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65 results about "Articular cavity" patented technology

A joint cavity, the potential space bounded by the synovial membrane and articular cartilages of all synovial joints. Normally, the articular cavity contains only sufficient synovial fluid to lubricate the internal surfaces.

Dynamic approach planning method and system for acupotomy mirror

The invention provides a dynamic approach planning method and system for an acupotomy scope, and relates to the technical field of approach planning of the acupotomy scope, and the technical scheme is characterized in that real-time image data of an articular cavity is acquired; the real-time image data and the preoperative image data are subjected to registration analysis, and anatomical structure changes in the articular cavity are recognized; according to the recognized anatomical structure change in the joint cavity and a preset anatomical partition rule, anatomical partition information is dynamically updated, and updated anatomical partition information is obtained; according to the updated anatomical partition information, an approach path is set before an operation, real-time path adjustment is carried out, and an optimized needle knife mirror safe approach path is generated; and displaying the real-time image data, the updated anatomical partition information and the optimized safe approach path of the acupotomy mirror in an overlapping manner so as to guide a doctor to operate. The dynamic approach planning method and system for the acupotomy scope have the advantages that the dynamic change of an anatomical structure in an intra-operative joint cavity can be adapted, and safe operation of surgical instruments is ensured.
Owner:FOSHAN NANHAI DISTRICT PEOPLES HOSPITAL

Porous magnetic hyaluronic acid microneedle for treating knee osteoarthritis and preparation method thereof

The invention provides a porous magnetic hyaluronic acid microneedle for treating knee osteoarthritis and a preparation method, and relates to the technical field of biological materials. The porous magnetic hyaluronic acid microneedle for treating knee osteoarthritis comprises a needle body and a matrix layer, the needle body is a porous drug-loading autolysis hyaluronic acid microneedle body, and the matrix layer is a magnetic hyaluronic acid matrix. The invention has the following beneficial effects: 1, a soluble biocompatible microneedle structure is adopted, so that the injury caused by the breakage of a metal microneedle is avoided, and the medicine can directly reach the subcutaneous part; 2, a porous structure is constructed through ice crystal recrystallization, and the drug loading content is increased through a secondary drying technology; 3, the drug carrier is added through the nano magnetic particles, so that diffusion and absorption of drug components are promoted; 4, the operation is simple, tedious steps such as injection in the articular cavity are not needed, and the infection risk in the articular cavity is reduced; 5, batch mold production can be realized, and the production cost is reduced; 6, the administration amount is increased through microneedle perforation administration and matrix layer permeation micropore administration.
Owner:FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA

Gadolinium-based cationic polymer contrast agent and preparation method thereof

The gadolinium-based cationic polymer contrast agent is synthesized by chelating a cationic polymer and gadolinium ions, has high biological safety and can be used for cartilage imaging. The prepared contrast agent adopts an articular cavity direct injection method, so that the imaging effect is improved, and the contrast dosage is reduced. When the cartilage activity is normal, the content of glycosaminoglycan in the matrix is rich, and when the cartilage is inactivated or the activity is reduced, the content of glycosaminoglycan in the matrix is obviously reduced. The gadolinium-based cationic polymer contrast agent is combined with negatively charged glycosaminoglycan in a cartilage matrix through the charge effect. The gadolinium-based cationic polymer contrast agent can be used for noninvasive and quantitative evaluation of cartilage activity in nuclear magnetic resonance imaging, especially cartilage activity and stability in transplantation.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH

Filling pump equipment applied to intra-articular flushing and control method

The invention relates to perfusion pump equipment applied to intra-articular flushing and a control method. The method comprises the steps that a liquid injection pump is driven by a liquid injection pump driving circuit to inject medical flushing liquid into an operation cavity; a pressure sensor is used for collecting real-time expansion pressure in the liquid injection process of the liquid injection pump; the difference value between the real-time expansion pressure and the set expansion pressure is calculated; calculating control parameters of the liquid injection pump by combining the difference value, the historical accumulated difference value and the difference value change trend; based on the control parameters, the flow speed of the liquid injection pump injected into the surgical cavity is adjusted through the liquid injection pump driving circuit. By dynamically regulating and controlling the liquid injection pump, the expansion pressure is kept stable, the problem of pressure fluctuation caused by intermittent liquid injection in the prior art is avoided, the surgical space and the surgical field definition can be effectively maintained, and the risk that air enters an articular cavity and causes embolism is reduced.
Owner:STAR SPORTS MEDICINE CO LTD

Full-automatic meniscus cutter

The full-automatic meniscus cutter comprises a plasma cutter head, a connecting rod, a rotating shaft, a joint insertion rod, a supporting frame and a control system, the plasma cutter head is connected to the front end of the connecting rod and used for cutting lesion tissue of a meniscus, and the rear end of the connecting rod is connected with the rotating shaft; the rotating shaft is rotationally connected to the rear end of the joint insertion rod and is perpendicular to the joint insertion rod, the front end of the joint insertion rod is used for being inserted into a joint cavity and abutting against a joint capsule, a rotating driver used for driving the rotating shaft to rotate is arranged on the supporting frame, and the connecting rod is of a telescopic rod structure and is provided with a telescopic driver used for driving the connecting rod to stretch out and draw back. The control system is electrically connected with the rotating driver and the telescopic driver and used for commanding and controlling the rotating shaft to rotate and commanding and controlling the plasma tool bit to reciprocate front and back. The meniscus cutter has the advantages that automatic cutting and precise cutting are achieved, operation time is shortened, damage to surrounding healthy tissue is reduced, and monitoring and precise control are achieved.
Owner:NINGBO FIRST HOSPITAL

Tissue engineering articular cartilage simulating four-layer structure of natural cartilage and in-situ 3D printing method of tissue engineering articular cartilage

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.
Owner:THE 958TH ARMY HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY

Injectable magnesium-loaded lipid-based super-lubricating hydrogel microsphere, articular cavity injection formulation, and preparation method therefor

The present invention provides an injectable magnesium-loaded lipid-based super-lubricating hydrogel microsphere, an articular cavity injection formulation, and a preparation method therefor. The method comprises the following steps: S1, preparing a magnesium-loaded multilamellar vesicular liposome suspension containing magnesium ions; S2, preparing an uncrosslinked magnesium-containing hydrogel; and S3, mixing the magnesium-loaded multilamellar vesicular liposome suspension with the magnesium-containing hydrogel to prepare hydrogel droplets, and carrying out crosslinking to form the magnesium-loaded lipid-based super-lubricating hydrogel microspheres. According to the present invention, the magnesium loading capacity of the lipid-based super-lubricating hydrogel microspheres can be greatly improved; on one hand, the biological function provided by the magnesium ions can be greatly prolonged, that is, the repair of cartilage by synovial liquid progenitor cells is continuously promoted; and on the other hand, the intrinsic lubricating effect of the lipid-based super-lubricating hydrogel microspheres can mitigate the further wear of newly formed cartilage; in addition, the magnesium ions can significantly promote the expression of PRG4 in chondrocytes, which not only facilitates the maintenance of chondrocyte homeostasis, but also further enhances articular lubrication.
Owner:THE CHINESE UNIVERSITY OF HONG KONG

Joint cavity puncture auxiliary positioning device

The application provides a joint cavity puncture auxiliary positioning device, which comprises a base, a liftable lifting frame arranged on the base, a hinged mounting frame arranged at one end of the lifting frame, two groups of swingable supporting rods arranged on the mounting frame, a mounting frame arranged in the mounting frame, a movable frame slidably arranged in the mounting frame, a control assembly arranged on the mounting frame and used for driving the movable frame to slide, a first fixing assembly arranged on the movable frame and connected with the lifting frame, a second fixing assembly arranged on the movable frame and connected with the supporting rods, a hinged bracket arranged at one end of each of the two groups of supporting rods, and a third fixing assembly arranged on the bracket and used for fixing the bracket on the supporting rod. The device can realize the adjustment and position fixing of the two groups of brackets at any angle, and fix the limbs of a patient through the brackets, so that the joints of the patient at various positions are fixed at multiple angles, the displacement of the joints of the patient during the operation is avoided, and the joint cavity puncture work is more stable.
Owner:CHINESE PEOPLES LIBERATION ARMY ARMY SPECIAL MEDICAL CENTER

A bridge movable joint device and construction method

The present application provides a bridge movable joint device and a construction method, which relate to the field of bridge engineering. The bridge movable joint device includes a first structural member, a second structural member, a joint head, a joint socket and a first elastic member. The second structural member is arranged on the top of the first structural member. The joint head is connected to the first structural member. The joint socket cover is arranged at one end of the joint head, and the joint socket is connected to the second structural member. A joint cavity is formed between the joint head and the joint socket. The first elastic member is arranged in the joint cavity, and the first elastic member is configured to allow the joint head and the joint socket to move relative to each other. The bridge movable joint device is connected to the first structural member through the joint head, and is connected to the second structural member through the joint socket. A first elastic member is arranged between the joint head and the joint socket, which can allow the first structural member to move relative to the second structural member, thereby releasing the bending moment and torque of the first structural member and the second structural member, improving the structural stress, and extending the life of the bridge.
Owner:ZHEJIANG INST OF COMM CO LTD

Arthroscopic approach water leakage prevention device

The present application relates to a kind of arthroscopic approach water leakage prevention device, including the elastic cover with dome structure, the sealing valve being arranged in the center position of cover and negative pressure suction mechanism, sealing valve has the conical hollow structure extending to base direction and gradually reducing outer diameter, reverse compensation sealing is realized using joint cavity infusion liquid pressure, cover base edge is equipped with flexible sealing skirt, by the negative pressure interface connection external negative pressure source, so that cover and skin form negative pressure sealing space, the device can be connected in series by negative pressure interface multiple occluder, and equipped with detachable guide rod auxiliary coaxial positioning.The present application uses non-insertion type surface adsorption occlusion, effectively solve the space interference and tissue damage problem in multiple tunnel operation, realize the dynamic water stop of pressure self-adaption, with the advantages of simple operation, sealing stable, strong dissection adaptability, can significantly improve the operation visual clarity and maintain joint cavity pressure stability.
Owner:NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A

Multicomponent synovitis treatment compositions for repairing cartilage tissue and uses thereof

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.
Owner:ENWEIDA (HAINAN) CONSULTING SERVICES CO LTD

Multi-component microcapsule with multiple ultrasonic responses as well as preparation method and application of multi-component microcapsule

The invention belongs to the field of biological materials, and particularly discloses a multi-component microcapsule with multiple ultrasonic responses as well as a preparation method and application of the multi-component microcapsule with the multiple ultrasonic responses, and a hydrogel microcapsule with structural and functional design is prepared through a microfluidic double-emulsion technology on the basis of light-cured methacrylic anhydride gelatin hydrogel and liquid decafluoropentane. According to the prepared multi-ultrasonic-responsive multi-component microcapsule, ultrasonic-responsive oxygen release and controllable generation of reactive oxygen free radicals are realized on the basis of curcumin loaded in methacrylic anhydride gelatin and oxygen dissolved in decafluoropentane; the released oxygen provides an oxygen raw material for sonodynamic therapy while relieving a hypoxic environment in an articular cavity, so that generation of reactive oxygen free radicals is enhanced, apoptosis of pathological synovial fibroblasts is induced, and synovial proliferation in the pathological articular cavity is inhibited.
Owner:NANJING DRUM TOWER HOSPITAL

Preparation method of chitosan-mussel mucin bionic polypeptide-SVF composite hydrogel

The invention relates to the technical field of biological materials, in particular to chitosan-mussel mucin bionic polypeptide-SVF composite hydrogel as well as a preparation method and application thereof. The mussel mucin bionic polypeptide endows the hydrogel with strong adhesion capacity, so that the hydrogel can be firmly adhered to the surface of cartilage, and SVF loss is prevented; as a carrier of the SVF, the hydrogel can be fixed in an articular cavity, the retention time of the hydrogel is prolonged, and the treatment effect is continuously achieved. Chitosan and mussel mucin bionic polypeptide have good biocompatibility and do not cause immunological rejection, an RGD sequence in the polypeptide can promote cell adhesion, chitosan provides a good cell growth microenvironment, and colonization, survival and function exertion of cells in SVF are facilitated. Chitosan has a certain cartilage repair promoting effect and has a synergistic effect with SVF, cartilage regeneration can be more effectively promoted, a hydrogel precursor solution has good fluidity, the hydrogel precursor solution can be injected into an articular cavity in a minimally invasive mode, and operation is easy and convenient.
Owner:NANHUA HOSPITAL AFFILIATED TO UNIV OF SOUTH CHINA

Hip arthroscopic surgery approach positioning device

The utility model relates to the technical field of medical instruments, in particular to a hip joint endoscope operation approach positioning device which is characterized by comprising a sheathing canal which is in a tubular shape matched with an arthroscope and allows the arthroscope to go in and out of an articular cavity; the arthroscope is arranged in the sheath tube; the left positioning arm is arranged on the sheathing canal, and one end of the left positioning arm is connected with the sheathing canal; the positioning sleeve is arranged on the side surface of the right positioning arm; the right positioning arm is arranged on the positioning sleeve, a connecting hole is formed in the right positioning arm, the circle center of the right positioning arm is the same as that of the left positioning arm, one end of the right positioning arm is connected with the positioning sleeve, the right positioning arm is movably connected with the left positioning arm, and any position of the positioning sleeve in the moving track range points to the center pointed by the arthroscope. The problem that an existing approach device can enter the articular cavity only after multiple times of puncture under perspective to correct deviation is solved, and the effect that the device can accurately puncture the articular cavity to enter the articular cavity is achieved.
Owner:HENGYANG CENT HOSPITAL +1

Puncture structure for articular cavity

The puncture structure for the articular cavity comprises a puncture body, an air bag and a connecting boss are arranged on the outer side wall of the puncture body, and an air inlet connector is arranged on one end face of the connecting boss. A cavity is formed in the connecting boss, a first air hole and a second air hole are formed in the inner wall of the cavity, the first air hole communicates with an inner cavity of the puncture body, and the second air hole communicates with the air bag. A scavenging valve element is movably connected into the cavity, and the scavenging valve element is moved to block the first air hole or the second air hole. When the scavenging valve element blocks the first air hole, air enters the air bag through the second air hole, and the air bag is inflated to be expanded for positioning; when the scavenging valve element blocks the second air hole, air enters the inner cavity of the puncture body through the first air hole, and air is provided for an articular cavity; according to the puncture structure, the airflow path can be controlled through simple movement of the valve element, switching of different functions is completed, the complexity of equipment is reduced, and the convenience and safety of an operation are improved.
Owner:JIANGSU DEJIAN MEDICAL TECH CO LTD

Hard tube arthroscope with rotatable lens

The invention discloses a hard tube arthroscope with a rotatable lens, and relates to the technical field of arthroscopes, the hard tube arthroscope comprises an arthroscope handle and a hard tube main body, one end of the hard tube main body is internally provided with an imaging module, and the imaging module is further provided with an imaging hard wire used for transmitting signals and transmitting electric power; the arthroscope handle is further provided with a locking mechanism used for limiting rotation and deflection of the imaging hard line, an adjusting screw is fixedly installed at the end, away from the imaging module, of the hard tube body, a funnel-shaped imaging bucket groove is further formed in the end, away from the adjusting screw, of the hard tube body, and the imaging bucket groove and the imaging module are arranged correspondingly. One end, penetrating through the imaging bucket groove, of the imaging hard line is fixedly mounted in the hard tube main body and extends out of the adjusting screw, and during use, through the linkage design of the imaging hard line and the adjusting screw and the eccentric inclined layout of the imaging module, the imaging visual angle can be flexibly adjusted without drawing out the hard tube main body; extra traction damage to joint cavity soft tissue caused by frequent drawing and inserting is avoided.
Owner:HUNAN ENDOSO LIFE TECH CO LTD

Application of composition of neoagaro-oligosaccharide and astaxanthin in preparation of transdermal medicine for treating osteoarthritis and composite gel preparation

ActiveCN121081366AOrganic active ingredientsAntipyreticGel preparationArthritis therapy
The invention belongs to the technical field of biology, and discloses application of a composition of neoagaro-oligosaccharide and astaxanthin in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the invention comprises neoagaro-oligosaccharide, astaxanthin, carbomer and alginate in a mass ratio of (1-10): (1-10): (0.01-0.5): (0.1-1), and can realize efficient enrichment of neoagaro-oligosaccharide and astaxanthin in an articular cavity through a substance diffusion path of skin penetration, deep tissue diffusion, joint capsule permeation and articular cavity enrichment, so that the content of neoagaro-oligosaccharide and astaxanthin in the articular cavity is improved, and the content of astaxanthin in the articular cavity is reduced. The new agar oligosaccharide and the astaxanthin have an excellent synergistic effect, so that the acute inflammation symptom of gouty osteoarthritis can be efficiently relieved, the progress of the disease course is blocked, the pathological change of joint tissue is repaired, and the new agar oligosaccharide and the astaxanthin have an excellent application prospect in preparation of the transdermal medicine for treating osteoarthritis.
Owner:THIRD INSTITUTE OF OCEANOGRAPHY STATE OCEANI C ADMINISTRATION

Application of fragile X intellectual disorder No.1 gene in treating or relieving osteoarthritis

The invention relates to application of a fragile X intellectual disorder No.1 gene in treating or relieving osteoarthritis, and belongs to the technical field of biological medicines. Researches show that the osteoarthritis is accompanied by increase of the concentration of fragile X chromosome intellectual retardation protein in serum and increase of synovial inflammatory macrophages, the fragile X chromosome intellectual retardation protein in the synovial inflammatory macrophages aggravates the progress of the osteoarthritis, articular cavity synovial inflammatory macrophage FMRP genes are inhibited in a targeted manner, and the osteoarthritis can be used for treating osteoarthritis. A new thought is provided for prevention and treatment of osteoarthritis, a support is provided for clinical transformation, and at present, related reports for treating or relieving osteoarthritis through target intervention are not found yet.
Owner:TONGJI UNIV

Dexamethasone single-phase zero-order release sustained-release microsphere as well as preparation method and application thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to dexamethasone single-phase zero-order release sustained-release microspheres as well as a preparation method and application thereof. The dexamethasone sustained-release microspheres are prepared by an emulsification-solvent evaporation method, the release platform phase of the microspheres is improved by adding a release accelerator, and finally the dexamethasone sustained-release microspheres with a single-phase zero-order release behavior are obtained. Experimental results show that various representations of the sustained-release microspheres meet the requirements of preparations, and in-vivo pharmacodynamic studies of rats also show that the sustained-release microspheres can protect articular cartilage and maintain a normal cartilage structure, and have the same curative effect as commercially available dexamethasone acetate injection. Therefore, the dexamethasone sustained-release microsphere which is used for articular cavity injection and has a good release behavior is successfully developed, the advantages of articular cavity injection drugs can be fully played, the drugs can be continuously and stably released, long-acting treatment of arthritis is achieved, and the dexamethasone sustained-release microsphere has important clinical application value and wide market prospects.
Owner:SHENYANG PHARMA UNIV

Retractor

A retractor is provided that can form a joint cavity internal space for a field of view for an endoscope and practice of a treatment in a state where a wound area is spread. A retractor includes first arm portions 2 and 3 and a second arm portion 4 positioned between the first arm portions 2 and 3. The first arm portions 2 and 3 include first claw portions 12 and 13 to be hung on a wound area entrance edge. The second arm portion 4 includes a second claw portion 14 to be hung on the wound area entrance edge. When the first arm portions 2 and 3 and the second arm portion 4 are in a closed state, the first claw portions 12 and 13 and the second claw portion 14 overlap with each other.
Owner:MOCHIDA PHARM CO LTD +1

Dual-module delivery system and application thereof in preparation of medicine for treating osteoarthritis or synovitis

The invention discloses a dual-module delivery system and application thereof in preparation of a medicine for treating osteoarthritis or synovitis. Comprising an articular cavity drug delivery module 1 and an articular cavity drug delivery module 2, the module 1 is a nanoparticle or an exosome or a microsphere wrapping an aging cell scavenger, and the module 2 is a nanoparticle or an exosome or a microsphere wrapping an M2 polarization inducer; the compound is applied to the treatment medicine for osteoarthritis or synovitis, can target senescence synovial fibroblasts and M1 macrophages, combines senescence cell removal with a macrophage reprogramming mechanism, solves the problems of generation of senescence-related secretory phenotypes and inflammatory polarization of macrophages, and has a good application prospect in treatment of osteoarthritis or synovitis. By reducing SASP sources and inflammatory reactions at the same time, vicious circle of senescence-inflammation cascade reactions is broken, stability of the environment in joints is recovered, and the application prospect is extremely high.
Owner:NANJING MEDICAL UNIV +1

Heme-based multifunctional nano-drug as well as preparation method and application thereof

The invention discloses a heme-based multifunctional nano-drug and a preparation method and application thereof, and relates to the technical field of nano-drugs, and the heme-based multifunctional nano-drug comprises heme and hydrophobic molecules wrapped in the heme. The hydrophobic molecules are wrapped in the heme, so that the bioavailability of the hydrophobic molecules is improved, the hydrophobic molecules are slowly released at bone joints, and the retention time of the hydrophobic molecules in the bone joints is prolonged; meanwhile, the nanostructure formed by the heme has better lubrication property, biocompatibility and cartilage steady state improving effect, can promote cartilage cell proliferation, and can enhance the capability of resisting oxygen deficit and continuously worsening articular cavity internal environment of cartilage tissues through synergistic effect, so that the cartilage steady state is better maintained. Therefore, the multifunctional nano-drug provided by the invention has universality in treatment of osteoarthritis.
Owner:HUAZHONG UNIV OF SCI & TECH

Extractor for free body in articular cavity

The invention relates to the technical field of free body taking-out devices, and discloses an intra-articular cavity free body taking-out device which comprises a shell sleeve, one end of the shell sleeve is provided with a catching head for catching free bodies, the catching head is of a soft structure, and one end of the shell sleeve is provided with an expanding and supporting mechanism for driving the catching head to be adjusted to be in a net cover shape. Compared with the prior art, the device has the advantages that the angle of the expanding and supporting mechanism can be adjusted through the adjusting mechanism, then the angle of the catching head is adjusted, a larger degree of freedom is obtained in the limited space of a joint cavity, the use convenience is improved, and the device is suitable for popularization and application. The catching head of the mesh-shaped structure can catch the free body in the articular cavity, the free body does not need to be grabbed, the catching head can be suitable for the small or special free body, the catching head of the mesh-shaped structure can catch a plurality of free bodies at the same time, the treatment time of a patient is shortened, and the pain of the patient is relieved.
Owner:SHANGHAI SIXTH PEOPLES HOSPITAL JINSHAN BRANCH (JINSHAN DISTRICT CENT HOSPITAL AFFILIATED TO SHANGHAI HEALTH MEDICAL COLLEGE SHANGHAI JINSHAN DISTRICT CENT HOSPITAL)

Joint cavity positioning method and device based on deep learning model

The invention relates to the technical field of articular cavity positioning, and particularly provides an articular cavity positioning method and device based on a deep learning model, and the method comprises the steps: S1, obtaining an arthroscopic image, and carrying out the preprocessing of the arthroscopic image, so as to obtain an enhanced image; s2, acquiring articular cavity position information according to a pre-trained articular cavity positioning model and the enhanced image; the pre-training of the joint cavity positioning model comprises the following steps: A1, training a pre-constructed deep learning model by using a pre-collected general medical image data set to obtain a preliminary positioning model; a2, expanding a pre-collected arthroscopic image data set of the rare bone joint disease to obtain an expanded image data set, and then dynamically adjusting the regularization intensity of the preliminary positioning model based on a self-adaptive regularization coefficient function according to an articular cavity form diversity index of the expanded image data set to obtain an articular cavity positioning model; according to the method, the articular cavity of the rare osteoarticular disease can be accurately positioned.
Owner:乐清市人民医院

Free body grasping forceps

The invention discloses a pair of free body grasping forceps. The pair of free body grasping forceps comprises a handle assembly, a clamping device and a driving assembly, the clamping device has an opening state and a tightening state, the clamping device in the opening state is opened and used for grabbing the free body, and the clamping device in the tightening state is contracted and used for wrapping the free body; the driving assembly is arranged on the handle assembly, connected with the clamping device and used for driving the clamping device to be switched between the opening state and the tightening state. According to the free body grasping forceps, when the clamping device is in the tightening state, the free body can be wrapped, so that the disengagement probability of the free body is reduced, the free body is not prone to disengagement, and the difficulty of taking out the free body is reduced. Besides, the free body is wrapped by the clamping device, the free body and the joint cavity can be separated through the clamping device, and therefore when the free body grasping forceps are separated from the joint cavity, the contact probability of the free body and the joint cavity is reduced, and the risk that the free body damages the joint cavity is reduced.
Owner:PEKING UNIVERSITY THIRD HOSPITAL (THE THIRD CLINICAL MEDICAL SCHOOL OF PEKING UNIVERSITY)

Rat articular cavity sampling method

PendingCN119791730ASurgical needlesSurgical veterinaryDiseaseSolid tissue
The invention belongs to the technical field of biomedicine, and particularly relates to a rat articular cavity sampling method. According to the method, the articular cavity sampling method is optimized, the optimized articular cavity is a complete articular cavity which contains few sclerotin and is free of subpatella ligaments and redundant periosteum and muscles, solid tissue interference is reduced to the maximum extent on the basis that the complete cavity is reserved, and the method has the advantages of being high in drug detection rate, high in drug concentration and good in data uniformity; the invention provides a material drawing scheme for subsequent preclinical test design, and has important scientific significance and application value for developing new medicines for treating joint diseases such as osteoarthritis and the like.
Owner:WESTCHINA-FRONTIER PHARMATECH CO LTD

Application of composition in treatment of knee osteoarthritis

The invention provides application of a composition in treatment of knee osteoarthritis. According to the invention, two rat knee osteoarthritis models (the former is called as an ACLT-induced KOA model for short, and the latter is called as a papain-induced KOA model for short) are established by respectively utilizing methods of combining anterior cruciate ligament transection (ACLT) with running and injecting papain composite L-cysteine into an articular cavity; the composition provided by the invention is used for treating two rat KOA models. Results show that the composition can improve knee joint swelling of two KOA rats, increase the pain threshold, improve the abnormal gait state, relieve cartilage injury, inhibit ACLT-induced abnormal change of a KOA rat knee joint subchondral bone microstructure and papain-induced PGE2 content in KOA rat synovial tissue, and can be used for preparing a medicine for treating osteoporosis. The level of inflammatory factors in serum and joint lavage fluid of the two KOA rats is reduced, and the discovery shows that the KOA has important application in treatment of knee osteoarthritis.
Owner:BEIJING TONGRENTANG CO LTD

A carbon dioxide gas-assisted surgical operating system for arthroscopy

The present invention belongs to the technical field of medical systems, and discloses a carbon dioxide gas-assisted surgical operating system for arthroscopy, comprising a constant temperature gas circulation host, a built-in circulation pipeline in the constant temperature gas circulation host, and a first pipeline and a second pipeline respectively connected to the circulation pipeline; wherein, one end of the first pipeline and the second pipeline are respectively provided with a puncture catheter, which is used to pierce the position of the arthroscope and introduce CO2 gas to establish a joint cavity; the constant temperature gas circulation host comprises a gas source component, a voltage stabilizing component, a circulation smoke removal component and a gas heating component; the stability of the joint cavity is established and maintained by low-pressure heated carbon dioxide gas, forming a small cavity support, and the blood foam and debris generated during the operation are discharged through the circulation smoke removal component, thereby effectively avoiding the problem of blurred surgical field of view caused by bleeding and floating debris, significantly improving the visibility and accuracy of the operation, and enhancing the safety of the operation, and is widely applicable to various joint treatment functions.
Owner:JIANGSU DEJIAN MEDICAL TECH CO LTD

Multifunctional intra-articular flushing pipe

The utility model is suitable for the technical field of medical equipment, and provides a multifunctional intra-articular flushing pipe. Comprising an outer sleeve; the medicine inlet pipe cavity is arranged in the outer sleeve, an output pipe is arranged at the first end of the medicine inlet pipe cavity and penetrates through the first end of the outer sleeve, the second end of the medicine inlet pipe cavity penetrates through the side wall close to the second end of the outer sleeve, and a medicine inlet pipe opening is formed in the second end of the medicine inlet pipe cavity; the suction tube cavity is arranged in the outer sleeve, one end of the suction tube cavity is communicated with a suction tube opening formed in the side wall of the outer sleeve, and the suction tube opening is arranged close to the second end of the outer sleeve; the suction pipe orifice is communicated with the suction pipe cavity; the water inlet and drainage holes are formed in the side wall, close to the first end, of the outer sleeve; and the water inlet and drainage hole is communicated with the suction pipe cavity. According to the multifunctional intra-articular flushing tube, effusion in the joint is smoothly drained, antibiotics can be conveniently and regularly used in the articular cavity, and meanwhile the multifunctional intra-articular flushing tube is more suitable for the joint.
Owner:ANHUI PROVINCIAL HOSPITAL

Articular cavity external expansion device for shoulder arthroscopy surgery

The invention provides an articular cavity external expansion device for a shoulder arthroscopy operation. The articular cavity external expansion device comprises an outer tube, a rotating knob, an inner tube, a supporting blade, a sealing structure and a drainage pipeline, during use, the outer tube is inserted into an established operation channel of the shoulder joint; the rotary knob is rotated to drive the inner pipe to move upwards, the supporting blades move upwards synchronously, and when the supporting blades move to be right opposite to the long-strip-shaped openings, the supporting blades are unfolded outwards through the long-strip-shaped openings; after the supporting blades are unfolded, the rotary knob continues to be rotated to drive the supporting blades to move upwards and compress surrounding soft tissue, and therefore the operation space in the joint cavity is expanded. During an operation, an operating instrument extends into the outer tube through the sealing structure and enters an articular cavity to perform corresponding operation. According to the articular cavity external expansion device for the shoulder arthroscopy surgery, soft tissue is compressed through the supporting blades, the operation space in an articular cavity can be remarkably expanded, it is ensured that surgical instruments are flexibly operated, the surgical field is not limited, and therefore the articular cavity external expansion device adapts to individual differences of patients with different body types.
Owner:QILU HOSPITAL(QINGDAO) CHEELOO COLLEGE OF MEDICINE SHANDONG UNIV