371 results about "Urine sample" patented technology

The ureter and urine bag comprises a urine bag body, a spiral pipe, a connecting pipe, a threaded connector pipe and a urine guiding pipe, the threaded connector pipe comprises a pipe body and an insertion pipe, internal threads with the thread pitch being 1.8-2.2 mm are machined on the inner wall of the pipe body, external threads matched with the internal threads are machined on the outer wall of the insertion pipe, and the spiral pipe is connected with the connecting pipe. Two groups of wing plates are symmetrically arranged on the outer wall of the cannula to provide rotating acting points, and a collecting assembly is integrated on the side wall of the urine bag and used for aseptically collecting urine samples. Traditional plug-pull type connection is replaced by a precise thread fit structure, a clear rotating force application point is provided for medical staff, operation is labor-saving and convenient, connector pollution is avoided, the urinary tract infection risk is effectively reduced, and the nursing comfort of a patient is improved.

The invention provides a diabetic nephropathy early warning method, system, equipment and medium, and relates to the technical field of medical data analysis and prediction.The method comprises the steps that multiple urine samples of a user are collected, target urine protein detection is conducted, and multiple urine protein concentrations are obtained; each urine protein concentration is combined with a normal urine protein concentration set to be input into an abnormal data recognition tree, the number of layers of multiple recognition nodes is obtained, and the detection confidence coefficient is obtained through calculation; configuring an abnormal proportion according to the detection confidence coefficient, inputting a plurality of urine protein concentration combination normal urine protein concentration sets into an abnormal data identification tree, deleting urine protein concentrations divided into abnormal data in the abnormal proportion before, and obtaining screened urine protein concentrations; according to the screened urine protein concentration, an auxiliary early warning coefficient is obtained through calculation, and early warning is carried out. The technical problem of low early warning accuracy of diabetic nephropathy in the prior art is solved.

Doubly labeled water with enhanced protocol. One embodiment is a method including providing, to a user, a doubly labeled water (DLW) dose for the user to ingest, the DLW dose including deuterium and oxygen-18, wherein an amount of the deuterium is less than 0.12 grams per kilogram (g / kg) of body water of the user, and wherein an amount of the oxygen-18 is less than 0.18 g / kg of body water of the user. The method also includes receiving, from the user, a non-cooled shipment of urine samples collected in connection with ingestion of the DLW dose, wherein the urine samples remain uncooled after collection and during transit for a period of up to 24 days. The method further includes processing the urine samples with a liquid water isotope analyzer to determine one or more metabolic parameters of the user.

The invention relates to methods, devices, and software for distinguishing hemoglobin (Hb) from myoglobin (Mb) in urine samples using peroxidase-reactive test strips. A time-resolved video of the color change on the test pad is recorded, and hue values are extracted and analyzed over time. Diagnostic differentiation between Hb and Mb is achieved by evaluating the hue-time curve, in particular via endpoint hue values and the ratio of integrated hue values in distinct time intervals. The invention further comprises a standardized optical setup for recording, a software-based evaluation algorithm, and a refillable cartridge for in-situ urine analysis devices containing appropriate test fields. The invention enables combined testing with additional urine parameters and is suitable for medical and non-clinical applications such as sport and home diagnostics.

The invention discloses a culture method of high-activity human urine-derived stem cells, which relates to the technical field of biological medicine, and is technically characterized by comprising the following steps: collecting urine samples of pregnant and lying-in women, coating a culture plate with gelatin, inducing adherence, performing passage amplification, performing immunofluorescence identification, performing function detection and other optimized conditions, and separating and culturing the stem cells. Compared with urine-derived stem cells of normal adults, the stem cells derived from pregnant women have stronger activity, higher dryness and faster multiplication capacity. The invention provides a novel and superior cell source for tissue engineering and regenerative medicine.

A method for characterizing disease activity in a systemic lupus erythematosus patient (SLE), comprising obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, assessing the dataset for a presence or an amount of protein expression of at least one innate serum or plasma mediator, assessing the dataset for a presence or an amount of protein expression of at least one adaptive serum or plasma mediator biomarker, assessing the dataset for a presence or an amount of at least one chemokine / adhesion molecule biomarker, assessing the dataset for a presence or an amount of at least one soluble TNF superfamily biomarker, assessing the dataset for a presence or an amount of at least one inflammatory mediator biomarker, assessing the dataset for a presence or an amount at least one SLE-associated autoantibody specificity biomarker and calculating a Lupus Disease Activity Immune Index (LDAII) score.

Device and methods for detection of kidney cancer using urine samples are disclosed herein. The device and methods enable isolation and quantification of kidney tumor cells in urine samples from a subject in need thereof.

The invention provides a urine HCG full-automatic detection and urine routine combined detection system, which comprises a host shell, an interactive interface, a sample interface, a USB interface, a sampling and sample introduction module, a urine detection module, a urine detection module, a urine detection module and a urine routine detection module, the microfluidic and reagent module is used for automatically distributing and reacting urine samples; the multifunctional automatic detection module is used for performing optical detection and electrochemical detection and completing combined detection of HCG and urine routine; the data processing module is used for collecting original signals and carrying out data processing and calculation to obtain HCG concentration, urine routine multi-parameter results and a detection report; and the intelligent diagnosis support module is used for performing medical correlation analysis and medical record intelligent diagnosis. Through combined detection of HCG and urine routine, HCG and urine routine results can be obtained at the same time, the detection efficiency is improved, and the detection accuracy and sensitivity are enhanced through optical detection and electrochemical detection processes.

The invention discloses a multi-nucleic acid probe rapid modification and multi-target detection device based on electric field regulation and control. An instrument main body in the device is integrated with an automatic liquid path system and a micro electrochemical workstation module, and is used for realizing programmable reagent and sample conveying and multi-channel electrochemical measurement. The detachable sensing chip is formed by bonding a microelectrode array chip and a micro-fluidic chip, and is switched through a PCB (Printed Circuit Board) to realize plug and play. According to the present invention, the positive suction-negative discharge strategy of the electric field is utilized, the preferred positive potential is applied to the target electrode to efficiently attract the probe, and the preferred negative potential is applied to the non-target electrode to inhibit the non-specific adsorption so as to achieve the spatial selective rapid fixation and the accurate density regulation and control of the multi-nucleic acid probe in the extremely short time; the device can be used for quantitatively detecting various body fluid disease markers in a plurality of urine samples at the same time in single operation, and an efficient, accurate and portable multi-marker comprehensive analysis solution is provided for early screening and instant diagnosis of tumors.

The invention relates to a urine metabolism combined marker for diagnosing bladder cancer and a screening method of the urine metabolism combined marker. The urine metabolism combined marker is prepared from 2-methyl furan, dimethyl disulfide, octylene and acetophenone. The method for screening the urine metabolism combined marker comprises the following steps: carrying out chromatographic separation and mass spectrometry detection on a urine sample on the basis of a headspace automatic sampler in combination with a chromatographic column and a photochemical ionization time-of-flight mass spectrometry, preprocessing mass spectrometry data, and extracting spectrum peak data of metabolites in urine; the urine metabolism combination marker for diagnosing bladder cancer is obtained through further statistical analysis. The screening method of the urine metabolism combined marker for diagnosing the bladder cancer has the advantages of non-invasiveness, high-throughput detection, simplicity in operation and accurate result, and has a wide application prospect.

The invention relates to the field of flush toilets, in particular to an intelligent closestool with a urine sample detection function. Comprising a closestool body, a penetrating hole is formed in the front end in the closestool body, and a conical plate is rotationally arranged at the lower end of the penetrating hole through a motor and can open the penetrating hole to allow midstream urine to penetrate through when rotating; an expansion plate for preventing urine from escaping is arranged at the lower end of the cone plate, a pressure sensor is arranged at the upper end of the cone plate, and an infrared sensor is arranged above the through hole; a urine guide mechanism is arranged on the side, away from the through hole, of the expansion plate and comprises a drainage arc plate fixedly connected with the closestool body, one end of the drainage arc plate is in movable sealing connection with the expansion plate, and a sampling pipe with two through ends is arranged below the other end of the drainage arc plate; the sampling pipe is coaxially provided with a sampling mechanism, the sampling mechanism comprises a plug which is in dynamic sealing connection with the inner wall of the sampling pipe, and the plug is coaxially provided with a probe for analyzing urine. The device can accurately collect midstream urine samples, realizes household automatic urine detection, is high in detection precision, and can effectively avoid sample pollution.

The invention relates to the technical field of test sample collection, in particular to an anti-pollution collection device for excrement and urine test samples. Comprising a sampling unit, the sampling unit comprises a sampling bedpan, and a urine sampling pool and an excrement sampling pool are arranged at the top of the sampling bedpan; the bottoms of the urine sampling pool and the excrement sampling pool are respectively communicated with a group of movable hoses, and the output ends of the two groups of movable hoses are respectively and movably connected with an excrement treatment unit and a urine treatment unit. Manual transfer and touch are not needed in the whole process, other external containers are not needed for transfer, excessive contact with external air is avoided, excrement and urine samples can be separately collected at the same time, the functionality of the device is improved, meanwhile, the purpose of pollution-free collection is achieved, the accuracy of follow-up inspection is guaranteed, and the detection efficiency is improved. And the automation degree of the device is also improved.

The invention discloses a urine sampling device, and relates to the technical field of medical care. Comprising a sampling tube, a liquid inlet formed in the bottom of the sampling tube, a liquid pumping handle slidably arranged in the sampling tube and used for pumping urine, a limiting block arranged on the outer wall of the sampling tube in a sleeving mode, a connecting frame fixedly connected to the outer wall of one side of the limiting block, a sliding rod allowing the connecting frame to vertically ascend, descend and slide, and a base fixedly connected to the bottom of the sliding rod. The shell is fixedly connected to the outer wall of one side of the sampling tube. By means of the midstream urine suction device, the problem that when midstream urine is sucked, urine close to the liquid level or urine at the liquid bottom is likely to be mixed due to the influence of factors such as the insertion angle of the suction pipe, the suction speed and the mobility of the urine is solved. The problems that urine is polluted by bacteria on the liquid level, and urine at the bottom of the liquid contains a large amount of precipitates which can interfere with the purity of a sample, so that the extracted sample cannot accurately represent the real condition of the middle area of the urine, and finally the actual data of urine detection is influenced are solved.

The present application relates to the field of environmental chemistry and biological sample analysis, and particularly relates to an analysis method for detecting organic ultraviolet absorbers and metabolites thereof in urine. The method comprises enzymolysis of a urine sample and addition of an internal standard, extraction and purification of 24 kinds of organic ultraviolet absorbers and metabolites thereof in the sample by extraction, and detection of the content of target substances in the urine sample by high performance liquid chromatography-mass spectrometer. The present application is simple in operation, high in accuracy and reliability, can simultaneously detect 24 kinds of organic ultraviolet absorbers and metabolites thereof in 8 categories at one time, some substances are reported for the first time in the human urine detection method, and the method has wide practical application value and significance for evaluating the residual situation of organic ultraviolet absorbers and metabolites thereof in human body.

The utility model discloses a medical examination sample collection anti-pollution device, and relates to the technical field of medical sample collection devices, in particular to a medical examination sample collection anti-pollution device, which comprises a collection kettle, a plurality of urine guide components and a plurality of sample test tubes, a second flow guide pipe is fixedly mounted at one end of the upper part of the collection kettle and is communicated with the collection kettle; a plastic corrugated pipe is fixedly mounted at the other end of the upper part of the collection kettle and is communicated with the collection kettle; when urine is collected, the funnel covers the genital organ of a patient, after the patient urinates, the urine sequentially flows through the funnel, the first flow guide pipe and the second flow guide pipe and then enters the collection pot, the collection pot is used for containing the urine, and the second cap covers the port of the inflow end of the second flow guide pipe; when a urine sample is taken, a test tube is inserted on the joint, the collection pot is inclined, a small amount of urine in the collection pot flows into the test tube through the plastic corrugated pipe, and after sampling is finished, the joint is covered by the first cap, so that the urine is effectively collected.

The invention provides a portable stable urine protein qualitative detection kit, and relates to the technical field of urine protein qualitative detection. A homogenizing tank is fixedly mounted at the front end in the kit body, a conveying pipe is connected to the middle in the homogenizing tank in a penetrating manner, through holes in an annular array are formed in the surface of the position, located in the homogenizing tank, of the conveying pipe, and a limiting sleeve is fixedly connected to the top of the conveying pipe. A uniform tank is arranged in the kit, a bevel gear and an annular gear are driven by a motor, and a vertical plate at the bottom of the annular gear is driven to rotate in the uniform tank, so that a liquid sample can be fully and uniformly stirred, protein in the sample can be more uniformly distributed, and a detection result can more accurately reflect the actual content of protein in urine; and the detection reliability is improved. The problems that a kit is lack of an effective sample uniform treatment mechanism, if a urine sample is not fully uniform before detection, the protein concentration of a detection part is inconsistent, and the detection result has deviation are solved.

The invention provides an automatic urine sample preprocessing method and system for pharmacokinetic parameter calculation. The method is realized through an integrated automatic process as follows: identifying a urine cup with an identity label, transferring a urine sample to a measuring cylinder, accurately measuring the volume of urine by using a sensor, adding a stabilizing solution according to a preset proportion, then performing standardized mixing to form a mixed solution, and finally sub-packaging the mixed solution into a cryopreservation tube in a high-flux manner. The technical problem that in the prior art, due to manual operation, urine volume measurement is not accurate, medicine components are degraded after being in vitro, data tracing is difficult and the like is solved, and finally the technical pain point that key pharmacokinetic parameter calculation results are seriously inaccurate is caused. By providing a high-precision and high-reproducibility qualified sample, the quality of subsequent analysis data is guaranteed from the source, and the accuracy, research efficiency and data compliance of PK parameter calculation are remarkably improved.

There is provided a urine analysis device (1) capable of analyzing a urine sample to determine a physicochemical property value of the urine sample, comprising: a first sampling module (2) configured to form a fluid channel connection with a user and comprising a first discharge conduit (20) configured to discharge the urine sample from the first sampling module (2); a first discharge conduit (20) comprising a containment portion (20a) defining a predetermined volume and configured to retain a first portion of urine, and a release portion (20b) configured to deliver a second portion of urine out of the first sampling module (2); a drainage bag (3) forming a fluid channel connection with at least the release portion (20b) and configured to collect the second portion; an analysis device (4) placed in a fluid channel connection with the containing portion (20a) and configured to analyze at least a portion of the first portion; a control device (5) configured to process at least the data collected by the analysis device (4); and acquisition means (6) operably connected to the drainage bag (3) and configured to acquire at least a first parameter corresponding to the weight of the second portion of urine wherein the control means (5) is further configured to calculate a second parameter corresponding to the volume of the second portion in combination with the first parameter given a third predetermined parameter corresponding to the urine density, and adding the second parameter and the predetermined volume to obtain the total volume of the urine.

The invention provides a multiple detection technology MMDEC for high-sensitivity detection of tumor methylated DNA from samples such as blood, belongs to the field of disease diagnosis markers, and more specifically relates to a method for detecting methylation of target DNA through the following steps: constructing oligonucleotide; the kit comprises a target specific multiple Rooptag primer capable of being complementarily combined with a plurality of tumor specific high-methylated CG island target DNAs (Deoxyribose Nucleic Acid) and a universal tag primer combined with the specific multiple Rooptag primer, wherein the target specific multiple Rooptag primer can be complementarily combined with a plurality of tumor specific high-methylated CG island target DNAs (Deoxyribose Nucleic Acid); the method comprises the following steps: performing exponential amplification on multiple methylation target DNA by using a specific multiple Rooptag primer as a primary primer to obtain a multiple amplification product; performing homogeneity amplification on the obtained multiplex amplification primer by using oligonucleotide (which can be complementarily combined with the linearly amplified target DNA) using a universal tag primer as a secondary primer; and detecting whether an amplification product exists or not through a probe. According to the method disclosed by the invention, MMDEC can be used for early screening and diagnosis of plasma / urine sample tumors, accords with clinical practice on the basis of research results, and has a good clinical application prospect.

The present disclosure relates to a biomarker for providing information on brain electrical stimulation, and a method for providing information for brain doping diagnosis (bD2) using the same. According to the present disclosure, there is provided a method for determining, using a urine sample, whether a subject has received brain electrical stimulation, which may be used as a means for establishing regulations and countermeasures for abuse of brain doping of which safety has not yet been confirmed.

The utility model discloses a rapid quantitative collection and storage device for an indwelling urine sample. The rapid quantitative collection and storage device comprises a negative pressure suction cap, a storage cylinder and a bottom storage device, the negative pressure suction device is characterized in that the negative pressure suction cap is detachably buckled at the top end of the storage barrel, the bottom storage device is detachably buckled at the bottom of the storage barrel, and the negative pressure suction cap can also be directly buckled at the top end of the bottom storage device. A urine sample storage main body is constructed by the negative pressure suction cap and the storage cylinder, the suction of a urine sample can be completed by extruding the negative pressure suction cap, the link of directly taking a measuring cup for scooping up is avoided, the sample extraction is rapid, and meanwhile, an operator cannot feel uncomfortable.

1. The name of the design product: urine test cup. 2. The use of the design product: the design product is used for storing urine samples. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The utility model provides a panda urine collecting device which comprises a urine sample collector located in a first hole site and matched with the first hole site, a circle of first outer edge is arranged on the periphery of the top of the urine sample collector, the first outer edge extends to the outer side of the top of the first hole site, and a second outer edge is arranged on the outer side of the top of the first hole site. A second hole site is formed in the middle of the urine sample collector; the liquid collecting barrel is matched with the second hole site, a circle of second outer edge is arranged on the periphery of the top of the liquid collecting barrel, and the second outer edge extends to the outer side of the top of the second hole site. Urine of pandas is stored through the liquid collecting cylinder, when urine samples need to be taken, the pandas are driven to another adjacent cage, then a worker directly extracts the urine from the liquid collecting cylinder through a needle tube or directly takes out the liquid collecting cylinder to pour out the urine in the liquid collecting cylinder, the convenience of collecting the urine of the pandas is improved, and the urine is prevented from flowing away or being absorbed and polluted by a cement floor. The pandas are prevented from attacking breeders, and the safety of workers is guaranteed.

The invention relates to a disposable urine sample automatic segmentation collector, and discloses a collector which can guide a urine sample through a leakage-proof device, can prevent urine from leaking out, can automatically segment the urine sample through an automatic segmentation collection device, and can conveniently reserve urine in a middle segment. The device is characterized in that the device is composed of a leakage-proof device and an automatic segmented collection device, the leakage-proof device is composed of a leakage-proof liquid guide plate, a collection supporting cylinder, a urine collection cylinder, an avoiding groove and a leakage-proof side edge, one end of the collection supporting cylinder is provided with one end of the leakage-proof liquid guide plate, the collection supporting cylinder is of a hollow cylindrical structure with one end open, and the other end of the collection supporting cylinder is provided with a drainage opening. An avoiding groove is formed in one end of the collection supporting cylinder, the avoiding groove corresponds to the leakage-proof liquid guide plate, the edge of the avoiding groove is connected with the edge of one end of the leakage-proof liquid guide plate, the included angle between one end of the collection supporting cylinder and one end of the leakage-proof liquid guide plate is an obtuse angle, and leakage-proof side edges are correspondingly arranged on the two sides of the leakage-proof liquid guide plate respectively.

The utility model discloses a urine sample collection and preservation device, which belongs to the technical field of sample experiment reaction and comprises a preservation container and a collection container, the collection container is sleeved outside the preservation container and is detachably matched with the preservation container, the collection container is provided with an open collection cavity, and the preservation container is provided with a sealed storage cavity; the storage container is of a transparent structure and is provided with at least a first scale mark and a second scale mark, in the storage cavity, a first capacity space is formed between the first scale mark and the bottom of the storage container, and a second capacity space is formed between the second scale mark and the bottom of the storage container. The volume of the second capacity space is larger than that of the first capacity space. The first scale mark and the second scale mark are used as marks, the preserving fluid is quantitatively added, the urine sample and the preserving fluid are quantitatively mixed and preserved, it is ensured that the urine sample is relatively stable, cells in the urine sample are well preserved, and the accuracy of detection data is obviously improved.

The invention relates to the technical field of biological detection devices, and discloses a biomarker detection device and application thereof.The biomarker detection device comprises a detection table, a urine bin and a detector and further comprises a fixing table; according to the device, when a urine sample of a patient is guided into a urine bin, a synchronous belt and a synchronous wheel are driven by an electric motor, and then two sets of stroke lead screws are synchronously driven, so that a positioning plate moves downwards from an initial position along a guide groove in the inner wall of a fixing frame, and a positioning groove in the positioning plate pushes a corresponding guide wheel to the left side; therefore, a sliding block corresponding to the back end of a connecting rod synchronously slides on a linear guide rail, a corresponding sealing plate abuts against and compresses an abutting spring along an opening groove, the sealing plate is separated from an opening in the top of a corresponding sorting bottle, and a urine sample of a patient is shunted to the multi-group sorting bottle for contrast detection. Urine samples of patients are synchronously sampled in multiple groups and then are compared and detected, so that the accuracy of detection data is improved.

The utility model discloses a urine sample storage device for nephrology department relates to urine storage device technical field. Including: main body frame, the inner wall of main body frame is connected with bearing device, the outer wall of main body frame is connected with seal cover, storage device, the storage device includes storage frame, the outer wall of storage frame is rotatably connected with storage cover through the lug, the outer wall fixedly connected with buffer washer of storage frame, the outer wall fixedly connected with the clamping tongue of storage frame, the inner wall fixedly connected with the fixed plate of storage frame, the outer wall fixedly connected with the clamping ring of storage cover. The urine sample that needs to store is placed in the hole of fixed plate through storage device, so this can make sample place stability and orderly, then close storage cover, and the clamping ring will be locked into the clamping tongue when closing storage cover, thereby realizes the closed preservation to the sample in storage device.

The utility model belongs to the technical field of urine sampling, in particular to a urine sample sampling device for animal husbandry and veterinary, which comprises an assembly plate, vertical rods are fixedly mounted on two sides of the top of the assembly plate, tension springs are movably mounted on the surfaces of the vertical rods, positioning plates are fixedly mounted on two sides of the assembly plate, and the positioning plates are movably mounted on the surfaces of the vertical rods. A clamping groove is formed in one side of the top of the front face of the positioning plate, a positioning rod is fixedly installed in the clamping groove, an abutting plate is movably installed on the surface of the positioning rod, a liquid inlet hopper conical face clamping base is fixedly installed on the top of the front face of the abutting plate, and a sampling measuring cup arc-shaped clamping plate is fixedly installed at the bottom of the front face of the abutting plate. Through the structural design of the assembling plate, the vertical rod, the tension spring, the positioning plate, the positioning rod, the abutting plate, the liquid inlet hopper conical surface clamping seat, the sampling measuring cup arc-shaped clamping plate, the connecting plate and the hanging rod, the function of rapidly disassembling and assembling the liquid collecting hopper and the sample measuring cup is achieved, so that the disassembling and assembling efficiency of the liquid collecting hopper and the sample measuring cup can be improved, and then the pollution risk between urine samples is reduced.

The present invention provides isolated polypeptides capable of specifically binding to a protein target selected from LGALS9, CRP, BTLA, SAA, EGF, or FGA, or to a peptide thereof, especially under urinary conditions, which may be used for predicting in a urine sample of a subject suspected of having an infection whether the infection is a bacterial infection or a viral infection. The present invention further provides methods of diagnostics and treatment using the isolated polypeptides, and suitable diagnostic kits.

The application relates to an 11-dehydrothromboxane B2 detection kit and a detection method thereof, relates to the technical field of biological detection, and comprises an activation solution, an equilibrium solution, an elution solution, an elution solution, a reconstitution solution, an internal standard solution, a calibrator and a quality control product. The detection method comprises the following steps: S1, adjusting the pH of a urine sample to 2.5-3.0 by adding phosphoric acid; S2, sucking the urine sample after pH adjustment, the calibrator and the quality control product into a centrifugal tube, reacting at 37 DEG C for 2.5-3.5 hours, adding the internal standard solution, centrifuging, and taking the supernatant for solid-phase extraction treatment; S3, solid-phase extraction; and S4, calculating the concentration of 11-DH-TXB2 in the urine according to the liquid chromatogram and the peak area of 11-DH-TXB2 in the detection sample and the corresponding internal standard peak area. The application has reliable results and is convenient to calculate.