8 results about "Pancreatic duct" patented technology

This invention provides a single-operated duodenal sphincter cutter, comprising: an outer sheath, a guidewire, a metal wire, and a handle. The guidewire is inserted into the interior of the outer sheath through its wall and exits from its tip. The handle is connected to the tail of the outer sheath. One end of the metal wire is fixedly connected to the front of the outer sheath, and the other end is inserted into the interior of the outer sheath and connected to the handle. This invention features a dual-channel tube, with the guidewire entering the guidewire channel through the side wall. Its outer diameter is thinner than that of a conventional three-channel tube. The guidewire is led out through the side wall of the tube. With the outer sheath fixed in place, the operator can insert the guidewire into the common bile duct or pancreatic duct without the assistance of an assistant, increasing the success rate of cannulation.

[Problem] To provide: a cannula that can be easily inserted into a common bile duct or a pancreatic duct via a major duodenal papilla; and an endoscopic system provided with such a cannula. [Solution] A second camera 30 of a cannula 12 captures an image of the entrance of a common bile duct or a pancreatic duct in a state where the second camera 30 is inserted from the opening of a major duodenal papilla. A transparent shield 124 provides a cavity around the second camera 30 and ensures a field of view Vf of the second camera 30 in a state where the transparent shield 124 is inserted from the opening. The shield 124 has a convex surface 124c around the central axis CA of the field of view Vf of the second camera 30. The portion having the convex surface 124c has a uniform thickness. A guide wire 15 is configured to advance within the field of view Vf of the second camera 30.

Systems and methods for treating, for example, strictures along a biliary tract and / or pancreatic duct are disclosed. An example system can include a handle (14) having a base, a first carriage (26) translatable relative to the base, and a second carriage (24) translatable relative to the base. A sheath (16) can be coupled to the first carriage. The system can also include a catheter shaft (12) having a proximal region and a steerable distal region. The proximal region can be coupled to the second carriage. A needle can be releasably coupled to the handle. The needle can be configured to pass through tissue to a location along a biliary tract and / or pancreatic duct. The system can also include a steering member (44) having a first end coupled to the steerable distal region of the catheter shaft and a second end disposed adjacent the handle.

The utility model relates to medical instrument technical field especially, and it is a kind of covered stent and implantation system.This covered stent includes support framework and film, wherein: support framework is the hollowed out cylinder structure of peripheral surface, it can be radially compressed and expand;Film is coated on part support framework, and drainage mesh is formed at the region of support framework not being coated by film.Due to film being coated on part support framework, drainage mesh is formed at the region of support framework not being coated by film, bile of gallbladder, bile in common hepatic duct and pancreatic juice in pancreatic duct can enter the inside of covered stent through drainage mesh and reach duodenal papilla, thereby avoiding the phenomenon that bile and pancreatic juice cannot flow out from common bile duct and reach duodenal papilla due to common bile duct being pressed by stent, and simultaneously, a plastic stent does not need to be additionally implanted in common bile duct to help common bile duct drainage, to achieve the purpose of reducing operation cost and operation complexity.

The utility model provides a kind of wire guide calculus extraction net basket, including net basket, guide wire, net basket cap, outer sheath and handle, tail end of guide wire is connected with the head end of net basket cap, net basket cap is placed in the head end outside of outer sheath, net basket is inserted to the inside of outer sheath through the tail end of outer sheath, one end of net basket is connected with the tail end of net basket cap, other end is connected with handle;Handle is located in the tail end outside of outer sheath.The utility model can be inserted through papilla incision knife, SpyGlass or insight pancreatic duct imaging system channel etc.Various instrument channels, realize the calculus extraction treatment of multiple scenes;During the release of net basket, soft guide wire head end crosses stone more easily into the distal bile duct, more conducive to the release of net basket, and net basket can be taken out of stone by pulling back.

An amplifying method of pancreatic cells is provided. The amplifying method includes performing digestion, resuspension, discontinuous density gradient centrifugation treatment and amplifying treatment sequentially. The mammalian pancreatic duct is used as the source of pancreatic precursor-like cells in the amplifying method, and islet cells and acinar cells in the cell clusters obtained by the discontinuous density gradient centrifugation treatment are removed. It is beneficial to improve the yield of the pancreatic precursor-like cells availably, and avoid the ethical restrictions and possible carcinogenic risks caused by using the embryonic stem cells. The amplifying medium used comprises a reprogramming substance composed of several small molecule compounds. It can avoid the risks of non-specific and off-target deletion that are easily caused by the use of the gene-editing methods to change the gene sequence. Also provided is a differentiation method and an application of the pancreatic precursor-like cells obtained by the amplifying method.

This invention relates to a novel use of synephrine in the preparation of drugs for treating cholestatic liver disease, belonging to the field of pharmaceutical technology. Cholestatic liver disease is characterized by jaundice and conjugated bilirubin and / or total bilirubin hyperconjugation caused by impaired bilirubin excretion due to various reasons. Its causes include common bile duct stones, pancreatic duct cancer, common bile duct malignant tumors, pancreatic cancer, biliary parasitic diseases, viral hepatitis cirrhosis, alcoholic liver disease, fatty liver disease, drug-induced liver injury, primary biliary cirrhosis, intrahepatic sclerosing cholangitis, and certain congenital diseases such as Dubin-Johnson syndrome and Rotor syndrome. This invention establishes a mouse cholestasis model using bile duct ligation and administers synephrine by gavage to evaluate its protective effect against liver injury. The results showed that synephrine significantly improved jaundice caused by cholestasis, reduced hepatocellular necrosis and inflammatory infiltration caused by cholestasis, alleviated bile duct dilation, decreased serum total bilirubin (TBIL) and direct bilirubin (DBIL), and reduced the levels of total bile acids (BA) in liver tissue and plasma. Furthermore, the above-mentioned effects of synephrine in improving cholestasis showed a clear dose-dependent effect. This invention reveals for the first time the application of synephrine in cholestatic liver disease, demonstrating good safety and promising clinical development prospects.

The utility model provides a kind of double guide wire nipple sphincter incision knife, comprising: outer sheath, handle, first guide wire, second guide wire and wire, first guide wire is inserted to the inside of outer sheath through the pipe wall of outer sheath, and it is worn from the pipe wall of outer sheath;Handle is connected with the tail end of outer sheath, second guide wire is inserted to the inside of outer sheath through handle, and it is worn from the head end of outer sheath;One end of wire is fixedly connected on the pipe wall of outer sheath, the other end is inserted into the inside of outer sheath, and is connected with handle.The utility model uses, assistant can implement guide wire auxiliary nipple sphincter incision knife cannula into pancreatic duct, on the basis of not increasing nipple incision knife pipe diameter, operator can operate second guide wire and insert into common bile duct through pipe wall lateral wall, realize double person multi-angle cannulation, increase the success rate of bile duct cannulation.