99 results about "Pancreatic duct" patented technology

A method and apparatus for treating a patient's health condition by diverting pancreatic exocrine secretions include a flow diverter of material compatible with chronic residence within a small intestine of the patient. The flow diverter has a cover end and a discharge end. The flow diverter is sized to be placed within the small intestine with the discharge end placed distally from said cover end and with said flow diverter further sized so permit passage of chyme through the small intestine and past the flow diverter. The cover end is sized to cover a discharge papilla of the pancreatic duct. The diverter is adapted to divert at least a portion of pancreatic exocrine secretion from the papilla to the distal discharge end.

An expandable biodegradable polymeric stent is fabricated with biodegradable polymer fibers (Poly-L-lactic acid, PLLA) in a coil shape that is constructed with both central and external or internal peripheral lobes. It is delivered and expanded using a conventional angioplasty balloon system. The disclosed stent can serve as a temporary scaffold for coronary vessels after PTCA or for peripheral endovascular stenting, or it can provide mechanical palliation for strictures of ductile organs (trachea, esophagus, bile and pancreatic ducts, ureter etc.). The disclosed stent also serves as a unique device for specific local drug delivery. Therapeutic agents (chemical compounds, protein enzyme and DNA sequences) and cells can be loaded into the stent and gradually released to target tissues. Local radiation therapy can also be delivered by a specially adapted stent.

Advanced Bioreactor Cell Culture Technology presents a method of cell culturing and bioprocessing incorporating molecular biology techniques, advanced process control methodology, and a process control interface applied to a two liquid phase cell culture bioreactors to proliferate, grow, and expand non-differentiated precursor cells, embryonic stem (ES) cells, endocrine progenitor cells, pancreatic progenitor cells, pancreatic stem cells, pancreatic duct epithelial cells, nestin-positive islet-derived progenitor cells (NIPs), or pluripotent non-embryonic stem (PNES) cells in the bioreactor, and influence, stimulate, and induce the non-differentiated precursors and progenitors into fully differentiated beta cell phenotypes; including microprocessor control of cell culture process variables and data acquisition during bioprocessing. The invention may be applied to precursors and progenitor cells either transgenic or non-transgenic derived from animals and mammals.

The invention belongs to the field of medical devices, and relates to a medical device for recovering targeted components of a cavity content. The device recovers the targeted components of the human body cavity content in vitro. The device can be used for greatly preparing a fecal bacterium solution with parasitic ova removed to support a preparation procedure of standardized fecal bacterium transplantation, used for greatly collecting the parasitic ova in a fecal suspension to increase a positive detection rate of the parasitic ova, used for collecting deslagged secretions in intestine and stomach cavities by an endoscope to meet requirements of checking and diagnosis, used for collecting lavage liquid in a trachea and removing slag by the endoscope to meet requirements of a hormone test and cytological examination, and used for collecting liquid of biliary and pancreatic ducts and a urogenital canal to meet requirements of the checking and the cytological examination. The method solves the practical problems of clinical applications, and has important innovation and an application value.

An electrosurgical resection instrument for applying to biological tissue radiofrequency electromagnetic energy has a protective hull comprising a shaped piece of dielectric material mounted to cover an underside of an instrument tip of the instrument. The protective hull acts as a shield to protect tissue that may lie under the instrument tip from damage during treatment. The instrument may be particularly useful in procedures performed in a gastrointestinal tract, where bowel perforation is a concern, or in the pancreas, where damage to the portal vein or the pancreatic duct may occur when a tumour or other abnormality is being resected, dissected or removed.

Devices, systems, and methods for facilitating access to the pancreaticobiliary system are disclosed. In particular, the present disclosure relates to devices used to apply suction to the papilla, e.g., duodenal tissue surrounding the papilla, to facilitate cannulation to reach the bile duct and / or pancreatic duct. Devices may include a suction cup or an endoscope cap configured to apply suction to a tissue surface.

The invention discloses a guide wire navigation method for endoscopic biliary stent implantation for portal stenosis and a guide wire navigation system thereof. The method comprises the following steps: S1, receiving an input magnetic resonance pancreatic duct imaging image of a patient with portal stenosis; S2, performing image segmentation on the magnetic resonance pancreatic duct imaging imageof the patient with the hilar biliary stenosis based on an image segmentation method of deep learning, and predicting a navigation line from the tail end of the biliary duct to a hilar stenosis part;S3, receiving a real-time perspective image in an endoscopic retrograde cholangiopancreatography; S4, registering the two images according to the key points of the biliary duct on a magnetic resonance cholangiopancreatography image and the key points of the guide wire on the perspective image in the endoscopic retrograde cholangiopancreatography; and S5, displaying a registered composite image, and when the predicted navigation line in the composite image is not matched with the inserted guide wire, changing the position of the guide wire until the predicted navigation line is matched with the inserted guide wire. The method and the system can guide a doctor to perform biliary duct intubation, help the doctor to judge whether biliary duct intubation is correct or not, and reduce the use amount of a contrast media during an operation so as to reduce postoperative complications.

The present invention relates to a multipotent stem cell, multipotent cell populations, and an enriched multipotent cell population, each found in fetal, neonatal, pediatric, and adult biliary tree tissue and up to 72 hours post mortem (although preferentially, within 10 hours post mortem) and capable of maturing into multiple endodermal tissues that include liver, biliary and pancreatic tissues. The multipotent stem / progenitor cell and cell populations are found in peribiliary glands, and progenitors descending from them are present throughout the biliary tree including in the gallbladder. High numbers of the peribiliary glands are found in the branching locations of the biliary tree such as hilum, common hepatic duct, cystic duct, common duct, common hepato-pancreatic duct and gallbladder. Related multipotent cells, multipotent cell populations and their descendent progenitors are found throughout the biliary tree including in the gall bladder, which does not have peribiliary glands. Compositions comprising same, methods of identifying and isolating same, maintaining same in culture, expanding same in culture and differentiating or lineage restricting the same in vitro or in vivo to hepatic, biliary or pancreatic fates (e.g., as hepatocytes, cholangiocytes, and / or pancreatic islet cells) are also provided. Methods of using the multipotent cells and / or multipotent cell populations are also provided.

The invention discloses a pancreatic ductal adenocarcinoma marker and a screening method thereof, which belongs to the field of clinical test and diagnosis. In view of the problem that the detection sensitivity and the detection specificity of the existing pancreatic ductal adenocarcinoma diagnosis marker are poor, serum of an early patient of early stage pancreatic duct adenocarcinoma is subjected to a trace metabolomics analysis by the high-performance liquid chromatography-tandem mass spectrometry technology, and different metabolites between normal human and the early stage pancreatic ductal adenocarcinoma patients are found. The different metabolites between normal human and pancreatic ductal adenocarcinoma patients are further analyzed by this technique to find the specific differentmetabolites C10:1 acyl carnitine and lysophosphatidyl choline LysoPC (14:0) of pancreatic ductal adenocarcinoma patients caused by cancer, i.e., the diagnostic molecules of the pancreatic ductal adenocarcinoma. According to the pancreatic ductal adenocarcinoma marker and the screening method thereof, the method can assist CA19-9 in diagnosing pancreatic duct adenocarcinoma patients, and can improve the diagnosis rate for the CA19-9 negative patients by 85%. The method is suitable for the screening of tumor markers.

The invention relates to a completely biodegradable composite scaffold. The completely biodegradable composite scaffold is characterized by comprising a skeleton structure composed of a medical degradable high-polymer material, a degradable high-polymer functional layer adhered on the surface of the skeleton structure and a drug-loaded layer. The biodegradable composite scaffold provided by the invention has excellent mechanical characteristics, biodegradability and compatibility, realizes active directional targeted treatment of lesion sites by carrying drugs like paclitaxel, sirolimus, actinomycin D and 5-fluorouracil and radioactive elements like 60Co, 125I and 192Ir and is a functional biodegradable scaffold. The degradable drug-loaded multifunctional scaffold is applicable to interventional therapy in vascular and non-vascular fields, especially to interventional therapy of stenosis, obstruction or tumors of non-vascular lumens of the esophagus, the bile duct, the pancreatic duct, the intestinal tract, the urethra, the trachea, the bronchus and the like.

A balloon catheter (400) may include a distal anchoring balloon (404) and a proximal hub (410) that is removable from the catheter body. The catheter body may include a valve structure (420) providing for maintaining the balloon in an inflated state during and after removal of the proximal hub. The valve preferably is constructed such that removal of the hub provides a low-profile proximal catheter end that will allow that proximal catheter end to pass through an endoscopic surgical device such as, for example, through an accessory channel of a standard duodenoscope and / or an ultra- slim endoscope / cholangioscope, facilitating a scope- exchange for use during, for example, a cholangioscopy or pancreatoscopy procedure. A method useful for scope exchange and / or introducing another elongate surgical device may utilize a balloon catheter with a distal anchoring balloon and a proximal hub that is removable from the catheter body.

The invention belongs to the field of medical devices, and relates to a medical device for recovering targeted components of a cavity content. The device recovers the targeted components of the human body cavity content in vitro. The device can be used for greatly preparing a fecal bacterium solution with parasitic ova removed to support a preparation procedure of standardized fecal bacterium transplantation, used for greatly collecting the parasitic ova in a fecal suspension to increase a positive detection rate of the parasitic ova, used for collecting deslagged secretions in intestine and stomach cavities by an endoscope to meet requirements of checking and diagnosis, used for collecting lavage liquid in a trachea and removing slag by the endoscope to meet requirements of a hormone test and cytological examination, and used for collecting liquid of biliary and pancreatic ducts and a urogenital canal to meet requirements of the checking and the cytological examination. The method solves the practical problems of clinical applications, and has important innovation and an application value.

The invention provides a stent drainage tube applied to pancreaticoenterostomy. The stent drainage tube comprises a pancreatic duct supporting drainage tube and a measuring device. The measuring device is arranged, an illuminating lamp, a first clamping and fixing device assembly, a second clamping and fixing device assembly, a pancreatic duct diameter measuring tube and a sterilizing lamp are arranged in the measuring device; after the pancreatic duct diameter measuring tube is clamped by the first clamping and fixing device assembly and the second clamping and fixing device assembly, the size of the pancreatic duct is measured and the contact between hands and a patient is reduced; and better observation is realized, a pancreatic duct supporting drainage tube with a proper specificationis selected according to the measured size; the pancreatic duct supporting drainage tube is arranged, barbs are arranged on the surface of the pancreatic duct supporting drainage tube; after the pancreas duct supporting drainage tube is inserted into the pancreas duct, the barbs are clamped and fixed in the pancreas duct, so that the situation of loosening is avoided; the operation process is verysimple, the pancreas section does not make contact with the interior of the jejunum, so that the novel support drainage tube applied to pancreaticoenterostomy has the effects that operation is easy,and the occurrence rate of pancreas fistula is effectively reduced.

The present invention relates to a multipotent stem cell, multipotent cell populations, and an enriched multipotent cell population, each found in fetal, neonatal, pediatric, and adult biliary tree tissue and up to 72 hours post mortem (although preferentially, within 10 hours post mortem) and capable of maturing into multiple endodermal tissues that include liver, biliary and pancreatic tissues. The multipotent stem / progenitor cell and cell populations are found in peribiliary glands, and progenitors descending from them are present throughout the biliary tree including in the gallbladder. High numbers of the peribiliary glands are found in the branching locations of the biliary tree such as hilum, common hepatic duct, cystic duct, common duct, common hepato-pancreatic duct and gallbladder. Related multipotent cells, multipotent cell populations and their descendent progenitors are found throughout the biliary tree including in the gall bladder, which does not have peribiliary glands. Compositions comprising same, methods of identifying and isolating same, maintaining same in culture, expanding same in culture and differentiating or lineage restricting the same in vitro or in vivo to hepatic, biliary or pancreatic fates (e.g., as hepatocytes, cholangiocytes, and / or pancreatic islet cells) are also provided. Methods of using the multipotent cells and / or multipotent cell populations are also provided.

Devices and methods for facilitating access to the pancreaticobiliary system are disclosed. In particular, the methods include bending a device having an elongate body with a first lumen, a second lumen, and respective first and second exit openings. The methods include inserting a first guidewire through the first lumen and out of the first exit opening to cannulate a pancreatic duct, and inserting a second guidewire through the second lumen and out of the second exit opening to cannulate a biliary duct.

The invention discloses an integrated drainage tube for pancreatic duct supporting and drainage and peripancreatic drainage. The integrated drainage tube comprises a bile and intestinal juice drainage tube, a pancreatic juice drainage tube and a breather tube, wherein the bile and intestinal juice drainage tube comprises an drainage body inner tube, a drainage connection tube and a drainage body outer tube which are connected to form a whole, the pancreatic juice drainage tube comprises a pancreatic juice drainage body inner tube, a pancreatic juice drainage connection tube and a pancreatic juice drainage body outer tube which are connected to form a whole, the drainage body inner tube and the pancreatic juice drainage body inner tube form a cross structure, and the breather tube comprises a breather inner tube, a breather connection tube and a breather body outer tube which are connected to form a whole. The integrated drainage tube can timely drain intestinal juice, bile and other liquid accumulated around a pancreatico-duodenal anastomotic stoma, or even can also perform timely drainage once pancreatic juice is leaked, so that no liquid is accumulated besides the pancreatico-duodenal anastomotic stoma, and good conditions are provided for the pancreas and intestine to anastomoseas early as possible.

The invention discloses a 3D (three-dimensional) printed stitch-free pancreatico-duodenectomy stent. The 3D printed stitch-free pancreatico-duodenectomy stent made of a degradable biological material by a 3D printing technology comprises a stent duct and protrusive spines protruding over the outer wall of the stent duct, a protrusive head is integrally connected with one end of the stent duct, and holes are formed in the wall of the stent duct. The manufacturing method of the 3D printed stitch-free pancreatico-duodenectomy stent includes the steps of (1) measuring the diameter of a pancreatic duct of a patient needing a hepatopancreat and obiliary reconstructive operation through CT (computed tomography); (2) according to a CT thin layer scanning result, acquiring needed 3D printing data through algorithmic conversion and image processing, designing the spines and the protrusive head structure on the pancreatico-duodenectomy contact face; (3) using the most precise 3D printer and the biological and degradable material to print the 3D pancreatico-duodenectomy stent which is applied to stitch-free pancreatico-duodenectomy. The 3D printed stitch-free pancreatico-duodenectomy stent has the advantages of simple structure, convenience in use, remarkable effect and capability of achieving stitch-free pancreatico-duodenectomy, the risks of leakage and narrowness are reduced, and operating difficulty and risks are reduced greatly.

The invention discloses a visualization endoscopic incision knife device which comprises an incision knife (3), further comprises a hard tube (1) which is internally provided with an imaging objective lens component (2) and an optical fiber image transmission beam (4), an eye lens (5) for receiving the reflected light of the optical fiber image transmission beam (4), a charge coupled device (CCD) image sensor (6) for acquiring and converting an optical signal focused by the eye lens (5), and an electronic computer terminal (7), wherein the incision knife (3) is arranged at one end of the hard tube (1) near the imaging objective lens component (2); and the eye lens (5) is arranged at one end outside the hard tube (1) near the optical fiber image transmission beam (4). The visualization endoscopic incision knife device has the advantages that endoscopic retrograde cholangiopancreatography (ERCP) intubation can be carried out at a visual state, and the pancreatic duct and the bile duct can be distinguished by observing the image, so that the time that doctors and patients are exposed to the X-ray is reduced; and meanwhile the success rate in selective intubation is improved, and the happening of complications is reduced.

The invention discloses an antibody composition for detecting pancreatic duct adenocarcinoma immunohistochemical marker protein compositions and application of the antibody composition. The pancreatic duct adenocarcinoma immunohistochemical marker protein compositions comprise TIMP1 and CD82. The antibody composition for detecting the protein compositions comprises monoclonal antibodies of the TIMP1 and monoclonal antibodies of the CD82. The antibody composition and the application have the advantages that the TIMP1 / CD82 compositions are used as novel pancreatic duct adenocarcinoma markers, the antibody composition can be widely used in disease identification and diagnosis and prognosis monitoring of pancreatic duct adenocarcinoma, and gaps on immunohistochemical detection in the two aspects can be filled.

The invention discloses a pancreatic duct adenocarcinoma related tumor marker LINC01133, and application of a kit for detecting expression level of LINC01133 in the detection and diagnosis of pancreatic duct adenocarcinoma or patient prognostic evaluation. The expression level of LINC01133 is closely related to the clinical pathological parameters of pancreatic duct adenocarcinoma and the patientprognosis, and can be adopted as a specific tumor marker in pancreatic duct adenocarcinoma detection and a prognostic indicator, and thus is of an important clinical value.

The invention discloses an application of netrin-1 protein in preparing a drug for treating tumor, wherein tumor is selected from pancreatic cancer, and preferably selected from pancreatic duct adenocarcinoma. The disclosure of the application has positive significances for preventing, diagnosing and treating pancreatic duct adenocarcinoma, and developing the drug for treating the pancreatic duct adenocarcinoma.

The invention provides a pancreaticojejunostomy support barb tube, belongs to the field of medical instruments, and solves the problem of high suture difficulty in the present pancreaticojejunostomy.The pancreaticojejunostomy support barb tube comprises a support tube which comprises a pancreatic duct and an intestinal duct. The pancreatic duct is used for being inserted into the pancreatic end.The intestinal duct is used for being inserted into the jejunum end. The surfaces of the pancreatic duct and the intestinal duct are provided with barbs. A mark ring is arranged at the junction of thepancreatic duct and the intestinal duct for marking the length of the pancreatic duct inserted into the pancreaticojejunum and the length of the intestinal duct inserted into the jejunum. The pancreaticojejunostomy support barb tube has the advantages of reducing the difficulty of the pancreaticojejunostomy.

The invention discloses a construction method of a pancreatic duct epithelial cell and pancreatic acinar cell co-culture system for simulating in vivo microenvironment, and belongs to the technical field of cell biology. The method comprises the steps of inoculating an upper layer of a Transwell dual-layer culturing chamber with original generation pancreatic acinar cells, inoculating a lower layer of the Transwell dual-layer culturing chamber with human pancreatic duct epithelial cells, performing co-culturing, adding sodium taurocholate in the pancreatic duct epithelial cells at the lower layer of the Transwell dual-layer culturing chamber, and observing the vitality, the shape and the apoptosis of the upper layer pancreatic acinar cells. Damage of the pancreatic duct epithelial cells and the pancreatic acinar cells are combined, a non-contact type co-culture manner is adopted for building the pancreatic duct epithelial cell and pancreatic acinar cell co-culture system. In the co-culture system, the two cells can exchange exocytosis secretion substances through Transwell transmembrane. The system can well simulate the pancreatitis induced by cholestasis, and the invention provides an in vitro cell model which can really reflect pancreatitis induced by cholestasis.

The invention discloses a medical composition for preventing or treating pancreatic cancer and a reagent kit for detecting pancreatic cancer. The medical composition for preventing or treating pancreatic cancer can reduce or restrain (a) the biological activity of BCAT2 or (b) the expression of a BCAT2 coding gene. The invention relates to a reagent kit containing a reagent for detecting BCAT2. For the first time, the invention discloses that the BCAT2 can promote pancreatic cancer cell proliferation, and in vivo knockout of BCAT2 restrains pancreatic duct intraepithelial neoplasia (PanIN). The invention provides a medical composition for preventing and treating the pancreatic cancer, and a pancreatic cancer assessment reagent kit.

The invention discloses a catheter drainage device for biliary and pancreatic surgery. The catheter drainage device comprises T-shaped catheter that is made of a bile indwelling catheter and a curvedplate having concave middle part. The upper end of the bile indwelling catheter is fixedly connected with the middle part of the lower side of the curved plate. A pancreatic catheter is sleeved on theinterior of the bile indwelling catheter. The lower end of the pancreatic catheter penetrates through side wall of a diverter valve and extends to outside of the diverter valve. The upper end of thepancreatic catheter successively penetrates through the bile indwelling catheter and the side wall of the curved plate and extends to outside of the curved plate. According to the invention, the pancreatic catheter is sleeved on the interior of the bile indwelling catheter to combine the pancreatic catheter and the bile indwelling catheter into a whole, thereby reducing amount of punctures on abdominal wall of a patient and reducing incidence of leakage complications caused by placement of an abdominal drainage catheter. The curved plate of the T-shaped catheter is placed at a bilioenteric anastomosis, and then the T-shaped catheter can be stably fixed in the body of the patient, thereby avoiding occurrence of shedding phenomenon.