the moving track range points to the center pointed by the arthroscope. The problem that an existing approach device can enter the articular cavity only after multiple times of puncture under perspective to correct deviation is solved, and the effect that the device can accurately puncture the articular cavity to enter the articular cavity is achieved.

The puncture structure for the articular cavity comprises a puncture body, an air bag and a connecting boss are arranged on the outer side wall of the puncture body, and an air inlet connector is arranged on one end face of the connecting boss. A cavity is formed in the connecting boss, a first air hole and a second air hole are formed in the inner wall of the cavity, the first air hole communicates with an inner cavity of the puncture body, and the second air hole communicates with the air bag. A scavenging valve element is movably connected into the cavity, and the scavenging valve element is moved to block the first air hole or the second air hole. When the scavenging valve element blocks the first air hole, air enters the air bag through the second air hole, and the air bag is inflated to be expanded for positioning; when the scavenging valve element blocks the second air hole, air enters the inner cavity of the puncture body through the first air hole, and air is provided for an articular cavity; according to the puncture structure, the airflow path can be controlled through simple movement of the valve element, switching of different functions is completed, the complexity of equipment is reduced, and the convenience and safety of an operation are improved.

The invention discloses a hard tube arthroscope with a rotatable lens, and relates to the technical field of arthroscopes, the hard tube arthroscope comprises an arthroscope handle and a hard tube main body, one end of the hard tube main body is internally provided with an imaging module, and the imaging module is further provided with an imaging hard wire used for transmitting signals and transmitting electric power; the arthroscope handle is further provided with a locking mechanism used for limiting rotation and deflection of the imaging hard line, an adjusting screw is fixedly installed at the end, away from the imaging module, of the hard tube body, a funnel-shaped imaging bucket groove is further formed in the end, away from the adjusting screw, of the hard tube body, and the imaging bucket groove and the imaging module are arranged correspondingly. One end, penetrating through the imaging bucket groove, of the imaging hard line is fixedly mounted in the hard tube main body and extends out of the adjusting screw, and during use, through the linkage design of the imaging hard line and the adjusting screw and the eccentric inclined layout of the imaging module, the imaging visual angle can be flexibly adjusted without drawing out the hard tube main body; extra traction damage to joint cavity soft tissue caused by frequent drawing and inserting is avoided.

The invention belongs to the technical field of biology, and discloses application of a composition of neoagaro-oligosaccharide and astaxanthin in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the invention comprises neoagaro-oligosaccharide, astaxanthin, carbomer and alginate in a mass ratio of (1-10): (1-10): (0.01-0.5): (0.1-1), and can realize efficient enrichment of neoagaro-oligosaccharide and astaxanthin in an articular cavity through a substance diffusion path of skin penetration, deep tissue diffusion, joint capsule permeation and articular cavity enrichment, so that the content of neoagaro-oligosaccharide and astaxanthin in the articular cavity is improved, and the content of astaxanthin in the articular cavity is reduced. The new agar oligosaccharide and the astaxanthin have an excellent synergistic effect, so that the acute inflammation symptom of gouty osteoarthritis can be efficiently relieved, the progress of the disease course is blocked, the pathological change of joint tissue is repaired, and the new agar oligosaccharide and the astaxanthin have an excellent application prospect in preparation of the transdermal medicine for treating osteoarthritis.

The invention relates to application of a fragile X intellectual disorder No.1 gene in treating or relieving osteoarthritis, and belongs to the technical field of biological medicines. Researches show that the osteoarthritis is accompanied by increase of the concentration of fragile X chromosome intellectual retardation protein in serum and increase of synovial inflammatory macrophages, the fragile X chromosome intellectual retardation protein in the synovial inflammatory macrophages aggravates the progress of the osteoarthritis, articular cavity synovial inflammatory macrophage FMRP genes are inhibited in a targeted manner, and the osteoarthritis can be used for treating osteoarthritis. A new thought is provided for prevention and treatment of osteoarthritis, a support is provided for clinical transformation, and at present, related reports for treating or relieving osteoarthritis through target intervention are not found yet.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to dexamethasone single-phase zero-order release sustained-release microspheres as well as a preparation method and application thereof. The dexamethasone sustained-release microspheres are prepared by an emulsification-solvent evaporation method, the release platform phase of the microspheres is improved by adding a release accelerator, and finally the dexamethasone sustained-release microspheres with a single-phase zero-order release behavior are obtained. Experimental results show that various representations of the sustained-release microspheres meet the requirements of preparations, and in-vivo pharmacodynamic studies of rats also show that the sustained-release microspheres can protect articular cartilage and maintain a normal cartilage structure, and have the same curative effect as commercially available dexamethasone acetate injection. Therefore, the dexamethasone sustained-release microsphere which is used for articular cavity injection and has a good release behavior is successfully developed, the advantages of articular cavity injection drugs can be fully played, the drugs can be continuously and stably released, long-acting treatment of arthritis is achieved, and the dexamethasone sustained-release microsphere has important clinical application value and wide market prospects.

The invention discloses a dual-module delivery system and application thereof in preparation of a medicine for treating osteoarthritis or synovitis. Comprising an articular cavity drug delivery module 1 and an articular cavity drug delivery module 2, the module 1 is a nanoparticle or an exosome or a microsphere wrapping an aging cell scavenger, and the module 2 is a nanoparticle or an exosome or a microsphere wrapping an M2 polarization inducer; the compound is applied to the treatment medicine for osteoarthritis or synovitis, can target senescence synovial fibroblasts and M1 macrophages, combines senescence cell removal with a macrophage reprogramming mechanism, solves the problems of generation of senescence-related secretory phenotypes and inflammatory polarization of macrophages, and has a good application prospect in treatment of osteoarthritis or synovitis. By reducing SASP sources and inflammatory reactions at the same time, vicious circle of senescence-inflammation cascade reactions is broken, stability of the environment in joints is recovered, and the application prospect is extremely high.

The invention discloses a heme-based multifunctional nano-drug and a preparation method and application thereof, and relates to the technical field of nano-drugs, and the heme-based multifunctional nano-drug comprises heme and hydrophobic molecules wrapped in the heme. The hydrophobic molecules are wrapped in the heme, so that the bioavailability of the hydrophobic molecules is improved, the hydrophobic molecules are slowly released at bone joints, and the retention time of the hydrophobic molecules in the bone joints is prolonged; meanwhile, the nanostructure formed by the heme has better lubrication property, biocompatibility and cartilage steady state improving effect, can promote cartilage cell proliferation, and can enhance the capability of resisting oxygen deficit and continuously worsening articular cavity internal environment of cartilage tissues through synergistic effect, so that the cartilage steady state is better maintained. Therefore, the multifunctional nano-drug provided by the invention has universality in treatment of osteoarthritis.

The invention discloses a pair of free body grasping forceps. The pair of free body grasping forceps comprises a handle assembly, a clamping device and a driving assembly, the clamping device has an opening state and a tightening state, the clamping device in the opening state is opened and used for grabbing the free body, and the clamping device in the tightening state is contracted and used for wrapping the free body; the driving assembly is arranged on the handle assembly, connected with the clamping device and used for driving the clamping device to be switched between the opening state and the tightening state. According to the free body grasping forceps, when the clamping device is in the tightening state, the free body can be wrapped, so that the disengagement probability of the free body is reduced, the free body is not prone to disengagement, and the difficulty of taking out the free body is reduced. Besides, the free body is wrapped by the clamping device, the free body and the joint cavity can be separated through the clamping device, and therefore when the free body grasping forceps are separated from the joint cavity, the contact probability of the free body and the joint cavity is reduced, and the risk that the free body damages the joint cavity is reduced.

The invention provides application of a composition in treatment of knee osteoarthritis. According to the invention, two rat knee osteoarthritis models (the former is called as an ACLT-induced KOA model for short, and the latter is called as a papain-induced KOA model for short) are established by respectively utilizing methods of combining anterior cruciate ligament transection (ACLT) with running and injecting papain composite L-cysteine into an articular cavity; the composition provided by the invention is used for treating two rat KOA models. Results show that the composition can improve knee joint swelling of two KOA rats, increase the pain threshold, improve the abnormal gait state, relieve cartilage injury, inhibit ACLT-induced abnormal change of a KOA rat knee joint subchondral bone microstructure and papain-induced PGE2 content in KOA rat synovial tissue, and can be used for preparing a medicine for treating osteoporosis. The level of inflammatory factors in serum and joint lavage fluid of the two KOA rats is reduced, and the discovery shows that the KOA has important application in treatment of knee osteoarthritis.

The present invention belongs to the technical field of medical systems, and discloses a carbon dioxide gas-assisted surgical operating system for arthroscopy, comprising a constant temperature gas circulation host, a built-in circulation pipeline in the constant temperature gas circulation host, and a first pipeline and a second pipeline respectively connected to the circulation pipeline; wherein, one end of the first pipeline and the second pipeline are respectively provided with a puncture catheter, which is used to pierce the position of the arthroscope and introduce CO2 gas to establish a joint cavity; the constant temperature gas circulation host comprises a gas source component, a voltage stabilizing component, a circulation smoke removal component and a gas heating component; the stability of the joint cavity is established and maintained by low-pressure heated carbon dioxide gas, forming a small cavity support, and the blood foam and debris generated during the operation are discharged through the circulation smoke removal component, thereby effectively avoiding the problem of blurred surgical field of view caused by bleeding and floating debris, significantly improving the visibility and accuracy of the operation, and enhancing the safety of the operation, and is widely applicable to various joint treatment functions.

The utility model is suitable for the technical field of medical equipment, and provides a multifunctional intra-articular flushing pipe. Comprising an outer sleeve; the medicine inlet pipe cavity is arranged in the outer sleeve, an output pipe is arranged at the first end of the medicine inlet pipe cavity and penetrates through the first end of the outer sleeve, the second end of the medicine inlet pipe cavity penetrates through the side wall close to the second end of the outer sleeve, and a medicine inlet pipe opening is formed in the second end of the medicine inlet pipe cavity; the suction tube cavity is arranged in the outer sleeve, one end of the suction tube cavity is communicated with a suction tube opening formed in the side wall of the outer sleeve, and the suction tube opening is arranged close to the second end of the outer sleeve; the suction pipe orifice is communicated with the suction pipe cavity; the water inlet and drainage holes are formed in the side wall, close to the first end, of the outer sleeve; and the water inlet and drainage hole is communicated with the suction pipe cavity. According to the multifunctional intra-articular flushing tube, effusion in the joint is smoothly drained, antibiotics can be conveniently and regularly used in the articular cavity, and meanwhile the multifunctional intra-articular flushing tube is more suitable for the joint.

The invention provides an articular cavity external expansion device for a shoulder arthroscopy operation. The articular cavity external expansion device comprises an outer tube, a rotating knob, an inner tube, a supporting blade, a sealing structure and a drainage pipeline, during use, the outer tube is inserted into an established operation channel of the shoulder joint; the rotary knob is rotated to drive the inner pipe to move upwards, the supporting blades move upwards synchronously, and when the supporting blades move to be right opposite to the long-strip-shaped openings, the supporting blades are unfolded outwards through the long-strip-shaped openings; after the supporting blades are unfolded, the rotary knob continues to be rotated to drive the supporting blades to move upwards and compress surrounding soft tissue, and therefore the operation space in the joint cavity is expanded. During an operation, an operating instrument extends into the outer tube through the sealing structure and enters an articular cavity to perform corresponding operation. According to the articular cavity external expansion device for the shoulder arthroscopy surgery, soft tissue is compressed through the supporting blades, the operation space in an articular cavity can be remarkably expanded, it is ensured that surgical instruments are flexibly operated, the surgical field is not limited, and therefore the articular cavity external expansion device adapts to individual differences of patients with different body types.

The invention discloses a segmented functionalized coating artificial ligament and a preparation method and application thereof. The segmented functionalized coating artificial ligament comprises an articular cavity section PET artificial ligament coating loaded with glucosamine and a bone tunnel section PET artificial ligament coating mineralized by hydroxyapatite. The method comprises the following steps: modifying a PET artificial ligament base material with a phosphate group, and reacting in an alkali solution to obtain a surface-modified PET artificial ligament; activating the modified PET artificial ligament with an MES buffer solution and an EDC / NHS coupling agent, and soaking the activated PET artificial ligament in a glucosamine solution to obtain a glucosamine-loaded PET artificial ligament; the surface-modified PET artificial ligament is placed in simulated body fluid to be mineralized, and the mineralized PET artificial ligament is obtained. The prepared PET artificial ligament has good anti-inflammatory activity and effectively relieves PTOA progress, the bone tunnel section mineralized PET artificial ligament has good osteogenic differentiation promoting capacity, and a new solution is provided for improving the tendon-bone healing capacity of implants after ACL reconstruction.

The invention relates to the technical field of medical instruments, and discloses a temporal-mandibular joint cavity flushing device which comprises a main body mechanism. Comprising a device shell, a piston cylinder body arranged on the inner wall of the device shell, a driving rod arranged on the inner side of the piston cylinder body, a piston plate arranged at the end of the driving rod, a mounting assembly arranged at the end of the device shell and a needle tube assembly arranged on the mounting assembly. And an adjusting mechanism. Opening and closing adjustment of a side needle hole is achieved through relative rotation of the outer needle tube and the inner needle tube, rotary cutting is matched with a cutting blade, the problem that the needle hole is blocked in the flushing process is effectively solved, lifting of a protection support is achieved through thread transmission of the protection assembly, the puncture depth can be controlled, the needle head can be protected, and the sealing assembly is reset through a spring. And the locking assembly is matched with a clamping block through a limiting pin, so that the state of the side needle hole is stably locked, and a doctor is effectively prevented from touching the side needle hole by mistake.

The utility model discloses a manual meniscus stitching instrument which comprises a flat handle, a quick assembly mechanism is arranged on the flat handle, a stitching mechanism is installed on the quick assembly mechanism, an anti-skid sleeve is arranged on the flat handle, the stitching mechanism comprises a main rod body and a replacement rod, the main rod body and the replacement rod are hollow, and the main rod body and the replacement rod are fixedly connected with the flat handle. A connecting thread groove is formed in the end part of the main rod body. According to the manual meniscus stitching instrument, the fusiform spine end and the main rod body with different radians and lengths are replaced to adapt to stitching of different parts of a meniscus, the repair range is enlarged, the maximum angle of the head is 26 degrees, the stitching instrument can reach the repair area of the rear angle and the body close to the front side more easily through the design, the repair range is enlarged, and the repair efficiency is improved. The cutting edge of the suturing instrument is shortened, the situation that the puncture rod needs to enter the articular cavity too much during external and internal suturing is avoided, the fracture risk is reduced, meanwhile, the price is low, and the suturing efficiency is high.

The application discloses an arthroscope adjusting device, system and control method. The arthroscope adjusting device comprises a box assembly, a base assembly and a connecting piece. The box assembly is connected with the base assembly, and the connecting piece is connected with the base assembly. The box assembly is used for being connected with an arthroscope, and the connecting piece is used for being connected on the end of a mechanical arm. The box assembly comprises a first driving piece and a connecting structure. The connecting structure is connected with the arthroscope, and the first driving piece is connected with the connecting structure. The base assembly comprises a second driving piece and a moving structure. The second driving piece is connected with the moving structure. The arthroscope adjusting device is used in the scene of robot-assisted surgery, can realize flexible movement of the arthroscope in the joint cavity in various different postures through feeding and rotation while reducing the volume, and improves the flexibility of operation using the arthroscope.

The invention discloses a method and system for monitoring the survival rate of articular cavity magnetically labeled stem cells based on improved comparative learning, and relates to the technical field of biomedical engineering, medical image analysis and artificial intelligence crossing. The method comprises the following steps: acquiring multi-sequence magnetic resonance imaging data of a stem cell transplantation region loaded with magnetic nanoparticles at an articular cavity part; preprocessing the data, inputting the preprocessed data into a physical perception double-domain contrast learning network, and extracting features by the network through a spatial domain encoder and a frequency domain encoder which are parallel to each other; a physical consistency constraint based on a Bloch equation is innovatively introduced, a joint loss function is constructed, and the network is driven to distinguish microscopic magnetic susceptibility difference caused by intracellular iron aggregation and extracellular iron dispersion in learning; and finally, performing regression prediction by using the optimized features, and outputting the survival rate of the stem cells. According to the method, the dependence on a large amount of labeled data is reduced, and nondestructive and high-precision longitudinal monitoring on the survival state of the transplanted stem cells is realized.

A liquid guided laser arthroscopic surgery device comprises a laser (1), a central control system (2), a handheld scalpel pen (12), a high-pressure liquid supply system (11), a low-pressure liquid supply system (13), a liquid pumping device (4), an optical fiber (3), a liquid pipeline (14), a liquid supply small hole (17), a liquid supply hose (18) and a joint cavity (23). A coupling cavity (7) is formed in the handheld scalpel pen (12), and a nozzle (9) is arranged at the front end of the handheld scalpel pen (12); and laser emitted by the laser (1) passes through the focusing mirror (5) and the transmitting mirror (6) and forms a coaxially-coupled laser liquid beam (10) with the isotonic normal saline in the coupling cavity (7) in the coupling cavity (7). The invention also claims to protect a method of use of the liquid guided laser arthroscopic surgical device. The operation is intelligent, safe and controllable; the operation application range is wide, and the biological action is accurate; the device is suitable for a non-contact operation mode, the operation process is simplified, the cost is low and the efficiency is high; and the comprehensive technical effect is excellent.

The application discloses a manufacturing method of a digital guide plate for temporomandibular joint cavity injection, and the CT and MRI data of a patient are subjected to image segmentation, three-dimensional reconstruction and image registration in a computer software, so that the models of the condylar process, the articular disc and the articular tubercle of the temporomandibular joint are obtained and the relative position relationship is confirmed, and thus the positions of the upper cavity and the lower cavity of the joint are determined. According to the patient's condition, the drug is injected into the upper cavity or the lower cavity of the joint, and the needle insertion position, angle and depth of the injector are simulated in the software. On the basis of the soft tissue of the maxillofacial part reconstructed by the CT of the patient, a 3D printing guide plate which can be attached to the surface of the soft tissue is designed individually, and the guide hole is determined on the guide plate in combination with the needle insertion position, angle and depth. The guide plate comprises a positioning wing for assisting installation and positioning and a preset needle insertion guide hole, and can be used for guiding the needle insertion of the injector and the drug injection in the joint cavity injection treatment.