Hepatic lobule-like bioreactor

Abstract

The invention discloses a hepatic lobule-like bioreactor, which belongs to the field of biomedical equipment. A nanofiber scaffold network is arranged in a shell of the bioreactor, an intrahepatic fibrovascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct, and hepatic cell collagen fiber microducts are distributed in the whole nanofiber scaffold network, and the bile capillary network is distributed at the peripheries of the hepatic cell collagen fiber microducts; the upper hepatic bile ducts and the lower hepatic bile ducts are communicated through the common bile duct; bile capillaries in the bile capillary network are provided with more than two bile capillary epidermal cell inlets; the hepatic cell collagen fiber microducts are provided with more than two hepatic cell injection ports; the intrahepatic fibrovascular network is provided with a liquid inlet and a liquid outlet; and the bile capillary epidermal cell inlets, the hepatic cell injection ports, the liquid inlet, the liquid outlet and an outlet at the lower end of the common bile duct pass through the shell. The hepatic lobule-like bioreactor truly simulates the structure of hepatic lobule, realizes the functions of metabolic detoxification, excretion and the like of livers, and is superior to the conventional bioreactor.

Description

technical field [0001] The invention belongs to the field of biomedical equipment, and relates to a bionic liver tissue engineering of a liver-like structural unit, in particular to a hepatic lobule bioreactor for artificial liver, which is a core device for biological or hybrid biological artificial liver treatment. Background technique [0002] The liver is one of the most important vital organs of the body, with a complex structure and various physiological functions. Acute and chronic liver diseases, especially liver failure, seriously affect people's health. Liver transplantation is the fundamental treatment for chronic liver disease and liver failure, but it is limited by the scarcity of donor livers, failure of xenografts, and the need for long-term use of immunosuppressants. Therefore, it is urgent to seek new methods for the treatment of liver diseases, and liver tissue engineering has brought new hope for the treatment of liver diseases. [0003] Tissue engineerin...

AI Technical Summary

Problems solved by technology

[0004] The bioreactor is the core device of the bioartificial liver. It is the place where exogenous liver cells and patient's blood or plasma exchange substances. Today, the development of bioreactors is slow in the world. The existing devices are in the material, structural design and effect How to make the bioreactor imitate the tissue structure of the normal liver to the greatest extent, and provide the living and metabolic environment similar to the body for the culture of liver cells is the difficulty in future research.

At present, the bioreactors studied in the bioartificial liver, such as flat plate bioreactors, hollow fiber reactors, microcapsule suspension reactors, and scaffold perfusion bioreactors, are far from the structure of the human liver, lacking a bile drainage system, And the material exchange efficiency is not high, so it is necessary to develop new materials and improve the design of bioreactors to make it closer to the physiological state in terms of fluid mechanics and geometry.

At present, no relevant hepatic lobules bioreactors have been retrieved at home and abroad.

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