35 results about "Articular cavity" patented technology

The invention relates to perfusion pump equipment applied to intra-articular flushing and a control method. The method comprises the steps that a liquid injection pump is driven by a liquid injection pump driving circuit to inject medical flushing liquid into an operation cavity; a pressure sensor is used for collecting real-time expansion pressure in the liquid injection process of the liquid injection pump; the difference value between the real-time expansion pressure and the set expansion pressure is calculated; calculating control parameters of the liquid injection pump by combining the difference value, the historical accumulated difference value and the difference value change trend; based on the control parameters, the flow speed of the liquid injection pump injected into the surgical cavity is adjusted through the liquid injection pump driving circuit. By dynamically regulating and controlling the liquid injection pump, the expansion pressure is kept stable, the problem of pressure fluctuation caused by intermittent liquid injection in the prior art is avoided, the surgical space and the surgical field definition can be effectively maintained, and the risk that air enters an articular cavity and causes embolism is reduced.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

The application provides a joint cavity puncture auxiliary positioning device, which comprises a base, a liftable lifting frame arranged on the base, a hinged mounting frame arranged at one end of the lifting frame, two groups of swingable supporting rods arranged on the mounting frame, a mounting frame arranged in the mounting frame, a movable frame slidably arranged in the mounting frame, a control assembly arranged on the mounting frame and used for driving the movable frame to slide, a first fixing assembly arranged on the movable frame and connected with the lifting frame, a second fixing assembly arranged on the movable frame and connected with the supporting rods, a hinged bracket arranged at one end of each of the two groups of supporting rods, and a third fixing assembly arranged on the bracket and used for fixing the bracket on the supporting rod. The device can realize the adjustment and position fixing of the two groups of brackets at any angle, and fix the limbs of a patient through the brackets, so that the joints of the patient at various positions are fixed at multiple angles, the displacement of the joints of the patient during the operation is avoided, and the joint cavity puncture work is more stable.

The present application relates to a kind of arthroscopic approach water leakage prevention device, including the elastic cover with dome structure, the sealing valve being arranged in the center position of cover and negative pressure suction mechanism, sealing valve has the conical hollow structure extending to base direction and gradually reducing outer diameter, reverse compensation sealing is realized using joint cavity infusion liquid pressure, cover base edge is equipped with flexible sealing skirt, by the negative pressure interface connection external negative pressure source, so that cover and skin form negative pressure sealing space, the device can be connected in series by negative pressure interface multiple occluder, and equipped with detachable guide rod auxiliary coaxial positioning.The present application uses non-insertion type surface adsorption occlusion, effectively solve the space interference and tissue damage problem in multiple tunnel operation, realize the dynamic water stop of pressure self-adaption, with the advantages of simple operation, sealing stable, strong dissection adaptability, can significantly improve the operation visual clarity and maintain joint cavity pressure stability.

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.

The invention relates to the technical field of biological materials, in particular to chitosan-mussel mucin bionic polypeptide-SVF composite hydrogel as well as a preparation method and application thereof. The mussel mucin bionic polypeptide endows the hydrogel with strong adhesion capacity, so that the hydrogel can be firmly adhered to the surface of cartilage, and SVF loss is prevented; as a carrier of the SVF, the hydrogel can be fixed in an articular cavity, the retention time of the hydrogel is prolonged, and the treatment effect is continuously achieved. Chitosan and mussel mucin bionic polypeptide have good biocompatibility and do not cause immunological rejection, an RGD sequence in the polypeptide can promote cell adhesion, chitosan provides a good cell growth microenvironment, and colonization, survival and function exertion of cells in SVF are facilitated. Chitosan has a certain cartilage repair promoting effect and has a synergistic effect with SVF, cartilage regeneration can be more effectively promoted, a hydrogel precursor solution has good fluidity, the hydrogel precursor solution can be injected into an articular cavity in a minimally invasive mode, and operation is easy and convenient.

The utility model relates to the technical field of medical instruments, in particular to a hip joint endoscope operation approach positioning device which is characterized by comprising a sheathing canal which is in a tubular shape matched with an arthroscope and allows the arthroscope to go in and out of an articular cavity; the arthroscope is arranged in the sheath tube; the left positioning arm is arranged on the sheathing canal, and one end of the left positioning arm is connected with the sheathing canal; the positioning sleeve is arranged on the side surface of the right positioning arm; the right positioning arm is arranged on the positioning sleeve, a connecting hole is formed in the right positioning arm, the circle center of the right positioning arm is the same as that of the left positioning arm, one end of the right positioning arm is connected with the positioning sleeve, the right positioning arm is movably connected with the left positioning arm, and any position of the positioning sleeve in the moving track range points to the center pointed by the arthroscope. The problem that an existing approach device can enter the articular cavity only after multiple times of puncture under perspective to correct deviation is solved, and the effect that the device can accurately puncture the articular cavity to enter the articular cavity is achieved.

The invention discloses a hard tube arthroscope with a rotatable lens, and relates to the technical field of arthroscopes, the hard tube arthroscope comprises an arthroscope handle and a hard tube main body, one end of the hard tube main body is internally provided with an imaging module, and the imaging module is further provided with an imaging hard wire used for transmitting signals and transmitting electric power; the arthroscope handle is further provided with a locking mechanism used for limiting rotation and deflection of the imaging hard line, an adjusting screw is fixedly installed at the end, away from the imaging module, of the hard tube body, a funnel-shaped imaging bucket groove is further formed in the end, away from the adjusting screw, of the hard tube body, and the imaging bucket groove and the imaging module are arranged correspondingly. One end, penetrating through the imaging bucket groove, of the imaging hard line is fixedly mounted in the hard tube main body and extends out of the adjusting screw, and during use, through the linkage design of the imaging hard line and the adjusting screw and the eccentric inclined layout of the imaging module, the imaging visual angle can be flexibly adjusted without drawing out the hard tube main body; extra traction damage to joint cavity soft tissue caused by frequent drawing and inserting is avoided.

The invention belongs to the technical field of biology, and discloses application of a composition of neoagaro-oligosaccharide and astaxanthin in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the invention comprises neoagaro-oligosaccharide, astaxanthin, carbomer and alginate in a mass ratio of (1-10): (1-10): (0.01-0.5): (0.1-1), and can realize efficient enrichment of neoagaro-oligosaccharide and astaxanthin in an articular cavity through a substance diffusion path of skin penetration, deep tissue diffusion, joint capsule permeation and articular cavity enrichment, so that the content of neoagaro-oligosaccharide and astaxanthin in the articular cavity is improved, and the content of astaxanthin in the articular cavity is reduced. The new agar oligosaccharide and the astaxanthin have an excellent synergistic effect, so that the acute inflammation symptom of gouty osteoarthritis can be efficiently relieved, the progress of the disease course is blocked, the pathological change of joint tissue is repaired, and the new agar oligosaccharide and the astaxanthin have an excellent application prospect in preparation of the transdermal medicine for treating osteoarthritis.

The invention relates to application of a fragile X intellectual disorder No.1 gene in treating or relieving osteoarthritis, and belongs to the technical field of biological medicines. Researches show that the osteoarthritis is accompanied by increase of the concentration of fragile X chromosome intellectual retardation protein in serum and increase of synovial inflammatory macrophages, the fragile X chromosome intellectual retardation protein in the synovial inflammatory macrophages aggravates the progress of the osteoarthritis, articular cavity synovial inflammatory macrophage FMRP genes are inhibited in a targeted manner, and the osteoarthritis can be used for treating osteoarthritis. A new thought is provided for prevention and treatment of osteoarthritis, a support is provided for clinical transformation, and at present, related reports for treating or relieving osteoarthritis through target intervention are not found yet.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to dexamethasone single-phase zero-order release sustained-release microspheres as well as a preparation method and application thereof. The dexamethasone sustained-release microspheres are prepared by an emulsification-solvent evaporation method, the release platform phase of the microspheres is improved by adding a release accelerator, and finally the dexamethasone sustained-release microspheres with a single-phase zero-order release behavior are obtained. Experimental results show that various representations of the sustained-release microspheres meet the requirements of preparations, and in-vivo pharmacodynamic studies of rats also show that the sustained-release microspheres can protect articular cartilage and maintain a normal cartilage structure, and have the same curative effect as commercially available dexamethasone acetate injection. Therefore, the dexamethasone sustained-release microsphere which is used for articular cavity injection and has a good release behavior is successfully developed, the advantages of articular cavity injection drugs can be fully played, the drugs can be continuously and stably released, long-acting treatment of arthritis is achieved, and the dexamethasone sustained-release microsphere has important clinical application value and wide market prospects.

The invention discloses a dual-module delivery system and application thereof in preparation of a medicine for treating osteoarthritis or synovitis. Comprising an articular cavity drug delivery module 1 and an articular cavity drug delivery module 2, the module 1 is a nanoparticle or an exosome or a microsphere wrapping an aging cell scavenger, and the module 2 is a nanoparticle or an exosome or a microsphere wrapping an M2 polarization inducer; the compound is applied to the treatment medicine for osteoarthritis or synovitis, can target senescence synovial fibroblasts and M1 macrophages, combines senescence cell removal with a macrophage reprogramming mechanism, solves the problems of generation of senescence-related secretory phenotypes and inflammatory polarization of macrophages, and has a good application prospect in treatment of osteoarthritis or synovitis. By reducing SASP sources and inflammatory reactions at the same time, vicious circle of senescence-inflammation cascade reactions is broken, stability of the environment in joints is recovered, and the application prospect is extremely high.

The invention provides application of a composition in treatment of knee osteoarthritis. According to the invention, two rat knee osteoarthritis models (the former is called as an ACLT-induced KOA model for short, and the latter is called as a papain-induced KOA model for short) are established by respectively utilizing methods of combining anterior cruciate ligament transection (ACLT) with running and injecting papain composite L-cysteine into an articular cavity; the composition provided by the invention is used for treating two rat KOA models. Results show that the composition can improve knee joint swelling of two KOA rats, increase the pain threshold, improve the abnormal gait state, relieve cartilage injury, inhibit ACLT-induced abnormal change of a KOA rat knee joint subchondral bone microstructure and papain-induced PGE2 content in KOA rat synovial tissue, and can be used for preparing a medicine for treating osteoporosis. The level of inflammatory factors in serum and joint lavage fluid of the two KOA rats is reduced, and the discovery shows that the KOA has important application in treatment of knee osteoarthritis.

The utility model is suitable for the technical field of medical equipment, and provides a multifunctional intra-articular flushing pipe. Comprising an outer sleeve; the medicine inlet pipe cavity is arranged in the outer sleeve, an output pipe is arranged at the first end of the medicine inlet pipe cavity and penetrates through the first end of the outer sleeve, the second end of the medicine inlet pipe cavity penetrates through the side wall close to the second end of the outer sleeve, and a medicine inlet pipe opening is formed in the second end of the medicine inlet pipe cavity; the suction tube cavity is arranged in the outer sleeve, one end of the suction tube cavity is communicated with a suction tube opening formed in the side wall of the outer sleeve, and the suction tube opening is arranged close to the second end of the outer sleeve; the suction pipe orifice is communicated with the suction pipe cavity; the water inlet and drainage holes are formed in the side wall, close to the first end, of the outer sleeve; and the water inlet and drainage hole is communicated with the suction pipe cavity. According to the multifunctional intra-articular flushing tube, effusion in the joint is smoothly drained, antibiotics can be conveniently and regularly used in the articular cavity, and meanwhile the multifunctional intra-articular flushing tube is more suitable for the joint.

The invention provides an articular cavity external expansion device for a shoulder arthroscopy operation. The articular cavity external expansion device comprises an outer tube, a rotating knob, an inner tube, a supporting blade, a sealing structure and a drainage pipeline, during use, the outer tube is inserted into an established operation channel of the shoulder joint; the rotary knob is rotated to drive the inner pipe to move upwards, the supporting blades move upwards synchronously, and when the supporting blades move to be right opposite to the long-strip-shaped openings, the supporting blades are unfolded outwards through the long-strip-shaped openings; after the supporting blades are unfolded, the rotary knob continues to be rotated to drive the supporting blades to move upwards and compress surrounding soft tissue, and therefore the operation space in the joint cavity is expanded. During an operation, an operating instrument extends into the outer tube through the sealing structure and enters an articular cavity to perform corresponding operation. According to the articular cavity external expansion device for the shoulder arthroscopy surgery, soft tissue is compressed through the supporting blades, the operation space in an articular cavity can be remarkably expanded, it is ensured that surgical instruments are flexibly operated, the surgical field is not limited, and therefore the articular cavity external expansion device adapts to individual differences of patients with different body types.

The invention relates to the technical field of medical instruments, and discloses a temporal-mandibular joint cavity flushing device which comprises a main body mechanism. Comprising a device shell, a piston cylinder body arranged on the inner wall of the device shell, a driving rod arranged on the inner side of the piston cylinder body, a piston plate arranged at the end of the driving rod, a mounting assembly arranged at the end of the device shell and a needle tube assembly arranged on the mounting assembly. And an adjusting mechanism. Opening and closing adjustment of a side needle hole is achieved through relative rotation of the outer needle tube and the inner needle tube, rotary cutting is matched with a cutting blade, the problem that the needle hole is blocked in the flushing process is effectively solved, lifting of a protection support is achieved through thread transmission of the protection assembly, the puncture depth can be controlled, the needle head can be protected, and the sealing assembly is reset through a spring. And the locking assembly is matched with a clamping block through a limiting pin, so that the state of the side needle hole is stably locked, and a doctor is effectively prevented from touching the side needle hole by mistake.

The utility model discloses a manual meniscus stitching instrument which comprises a flat handle, a quick assembly mechanism is arranged on the flat handle, a stitching mechanism is installed on the quick assembly mechanism, an anti-skid sleeve is arranged on the flat handle, the stitching mechanism comprises a main rod body and a replacement rod, the main rod body and the replacement rod are hollow, and the main rod body and the replacement rod are fixedly connected with the flat handle. A connecting thread groove is formed in the end part of the main rod body. According to the manual meniscus stitching instrument, the fusiform spine end and the main rod body with different radians and lengths are replaced to adapt to stitching of different parts of a meniscus, the repair range is enlarged, the maximum angle of the head is 26 degrees, the stitching instrument can reach the repair area of the rear angle and the body close to the front side more easily through the design, the repair range is enlarged, and the repair efficiency is improved. The cutting edge of the suturing instrument is shortened, the situation that the puncture rod needs to enter the articular cavity too much during external and internal suturing is avoided, the fracture risk is reduced, meanwhile, the price is low, and the suturing efficiency is high.

The application discloses an arthroscope adjusting device, system and control method. The arthroscope adjusting device comprises a box assembly, a base assembly and a connecting piece. The box assembly is connected with the base assembly, and the connecting piece is connected with the base assembly. The box assembly is used for being connected with an arthroscope, and the connecting piece is used for being connected on the end of a mechanical arm. The box assembly comprises a first driving piece and a connecting structure. The connecting structure is connected with the arthroscope, and the first driving piece is connected with the connecting structure. The base assembly comprises a second driving piece and a moving structure. The second driving piece is connected with the moving structure. The arthroscope adjusting device is used in the scene of robot-assisted surgery, can realize flexible movement of the arthroscope in the joint cavity in various different postures through feeding and rotation while reducing the volume, and improves the flexibility of operation using the arthroscope.

The invention discloses a method and system for monitoring the survival rate of articular cavity magnetically labeled stem cells based on improved comparative learning, and relates to the technical field of biomedical engineering, medical image analysis and artificial intelligence crossing. The method comprises the following steps: acquiring multi-sequence magnetic resonance imaging data of a stem cell transplantation region loaded with magnetic nanoparticles at an articular cavity part; preprocessing the data, inputting the preprocessed data into a physical perception double-domain contrast learning network, and extracting features by the network through a spatial domain encoder and a frequency domain encoder which are parallel to each other; a physical consistency constraint based on a Bloch equation is innovatively introduced, a joint loss function is constructed, and the network is driven to distinguish microscopic magnetic susceptibility difference caused by intracellular iron aggregation and extracellular iron dispersion in learning; and finally, performing regression prediction by using the optimized features, and outputting the survival rate of the stem cells. According to the method, the dependence on a large amount of labeled data is reduced, and nondestructive and high-precision longitudinal monitoring on the survival state of the transplanted stem cells is realized.

A liquid guided laser arthroscopic surgery device comprises a laser (1), a central control system (2), a handheld scalpel pen (12), a high-pressure liquid supply system (11), a low-pressure liquid supply system (13), a liquid pumping device (4), an optical fiber (3), a liquid pipeline (14), a liquid supply small hole (17), a liquid supply hose (18) and a joint cavity (23). A coupling cavity (7) is formed in the handheld scalpel pen (12), and a nozzle (9) is arranged at the front end of the handheld scalpel pen (12); and laser emitted by the laser (1) passes through the focusing mirror (5) and the transmitting mirror (6) and forms a coaxially-coupled laser liquid beam (10) with the isotonic normal saline in the coupling cavity (7) in the coupling cavity (7). The invention also claims to protect a method of use of the liquid guided laser arthroscopic surgical device. The operation is intelligent, safe and controllable; the operation application range is wide, and the biological action is accurate; the device is suitable for a non-contact operation mode, the operation process is simplified, the cost is low and the efficiency is high; and the comprehensive technical effect is excellent.

The application discloses a manufacturing method of a digital guide plate for temporomandibular joint cavity injection, and the CT and MRI data of a patient are subjected to image segmentation, three-dimensional reconstruction and image registration in a computer software, so that the models of the condylar process, the articular disc and the articular tubercle of the temporomandibular joint are obtained and the relative position relationship is confirmed, and thus the positions of the upper cavity and the lower cavity of the joint are determined. According to the patient's condition, the drug is injected into the upper cavity or the lower cavity of the joint, and the needle insertion position, angle and depth of the injector are simulated in the software. On the basis of the soft tissue of the maxillofacial part reconstructed by the CT of the patient, a 3D printing guide plate which can be attached to the surface of the soft tissue is designed individually, and the guide hole is determined on the guide plate in combination with the needle insertion position, angle and depth. The guide plate comprises a positioning wing for assisting installation and positioning and a preset needle insertion guide hole, and can be used for guiding the needle insertion of the injector and the drug injection in the joint cavity injection treatment.

The invention discloses a continuous drug delivery device used in an infected articular cavity around a knee joint prosthesis, and belongs to the field of medical instruments, the same as the prior art, the continuous drug delivery device comprises an infusion tube, the infusion tube comprises a connecting section and a liquid delivery section, the liquid delivery section is located in the articular cavity, a plurality of holes are evenly formed in the tube wall of the liquid delivery section, and the holes are distributed in a spiral shape. Compared with the prior art, the infusion tube is formed by combining a plurality of pipelines which are detachably connected together, an injector connector and a liquid pumping device connector are arranged at the tail end of a connecting section, a balloon tube is arranged on one side close to the connectors, one end of the balloon tube is communicated with a balloon, and the other end of the balloon tube extends out of the body. According to the continuous drug delivery device, accurate delivery of liquid medicine and safety and reliability of the treatment process are guaranteed from different angles, the cure rate of infection around the knee joint prosthesis is increased, the treatment and rehabilitation cycle of a patient is shortened, and prognosis of the patient is improved.

The invention relates to a double-cavity rheumatoid arthritis hydrops puncture needle and an application method. The double-cavity rheumatoid arthritis hydrops puncture needle comprises a needle head and a socket, the socket comprises a large sleeve and a small sleeve which are sleeved in a sliding manner, the large sleeve is matched with the outer diameter of the injector, and one end, far away from the large sleeve, of the small sleeve is connected with the needle through a hose; a spacer is arranged in the middle of the interior of the large sleeve, a spacer cap is formed on the spacer, and an extrusion needle is arranged on the spacer cap in a penetrating manner; a rubber plug is arranged in the small sleeve, a through hole is formed in the rubber plug, one end of the through hole is hermetically communicated with the hose, and the other end is matched with the extrusion needle; an overflow groove is formed in the surface of the side, facing the small sleeve, of the partition piece, a protruding strip corresponding to the overflow groove is arranged on the rubber plug, and an overflow hole corresponding to the overflow groove is formed in the large sleeve. In conclusion, the invention provides a safe, efficient, convenient and economical joint cavity effusion puncture injection solution, and the medical experience and the medical safety of the patient are improved to the maximum extent while the treatment effect is guaranteed.

The present invention belongs to the field of biotechnology. Provided are a circular IL-10 mRNA nano-preparation, and a preparation method therefor and the use thereof. The circular IL-10 mRNA nano-preparation is prepared by means of the following method: 1, synthesizing a chemically modified circular IL-10 mRNA in vitro; and 2, preparing, by means of self-assembly, a circular IL-10 mRNA nano-preparation that can be delivered in vivo. The circular IL-10 mRNA inhibits injury of articular cartilage by means of regulating immune cells in the synovial membrane of an articular cavity, thereby achieving the effect of treating inflammatory joint diseases.

The invention belongs to the technical field of biological materials, and provides bionic joint lubricating liquid for anchoring engineered stem cell apoptosis vesicles as well as a preparation method and application of the bionic joint lubricating liquid. According to the lubricating liquid, phenylboronic acid grafted hyaluronic acid (PHA) and engineering apoptosis vesicles (AVs-CS) modified by phospholipid-polyethylene glycol-chondroitin sulfate (DSPE-PEG-CS) are crosslinked through dynamic phenylboronic acid ester bonds to form a three-dimensional network structure. The bionic joint lubricating liquid has excellent lubricating performance and stable anchoring capability of AVs-CS, can prevent loss of the AVs-CS, and can realize responsive release of reactive oxygen species (ROS). The bionic joint lubricating liquid can remove excessive ROS in an articular cavity, improve an inflammatory microenvironment, effectively inhibit inflammatory response in the articular cavity in cooperation with AVs-CS, and promote cartilage repair and regeneration. The technology provides a safe and efficient novel biological preparation approach for prevention and treatment of joint inflammatory diseases.

The invention relates to the technical field of transplanted ligaments, and provides a transplanted ligament with indirect dead points, which comprises a thighbone side direct dead point, a thighbone side indirect dead point, a free fiber segment, a tibia side direct dead point and a tibia side indirect dead point, the free fiber section is located in an articular cavity and does not participate in ligament fixation, and the thighbone side direct dead center and the tibia side direct dead center are connected with the free fiber section; the thighbone side direct dead center and the tibia side direct dead center are fixed in a bone tunnel, the thighbone side indirect dead center and the tibia side indirect dead center are fixed on a bone surface, and the thighbone side indirect dead center and the tibia side indirect dead center exist at the same time or only one exists; the thighbone side indirect dead point is connected with any one of the thighbone side direct dead point and the free fiber section; the tibia side indirect dead center is connected with any one of the tibia side direct dead center and the free fiber segment. And precise bionic adaptation is achieved, and the original movement function of the joint is recovered.

The invention discloses an intraoperative omnidirectional tracing probe based on an optical marker and a parameter optimization method of the intraoperative omnidirectional tracing probe. The intraoperative omnidirectional tracing probe comprises a sampling probe and an optical marker array, the sampling probe comprises a long and thin rod-shaped probe body; a hook-shaped needle point is arranged at the front end of the probe body; the hook-shaped needle tip can flexibly enter different directions in a narrow space of an articular cavity, so that fixed-point sampling of subchondral tissues, synovial membranes and local focus tissues is realized; the optical mark array is installed at the tail end of the probe body and comprises at least five near-optical reflective mark balls of an asymmetric structure. The at least five near-optical reflective marking balls are non-coplanar in space and have a multi-ball coplanar distribution structure. The intraoperative omni-directional tracing probe has high flexibility and high recognition degree, and omni-directional sampling and accurate navigation positioning can be achieved in the complex space environment of an articular cavity.

The invention belongs to the technical field of biomedical materials, and particularly relates to in-situ drug-loading hydrogel based on a nano-bottle packaging technology and a preparation method and application thereof.The in-situ drug-loading hydrogel is formed by crosslinking copper chloride encapsulated in a drug-loading polydopamine nano-bottle and reduced thiourea group grafted hyaluronic acid under irradiation of near-infrared light; the diclofenac sodium is dispersed in the periphery and pores of the in-situ drug-loading hydrogel; and Kartogenin is encapsulated in the drug-loaded polydopamine nano bottle. Compared with the prior art, in-situ gelation and medicine time sequence controllable release are realized by adopting a nano bottle packaging technology, and the problems that ex-situ hydrogel cannot be attached to irregular tissues and the in-situ hydrogel is difficult to have the medicine time sequence controllable release capability at the same time are solved. According to the scheme, the hydrogel is perfectly attached to an articular cavity through controllable in-situ gelation so as to protect the joint; meanwhile, the effects of quickly releasing diclofenac sodium and continuously releasing Kartogenin can be realized, so that the phased treatment of osteoarthritis is realized.

The invention discloses an articular cavity puncture positioning method and system based on ultrasonic image guidance, and belongs to the technical field of articular cavity puncture positioning, and the method comprises the following steps: ultrasonic image acquisition, sound shadow area identification, articular cavity model construction, puncture path planning and path visual guidance. The method comprises the following steps: constructing three-dimensional ultrasonic body data through multi-view ultrasonic scanning, and establishing a space model of bones and sound shadow on this basis; then, an anatomical prior model is introduced for registration, so that intelligent form completion is carried out on the articular cavity under sound shadow shielding; then, double constraints of obstacle avoidance skeleton and sound shadow blind area avoidance are comprehensively considered, and optimization calculation is conducted on a puncture path; and finally, the optimized puncture path is mapped to a two-dimensional ultrasonic image to be displayed in an overlapped mode. Accurate positioning and safe puncture guiding of the articular cavity can be achieved under the sound shadow interference condition, and the problem that due to the fact that a blind area exists in an ultrasonic image, articular cavity puncture positioning is inaccurate is effectively solved.

The present invention relates to a device for measuring, recording, and acting in response to changes in air pressures encountered through the lumen of a connected needle. The device signals when it has been powered and signals when the device recognizes both pressures and pressure change rates indicative of synovial cavity joint penetration, such as knee joint penetration. Synovial cavity pressures detected and acted upon may either be supra- (positive) or sub-atmospheric (negative). Internal light emitting diodes and a laptop connected display are demonstrated as signaling and communication mechanisms. Methods for delivering medicaments into human and animal intra-articular cavities or joints such as synovial cavities are provided. Furthermore, methods for facilitating the diagnoses of joint effusion also are provided.