242 results about "Urine sample" patented technology

The ureter and urine bag comprises a urine bag body, a spiral pipe, a connecting pipe, a threaded connector pipe and a urine guiding pipe, the threaded connector pipe comprises a pipe body and an insertion pipe, internal threads with the thread pitch being 1.8-2.2 mm are machined on the inner wall of the pipe body, external threads matched with the internal threads are machined on the outer wall of the insertion pipe, and the spiral pipe is connected with the connecting pipe. Two groups of wing plates are symmetrically arranged on the outer wall of the cannula to provide rotating acting points, and a collecting assembly is integrated on the side wall of the urine bag and used for aseptically collecting urine samples. Traditional plug-pull type connection is replaced by a precise thread fit structure, a clear rotating force application point is provided for medical staff, operation is labor-saving and convenient, connector pollution is avoided, the urinary tract infection risk is effectively reduced, and the nursing comfort of a patient is improved.

A method for characterizing disease activity in a systemic lupus erythematosus patient (SLE), comprising obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, assessing the dataset for a presence or an amount of protein expression of at least one innate serum or plasma mediator, assessing the dataset for a presence or an amount of protein expression of at least one adaptive serum or plasma mediator biomarker, assessing the dataset for a presence or an amount of at least one chemokine / adhesion molecule biomarker, assessing the dataset for a presence or an amount of at least one soluble TNF superfamily biomarker, assessing the dataset for a presence or an amount of at least one inflammatory mediator biomarker, assessing the dataset for a presence or an amount at least one SLE-associated autoantibody specificity biomarker and calculating a Lupus Disease Activity Immune Index (LDAII) score.

Device and methods for detection of kidney cancer using urine samples are disclosed herein. The device and methods enable isolation and quantification of kidney tumor cells in urine samples from a subject in need thereof.

The invention provides a urine HCG full-automatic detection and urine routine combined detection system, which comprises a host shell, an interactive interface, a sample interface, a USB interface, a sampling and sample introduction module, a urine detection module, a urine detection module, a urine detection module and a urine routine detection module, the microfluidic and reagent module is used for automatically distributing and reacting urine samples; the multifunctional automatic detection module is used for performing optical detection and electrochemical detection and completing combined detection of HCG and urine routine; the data processing module is used for collecting original signals and carrying out data processing and calculation to obtain HCG concentration, urine routine multi-parameter results and a detection report; and the intelligent diagnosis support module is used for performing medical correlation analysis and medical record intelligent diagnosis. Through combined detection of HCG and urine routine, HCG and urine routine results can be obtained at the same time, the detection efficiency is improved, and the detection accuracy and sensitivity are enhanced through optical detection and electrochemical detection processes.

The invention relates to the field of flush toilets, in particular to an intelligent closestool with a urine sample detection function. Comprising a closestool body, a penetrating hole is formed in the front end in the closestool body, and a conical plate is rotationally arranged at the lower end of the penetrating hole through a motor and can open the penetrating hole to allow midstream urine to penetrate through when rotating; an expansion plate for preventing urine from escaping is arranged at the lower end of the cone plate, a pressure sensor is arranged at the upper end of the cone plate, and an infrared sensor is arranged above the through hole; a urine guide mechanism is arranged on the side, away from the through hole, of the expansion plate and comprises a drainage arc plate fixedly connected with the closestool body, one end of the drainage arc plate is in movable sealing connection with the expansion plate, and a sampling pipe with two through ends is arranged below the other end of the drainage arc plate; the sampling pipe is coaxially provided with a sampling mechanism, the sampling mechanism comprises a plug which is in dynamic sealing connection with the inner wall of the sampling pipe, and the plug is coaxially provided with a probe for analyzing urine. The device can accurately collect midstream urine samples, realizes household automatic urine detection, is high in detection precision, and can effectively avoid sample pollution.

The invention relates to the technical field of test sample collection, in particular to an anti-pollution collection device for excrement and urine test samples. Comprising a sampling unit, the sampling unit comprises a sampling bedpan, and a urine sampling pool and an excrement sampling pool are arranged at the top of the sampling bedpan; the bottoms of the urine sampling pool and the excrement sampling pool are respectively communicated with a group of movable hoses, and the output ends of the two groups of movable hoses are respectively and movably connected with an excrement treatment unit and a urine treatment unit. Manual transfer and touch are not needed in the whole process, other external containers are not needed for transfer, excessive contact with external air is avoided, excrement and urine samples can be separately collected at the same time, the functionality of the device is improved, meanwhile, the purpose of pollution-free collection is achieved, the accuracy of follow-up inspection is guaranteed, and the detection efficiency is improved. And the automation degree of the device is also improved.

There is provided a urine analysis device (1) capable of analyzing a urine sample to determine a physicochemical property value of the urine sample, comprising: a first sampling module (2) configured to form a fluid channel connection with a user and comprising a first discharge conduit (20) configured to discharge the urine sample from the first sampling module (2); a first discharge conduit (20) comprising a containment portion (20a) defining a predetermined volume and configured to retain a first portion of urine, and a release portion (20b) configured to deliver a second portion of urine out of the first sampling module (2); a drainage bag (3) forming a fluid channel connection with at least the release portion (20b) and configured to collect the second portion; an analysis device (4) placed in a fluid channel connection with the containing portion (20a) and configured to analyze at least a portion of the first portion; a control device (5) configured to process at least the data collected by the analysis device (4); and acquisition means (6) operably connected to the drainage bag (3) and configured to acquire at least a first parameter corresponding to the weight of the second portion of urine wherein the control means (5) is further configured to calculate a second parameter corresponding to the volume of the second portion in combination with the first parameter given a third predetermined parameter corresponding to the urine density, and adding the second parameter and the predetermined volume to obtain the total volume of the urine.

The invention provides a multiple detection technology MMDEC for high-sensitivity detection of tumor methylated DNA from samples such as blood, belongs to the field of disease diagnosis markers, and more specifically relates to a method for detecting methylation of target DNA through the following steps: constructing oligonucleotide; the kit comprises a target specific multiple Rooptag primer capable of being complementarily combined with a plurality of tumor specific high-methylated CG island target DNAs (Deoxyribose Nucleic Acid) and a universal tag primer combined with the specific multiple Rooptag primer, wherein the target specific multiple Rooptag primer can be complementarily combined with a plurality of tumor specific high-methylated CG island target DNAs (Deoxyribose Nucleic Acid); the method comprises the following steps: performing exponential amplification on multiple methylation target DNA by using a specific multiple Rooptag primer as a primary primer to obtain a multiple amplification product; performing homogeneity amplification on the obtained multiplex amplification primer by using oligonucleotide (which can be complementarily combined with the linearly amplified target DNA) using a universal tag primer as a secondary primer; and detecting whether an amplification product exists or not through a probe. According to the method disclosed by the invention, MMDEC can be used for early screening and diagnosis of plasma / urine sample tumors, accords with clinical practice on the basis of research results, and has a good clinical application prospect.

The present disclosure relates to a biomarker for providing information on brain electrical stimulation, and a method for providing information for brain doping diagnosis (bD2) using the same. According to the present disclosure, there is provided a method for determining, using a urine sample, whether a subject has received brain electrical stimulation, which may be used as a means for establishing regulations and countermeasures for abuse of brain doping of which safety has not yet been confirmed.

The utility model discloses a rapid quantitative collection and storage device for an indwelling urine sample. The rapid quantitative collection and storage device comprises a negative pressure suction cap, a storage cylinder and a bottom storage device, the negative pressure suction device is characterized in that the negative pressure suction cap is detachably buckled at the top end of the storage barrel, the bottom storage device is detachably buckled at the bottom of the storage barrel, and the negative pressure suction cap can also be directly buckled at the top end of the bottom storage device. A urine sample storage main body is constructed by the negative pressure suction cap and the storage cylinder, the suction of a urine sample can be completed by extruding the negative pressure suction cap, the link of directly taking a measuring cup for scooping up is avoided, the sample extraction is rapid, and meanwhile, an operator cannot feel uncomfortable.

1. The name of the design product: urine test cup. 2. The use of the design product: the design product is used for storing urine samples. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The utility model provides a panda urine collecting device which comprises a urine sample collector located in a first hole site and matched with the first hole site, a circle of first outer edge is arranged on the periphery of the top of the urine sample collector, the first outer edge extends to the outer side of the top of the first hole site, and a second outer edge is arranged on the outer side of the top of the first hole site. A second hole site is formed in the middle of the urine sample collector; the liquid collecting barrel is matched with the second hole site, a circle of second outer edge is arranged on the periphery of the top of the liquid collecting barrel, and the second outer edge extends to the outer side of the top of the second hole site. Urine of pandas is stored through the liquid collecting cylinder, when urine samples need to be taken, the pandas are driven to another adjacent cage, then a worker directly extracts the urine from the liquid collecting cylinder through a needle tube or directly takes out the liquid collecting cylinder to pour out the urine in the liquid collecting cylinder, the convenience of collecting the urine of the pandas is improved, and the urine is prevented from flowing away or being absorbed and polluted by a cement floor. The pandas are prevented from attacking breeders, and the safety of workers is guaranteed.

The invention relates to a disposable urine sample automatic segmentation collector, and discloses a collector which can guide a urine sample through a leakage-proof device, can prevent urine from leaking out, can automatically segment the urine sample through an automatic segmentation collection device, and can conveniently reserve urine in a middle segment. The device is characterized in that the device is composed of a leakage-proof device and an automatic segmented collection device, the leakage-proof device is composed of a leakage-proof liquid guide plate, a collection supporting cylinder, a urine collection cylinder, an avoiding groove and a leakage-proof side edge, one end of the collection supporting cylinder is provided with one end of the leakage-proof liquid guide plate, the collection supporting cylinder is of a hollow cylindrical structure with one end open, and the other end of the collection supporting cylinder is provided with a drainage opening. An avoiding groove is formed in one end of the collection supporting cylinder, the avoiding groove corresponds to the leakage-proof liquid guide plate, the edge of the avoiding groove is connected with the edge of one end of the leakage-proof liquid guide plate, the included angle between one end of the collection supporting cylinder and one end of the leakage-proof liquid guide plate is an obtuse angle, and leakage-proof side edges are correspondingly arranged on the two sides of the leakage-proof liquid guide plate respectively.

The utility model discloses a urine sample collection and preservation device, which belongs to the technical field of sample experiment reaction and comprises a preservation container and a collection container, the collection container is sleeved outside the preservation container and is detachably matched with the preservation container, the collection container is provided with an open collection cavity, and the preservation container is provided with a sealed storage cavity; the storage container is of a transparent structure and is provided with at least a first scale mark and a second scale mark, in the storage cavity, a first capacity space is formed between the first scale mark and the bottom of the storage container, and a second capacity space is formed between the second scale mark and the bottom of the storage container. The volume of the second capacity space is larger than that of the first capacity space. The first scale mark and the second scale mark are used as marks, the preserving fluid is quantitatively added, the urine sample and the preserving fluid are quantitatively mixed and preserved, it is ensured that the urine sample is relatively stable, cells in the urine sample are well preserved, and the accuracy of detection data is obviously improved.

The invention relates to the technical field of biological detection devices, and discloses a biomarker detection device and application thereof.The biomarker detection device comprises a detection table, a urine bin and a detector and further comprises a fixing table; according to the device, when a urine sample of a patient is guided into a urine bin, a synchronous belt and a synchronous wheel are driven by an electric motor, and then two sets of stroke lead screws are synchronously driven, so that a positioning plate moves downwards from an initial position along a guide groove in the inner wall of a fixing frame, and a positioning groove in the positioning plate pushes a corresponding guide wheel to the left side; therefore, a sliding block corresponding to the back end of a connecting rod synchronously slides on a linear guide rail, a corresponding sealing plate abuts against and compresses an abutting spring along an opening groove, the sealing plate is separated from an opening in the top of a corresponding sorting bottle, and a urine sample of a patient is shunted to the multi-group sorting bottle for contrast detection. Urine samples of patients are synchronously sampled in multiple groups and then are compared and detected, so that the accuracy of detection data is improved.

The utility model discloses a urine sample storage device for nephrology department relates to urine storage device technical field. Including: main body frame, the inner wall of main body frame is connected with bearing device, the outer wall of main body frame is connected with seal cover, storage device, the storage device includes storage frame, the outer wall of storage frame is rotatably connected with storage cover through the lug, the outer wall fixedly connected with buffer washer of storage frame, the outer wall fixedly connected with the clamping tongue of storage frame, the inner wall fixedly connected with the fixed plate of storage frame, the outer wall fixedly connected with the clamping ring of storage cover. The urine sample that needs to store is placed in the hole of fixed plate through storage device, so this can make sample place stability and orderly, then close storage cover, and the clamping ring will be locked into the clamping tongue when closing storage cover, thereby realizes the closed preservation to the sample in storage device.

The present invention provides isolated polypeptides capable of specifically binding to a protein target selected from LGALS9, CRP, BTLA, SAA, EGF, or FGA, or to a peptide thereof, especially under urinary conditions, which may be used for predicting in a urine sample of a subject suspected of having an infection whether the infection is a bacterial infection or a viral infection. The present invention further provides methods of diagnostics and treatment using the isolated polypeptides, and suitable diagnostic kits.

The application relates to an 11-dehydrothromboxane B2 detection kit and a detection method thereof, relates to the technical field of biological detection, and comprises an activation solution, an equilibrium solution, an elution solution, an elution solution, a reconstitution solution, an internal standard solution, a calibrator and a quality control product. The detection method comprises the following steps: S1, adjusting the pH of a urine sample to 2.5-3.0 by adding phosphoric acid; S2, sucking the urine sample after pH adjustment, the calibrator and the quality control product into a centrifugal tube, reacting at 37 DEG C for 2.5-3.5 hours, adding the internal standard solution, centrifuging, and taking the supernatant for solid-phase extraction treatment; S3, solid-phase extraction; and S4, calculating the concentration of 11-DH-TXB2 in the urine according to the liquid chromatogram and the peak area of 11-DH-TXB2 in the detection sample and the corresponding internal standard peak area. The application has reliable results and is convenient to calculate.

The utility model discloses a urine sample transfer device which comprises a rectangular bottom plate and a right fixing side plate fixed at the top of the right end of the rectangular bottom plate, a left fixing side plate is fixed at the top of the left end of the rectangular bottom plate, and a lower fixing plate is connected between the center of the right fixing side plate and the center of the left fixing side plate. An upper fixing plate is arranged above the lower fixing plate, a plurality of transfer anti-falling protection devices are additionally arranged at the rear end of the upper fixing plate, and the protection devices located right behind the multiple sets of sample tube inserting holes can be rapidly buckled and fixed to the corresponding positions when urine sample tubes are inserted into the urine sample tube inserting holes to be transferred. The pressing fixing strip is tightly pressed at the top end of the sample tube sealing end cover through the soft protection pad, in the transferring process, the soft protection pad provides moderate pressure, the sample tube is prevented from loosening and toppling over, the sealing performance and stability of a sample are guaranteed, the environment is prevented from being polluted, and the detection result is prevented from being influenced; the fixing clamping block is buckled to the bottom of the front end of the upper fixing plate, and installation can be rapidly completed.

The utility model belongs to the technical field of molds, and relates to an injection mold of a urine sampling device for clinical detection. The urine collecting cylinder forming die comprises a urine collecting cylinder forming lower die and a urine collecting cylinder forming upper die. In the injection molding process, the urine collecting cylinder forming lower mold and the urine collecting cylinder forming upper mold are close to each other, so that the insertion type built-in cooling forming structure is inserted into the collecting cylinder forming outer cylinder to form the cavities, and a molten material is injected into the cavities through the injection molding flow dividing piece; the splicing type sealing fixing piece can prevent molten materials from leaking from the lower portion, the sealing degree is improved, the bearing piece is used for bearing and fixing the splicing type sealing fixing piece, after injection molding is completed, cooling water is introduced into a built-in cooling structure and a spiral cooling part in the insertion type built-in cooling forming structure, internal and external dual cooling is adopted, and the sealing performance is improved. And the molded plastic part is subjected to large-area omnibearing cooling, internal and external cooling is consistent, the uniformity of the internal and external quality of the plastic part is improved, and the yield is increased.

This invention relates to the fields of environmental chemistry and biological sample analysis, specifically to an analytical method for detecting oxidative stress biomarkers in urine. Based on liquid chromatography-tandem mass spectrometry (LC-MS / MS), this invention provides an analytical method for the simultaneous detection of dityrosine, 8-hydroxyguanosine, 8-hydroxydeoxyguanosine, and 4-hydroxynonenal mercaptouric acid in human urine. This method achieves effective purification of urine samples through specific pretreatment, reducing matrix effects, and, combined with specific LC parameters, enables the simultaneous detection of four oxidative stress biomarkers. This method exhibits good selectivity, high sensitivity, and fast detection speed, solving the current problem of the inability to simultaneously determine polar and nonpolar components. It includes a more comprehensive and rational list of oxidative stress biomarkers, better reflecting the body's oxidative stress damage.

This invention relates to the field of in vitro diagnostic technology, and more particularly to a method for determining cortisol levels and its application. This invention provides a pretreatment reagent combination for liquid chromatography, a method for pretreating urine samples in liquid chromatography, and a method for detecting cortisol levels in urine. The method for detecting cortisol levels in urine samples provided by this invention offers convenient and rapid pretreatment, and through method validation, demonstrates excellent performance indicators.

This application relates to the field of biomedical technology, and in particular to a method for evaluating the effectiveness of autism intervention and its application. The method includes the following steps: collecting a test sample and a control sample; the test sample is a urine sample from an autism patient, and the control sample is a urine sample from a healthy volunteer; processing the test sample and the control sample separately to obtain NMR samples; testing the NMR samples using an NMR spectrometer to obtain NMR spectra; performing multivariate statistical analysis on the NMR spectra to construct a urinary metabolite model; and using the urinary metabolite model to screen and evaluate autism patients. This application provides a method for evaluating the effectiveness of autism intervention and its application, constructing a urinary metabolite model through NMR metabolomics technology, providing practical evidence for establishing methods for early screening and treatment process evaluation of autism.

The present invention is a urinal system that includes a urinal bowl, a drain, a urinal screen, a spreading layer, an image capturing unit, an optical sensing unit, a urine analysis unit, and a display unit. The spreading layer attached to the urinal screen contains a reagent that can react with glucose in a urine sample to cause a color change in the reagent. The image capturing unit is configured to capture an image of the color change in the reagent when the optical sensing unit detects the color change in the reagent. The urine analysis unit is configured to perform operations to analyze the image of the color change in the reagent and generate a test result based on the operations about the components of the urine sample. The display unit is configured to display the test result for presentation to a user.

The invention discloses a fluorescent reagent composition for detecting hyaluronidase and application thereof, and is characterized in that the fluorescent reagent composition comprises a sodium hyaluronate or hyaluronic acid solution, a magnetic nano material Fe3O4NPs solution and a fluorescent nano material UCNPs solution, the detection of hyaluronidase comprises the following steps: adding a to-be-detected urine sample containing hyaluronidase into a sodium hyaluronate solution to degrade sodium hyaluronate; adding a fluorescent nano-material UCNPs solution into the reaction product, enabling the fluorescent nano-material UCNPs solution to generate electrostatic adsorption with the unhydrolyzed sodium hyaluronate, and outputting a fluorescent signal F0; adding a magnetic nano material Fe3O4NPs solution for magnetic separation, and taking supernate to measure a fluorescence signal F; calculating the concentration of hyaluronidase in the urine sample to be detected by taking F / F0 as an output signal; the kit has the advantages of high sensitivity, strong specificity, high accuracy and simplicity in operation, and is used for ultra-sensitive detection of the bladder cancer biomarker HAase.

This invention provides a physiological age prediction model that predicts the physiological age of a subject by detecting urinary proteins and metabolites in a urine sample. The aforementioned urinary proteins and metabolites are those that change significantly with age, including one or more selected from the following: cartilage intermediate layer protein (CILP2), collagen Alpha 1 chain (COFA1), myristic acid, 12-methyltridecanoic acid, CN family member 5 (CCN5), Sushi domain-containing protein 5 (SUSD5), procollagen C endopeptidase enhancer 1 (PCOLCE), and L-lactate oxidase (LOX), preferably including all of the aforementioned urinary proteins and metabolites.

The invention belongs to the technical field of urine sampling devices for examination, and particularly relates to a sanitary urine sampling device for medical examination, which comprises a shell, the shell is hollow, a three-way valve is fixedly connected to the inner top wall of the shell, a communicating pipe is fixedly connected to the top wall of the shell, and the communicating pipe is communicated with the input end of the three-way valve. A placement shell is fixedly connected to the inner wall of one side of the shell, a middle cylinder is fixedly connected to the inner bottom wall of the placement shell, a detection assembly is arranged on the inner bottom wall of the placement shell, and a hollow part of the middle cylinder communicates with the detection assembly through an air pipe; through cooperation of the impeller torsion spring in the detection valve and the friction disc, the dripping state and the normal urination state are intelligently recognized, the flow direction of the three-way valve is automatically switched, automatic judgment and flow division of the urine discharge mode are achieved, and sampling opportunity errors or sample confusion caused by dependence on manual observation and judgment are avoided.

The application discloses a biomarker for diagnosing diabetic nephropathy and application thereof, and relates to the technical field of biological medicine. The biomarker for diagnosing diabetic nephropathy comprises urine MBP-1 or urine MBP-1 / urine creatinine. The urine MBP-1 or urine MBP-1 / urine creatinine biomarker has high identification efficiency: when the urine MBP-1 or urine MBP-1 / urine creatinine ratio is used for identifying DKD and NDRD, the area under the ROC curve (AUC) reaches 0.899, the sensitivity and the specificity are both higher than 0.85, and the two diseases can be efficiently distinguished. The method is non-invasive and convenient: only urine samples need to be collected, the risk of complications such as bleeding and infection caused by invasive operations such as kidney biopsy is avoided, the patient has high acceptance, repeated detection can be performed to dynamically track the disease condition, and special equipment is not needed, so that the method is convenient for clinical popularization and application. Through kidney tissue immunofluorescence verification, MBP-1 is deposited in a large amount in the glomerulus of DKD and is not deposited in NDRD, and thus the kidney local pathological change can be directly reflected.

This invention relates to a urine test strip color recognition detection method based on image analysis, comprising the following steps: Step 1, acquiring a color image; Step 2, detecting black calibration blocks at the four corners; Step 3, geometric correction of the test strip area based on four-point perspective transformation; Step 4, adaptive extraction of the effective area of ​​the test strip; Step 5, precise segmentation of color blocks; Step 6, correction of uneven illumination and color standardization; Step 7, multidimensional similarity calculation based on weighted Lab color space; Step 8, outputting the detection results and marking abnormalities. The beneficial effects of this invention are: the positioning accuracy remains ≥99.8% even in complex scenarios, far exceeding existing template matching and QR code solutions; it is completely unaffected by test strip deformation or printing offset; the CV value of the same urine sample repeated under different mobile phones and different lighting conditions is <3%; it successfully solves the problems of batch-to-batch color difference and test strip aging, with a clinical concordance rate ≥98%; the entire algorithm has a small computational load, fully meeting the needs of real-time detection.

A method for detecting and treating Type II Diabetes includes the use of hsa_piR_020485, a PIWI-interacting RNA isolated from urinary extracellular vesicles (ECVs), as a biomarker for the diagnosis and treatment of Type 2 diabetes mellitus (T2DM). The method is non-invasive, utilizing the differential expression of hsa_piR_020485 in diabetic versus non-diabetic subjects to identify subjects in need of treatment for T2DM. The method includes obtaining a urine sample from a subject, isolating urinary ECVs from the urine sample, extracting total RNA from the isolated urinary ECVs, quantifying hsa_piR_020485 levels from the total RNA, determining if the hsa_piR_020485 expression level exceeds a threshold, and administering one or more T2DM treatments.