The invention provides a painless anesthesia massage ultrasonic periodontal treatment instrument, which includes a device main body, a disinfection mechanism and a pipeline arrangement mechanism. There is a needle cutter head, the rear end of the handle is equipped with a catheter cable, the groove cup is assembled on the right side of the upper end of the base, and the anesthetic cartridge is installed on the left side of the upper end of the base. The disinfection mechanism includes a hollow cavity, an upper cover, a lower cover, and a semicircular groove. , hose, leaking port, connecting pipe, disinfectant solution chamber, one-way valve one, one-way valve two, suction pipe, spring, piston, permanent magnet, circular hole, electromagnet, semicircular groove two and liquid outlet , the pipeline arrangement mechanism includes a slider, a through groove, a round rod, a groove, a sponge ring and a box body. Compared with the prior art, the present invention has the following beneficial effects: the purpose of automatically disinfecting the handle and the needle cutter head is achieved , also achieved the purpose of finishing the conduit cable.