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109 results about "Left ureter" patented technology

The ureters are tubes that carry urine and connect the kidneys to the bladder. 1. Human urinary system: 2. Kidney, 3. Renal pelvis, 4. Ureter, 5. Urinary bladder, 6. Urethra. (Left side with frontal section), 7.

Combination ureteral infusion catheter/drainage stent

A method of treating the upper urinary tract of a mammal having a urethra extending to a bladder and a ureter extending from the bladder to a kidney. The method comprises initially extending a catheter system into the upper urinary tract, the catheter system having a urethral catheter infusion tube section extending through the urethra for infusion of a liquid; a urethral catheter drain tube section extending through the urethra for drainage of a liquid; a ureteral catheter tube section extending through a ureter into the kidney and having a first tube portion for infusion of a liquid connected to the urethral catheter infusion tube section, and a second tube portion for drainage of a liquid. The method then includes flowing a therapeutically effective liquid into the kidney through the urethral catheter infusion tube section and the ureteral catheter first, infusion tube portion, and, simultaneously with the flowing of the fluid into the kidney, draining fluid from the kidney through the urethral catheter drain tube section and the ureteral catheter second, drain tube portion.
Owner:HAYNER GEORGE M +1

Ultrasonic device and method for treating stones within the body

A system and method to be used in ultrasonic lithotripsy of a stone in a ureter, the system including a catheter having a probe tip capable of transmitting and receiving ultrasonic energy. The catheter can include an inflatable balloon adjacent to the probe tip, the balloon capable of pooling some urine in the ureter to be used as an ultrasonic transmission media. The ultrasonic probe is connected to a source of energy capable of driving the probe tip to deliver ultrasonic energy of a high frequency and relatively low energy to image a stone. Then the probe can be connected to a source of energy capable of driving the probe to deliver a low frequency, high energy ultrasonic to disintegrate the stone.
Owner:ETHICON ENDO SURGERY INC

Combination ureteral infusion catheter/drainage stent

A method of treating the upper urinary tract of a mammal having a urethra extending to a bladder and a ureter extending from the bladder to a kidney. The method comprises initially extending a catheter system into the upper urinary tract, the catheter system having a urethral catheter infusion tube section extending through the urethra for infusion of a liquid; a urethral catheter drain tube section extending through the urethra for drainage of a liquid; a ureteral catheter tube section extending through a ureter into the kidney and having a first tube portion for infusion of a liquid connected to the urethral catheter infusion tube section, and a second tube portion for drainage of a liquid. The method then includes flowing a therapeutically effective liquid into the kidney through the urethral catheter infusion tube section and the ureteral catheter first, infusion tube portion, and, simultaneously with the flowing of the fluid into the kidney, draining fluid from the kidney through the urethral catheter drain tube section and the ureteral catheter second, drain tube portion.
Owner:HAYNER GEORGE M +1

Expandable biodegradable polymeric stents for combined mechanical support and pharmacological or radiation therapy

An expandable biodegradable polymeric stent is fabricated with biodegradable polymer fibers (Poly-L-lactic acid, PLLA) in a coil shape that is constructed with both central and external or internal peripheral lobes. It is delivered and expanded using a conventional angioplasty balloon system. The disclosed stent can serve as a temporary scaffold for coronary vessels after PTCA or for peripheral endovascular stenting, or it can provide mechanical palliation for strictures of ductile organs (trachea, esophagus, bile and pancreatic ducts, ureter etc.). The disclosed stent also serves as a unique device for specific local drug delivery. Therapeutic agents (chemical compounds, protein enzyme and DNA sequences) and cells can be loaded into the stent and gradually released to target tissues. Local radiation therapy can also be delivered by a specially adapted stent.
Owner:DUNING

Stent kidney curl improvements

The present invention provides embodiments of medical devices that provide for fluid drainage while maintaining patient comfort. An embodiment of the present invention provides a stent comprising a body portion and a kidney curl portion, the body portion comprising a tubular member having an axial lumen therein adapted to provide fluid communication from one body location to another. The kidney curl portion comprises an elongated filament that has a three-dimensional configuration that substantially conforms to the three-dimensional randomly convoluting calyx space of a kidney. In another embodiment, the kidney curl portion comprises a plurality of petals adapted to flare outwardly from the body portion distal end when in a free state in the space of a kidney so as to prevent the migration of the kidney curl portion into the ureter.
Owner:GYRUS ACMI INC (D B A OLYMPUS SURGICAL TECH AMERICA)

Ureteral stent with small bladder tail(s)

InactiveUS6945950B2Decreases patient discomfortInhibit migrationUrinary bladderStentsInsertion stentLeft ureter
A ureteral stent for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region and to transport urine from there across the ureter / bladder junction and into the bladder. The tails include an elongated external urine-transport surface configured to transport urine. The transporting surface(s) are configured to extend along at least part of the ureter, across the ureter / bladder junction, and into the bladder.
Owner:BOSTON SCI SCIMED INC +1

Ureteral stent

A ureteral stent assembly includes an elongate member having a distal end portion for placement within a kidney of a patient and a proximal end portion for placement in at least one of a ureter of the patient and a bladder of the patient. The distal end portion has a retention portion configured to help retain at least a portion of the elongate member in the kidney of the patient. The elongate member is configured to be passed through the ureter of the patient from the kidney to the bladder to remove the elongate member from the patient. In one embodiment, the retention portion is configured such that a distal tip of the distal end portion of the ureteral stent is spaced from a sidewall of the ureter when the elongate member is passed through the ureter of the patient to remove the elongate member from the patient.
Owner:BOSTON SCI SCIMED INC

Method of disposing a linearly expandable ureteral stent within a patient

ActiveUS9060888B2Keep openMinimizing pain and discomfortStentsDiagnosticsInsertion stentCurve shape
A method includes placing a ureteral stent on an insertion tool. The ureteral stent includes an elongate member having a distal end coupled to a distal retention member. The elongate member includes a solid spring wire having a plurality of coils defining a lumen. A first portion of the insertion tool is disposed within the lumen, and the distal retention member, which has a nominally curved shape, is disposed about a second portion of the insertion tool such that the distal retention member is substantially linear. The insertion tool is inserted into the body of the patient and the ureteral stent is moved along the insertion tool such that at least a portion of the distal retention member is disposed within the kidney and a portion of the elongate member is disposed within the ureter.
Owner:BOSTON SCI SCIMED INC

Implantable human kidney replacement unit

An implantable human kidney replacement unit. Fully functional self contained, providing patients with end stage renal disease the freedom of traveling and moving about normally. Replacing donor kidneys. Implanted in the flank with at least one inlet and outlet tube each, sutured to the iliac artery and vain, at least one urine tube to the ureter. The housing constructed of anti-coagulant bacteriostatic materials has a plurality of reverse-osmosis process chambers with semipemeable membranes through the unit, followed by osmosis-diffusion chambers and membranes. Blood from the artery enters the first of the chambers. Small molecules such as water, magnesium, sodium, potassium, calcium, urea etc. are extracted from the blood according to their weight in atomic mass units as blood wipes past the self-cleaning membrane cartridges in the chambers. Molecules are further separated and urea sent to the bladder with excess water and electrolytes. The remainder is channeled to at least one diffusion chamber and reabsorbed into the blood. The same process is repeated in the other chambers where selected larger molecules such as creatinine and phosphorus are excreted, and some diffused back into the blood.
Owner:LUDLOW ROLAND G

Ureteral stent for improved patient comfort

A ureteral stent for assisting the movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region of the tubular segment and to transport urine from there across the ureter / bladder junction and into the bladder. The tails include an elongated external urine-transport surface sized and configured to transport urine along the ureter. The urine transporting surface(s) are sized and configured to extend along at least part of the ureter, across the ureter / bladder junction, and from there into the bladder. In some embodiments, the distal region includes a tubular body with a lumen in fluid communication with an interstitial area defined by one or more flexible filaments of the proximal region forming at least one loop.
Owner:BOSTON SCI SCIMED INC

Medical device with tail(s) for assisting flow of urine

InactiveUS6849069B1Decrease patient discomfortDecreases patient discomfortUrinary bladderStentsInsertion stentLeft ureter
A ureteral stent for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region of the tubular segment and to transport urine from there across the ureter / bladder junction and into the bladder. The tails include an elongated external urine-transport surface sized and configured to transport urine along the ureter. The urine transporting surface(s) are sized and configured to extend along at least part of the ureter, across the ureter / bladder junction, and from there into the bladder.
Owner:BOSTON SCI CORP

Method for using tropoelastin and for producing tropoelastin biomaterials

It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue using tropoelastin, preferably crosslinked tropoelastin and specifically to provide a tropoelastin biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The tropoelastin biomaterial itself can also be used as a stent or conduit covering or coating or lining.
Owner:BAROFSKY ANDREW D +1

Adjustable implantable genitourinary device

InactiveUS20050027161A1Easy to adjustContinence of the patientAnti-incontinence devicesLigamentsGynecologyUrethra
An implantable medical device and method for adjustably restricting a selected body lumen such as a urethra or ureter of a patient to treat urinary incontinence or ureteral reflux. The device includes an adjustable, self-sealing element having a continuous wall, including an inner surface defining a chamber. The adjustable element expands or contracts due to fluid volume introduced into the chamber for restricting a body lumen. After being implanted into a patient, the size of the adjustable element is altered by first locating the adjustable element implanted adjacent the body lumen, and then establishing fluid communication with the adjustable element. The volume of the adjustable element is then adjusted by either introducing or removing volume from the chamber of the adjustable element.
Owner:UROMEDICA INC

Ureter mirror with flexible end

The invention discloses a mini-incision endoscope for diagnosis and treatment of upper urinary tract diseases, which is a novel ureter endoscope comprising an end flexible base 1, an operating grip 4, an operational key 3 for controlling the bending motion of the base end, since the main portion of the base of the end flexible ureter endoscope is of hard structure, whose end portion can be bent upwards or downwards by 180 degrees, the viewing field blind area and operation blind area of the hard ureter endoscope can be eliminated.
Owner:孙颖浩 +2

Ureter nephroscope with bendable head end

InactiveCN103405261ARealize the bendable functionEasy to insertSuture equipmentsInternal osteosythesisKidney CalicesURETEROSCOPE
The invention relates to a surgical instrument. A ureter nephroscope with a bendable head end comprises an operating body which is connected with a nephroscope tube. The operating body comprises a nephroscope body, an assembling and disassembling mechanism and a retractable mechanism all of which are sequentially connected. The nephroscope tube comprises an inserting part, a bending part and a head end part all of which are sequentially connected. The inserting part is connected with the nephroscope body, the nephroscope tube is sleeved with a sheathing tube, the length of the sheathing tube is smaller than that of the nephroscope tube, and the retractable mechanism is located at one end of the sheathing tube and is connected with the nephroscope body through the assembling and disassembling mechanism. The ureter nephroscope with the bendable head end integrates the functions of a hard ureter nephroscope and a soft ureter nephroscope, and can be fast mounted and dismounted so that all components can be disinfected conveniently, the ureter nephroscope can be inserted into the ureter easily and can be inserted into kidney calices, especially into the lower kidney calices smoothly, and the situation inside the lower kidney calices can be well observed. The technical problems that an existing ureterocope in the prior art is inserted into the ureter difficultly, the situation inside the lower kidney calices cannot be well observed, the treatment cannot be well carried out, and the components cannot be fast mounted, dismounted or disinfected are solved.
Owner:孙颖浩

Ureteral stent with end-effector and related methods

A system and related methods for maintaining the patentcy of the ureter comprising a pusher tube having a pusher tube lumen and an inflate lumen disposed within a wall of the pusher tube and a urinary stent having a proximal and distal portions with an elongated body portion therebetween configured to fit the ureter of the patient and defining a lumen. The system further includes an end-effector that may comprise an inflatable balloon positioned at the proximal portion of the urinary stent for retaining the proximal portion in the urinary bladder. At the distal portion, a retention end-piece is positioned for retaining the distal portion of the stent in the renal pelvis. The end-effector and the retention end-piece of the stent maintain the elongated body portion in situ. The end-effector may also include an inflatable balloon and may contain pharmaceutical or biologic agents for controlled release into the bladder.
Owner:BOSTON SCI SCIMED INC

Screw-device for anastomosis

The present invention, the screw-device, is a mechanical device for anastomosing hollow tube-like structures in the human body, such as blood vessels, bowels and ureters. It is thus not restricted to (micro-)vessels. It can be used in every surgical operation dealing with anastomosis and bypass operations. It allows anastomosing end to side or side to side. The screw-device is very easy to apply onto the vessel wall. Screwing is a fast technique saving operating time and requiring only basic microsurgical skills. The manufacturing is easy. Another advantage is that the screw-device can be mounted onto the receptor vessel without first opening and / or occluding this vessel. Later on, the receptor vessel wall can be opened with laser or scalpel. It should be understood that the foregoing is illustrative and not limiting, and that modifications may be made by those skilled in the art, without departing from the scope of the invention.
Owner:UMC UTRECHT HLDG BV

Urinary catheter device

A urinary catheter device is shown which improves on prior devices by providing for a means to lengthen and shorten the tube used to transport urine to a collection receptacle. A transport tube is provided which is connected to the catheter or in fluid direct communication with the ureters where a stoma opening is instead provided. The transport tubing includes a contraction region, which can in an example be crests and groves or a helical coil, which allows for the region to be contracted during movement, transport or the like of the patient.
Owner:ARKANSAS STATE UNIVERSITY

Numerical control system capable of performing real-time control on renal pelvis pressure in ureteroscopy based on sheath-side optical fiber pressure sensor monitoring

The invention discloses a numerical control system capable of performing real-time control on renal pelvis pressure in ureteroscopy based on sheath-side optical fiber pressure sensor monitoring, whichcomprises an optical fiber pressure measuring system, an independent double-channel ureter leading-in sheath, a numerical control platform with a perfusion / attraction function and an intelligent terminal. In the system, a perfusion pump of a soft mirror connected with the numerical control platform enters a kidney through a main channel of the ureter leading-in sheath; an optical fiber pressure sensor enters a renal pelvis through a side channel to monitor the pressure of the renal pelvis, and both channels can be connected with negative pressure suction of the numerical control platform. According to the measured pressure feedback, the numerical control platform carries out data interaction with the intelligent terminal through wire / wireless; the intelligent terminal collects and analyzes the data in the operation, synchronously optimizes the working mode and can carry out later maintenance on the numerical control platform. The numerical control system has the advantages of real-time accurate pressure control, convenient adjustment and maintenance and the like, can effectively prevent complications such as kidney injury, serious infection and the like caused by high pressure inthe soft mirror operation, and improves the safety and the efficiency of the operation.
Owner:FUJIAN MEDICAL UNIV UNION HOSPITAL

Ureter bracket

The invention discloses a ureteral stent, which comprises a tubular body made of medical-grade polymer materials, wherein the ends of the tubular body are inwardly bent in opposite directions to a pigtail shape, and a larger groove (1) and a smaller groove (2) are symmetrically arranged at side walls of the tubular body with H-shaped cross sections. The diameter of the tubular body is 1.4-3.2 and the length thereof is 180-290 mm. The diameters of the larger (1) and the smaller (2) grooves are 0.8-2.0 mm and 0.4-0.8 mm respectively. One of the two pigtail-shaped ends has only the smaller groove (2) side, without the larger groove (1) side. The special open H-shaped structure can prevent blockage due to urine crystals when draining urine, so that the urine can be drained into bladder smoothly.
Owner:西安远大德天药业股份有限公司

Ureteral stone movement plugging device

PendingCN106725722AAvoid destructionPrevent postoperative residual stone rateSurgeryUreteroscopesRenal pelvis
The invention provides a ureteral stone movement plugging device. The ureteral stone movement plugging device consists of a catheter (1), an expandable compressed airbag (2) and a valve (3), wherein the catheter (1) adopts a hollow long tubular structure with elasticity and is made of elastic silica gel or latex; an opening is formed in the front end of the catheter (1); the opening is positioned inside the expandable compressed airbag (2); the expandable compressed airbag (2) is arranged at the front end of the catheter (1), and in the expanded state, the expandable compressed airbag (2) is ellipsoid-shaped; the valve (3) is positioned at the tail end of the catheter (1), and a syringe connecting port (4) is formed in the valve (3). The front section of the catheter (1) of the ureteral stone movement plugging device can enter a ureter through an operating chamber of a ureteroscope to relatively fix the airbag (2) into a ureteral cavity at the upstream of a stone or at an outlet of a renal pelvis, so that a kidney filling and expanding destructive effect of a water flow injected by the ureteroscope is eliminated and any passage through which the stone may move or escape into the renal pelvis is completely blocked.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Disposable cystoscope sheath

The invention relates to a disposable cystoscope sheath used with endoscope, which comprises an endoscope channel and an operating channel which are arranged inside the cystoscope sheath, wherein the endoscope channel is connected in parallel with the operating channel with inner cavities thereof communicated with each other, the endoscope channel made of medical hard plastic has the cross section in an elliptical shape with a gap, and the axial edge of the gap is connected with the axial edge of the gap of the section of the operating channel which is made of soft silica gel material. The disposable cystoscope sheath has the advantage that: since the elliptical endoscope channel reduces the area of an insertion opening, relatively small damage is caused to urethra so that patient feels comfortable; certain elasticity resulted from the soft silica gel material of the operating channel relatively increases the space of the operating channel, thereby facilitating operation; the disposable cystoscope sheath has the characteristics of low manufacturing cost, disposability, good cleanness and avoiding cross infection among patients, and can also serve as an outer sheath for ureteroscope and simultaneously monitor images of bladder and ureter, thus operation time is saved and operations are safer.
Owner:SHANGHAI KINDBEST MEDICAL TECH

Ureter indwelling device capable of controlling urination function

InactiveCN104324423AAchieve normal bladder functionMonitor health status at all timesMedical devicesIntravenous devicesDrainage amountUrination functions
The invention discloses a special urine bag for a critical patient carrying with an indwelling ureter for a long time. A main body comprises a ureter and a urine bag and further comprises a pressure sensor, a pressure valve, a flow sensor, a urine component detection element, a weight sensor, an alarm and a communication module. Since the pressure sensor and the pressure valve are arranged on the traditional urine bag structure, the pressure sensor can detect the internal pressure of a human bladder, so that drainage is realized in cooperation with the pressure valve and the effect of simulating a human normal bladder function is achieved. Since the flow sensor and the urine component detection element are arranged, urine drainage amount and urine components at each time can be acquired and analyzed and can be transmitted to an intelligent terminal, so that the health condition can be always monitored, and doctors can know the illness state of the patient in the first time and change the treatment plan in time. Since the weight sensor and the alarm are arranged at the lower end of the urine bag, when the urine amount in the urine bag exceeds the range set by nurses, an alarm can be given out.
Owner:NANTONG MATERNAL & CHILD HEALTH CARE HOSPITAL

Disposable soft ureter catheter

The invention discloses a disposable soft ureter catheter. The disposable soft ureter catheter comprises a work part and an operation part, wherein the work part comprises a multi-cavity pipe; one end of the multi-cavity pipe is connected with the operation part; a head end cap is arranged at the other end of the multi-cavity pipe; the operation part comprises a handle, a water inlet, an instrument hole, an illumination hole, an image hole, a pushing rod, a distributor and a steel wire rope; the water inlet, the instrument hole, the illumination hole, the image hole and the push rod are arranged on the handle; the distributor is also arranged in the handle; an inlet end of the distributor is respectively connected with the water inlet, the instrument hole, the illumination hole and the image hole; an outlet end of the distributor is connected with the multi-cavity pipe; the steel wire rope is arranged in the multi-cavity pipe; one end of the steel wire rope is connected to the pushing rod; the other end of the steel wire rope is connected with the head end cap; a hydrophilic coating is arranged on the outer wall of the multi-cavity pipe; a plurality of work passages are arranged in the multi-cavity pipe; a polytetrafluoroethylene coating is arranged on the inner wall of each work passage. According to the disposable soft ureter catheter provided by the invention, due to the fact that the work part is the soft multi-cavity pipe, the operation is convenient and the patient experience is better.
Owner:姚鹏

Self-cleaning type feces piss collector for female and male

InactiveCN1803110AAnti-slide driftPrevent leakageMedical transportBodily discharge devicesFecesAdult type
The invention discloses a self-cleaning closet device of universal male and female in the nursed personnel closet domain, which comprises the following parts: girdle 1, prenex taut band 2, toe-out taut band3, reinforced taut band 18, urination container 4, defecation container 5, connection band 6, ureter 9 and urine bag 11, wherein the girdle 1, prenex taut band 2, toe-out taut band3 and reinforced taut band 18 are set on the surface, which adapts ultra-two-scanty boundary material; the surface of urination container 4, defecation container 5 and urination container vulva sleeve adapts the face material of ultra-two-scanty boundary material or through the disposal of ultra-two-scanty boundary material, which possesses the self-cleaning, antibiotic and antimoudly function. The invention can be made into infant type and adult type, which satisfies the comfortable and sanitary property for the nursed personnel.
Owner:唐毓强 +1

Ureteroscope

The invention discloses a ureteroscope, comprising at least two parts of lenses and a lens body, wherein each part of the lenses are connected in sequence; the tail end of the rear part lens is connected with the lens body; communicated tube cavities are arranged in each part of the lenses and the lens body; the external wall of the front part lens is provided with a groove; a tube wall of the rear part lens is provided with a drainage channel; and the groove and the drainage channel are communicated with each other. By additionally arranged a water drainage channel, the invention can accelerate the water drainage speed during an operation, forms continuous water cycle, increases the water drainage amount during the operation on the premise of not influencing the execution in the operation, thus not only can keeping clear view during the operation process and improving operation efficiency, but also reducing water pressure in a kidney and an ureter, preventing occurrence of hyperpyrexia bacteremia after the operation and avoiding rise of the water pressure in a bladder.
Owner:SHANGHAI LINCHAO MEDICAL INSTR

Ureteral stent

A ureteral stent assembly includes an elongate member having a distal end portion for placement within a kidney of a patient and a proximal end portion for placement in at least one of a ureter of the patient and a bladder of the patient. The distal end portion has a retention portion configured to help retain at least a portion of the elongate member in the kidney of the patient. The elongate member is configured to be passed through the ureter of the patient from the kidney to the bladder to remove the elongate member from the patient. In one embodiment, the retention portion is configured such that a distal tip of the distal end portion of the ureteral stent is spaced from a sidewall of the ureter when the elongate member is passed through the ureter of the patient to remove the elongate member from the patient.
Owner:BOSTON SCI SCIMED INC

Intelligent in-situ implanted artificial bladder

InactiveCN1339290APrevent complications from intestinal obstructionAvoid intestinal obstructionProsthesisInterstitial cystitisPressure sense
The intelligent in-situ implanted artificial bladder consists of urine conveying and storing system and automatic intelligent system, the former includes artificial ureter, artificial bladder body and artificial urethra; and the latter incldues pressure sensing alarm, automatic flow returning mechanisms, urine pump and controller. The present invention is used mainly for patient needling bladder reconstruction and urethra reformation owing to bladder tumor, necrotic and interstitial cystitis, traumatic bladder damage, etc. After the body's bladder is ablated, the artificial bladder is in-situimplanted into the pelvic cavityk, the artificial ureter is anastomosed with the ureter stump, the artificial urethra is anastomosed with the urethra strump, and the urine conveying and storing system is reconstructed. The present invention makes it possible for the patient to control urination time autonomously.
Owner:靳凤烁 +1
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