85 results about "Articular cavity" patented technology

The invention provides a dynamic approach planning method and system for an acupotomy scope, and relates to the technical field of approach planning of the acupotomy scope, and the technical scheme is characterized in that real-time image data of an articular cavity is acquired; the real-time image data and the preoperative image data are subjected to registration analysis, and anatomical structure changes in the articular cavity are recognized; according to the recognized anatomical structure change in the joint cavity and a preset anatomical partition rule, anatomical partition information is dynamically updated, and updated anatomical partition information is obtained; according to the updated anatomical partition information, an approach path is set before an operation, real-time path adjustment is carried out, and an optimized needle knife mirror safe approach path is generated; and displaying the real-time image data, the updated anatomical partition information and the optimized safe approach path of the acupotomy mirror in an overlapping manner so as to guide a doctor to operate. The dynamic approach planning method and system for the acupotomy scope have the advantages that the dynamic change of an anatomical structure in an intra-operative joint cavity can be adapted, and safe operation of surgical instruments is ensured.

The invention provides a porous magnetic hyaluronic acid microneedle for treating knee osteoarthritis and a preparation method, and relates to the technical field of biological materials. The porous magnetic hyaluronic acid microneedle for treating knee osteoarthritis comprises a needle body and a matrix layer, the needle body is a porous drug-loading autolysis hyaluronic acid microneedle body, and the matrix layer is a magnetic hyaluronic acid matrix. The invention has the following beneficial effects: 1, a soluble biocompatible microneedle structure is adopted, so that the injury caused by the breakage of a metal microneedle is avoided, and the medicine can directly reach the subcutaneous part; 2, a porous structure is constructed through ice crystal recrystallization, and the drug loading content is increased through a secondary drying technology; 3, the drug carrier is added through the nano magnetic particles, so that diffusion and absorption of drug components are promoted; 4, the operation is simple, tedious steps such as injection in the articular cavity are not needed, and the infection risk in the articular cavity is reduced; 5, batch mold production can be realized, and the production cost is reduced; 6, the administration amount is increased through microneedle perforation administration and matrix layer permeation micropore administration.

The gadolinium-based cationic polymer contrast agent is synthesized by chelating a cationic polymer and gadolinium ions, has high biological safety and can be used for cartilage imaging. The prepared contrast agent adopts an articular cavity direct injection method, so that the imaging effect is improved, and the contrast dosage is reduced. When the cartilage activity is normal, the content of glycosaminoglycan in the matrix is rich, and when the cartilage is inactivated or the activity is reduced, the content of glycosaminoglycan in the matrix is obviously reduced. The gadolinium-based cationic polymer contrast agent is combined with negatively charged glycosaminoglycan in a cartilage matrix through the charge effect. The gadolinium-based cationic polymer contrast agent can be used for noninvasive and quantitative evaluation of cartilage activity in nuclear magnetic resonance imaging, especially cartilage activity and stability in transplantation.

The invention belongs to the technical field of biomedical materials, and particularly relates to a carboxymethyl chitin composite material for an articular cavity and a preparation method of the carboxymethyl chitin composite material. The carboxymethyl chitin composite material for the articular cavity is prepared by selecting carboxymethyl chitin, hyaluronic acid, sodium alginate and chitosan which are good in biocompatibility as raw materials and performing functional modification treatment respectively, and through the synergistic effect of all the components, the elasticity modulus of the composite material is effectively improved, the swelling rate is reduced, and the joint cavity is more stable. And meanwhile, the composite material also has proper viscosity and degradation performance, and can meet application requirements.

The invention belongs to the technical field of medicines, provides an in-situ bubble generation hyaluronic acid composition for ultrasonic introduction and a patch thereof, and relates to the hyaluronic acid composition, a method for preparing and introducing the patch from the composition and an ultrasonic introduction method. The hyaluronic acid composition comprises the following raw materials: hyaluronic acid, a foaming agent and a penetration enhancer, the preparation method of the lead-in patch comprises the steps of mixing the components and applying. The ultrasonic leading-in method comprises the steps of setting ultrasonic leading-in instrument parameters and leading-in time, and carrying out specific ultrasonic leading-in operation. According to the ultrasonic introduction mode, bubbles are generated in situ, the efficiency is higher than that of pure ultrasonic introduction, and the concentration of hyaluronic acid in the articular cavity can be rapidly increased. Compared with hyaluronic acid injection administration, the administration technology is noninvasive, painless, good in clinical compliance, simple and convenient to operate and low in cost; compared with oral administration of hyaluronic acid, the composition has the advantages of good directionality, accurate and controllable action range and small gastrointestinal irritation.

The invention relates to perfusion pump equipment applied to intra-articular flushing and a control method. The method comprises the steps that a liquid injection pump is driven by a liquid injection pump driving circuit to inject medical flushing liquid into an operation cavity; a pressure sensor is used for collecting real-time expansion pressure in the liquid injection process of the liquid injection pump; the difference value between the real-time expansion pressure and the set expansion pressure is calculated; calculating control parameters of the liquid injection pump by combining the difference value, the historical accumulated difference value and the difference value change trend; based on the control parameters, the flow speed of the liquid injection pump injected into the surgical cavity is adjusted through the liquid injection pump driving circuit. By dynamically regulating and controlling the liquid injection pump, the expansion pressure is kept stable, the problem of pressure fluctuation caused by intermittent liquid injection in the prior art is avoided, the surgical space and the surgical field definition can be effectively maintained, and the risk that air enters an articular cavity and causes embolism is reduced.

The utility model discloses a flexible joint lens which comprises a handle part, a lens sheath and a flexible lens, the lens sheath is connected with the handle part, the flexible lens is arranged in the handle part and the lens sheath in a penetrating mode, and a traction wheel used for driving the flexible lens to move in the lens sheath and the handle part under the action of external force is arranged on the handle part. The handle part is also provided with a locking mechanism for locking and fixing the position of the soft lens in the lens sheath and the handle part; the traction wheel is arranged on the handle portion in a pivoted mode, the traction wheel is a gear, and a hole, used for being connected with the traction wheel in a pivoted mode, in the handle portion is a vertical kidney-shaped hole. According to the flexible arthroscope, the length of the flexible arthroscope in an articular cavity can be flexibly controlled, the front end of the flexible arthroscope can reliably move to a focus position, and the flexible arthroscope is matched with a locking mechanism, so that the position of the flexible arthroscope can be fixed, surgical operation is facilitated, and focuses at different positions can be observed.

The full-automatic meniscus cutter comprises a plasma cutter head, a connecting rod, a rotating shaft, a joint insertion rod, a supporting frame and a control system, the plasma cutter head is connected to the front end of the connecting rod and used for cutting lesion tissue of a meniscus, and the rear end of the connecting rod is connected with the rotating shaft; the rotating shaft is rotationally connected to the rear end of the joint insertion rod and is perpendicular to the joint insertion rod, the front end of the joint insertion rod is used for being inserted into a joint cavity and abutting against a joint capsule, a rotating driver used for driving the rotating shaft to rotate is arranged on the supporting frame, and the connecting rod is of a telescopic rod structure and is provided with a telescopic driver used for driving the connecting rod to stretch out and draw back. The control system is electrically connected with the rotating driver and the telescopic driver and used for commanding and controlling the rotating shaft to rotate and commanding and controlling the plasma tool bit to reciprocate front and back. The meniscus cutter has the advantages that automatic cutting and precise cutting are achieved, operation time is shortened, damage to surrounding healthy tissue is reduced, and monitoring and precise control are achieved.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

The present invention provides an injectable magnesium-loaded lipid-based super-lubricating hydrogel microsphere, an articular cavity injection formulation, and a preparation method therefor. The method comprises the following steps: S1, preparing a magnesium-loaded multilamellar vesicular liposome suspension containing magnesium ions; S2, preparing an uncrosslinked magnesium-containing hydrogel; and S3, mixing the magnesium-loaded multilamellar vesicular liposome suspension with the magnesium-containing hydrogel to prepare hydrogel droplets, and carrying out crosslinking to form the magnesium-loaded lipid-based super-lubricating hydrogel microspheres. According to the present invention, the magnesium loading capacity of the lipid-based super-lubricating hydrogel microspheres can be greatly improved; on one hand, the biological function provided by the magnesium ions can be greatly prolonged, that is, the repair of cartilage by synovial liquid progenitor cells is continuously promoted; and on the other hand, the intrinsic lubricating effect of the lipid-based super-lubricating hydrogel microspheres can mitigate the further wear of newly formed cartilage; in addition, the magnesium ions can significantly promote the expression of PRG4 in chondrocytes, which not only facilitates the maintenance of chondrocyte homeostasis, but also further enhances articular lubrication.

The application provides a joint cavity puncture auxiliary positioning device, which comprises a base, a liftable lifting frame arranged on the base, a hinged mounting frame arranged at one end of the lifting frame, two groups of swingable supporting rods arranged on the mounting frame, a mounting frame arranged in the mounting frame, a movable frame slidably arranged in the mounting frame, a control assembly arranged on the mounting frame and used for driving the movable frame to slide, a first fixing assembly arranged on the movable frame and connected with the lifting frame, a second fixing assembly arranged on the movable frame and connected with the supporting rods, a hinged bracket arranged at one end of each of the two groups of supporting rods, and a third fixing assembly arranged on the bracket and used for fixing the bracket on the supporting rod. The device can realize the adjustment and position fixing of the two groups of brackets at any angle, and fix the limbs of a patient through the brackets, so that the joints of the patient at various positions are fixed at multiple angles, the displacement of the joints of the patient during the operation is avoided, and the joint cavity puncture work is more stable.

The present application provides a bridge movable joint device and a construction method, which relate to the field of bridge engineering. The bridge movable joint device includes a first structural member, a second structural member, a joint head, a joint socket and a first elastic member. The second structural member is arranged on the top of the first structural member. The joint head is connected to the first structural member. The joint socket cover is arranged at one end of the joint head, and the joint socket is connected to the second structural member. A joint cavity is formed between the joint head and the joint socket. The first elastic member is arranged in the joint cavity, and the first elastic member is configured to allow the joint head and the joint socket to move relative to each other. The bridge movable joint device is connected to the first structural member through the joint head, and is connected to the second structural member through the joint socket. A first elastic member is arranged between the joint head and the joint socket, which can allow the first structural member to move relative to the second structural member, thereby releasing the bending moment and torque of the first structural member and the second structural member, improving the structural stress, and extending the life of the bridge.

The present application relates to a kind of arthroscopic approach water leakage prevention device, including the elastic cover with dome structure, the sealing valve being arranged in the center position of cover and negative pressure suction mechanism, sealing valve has the conical hollow structure extending to base direction and gradually reducing outer diameter, reverse compensation sealing is realized using joint cavity infusion liquid pressure, cover base edge is equipped with flexible sealing skirt, by the negative pressure interface connection external negative pressure source, so that cover and skin form negative pressure sealing space, the device can be connected in series by negative pressure interface multiple occluder, and equipped with detachable guide rod auxiliary coaxial positioning.The present application uses non-insertion type surface adsorption occlusion, effectively solve the space interference and tissue damage problem in multiple tunnel operation, realize the dynamic water stop of pressure self-adaption, with the advantages of simple operation, sealing stable, strong dissection adaptability, can significantly improve the operation visual clarity and maintain joint cavity pressure stability.

The invention relates to the technical field of nano medicines, in particular to a tanshinol-containing copper-based metal organic framework nano material and a preparation method and application thereof.According to the prepared tanshinol-containing copper-based metal organic framework nano material, tanshinol is dissolved in a dimethylimidazole aqueous solution, copper ions are rapidly added into the solution, and the tanshinol-containing copper-based metal organic framework nano material is obtained after the tanshinol is dissolved in the dimethylimidazole aqueous solution; the tanshinol-loaded copper-based metal organic framework nano-material is prepared from the copper-based metal organic framework nano-material, the tanshinol-loaded copper-based metal organic framework nano-material has high drug loading rate and acid-sensitive drug release performance, and the defects that a small-molecule drug tanshinol is poor in stability in an articular cavity and is easily removed by synovial fluid can be overcome. Compared with a natural enzyme, the nano-enzyme formed by combining tanshinol and copper-based MOF has the active oxygen scavenging capacity, and the treatment effect on osteoarthritis is jointly improved.

The utility model discloses an orthopedic surgery bone tunnel positioning and line grasping integrated sighting device which comprises a base body and a sliding handle connected to one side of the base body, an arc-shaped sliding groove is formed in the sliding handle, an arc-shaped rod is connected into the arc-shaped sliding groove in a sliding mode, a connecting handle is arranged at the end of the arc-shaped rod, and the arc-shaped rod and the sliding handle are fixed through a fastener. An anchoring ring is arranged at the end of the connecting handle, a clamping mechanism is arranged on one side of the anchoring ring, a guide hole is formed in the seat body, and a hollow drill bit is arranged in the guide hole. The hollow drill bit and the guide rod are drilled into the anchoring circular ring at the same time, then the guide rod is taken out, the suture penetrates into the hollow drill bit, the suture penetrates into the anchoring circular ring, pressure is applied to the pressing button at the moment, the arc-shaped pressing head is pushed towards the far end on the plane of the anchoring circular ring, and the anchoring circular ring and the arc-shaped pressing head are tightly closed to jointly clamp the suture at the moment. Then the sighting device is taken out, the suture is clamped out of the articular cavity, the operation efficiency is improved, and repeated operation in the articular cavity is not needed.

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.

The invention belongs to the field of biological materials, and particularly discloses a multi-component microcapsule with multiple ultrasonic responses as well as a preparation method and application of the multi-component microcapsule with the multiple ultrasonic responses, and a hydrogel microcapsule with structural and functional design is prepared through a microfluidic double-emulsion technology on the basis of light-cured methacrylic anhydride gelatin hydrogel and liquid decafluoropentane. According to the prepared multi-ultrasonic-responsive multi-component microcapsule, ultrasonic-responsive oxygen release and controllable generation of reactive oxygen free radicals are realized on the basis of curcumin loaded in methacrylic anhydride gelatin and oxygen dissolved in decafluoropentane; the released oxygen provides an oxygen raw material for sonodynamic therapy while relieving a hypoxic environment in an articular cavity, so that generation of reactive oxygen free radicals is enhanced, apoptosis of pathological synovial fibroblasts is induced, and synovial proliferation in the pathological articular cavity is inhibited.

The invention relates to the technical field of biological materials, in particular to chitosan-mussel mucin bionic polypeptide-SVF composite hydrogel as well as a preparation method and application thereof. The mussel mucin bionic polypeptide endows the hydrogel with strong adhesion capacity, so that the hydrogel can be firmly adhered to the surface of cartilage, and SVF loss is prevented; as a carrier of the SVF, the hydrogel can be fixed in an articular cavity, the retention time of the hydrogel is prolonged, and the treatment effect is continuously achieved. Chitosan and mussel mucin bionic polypeptide have good biocompatibility and do not cause immunological rejection, an RGD sequence in the polypeptide can promote cell adhesion, chitosan provides a good cell growth microenvironment, and colonization, survival and function exertion of cells in SVF are facilitated. Chitosan has a certain cartilage repair promoting effect and has a synergistic effect with SVF, cartilage regeneration can be more effectively promoted, a hydrogel precursor solution has good fluidity, the hydrogel precursor solution can be injected into an articular cavity in a minimally invasive mode, and operation is easy and convenient.

The invention discloses a preparation method of biological glue with a layer-by-layer progressive function, which comprises the following steps: 1) uniformly mixing a silk fibroin solution and tadpole-shaped silk fibroin particles, adding a tannic acid solution, and mixing to form a viscous gel material; and 2) adding a cartilage matrix material / bone repair material into the viscous gel material prepared in the step 1), and uniformly mixing to obtain the biological glue. According to the invention, a reactant formed by the silk fibroin and the tannic acid has strong adhesion in an articular cavity wetting state, and rapid adhesion is realized; meanwhile, a viscous gel material formed by the silk fibroin, the tannic acid and the tadpole-shaped silk fibroin particles provides a three-dimensional environment for cell proliferation, so that the functions of adhesion, migration, differentiation, proliferation and the like of related cells are collected favorably, and the extrinsic repair effect of cartilage is realized; the biological glue is mainly used in the field of osteochondral injury repair, and the function of repairing osteochondral layer by layer is realized by adopting a layer-by-layer injection and rapid adhesion technology.

The utility model relates to a probing hook for medical arthroscopic surgery, and relates to the technical field of medical auxiliary instruments, the probing hook comprises a probing part and a rod body, the probing part is provided with a plurality of groups of scale marks at intervals and is used for probing the damage condition of a damaged position, and the rod body is connected with the probing part and is convenient for a doctor to operate the probing hook. A liquid discharging channel used for discharging accumulated liquid at the position of the detection part is arranged in the detection part and the rod body. According to the detection hook, the damage condition of a damaged position can be conveniently detected through the multiple sets of scales on the detection part, meanwhile, effusion in a joint cavity enters the liquid discharging channel through the detection part, the effusion in the detection part is discharged from the tail end of the rod body through the liquid discharging channel, and therefore the effusion discharging efficiency of the detection hook is improved.

The utility model relates to the technical field of arthroscopic surgeries, in particular to a film pasting device for collecting and treating waste liquid of an articular cavity in the arthroscopic surgeries, which comprises a first collecting component, a film pasting body is fixedly connected to the lower portion of the rear end of the first collecting component in an adhering mode, and a second collecting component is fixedly connected to the lower portion of the front end of the film pasting body in an adhering mode. The upper portion of the outer surface of the first collecting assembly and the lower portion of the outer surface of the second collecting assembly are fixedly connected with connecting assemblies in a penetrating mode. The connecting assembly comprises a communicating pipe, the lower end of the communicating pipe is fixedly connected with a fixing ring in a penetrating mode, the lower portion of the outer surface of the fixing ring is fixedly sleeved with a rubber sleeve, the lower end of the communicating pipe is fixedly connected with a pipeline in a penetrating mode, and the communicating pipe is fixedly connected with the second collecting assembly in a penetrating mode. According to the film pasting device for collecting and treating the waste liquid of the articular cavity in the arthroscopic surgery, the waste liquid of the articular cavity can be conveniently collected through the collecting assembly and the connecting assembly.

The utility model relates to the technical field of medical instruments, in particular to a hip joint endoscope operation approach positioning device which is characterized by comprising a sheathing canal which is in a tubular shape matched with an arthroscope and allows the arthroscope to go in and out of an articular cavity; the arthroscope is arranged in the sheath tube; the left positioning arm is arranged on the sheathing canal, and one end of the left positioning arm is connected with the sheathing canal; the positioning sleeve is arranged on the side surface of the right positioning arm; the right positioning arm is arranged on the positioning sleeve, a connecting hole is formed in the right positioning arm, the circle center of the right positioning arm is the same as that of the left positioning arm, one end of the right positioning arm is connected with the positioning sleeve, the right positioning arm is movably connected with the left positioning arm, and any position of the positioning sleeve in the moving track range points to the center pointed by the arthroscope. The problem that an existing approach device can enter the articular cavity only after multiple times of puncture under perspective to correct deviation is solved, and the effect that the device can accurately puncture the articular cavity to enter the articular cavity is achieved.

The puncture structure for the articular cavity comprises a puncture body, an air bag and a connecting boss are arranged on the outer side wall of the puncture body, and an air inlet connector is arranged on one end face of the connecting boss. A cavity is formed in the connecting boss, a first air hole and a second air hole are formed in the inner wall of the cavity, the first air hole communicates with an inner cavity of the puncture body, and the second air hole communicates with the air bag. A scavenging valve element is movably connected into the cavity, and the scavenging valve element is moved to block the first air hole or the second air hole. When the scavenging valve element blocks the first air hole, air enters the air bag through the second air hole, and the air bag is inflated to be expanded for positioning; when the scavenging valve element blocks the second air hole, air enters the inner cavity of the puncture body through the first air hole, and air is provided for an articular cavity; according to the puncture structure, the airflow path can be controlled through simple movement of the valve element, switching of different functions is completed, the complexity of equipment is reduced, and the convenience and safety of an operation are improved.

The invention discloses a hard tube arthroscope with a rotatable lens, and relates to the technical field of arthroscopes, the hard tube arthroscope comprises an arthroscope handle and a hard tube main body, one end of the hard tube main body is internally provided with an imaging module, and the imaging module is further provided with an imaging hard wire used for transmitting signals and transmitting electric power; the arthroscope handle is further provided with a locking mechanism used for limiting rotation and deflection of the imaging hard line, an adjusting screw is fixedly installed at the end, away from the imaging module, of the hard tube body, a funnel-shaped imaging bucket groove is further formed in the end, away from the adjusting screw, of the hard tube body, and the imaging bucket groove and the imaging module are arranged correspondingly. One end, penetrating through the imaging bucket groove, of the imaging hard line is fixedly mounted in the hard tube main body and extends out of the adjusting screw, and during use, through the linkage design of the imaging hard line and the adjusting screw and the eccentric inclined layout of the imaging module, the imaging visual angle can be flexibly adjusted without drawing out the hard tube main body; extra traction damage to joint cavity soft tissue caused by frequent drawing and inserting is avoided.

The invention belongs to the technical field of biology, and discloses application of a composition of neoagaro-oligosaccharide and astaxanthin in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the invention comprises neoagaro-oligosaccharide, astaxanthin, carbomer and alginate in a mass ratio of (1-10): (1-10): (0.01-0.5): (0.1-1), and can realize efficient enrichment of neoagaro-oligosaccharide and astaxanthin in an articular cavity through a substance diffusion path of skin penetration, deep tissue diffusion, joint capsule permeation and articular cavity enrichment, so that the content of neoagaro-oligosaccharide and astaxanthin in the articular cavity is improved, and the content of astaxanthin in the articular cavity is reduced. The new agar oligosaccharide and the astaxanthin have an excellent synergistic effect, so that the acute inflammation symptom of gouty osteoarthritis can be efficiently relieved, the progress of the disease course is blocked, the pathological change of joint tissue is repaired, and the new agar oligosaccharide and the astaxanthin have an excellent application prospect in preparation of the transdermal medicine for treating osteoarthritis.

The invention relates to application of a fragile X intellectual disorder No.1 gene in treating or relieving osteoarthritis, and belongs to the technical field of biological medicines. Researches show that the osteoarthritis is accompanied by increase of the concentration of fragile X chromosome intellectual retardation protein in serum and increase of synovial inflammatory macrophages, the fragile X chromosome intellectual retardation protein in the synovial inflammatory macrophages aggravates the progress of the osteoarthritis, articular cavity synovial inflammatory macrophage FMRP genes are inhibited in a targeted manner, and the osteoarthritis can be used for treating osteoarthritis. A new thought is provided for prevention and treatment of osteoarthritis, a support is provided for clinical transformation, and at present, related reports for treating or relieving osteoarthritis through target intervention are not found yet.

The invention provides an articular cavity puncture needle with an antibacterial coating and a preparation method of the articular cavity puncture needle, and belongs to the technical field of medical instruments. The preparation method of the articular cavity puncture needle with the antibacterial coating comprises the following steps: (1) mixing a polyacrylamide solution, a sodium carboxymethyl cellulose solution and a surfactant solution to obtain an antibacterial coating solution; and (2) coating an articular cavity puncture needle with the antibacterial coating liquid obtained in the step (1) to obtain the articular cavity puncture needle with the antibacterial coating. The surface of the articular cavity puncture needle is coated with the antibacterial coating liquid, the antibacterial performance of the articular cavity puncture needle can be remarkably improved, good stability can be kept in an organic solvent (such as ethyl alcohol), and the prepared articular cavity puncture needle with the antibacterial coating is more suitable for the complex internal environment of a human body.

The utility model relates to the field of medical instruments, in particular to an arthroscopic surgery field maintainer which comprises a maintainer body, an elastic fixator is arranged at one end of the maintainer body, a screw-in screw ring is arranged at the other end of the maintainer body, and a screw-in device is screwed on the outer wall of the screw-in screw ring. The opening of the arthroscope is complete, an instrument with a large size can conveniently enter an articular cavity, meanwhile, other skin wounds of the arthroscope can be prevented from being opened, the wound surface of the arthroscope operation is further reduced, and postoperative healing is facilitated.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to dexamethasone single-phase zero-order release sustained-release microspheres as well as a preparation method and application thereof. The dexamethasone sustained-release microspheres are prepared by an emulsification-solvent evaporation method, the release platform phase of the microspheres is improved by adding a release accelerator, and finally the dexamethasone sustained-release microspheres with a single-phase zero-order release behavior are obtained. Experimental results show that various representations of the sustained-release microspheres meet the requirements of preparations, and in-vivo pharmacodynamic studies of rats also show that the sustained-release microspheres can protect articular cartilage and maintain a normal cartilage structure, and have the same curative effect as commercially available dexamethasone acetate injection. Therefore, the dexamethasone sustained-release microsphere which is used for articular cavity injection and has a good release behavior is successfully developed, the advantages of articular cavity injection drugs can be fully played, the drugs can be continuously and stably released, long-acting treatment of arthritis is achieved, and the dexamethasone sustained-release microsphere has important clinical application value and wide market prospects.

The invention discloses an efficient collecting device for obtaining tissue specimens under an arthroscope, and belongs to the technical field of medical instruments, the efficient collecting device comprises a shell, a water inlet is integrally formed in the lower portion of the left side of the shell, a water outlet is integrally formed in the upper portion of the right side of the shell, and a fixed base is arranged below the shell; a filter screen is arranged on the upper portion of the interior of the shell, a fixing rubber ring is fixedly connected to the outer side wall of the filter screen, a groove is formed in the position, located on the outer side of the filter screen, of the inner side wall of the shell, and the outer side of the fixing rubber ring extends into the groove; the system has a multi-point sampling function, can accurately position a suspicious lesion area in an articular cavity for tissue sampling, remarkably reduces the randomness of sample acquisition, and ensures the representativeness and accuracy of the obtained sample through more comprehensive multi-point sampling, thereby improving the reliability of pathological and microbiological detection.