7 results about "Into bladder" patented technology

An intravesical intermittent instillation catheter includes a tube containing a urinary lumen and an instillation lumen. The proximal end has a set of drainage eyelets, formed in a wall of the tube, that are in communication with the urinary lumen as well as a set of instillation eyelets, formed at a tip of the proximal end, in communication with the instillation lumen. A sheath is slidably mounted to surround the tube and having first and second axial positions wherein, in the first position, the drainage eyelets are exposed and, in the second position, the drainage eyelets are covered by the proximal end of the sheath. In operation of the catheter, when the sheath is in the first position, drainage of urine can proceed through a path including the drainage eyelets, the urinary lumen, a drainage connector, and a urinary collection bag and, when the sheath is in the second position, instillation of the medicament can thereafter proceed from a syringe, through an instillation connector, the instillation lumen, and the instillation eyelets and into the bladder.

The utility model discloses a kind of air spring bladder with vulcanization supporting ring composite cord structure, including bladder, the bladder is divided into bladder big head, bladder working area and bladder small head, the bladder big head part is three layer cord structure, the bladder working area and bladder small head part are single layer cord structure, and the overall thickness of bladder working area and bladder small head part is thinner than the thickness of bladder big head part, the inner diameter of bladder working area gradually decreases from bladder big head to bladder small head area, and supporting ring is fixed on the inner wall of bladder big head by vulcanization bonding mode. The air spring bladder of the utility model uses different reinforcing layer structure design, which can not only ensure the expansion outer diameter and burst pressure of the product, but also effectively reduce the product thickness of working area to improve its flexibility, reduce the air spring hysteresis force and improve the product comfort.

The invention discloses a targeted drug delivery biological hybrid micro-robot as well as a preparation method and application thereof. The micro-robot takes sperms as an active propulsion unit, and is constructed by combining PDA-DOX-FA nanoparticles through a coupling strategy; stable coupling of sperms and nanoparticles is realized through electrostatic adsorption, a biotin-streptavidin system or covalent binding. The micro-robot can enter the bladder through urethra perfusion, arrives at a tumor area depending on the autonomous propelling speed of sperms, realizes stable retention through folic acid targeted recognition and adhesion of neutrophil extracellular trapping nets (NETs), and realizes controllable release of adriamycin and deep penetration of tumors through a photothermal effect triggered by 808 nm near-infrared light. The problems of short retention, non-uniform distribution, insufficient permeation and the like of traditional bladder cancer perfusion treatment medicines are solved, the treatment efficiency and safety are remarkably improved, and the method is suitable for local precise treatment of bladder cancer.

This invention discloses an engineered extracellular vesicle system for constructing an in situ cell factory, its preparation method, and its applications. Specifically, it involves the in situ production of drug molecules with cytotoxic effects within bladder cancer cells under urea-mediated conditions, enabling the application of a urea-mediated targeted in situ killing system for the precision treatment of bladder cancer. Leveraging the unique microenvironment of a high urea concentration of 300 mmol / L within the bladder where bladder cancer lesions are located, an engineered extracellular vesicle system, P@EV, is constructed. VR+U Through the synergistic effect of RGD tumor targeting, VSVG pH-responsive membrane fusion and UTB urea transport function, PGA-1 can be efficiently delivered into bladder cancer cells, promoting intracellular urea accumulation and in situ generation of the cytotoxic product Compound-1.

An intravesical intermittent instillation catheter (100) includes a tube (100) containing a urinary lumen (108) and an instillation lumen (107). The proximal end has a set of drainage eyelets (104), formed in a wall of the tube, that are in communication with the urinary lumen as well as a set of instillation eyelets, formed at a tip of the proximal end, in communication with the instillation lumen. A sheath (122) is slidably mounted to surround the tube and having first and second axial positions wherein, in the first position, the drainage eyelets are exposed and, in the second position, the drainage eyelets are covered by the proximal end of the sheath. In operation of the catheter, when the sheath is in the first position, drainage of urine can proceed through a path including the drainage eyelets, the urinary lumen, a drainage connector, and a urinary collection bag (180) and, when the sheath is in the second position, instillation of the medicament can thereafter proceed from a syringe, through an instillation connector, the instillation lumen, and the instillation eyelets and into the bladder.

This application discloses a method for predicting bladder volume between and within radiotherapy fractions, belonging to the field of precision radiotherapy. The method includes: acquiring a sequence of fan-beam CT images of multiple completed treatment fractions for a patient, including pre-treatment images, pre-exit images, and post-exit images for each fraction; segmenting the images into bladder regions to construct a temporal volume dataset; determining the predicted bladder volume before the next treatment fraction using an inter-fraction prediction model; and determining the predicted bladder volume at a specified time point during the current treatment fraction using an intra-fraction dynamics model. The input to the inter-fraction prediction model includes at least one of volume sequence, water intake information, and extracted features; the input to the intra-fraction dynamics model includes at least one of the current pre-treatment bladder volume and daily water intake information. This application achieves dual-timescale prediction of bladder volume, providing a prospective decision-making basis for adaptive radiotherapy and improving the accuracy and safety of radiotherapy.

The utility model is suitable for medical consumable technical field, provide a kind of fast insertion switching type bladder irrigation tube, including catheter and conversion joint, conversion joint includes cylindrical casing, and casing one end has first pipe orifice, side wall is provided with second pipe orifice and third pipe orifice, catheter is connected with second pipe orifice, and switching core is equipped in casing.When needing to flush, directly flush connector is inserted into first pipe orifice, drives inside switching core to move, so that flush connector is communicated with second pipe orifice, and flushing fluid can enter into bladder, and flush connector is removed after flushing, and switching core is automatically reset, and second pipe orifice and third pipe orifice are automatically communicated, so that flushing waste liquid in bladder can be discharged into urine collection bag from third pipe orifice. The whole process only needs to plug flush connector, and it is simple to operate.