97 results about "Common bile duct dilatation" patented technology

1. The name of the product of this design: bile duct drainage tube. 2. Purpose of the product of this design: A disposable soft catheter used for drainage of bile after common bile duct incision and exploration. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention discloses an ERCP postoperative common bile duct calculus recurrence prediction system based on machine learning, and the system comprises the following steps: a data collection module which is used for forming an original clinical data set; the data preprocessing module is used for constructing a standardized preprocessed clinical data set; the feature construction and hyper-parameter search space definition module is used for defining a hyper-parameter search space of the improved bidirectional gating loop unit network model; the improved bidirectional gating circulation unit network model construction module is used for outputting a recurrence risk prediction value; the grey wolf optimization hyper-parameter tuning module is used for finally generating an optimized improved bidirectional gating circulation unit network model; the model training and prediction module is used for constructing a risk classification rule according to the prediction probability and the postoperative key indexes; and the individualized result output module is used for outputting the prediction result and pushing the prediction result to a doctor end. The method has significant clinical value in early recognition of high-risk individuals in actual deployment.

The duodenal papilla dilatation balloon catheter with the pressure measuring function comprises an outer sheath tube, a combination body and a plurality of branch tubes, the outer sheath tube comprises a drainage tube section I, a drainage tube section II and a drainage tube section III which are sequentially connected from head to tail, and the surface of the drainage tube section II is wrapped with a double-layer cylindrical dilatation film; the double-layer cylindrical expansion membrane comprises an inner-layer membrane and an outer-layer membrane, the outer-layer membrane is provided with an opening, and a pressure sensor is arranged in the opening; the combined body is connected with the tail end of the drainage tube section III, and a plurality of branch tubes are connected with the combined body. According to the catheter, common bile duct or pancreatic duct intubation can be carried out under the assistance of the guide wire, the pressure between the balloon and the duodenal papilla sphincter can be detected while the duodenal papilla sphincter is expanded, the nipple expansion size is determined according to the pressure value, and the occurrence rate of complications such as tearing bleeding of the duodenal papilla sphincter, bile leakage and enterobiliary regurgitation is avoided.

The present application relates to the technical field of endoscopy, and particularly discloses a tube sheath and an endoscope system, the tube sheath comprising a tube sheath body, the tube sheath body having an axially-through first channel, and a second channel radially penetrating the tube sheath body and communicating with the first channel being arranged at the distal end of the tube sheath body; in the above scheme, in the insertion stage of the tube sheath body, the endoscope can clearly see the tissue structure and obstacles in front through the first channel, improving the visibility of the insertion process and reducing the risk of blind insertion, and after the tube sheath body reaches the target position, the endoscope can be retracted so that the front end thereof is located at the communication position of the first channel and the second channel, and then the endoscope is operated so that the front end thereof is bent and inserted into the second channel, based on the guiding effect of the second channel on the front end of the endoscope, so that the endoscope can accurately enter the common bile duct from the side of the tube sheath body, thereby avoiding the dependence of the endoscope on the duodenoscope when exploring the common bile duct, and reducing the cost.

The present application discloses a bile duct stone removal device, including a sheath and a net basket, wherein a guide head is provided at the end of the net basket, and further comprising a connecting component fixed on the guide head and a guide ring sleeved on the connecting component and through which a guide wire can pass, wherein the guide ring is hinged to the connecting component. The bile duct stone removal device provided by the present application limits the guide ring on the guide head through the setting of the connecting component, and the guide ring is hinged to the connecting component, which can ensure that the guide ring can swing flexibly, so that the cooperation between the guide ring and the guide wire is smoother, and the net basket can be smoothly pushed into the common bile duct.

The duodenal papilla sphincter incision knife with the pressure measuring function comprises an outer sheath tube, a guide wire, a metal wire and a handle, the outer sheath tube comprises a drainage tube section I, a drainage tube section II, a drainage tube section III and a drainage tube section IV which are sequentially connected from head to tail, and the handle is connected with the tail end of the drainage tube section IV. A mounting groove is formed in the tube wall of the drainage tube section II, a pressure sensor is arranged in the mounting groove, one end of a metal wire is connected with the tube wall of the outer sheath tube, and the other end of the metal wire is inserted into the outer sheath tube and the handle; the guide wire is inserted through the handle, sequentially penetrates through the drainage tube section IV, the drainage tube section III, the drainage tube section II and the drainage tube section I and penetrates out. According to the invention, common bile duct or pancreatic duct intubation can be carried out under the assistance of the guide wire, the pressure of common bile duct, pancreatic duct and duodenal papilla sphincter is detected while papilla sphincter is incised under an endoscope, and the incised size of the papilla sphincter is determined according to the pressure value, so that the papilla sphincter is prevented from being incised too small or too large.

The present invention discloses an insertion component and an endoscope, and relates to the technical field of medical devices. The insertion component includes: an outer catheter and an inner catheter. The outer catheter includes a connecting portion and a toggle portion that are connected to each other, and the inner diameter of the toggle portion is smaller than the inner diameter of the connecting portion. The inner catheter is slidably embedded in the interior of the outer catheter, and can selectively extend out of the toggle portion. The distal diameter of the inner catheter is larger than the inner diameter of the toggle portion, so that the inner diameter and / or outer diameter of the toggle portion can be enlarged when the inner catheter extends out of the toggle portion. Since the toggle portion of the insertion component will abut against the duodenal papilla during use, the inner diameter and / or outer diameter of the toggle portion can drive the duodenal papilla to expand after the inner diameter and / or outer diameter of the toggle portion is enlarged, and the insertion component can be quickly and accurately extended into the common bile duct or the common pancreatic duct. The endoscope using the above-mentioned insertion component can enable the doctor to accurately or quickly extend the endoscope into the common bile duct or the common pancreatic duct.

The utility model discloses a biliary stent and a delivery system. The biliary tract stent comprises an integrally-formed stent body, the stent body comprises a first stent tube body and a second stent tube body which are connected, and the outer diameter of the first stent tube body is set to be smaller than that of the second stent tube body. By the adoption of the biliary tract stent, the size of the first stent tube body can be matched with the size of a gallbladder tube, the size of the second stent tube body can be matched with the size of a common bile duct so that the biliary tract stent can be lowered, and the first stent tube body and the second stent tube body are integrally formed, so that in the process that the biliary tract stent is released through a conveying device, the biliary tract stent is not damaged. The biliary stent can be conveniently recycled at any time, so that the release position of the whole biliary stent can be conveniently adjusted, and the placement difficulty of the biliary stent can be reduced.

The invention relates to a T-tube implantation double-layer sheathing canal pushing device for laparoscopic surgery. The device is mainly composed of an outer sheath tube, an inner sheath tube and a push rod. The outer sheath tube and the inner sheath tube are both of tubular structures, axial openings are formed in one sides of the tube walls, the push rod is arranged in the inner sheath tube and can slide in the axial direction of the inner sheath tube, and an elastic fixing mechanism is arranged at the far end of the push rod. By means of the half-opening design of the double-layer sheathing canal, convenient pre-loading of the T-tube is achieved; an elastic fixing mechanism of the push rod is utilized, so that the stability of the T-shaped pipe in the pushing process is ensured; and finally, through the pushing action of the pushing rod and the withdrawing action of the sheathing canal, the precise release of the T-tube in the common bile duct is realized. The invention aims to solve the problems of complicated T-tube implantation operation, infirm fixation, easy tissue damage and the like in the prior art, and is particularly suitable for minimally invasive surgery environments such as laparoscopes and the like.

The invention provides a double-guide-wire nipple sphincter incision knife which comprises an outer sheath tube, a handle, a first guide wire, a second guide wire and a metal wire, and the first guide wire is inserted into the outer sheath tube through the tube wall of the outer sheath tube and penetrates out of the tube wall of the outer sheath tube; the handle is connected with the tail end of the outer sheath tube, and the second guide wire is inserted into the outer sheath tube through the handle and penetrates out of the head end of the outer sheath tube. One end of the metal wire is fixedly connected to the tube wall of the outer sheath tube, and the other end of the metal wire is inserted into the outer sheath tube and connected with the handle. During use, an assistant can implement the guide wire to assist the nipple sphincter incision knife in intubation into the pancreatic duct, an operator can operate the second guide wire to enter the common bile duct through intubation on the side wall of the duct wall on the basis that the duct diameter of the nipple incision knife is not increased, double-person multi-angle intubation is achieved, and the bile duct intubation success rate is increased.

The invention relates to the technical field of ultrasonic examination, in particular to an ultrasonic lateral clinostatism examination bed beneficial for displaying a long axis of a common bile duct pancreatic segment, which comprises a support, wheels symmetrically arranged are rotatably mounted at the bottom of the support, and a fixing plate is fixed on the support; the first bed plate and the second bed plate are arranged on the fixing plate, and a supporting mechanism connected with the first bed plate and the second bed plate is arranged on the fixing plate; the lifting mechanism is arranged on the fixing plate and connected with the supporting mechanism; the nursing bed is characterized by further comprising an adjusting assembly which is arranged on the fixing plate and connected with the supporting mechanism, and the adjusting assembly can drive the first bed plate and the second bed plate to move through the supporting mechanism; the overturning assembly is arranged on the fixing plate and connected with the supporting mechanism; and the protective fences are symmetrically arranged on the fixing plate, and the fixing plate is further provided with a protective mechanism connected with the protective fences and the supporting mechanism.

The present invention discloses a machine learning-based system for predicting the recurrence of common bile duct stones after ERCP. The system comprises the following steps: a data acquisition module for forming an original clinical data set; a data preprocessing module for constructing a standardized preprocessed clinical data set; a feature construction and hyperparameter search space definition module for defining the hyperparameter search space of an improved bidirectional gated recurrent unit network model; an improved bidirectional gated recurrent unit network model construction module for outputting a recurrence risk prediction value; a Gray Wolf optimization hyperparameter tuning module for ultimately generating an optimized improved bidirectional gated recurrent unit network model; a model training and prediction module for constructing risk classification rules based on predicted probabilities and postoperative key indicators; and an individualized result output module for outputting and delivering the predicted results to the physician. The present invention has significant clinical value in the early identification of high-risk individuals in actual deployment.

This invention provides a single-operated duodenal sphincter cutter, comprising: an outer sheath, a guidewire, a metal wire, and a handle. The guidewire is inserted into the interior of the outer sheath through its wall and exits from its tip. The handle is connected to the tail of the outer sheath. One end of the metal wire is fixedly connected to the front of the outer sheath, and the other end is inserted into the interior of the outer sheath and connected to the handle. This invention features a dual-channel tube, with the guidewire entering the guidewire channel through the side wall. Its outer diameter is thinner than that of a conventional three-channel tube. The guidewire is led out through the side wall of the tube. With the outer sheath fixed in place, the operator can insert the guidewire into the common bile duct or pancreatic duct without the assistance of an assistant, increasing the success rate of cannulation.

[Problem] To provide: a cannula that can be easily inserted into a common bile duct or a pancreatic duct via a major duodenal papilla; and an endoscopic system provided with such a cannula. [Solution] A second camera 30 of a cannula 12 captures an image of the entrance of a common bile duct or a pancreatic duct in a state where the second camera 30 is inserted from the opening of a major duodenal papilla. A transparent shield 124 provides a cavity around the second camera 30 and ensures a field of view Vf of the second camera 30 in a state where the transparent shield 124 is inserted from the opening. The shield 124 has a convex surface 124c around the central axis CA of the field of view Vf of the second camera 30. The portion having the convex surface 124c has a uniform thickness. A guide wire 15 is configured to advance within the field of view Vf of the second camera 30.

The utility model provides a double-channel biliopancreatic pressure measuring catheter which comprises a catheter section I, a catheter section II, a catheter section III and a catheter section IV, a first guide wire channel is arranged in the catheter section I, the catheter section I is connected with the catheter section II, and a second guide wire channel and a first data transmission line channel are arranged in the catheter section II; the front end of the catheter section II is wrapped with a metal tube, the metal tube is provided with an open groove, and a pressure sensor is arranged in the open groove; the catheter section III and the catheter section IV are connected with the catheter section II, and a second data transmission line channel and a third guide wire channel are arranged in the catheter section III and the catheter section IV respectively; the tail of the catheter section III is provided with a pressure sensor connector, and the tail of the catheter section IV is provided with a guide wire connector. The pressure measuring device can be placed into duodenal papilla sphincter, common bile duct and pancreatic duct through a duodenoscope and a gastroscope forceps channel under the guide of a guide wire to measure the pressure in the duodenal papilla sphincter, the common bile duct and the pancreatic duct.

The utility model provides a three-channel biliopancreatic pressure measuring catheter. The three-channel biliopancreatic pressure measuring catheter comprises a first catheter section, a second catheter section, a third catheter section and a fourth catheter section. A first guide wire channel and a first injection channel are arranged in the first catheter section; a second guide wire channel, a second injection channel and a first data transmission line channel are arranged in the second catheter section; the front end of the second conduit section wraps a metal tube; a pressure sensor is arranged in a groove of the metal tube; a third guide wire channel and a third injection channel are arranged in the third catheter section; a second data transmission line channel is arranged in the fourth conduit section; a guide wire joint and an injection joint are arranged at the tail of the third catheter section; the tail of the fourth catheter section is provided with a pressure sensor interface. The pressure measuring device can be placed into duodenal papilla sphincter, common bile duct and pancreatic duct through a duodenoscope and a gastroscope forceps channel under the guide of a guide wire to measure the pressure in the duodenal papilla sphincter, the common bile duct and the pancreatic duct, contrast agents or saline water can be injected to adjust the pressure of the common bile duct or the main pancreatic duct while the pressure is measured, and the maximum tolerance pressure is measured.

The invention relates to the technical field of common bile duct calculus removing devices, and discloses a common bile duct calculus removing device through gallbladder duct dilatation, the common bile duct calculus removing device comprises a catheter, a controller and a display, rubber tubes are uniformly and fixedly mounted on the side surface of the right end of the catheter, and the right ends of the rubber tubes are fixedly connected with steering sleeves; and gas conveying pipes are evenly and fixedly installed on the inner wall of the guide pipe, a breather pipe is arranged in the gas guide pipe, the right end of the gas guide pipe fixedly communicates with the gas conveying pipe, and the gas conveying pipe communicates with an inner cavity of the rubber pipe. Through the arrangement of the six rubber pipes, when a turning is encountered, the turning direction is determined through observation, then the rubber pipe opposite to the turning direction is inflated with air, then the rubber pipes expand and stretch, the steering sleeve is forced to be bent and steered, the steering sleeve quickly determines the advancing direction, and the steering effect is improved. Therefore, a calculus removing position can be quickly reached, the catheter inserting speed in the operation process is increased, and then the calculus removing efficiency is improved.

The utility model provides a gall bladder stent which is characterized in that the gall bladder stent comprises a stent body, the stent body can contract in the radial direction so that the stent body can penetrate through a duodenal papilla opening to enter a gall bladder opening, and the stent can be expanded in the radial direction so that the stent body can expand a common bile duct and a gall bladder duct and enter the gall bladder opening; the outer diameter of the stent body is gradually reduced from the near end to the far end, and the section is circular. The gall bladder stent is placed into a body through a special conveyor, and the released gall bladder stent covers a gall bladder opening, a gall bladder tube and a common bile duct, so that a channel for surgical instruments to go in and out is formed in the stent body, instruments such as a biliary tract sub-endoscope can enter the gall bladder conveniently to carry out lithotripsy and lithotripsy, stones in the gall bladder are taken out, and the gall bladder does not need to be cut off.

The invention relates to the technical field of medical instruments, in particular to an inner and outer layer biliary tract fixing drainage pipeline which is made of latex materials and provided with a T-shaped part arranged in a common bile duct for supporting and guiding and a drainage part led out of the body through the abdominal wall, and the drainage part is connected with an external drainage bag for collecting bile. The T-shaped part comprises a supporting part which is formed by sectioning the end part of the drainage part along the diameter of the section, and the supporting part is arranged and supported along the common bile duct; when the drainage pipeline is taken out, the operating rod enters the drainage part from one end of the drainage part and forms a supporting end part at a connecting port of the drainage part and the supporting part, and the supporting part is driven by the binding piece to be collected towards the supporting end part and then falls out of the body along with the drainage part. An existing T-shaped drainage tube is improved with a low-cost simple structure, the size can be reduced during tube drawing, and tube drawing is facilitated.

The invention relates to a method for improving safety of laparoscopic cholecystectomy based on an FMEA model and a related device. The method comprises the following steps: constructing the FMEA model containing a plurality of initial elements according to a laparoscopic cholecystectomy process in a daytime ward; acquiring real-time gallbladder images of the gallbladder and surrounding tissues through a laparoscope system, and identifying a plurality of key anatomical structures of the real-time gallbladder images; the key anatomical structure comprises a gallbladder duct, a gallbladder artery, a common hepatic duct, a common bile duct, a right hepatic artery, a Calo triangular area and peripheral blood vessel distribution; inputting the key anatomical structure, the preoperative evaluation information of the patient and the surgical operation record into an FMEA model, and prompting a risk level and a high-risk anatomical region to an operator in a visual manner; the preoperative evaluation information of the patient comprises liver function, blood coagulation function, BMI and past abdominal operation history; the surgical operation record comprises the electrocoagulation use frequency, the traction force and the surgical time. According to the method, the FMEA model is combined with the laparoscopic cholecystectomy, so that the safety and efficiency of the operation are improved.

The invention relates to a gallbladder triangular identification and labeling method in a laparoscopic surgery, which comprises the following steps of: fusing a standard surgical field image with light source angle change data in a micro-operation process of an operator so as to enhance a tissue level separation contrast ratio; dynamic textures including gallbladder venation pulsation and liver surface breathing rhythm in the intraoperative image are extracted to serve as spatial reference marks, and anatomical boundary reduction is assisted; through time sequence image difference calculation, a regional saliency heat map is established frame by frame, so that the distinction degree of a gallbladder triangular region relative to surrounding tissues is displayed; an anatomical deformation track and a boundary transfer function are established, and the direction and angle of the gall bladder traction operation of the operator are associated with the local tissue deformation trend; identifying the variation trend of the included angle between the gallbladder duct and the common bile duct in the continuous frames, and reasoning the formation rule of the triangular closed boundary; the gallbladder triangle is divided into a plurality of structure segments including an included angle between a gallbladder duct and a common bile duct and a gallbladder artery intersection; and independently evaluating the identification confidence of each fragment.

The utility model relates to medical instrument technical field especially, and it is a kind of covered stent and implantation system.This covered stent includes support framework and film, wherein: support framework is the hollowed out cylinder structure of peripheral surface, it can be radially compressed and expand;Film is coated on part support framework, and drainage mesh is formed at the region of support framework not being coated by film.Due to film being coated on part support framework, drainage mesh is formed at the region of support framework not being coated by film, bile of gallbladder, bile in common hepatic duct and pancreatic juice in pancreatic duct can enter the inside of covered stent through drainage mesh and reach duodenal papilla, thereby avoiding the phenomenon that bile and pancreatic juice cannot flow out from common bile duct and reach duodenal papilla due to common bile duct being pressed by stent, and simultaneously, a plastic stent does not need to be additionally implanted in common bile duct to help common bile duct drainage, to achieve the purpose of reducing operation cost and operation complexity.

The invention relates to the technical field of experimental animal model construction in biomedical research, and discloses a common bile duct flow limiting tube for constructing a chronic cholestasis rat model and a construction method, the flow limiting tube comprises a hard tubular body and a soft protective fixing wing wrapping the tubular body, the inner diameter of the tubular body is 0.12-0.15 mm, and the outer diameter of the tubular body is 0.12-0.15 mm. The length of the tubular body is 0.5 to 0.8 cm; protruding fixing rings are arranged at the two ends of the protection fixing wing, and the total outer diameter of the flow limiting pipe is smaller than or equal to 0.7 mm. The common bile duct flow limiting tube is implanted into the specified position of the common bile duct of an experimental animal through a precise operation, precise control over bile flow is achieved, and therefore a standardized animal model capable of highly simulating the human chronic cholestatic liver disease in the aspects of the pathological process, physiological compensation and systematic expression is established. The model and the construction method thereof can be directly applied to multiple directions of liver pathophysiology mechanism research, drug target verification, new drug curative effect and safety evaluation and the like.

The invention relates to the technical field of endoscopes, and particularly discloses a tube sheath and an endoscope system.The tube sheath comprises a tube sheath body, the tube sheath body is provided with an axially-through first channel, and the far end of the tube sheath body is provided with a second channel communicating with the first channel and penetrating through the tube sheath body in the radial direction; according to the scheme, in the insertion stage of the pipe sheath body, an endoscope can clearly see the tissue structure and obstacles in front through the first channel, the visibility of the insertion process is improved, the risk of blind insertion is reduced, after the pipe sheath body reaches the target position, the endoscope can be retreated to enable the front end of the endoscope to be located at the communicating position of the first channel and the second channel, and therefore the endoscope can be conveniently inserted into the pipe sheath body. The endoscope is operated to enable the front end of the endoscope to be bent and extend into the second channel, based on the guiding effect of the second channel on the front end of the endoscope, it is ensured that the endoscope can accurately enter the common bile duct from the side direction of the duct sheath body, and therefore the situation that the endoscope depends on a duodenoscope when extending into the common bile duct is avoided, and cost is reduced.

The utility model provides a multifunctional calculus extraction net basket, including net basket cap, outer sheath, net basket, connecting pipe and handle, net basket cap sets up at the head end outside of outer sheath, net basket and connecting pipe are placed in the inside of outer sheath, the head end of net basket is connected with the tail end of net basket cap, and the tail end is connected with the head end of connecting pipe, connecting pipe is inserted to the inside of outer sheath through the tail end of outer sheath, and the tail end of connecting pipe is connected with handle, and handle is located at the tail end outside of outer sheath, the utility model has multiple functions, can be directly placed into to common bile duct and carries out calculus extraction, also can be placed into to common bile duct, intrahepatic bile duct and gallbladder duct under the guidance of guide wire and carries out positioning calculus extraction, when the huge calculus is taken out, can be placed into the guide wire and carries out lithotripsy through the guide wire channel, and then the broken stone is taken out.

The utility model provides a common bile duct inner support. The common bile duct inner support comprises a first hook-shaped part used for supporting a common bile duct, a second hook-shaped part used for being connected with a duodenum and a drainage part. Two ends of the drainage part are respectively connected with a first hook-shaped part and a second hook-shaped part, and the second hook-shaped part is arranged at one end far away from the first hook-shaped part; the radian angle of the first hook-shaped part is larger than that of the second hook-shaped part; a certain included angle is formed between the plane where the first hook-shaped part is located and the plane where the second hook-shaped part is located. And at least two drainage holes are formed in the drainage part. The first hook-shaped part used for supporting the common bile duct and the second hook-shaped part used for being connected with the duodenum are arranged, the common bile duct is supported through the first hook-shaped part, and the duodenum is connected through the second hook-shaped part, so that the stent in the common bile duct is not prone to retracting into the common bile duct, and the problem of bile leakage caused by premature falling is solved. A drainage hole is formed in the drainage part, and the problem that circulation of bile and pancreatic juice is affected is solved.

The invention discloses a bile duct millstone stent for ERCP. The bile duct millstone stent comprises a stent inner opening, anti-falling fins, a stent cylinder, stent millstone teeth, stent pore channels, stent outer fins and a stent outer opening. According to the bile duct millstone stent for ERCP, stone can be conveniently and automatically ground and discharged, after the stent bile duct is placed, under the combined action of duodenum physiologic peristalsis, bile flow and human body daily activities, the stent can generate micro-amplitude rotation and axial displacement, so that the stent millstone teeth can effectively scrape and grind common bile duct stone in contact with the stent cylinder, and the stent can be used for effectively removing the bile duct stone. The ground calculus can pass through a pore channel of the stent and is smoothly discharged into the duodenum under the flushing of bile which increases the flow rate and is generated due to the fact that the inner opening is large and the outer opening is small, the design is particularly suitable for emergency treatment of patients who suffer from bile duct calculus obstruction or cannot tolerate long-time ERCP operation, and through clinical use, the surgical instrument is convenient, rapid and flexible to use and operate, and has a wide application prospect. The problem of treatment of complex biliary calculi is effectively solved, and surgical operation safety is guaranteed.

This invention belongs to the field of biomedical technology, specifically relating to the application of spermine in the preparation of drugs for treating biliary atresia. This invention is the first to verify, through animal experiments (RRV mouse model), that spermine has a clear therapeutic effect on biliary atresia, achieving common bile duct recanalization and significantly reducing liver inflammation. Spermine itself possesses multiple functions including antioxidant, anti-inflammatory, and direct JAK1 inhibition, potentially working synergistically through multiple mechanisms such as mitigating initial damage and regulating immune responses, providing a more comprehensive pathological intervention than single-target inhibitors. Furthermore, spermine, as a known compound, has low production costs, and its application will greatly improve the accessibility of treatment.

The invention relates to an animal bile long-term collecting device, and belongs to the field of animal bile extraction.The animal bile long-term collecting device comprises a dosing bin and a connecting pipe, the dosing bin comprises a bin body and a needle threading rubber plate, a needle threading opening is formed in the bin body, the needle threading rubber plate is fixedly connected to the bin body and seals the needle threading opening, two pipe joints are arranged on the bin body, and the connecting pipe is connected with the connecting pipe. The number of the connecting pipes is two, one end of each connecting pipe is correspondingly connected with one pipe connector, the end, away from the bin body, of one connecting pipe is connected with the common bile duct, and the end, away from the bin body, of the other connecting pipe is connected with the duodenum. The device is simple in structure, the using method is more convenient to operate compared with a traditional operation method, the service cycle is long, animal postoperative recovery is fast, and the infection risk is lower.

The utility model provides a duodenum papilla dilatation balloon catheter with pressure measurement function, including outer sheath, combination and a plurality of branch pipes, the outer sheath includes drainage pipe section I, drainage pipe section II and drainage pipe section III connected in proper order from head to tail, the surface of drainage pipe section II is wrapped double -deck cylindrical dilatation film, double -deck cylindrical dilatation film includes inner layer film and outer layer film, and the outer layer film is equipped with opening, and the opening is equipped with pressure sensor, the combination is connected with the tail end of drainage pipe section III, and a plurality of branch pipes are connected with the combination, the utility model can be under the assistance of guide wire and carry out common bile duct or pancreatic duct intubation, can detect the pressure between balloon and duodenum papilla sphincter while dilating duodenum papilla sphincter, and the size of papilla dilatation is determined through pressure value, avoids the incidence of complications such as papilla sphincter laceration hemorrhage, bile leakage, intestinal bile reflux etc.