557 results about "Urine sample" patented technology

The ureter and urine bag comprises a urine bag body, a spiral pipe, a connecting pipe, a threaded connector pipe and a urine guiding pipe, the threaded connector pipe comprises a pipe body and an insertion pipe, internal threads with the thread pitch being 1.8-2.2 mm are machined on the inner wall of the pipe body, external threads matched with the internal threads are machined on the outer wall of the insertion pipe, and the spiral pipe is connected with the connecting pipe. Two groups of wing plates are symmetrically arranged on the outer wall of the cannula to provide rotating acting points, and a collecting assembly is integrated on the side wall of the urine bag and used for aseptically collecting urine samples. Traditional plug-pull type connection is replaced by a precise thread fit structure, a clear rotating force application point is provided for medical staff, operation is labor-saving and convenient, connector pollution is avoided, the urinary tract infection risk is effectively reduced, and the nursing comfort of a patient is improved.

The invention provides a diabetic nephropathy early warning method, system, equipment and medium, and relates to the technical field of medical data analysis and prediction.The method comprises the steps that multiple urine samples of a user are collected, target urine protein detection is conducted, and multiple urine protein concentrations are obtained; each urine protein concentration is combined with a normal urine protein concentration set to be input into an abnormal data recognition tree, the number of layers of multiple recognition nodes is obtained, and the detection confidence coefficient is obtained through calculation; configuring an abnormal proportion according to the detection confidence coefficient, inputting a plurality of urine protein concentration combination normal urine protein concentration sets into an abnormal data identification tree, deleting urine protein concentrations divided into abnormal data in the abnormal proportion before, and obtaining screened urine protein concentrations; according to the screened urine protein concentration, an auxiliary early warning coefficient is obtained through calculation, and early warning is carried out. The technical problem of low early warning accuracy of diabetic nephropathy in the prior art is solved.

Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers demonstrating sufficient accuracy and specificity for identifying kidney injuries. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of continuous monitoring for kidney injury.

The invention discloses a urine sampling device for the endocrinology department and a sampling method, and belongs to the technical field of medical analysis. Comprising the following modules: an automatic sampling control module for realizing automatic control of the whole urine sampling process, ensuring that sampling accords with a standard process, and supporting automatic sub-packaging and storage management of samples; the sample quality control module is used for monitoring the physical characteristics of the samples in real time, automatically evaluating the effectiveness of the samples in combination with environmental parameter monitoring, and identifying and marking abnormal samples; the data acquisition and processing module is used for comprehensively acquiring physiological data, nutrition metabolism data, operation process data and sample tracing information, and performing cleaning, standardization and fusion processing to generate a standardized data set; the intelligent diagnosis and analysis module is used for intelligently detecting abnormal physiological indexes and carrying out disease risk prediction and early warning; and the man-machine interaction module provides a visual operation interface and integrates multi-level user authority management, automatic report generation and remote monitoring.

Doubly labeled water with enhanced protocol. One embodiment is a method including providing, to a user, a doubly labeled water (DLW) dose for the user to ingest, the DLW dose including deuterium and oxygen-18, wherein an amount of the deuterium is less than 0.12 grams per kilogram (g / kg) of body water of the user, and wherein an amount of the oxygen-18 is less than 0.18 g / kg of body water of the user. The method also includes receiving, from the user, a non-cooled shipment of urine samples collected in connection with ingestion of the DLW dose, wherein the urine samples remain uncooled after collection and during transit for a period of up to 24 days. The method further includes processing the urine samples with a liquid water isotope analyzer to determine one or more metabolic parameters of the user.

The invention relates to methods, devices, and software for distinguishing hemoglobin (Hb) from myoglobin (Mb) in urine samples using peroxidase-reactive test strips. A time-resolved video of the color change on the test pad is recorded, and hue values are extracted and analyzed over time. Diagnostic differentiation between Hb and Mb is achieved by evaluating the hue-time curve, in particular via endpoint hue values and the ratio of integrated hue values in distinct time intervals. The invention further comprises a standardized optical setup for recording, a software-based evaluation algorithm, and a refillable cartridge for in-situ urine analysis devices containing appropriate test fields. The invention enables combined testing with additional urine parameters and is suitable for medical and non-clinical applications such as sport and home diagnostics.

There is a provided a urine collection device for collecting an uncontaminated urine sample from a pre-continent or an incontinent user, the urine collection device comprising: a receptacle configured to be placed within a nappy or an incontinence pad of the user to receive and retain a urine sample collected from the user in use, wherein the receptacle comprises: a receiving portion for receiving the urine sample, the receiving portion comprising an opening configured to engage with a human body portion surrounding external genitalia of the user, thereby enabling urine exiting the body of the user to be captured directly in use; a reservoir for retaining the received urine sample in use; and an outlet for draining the retained urine sample in use, wherein the opening is larger than the outlet.

An intermittent catheter package including a plurality of components and a catheterization tray configured to facilitate a catheterization procedure. The plurality of components include a urinary catheter fluidly connected to a urine-drainage bag and a sampling-port access device configured to fluidly connect to a urine-sampling port of the urinary catheter or the urine-drainage bag for aseptic collection of one or more urine samples.The catheterization tray includes at least a first compartment, a second compartment, a third compartment, and a fourth compartment. The second compartment is connected to the third compartment Step-by-step surface instructions for performing the catheterization procedure are incorporated into the catheterization tray.

The invention relates to the field of medical treatment, in particular to application, a model and a method of a protein fragment of urine regulatory protein in preparation of a kidney disease early detection product, and the amino acid sequence of the protein fragment of the urine regulatory protein is any shown in SEQ ID NO.1-8. The model constructed according to the protein fragment of the urine regulatory protein can be used as a non-invasive tool for early detection and monitoring of kidney diseases, and by analyzing the unique mode of the protein fragment existing in a urine sample, the model which indicates renal insufficiency, renal function and renal function can be identified before the traditional clinical biomarker is abnormal. Therefore, intervention can be carried out earlier.

The present invention provides a kit and a detection method for synchronously detecting catecholamines and their metabolites, which relates to the technical field of analytical detection. The kit contains a diluent, a solid-phase extraction reagent, an LC-MS / MS detection reagent, a solid-phase extraction device, and a solid-phase extraction packing material. Among them, the solid-phase extraction packing material creatively adopts zwitterionic exchange microspheres containing both carboxyl and quaternary ammonium groups. The kit can not only synchronously and efficiently separate and detect 8 kinds of catecholamines and their metabolites in urine samples, but also separate and detect 6 kinds of amino-containing catecholamines and their metabolites in blood samples. When the above kit is used to separate and detect catecholamines and their metabolites, the extraction recovery rate is relatively high, and the linear range covers the reference value range of normal detection, which can significantly shorten the detection time of urine samples, improve the detection efficiency of mass spectrometry, and is conducive to popularization and application in clinical detection.

The invention discloses a urine collection and storage device, and relates to the technical field of urine collection devices, the urine collection and storage device comprises a base frame for receiving urine and a liquid guide channel fixedly arranged on the base frame, the base frame is provided with a floating collection mechanism for quantitatively collecting urine at the middle end, and the floating collection mechanism comprises a horizontal base fixedly connected to the inner wall of the base frame; the horizontal base is provided with a horizontal assembly for adjusting the relative position of the transverse base and the liquid guide channel, the two horizontal sides of the middle clamping base are provided with a main inner cavity column and a slave inner cavity column respectively, and the partition frame is provided with a blocking assembly for partitioning and sealing the internal space of the main inner cavity column and the slave inner cavity column. By arranging the floating collection mechanism, midstream urine of a patient can be accurately collected, and meanwhile, tissues and impurities deposited at the bottom of a urine bag are abandoned, so that the purity and representativeness of a urine sample are effectively improved, the accuracy of a detection result is ensured, and the misdiagnosis risk caused by sample pollution or impurity mixing is reduced.

The invention discloses a culture method of high-activity human urine-derived stem cells, which relates to the technical field of biological medicine, and is technically characterized by comprising the following steps: collecting urine samples of pregnant and lying-in women, coating a culture plate with gelatin, inducing adherence, performing passage amplification, performing immunofluorescence identification, performing function detection and other optimized conditions, and separating and culturing the stem cells. Compared with urine-derived stem cells of normal adults, the stem cells derived from pregnant women have stronger activity, higher dryness and faster multiplication capacity. The invention provides a novel and superior cell source for tissue engineering and regenerative medicine.

The invention discloses a metabolite detection method for diagnosing lithangiuria, and relates to the technical field of metabolite detection. The method comprises the following steps: collecting and preprocessing a urine sample, and generating a composite fluorescence signal based on the preprocessed urine sample so as to obtain a composite function; constructing an orbital function system, and performing projection processing on a composite function to obtain initial orbital energy; based on the initial orbital energy, a mutual exclusion function between metabolites is introduced, an effective energy contribution value is calculated, and a decoupled energy response amount is obtained; converting the decoupled energy response quantity into a concentration estimation value, and generating a rotation response value based on the concentration estimation value; generating a coupling threshold based on the concentration estimation value and the rotation response value; and carrying out risk scoring based on the coupling threshold value to obtain an individual risk score value of the urinary calculi. The invention solves the problems of inaccurate concentration estimation of the metabolite and low metabolite detection precision caused by inaccurate analysis of the metabolite under complex interference conditions in the existing metabolite detection method.

A method for characterizing disease activity in a systemic lupus erythematosus patient (SLE), comprising obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, assessing the dataset for a presence or an amount of protein expression of at least one innate serum or plasma mediator, assessing the dataset for a presence or an amount of protein expression of at least one adaptive serum or plasma mediator biomarker, assessing the dataset for a presence or an amount of at least one chemokine / adhesion molecule biomarker, assessing the dataset for a presence or an amount of at least one soluble TNF superfamily biomarker, assessing the dataset for a presence or an amount of at least one inflammatory mediator biomarker, assessing the dataset for a presence or an amount at least one SLE-associated autoantibody specificity biomarker and calculating a Lupus Disease Activity Immune Index (LDAII) score.

The invention relates to the technical field of medical detection, in particular to an endocrine hypertension screening method based on immunological analysis, which comprises the following steps: collecting a random urine sample, removing interferents by using a composite nano adsorbent, and synchronously detecting hormones such as aldosterone, methoxyadrenaline and cortisol and metabolites thereof by using a high-throughput immunity analyzer; integrating detection data based on a dynamic threshold algorithm to generate a screening report, carrying out weighted scoring on positive samples in combination with clinical features, screening high-risk candidate samples, carrying out 24-hour urine retest on the high-risk samples, and if a retest result is still positive, carrying out referral treatment to a specialized department for disease cause definite diagnosis; according to the method, the technical problems of complex sample treatment, low multi-step efficiency and high false positive rate in the prior art are solved, efficient and accurate screening of endocrine hypertension is realized, and reliable support is provided for early diagnosis and targeted treatment.

Device and methods for detection of kidney cancer using urine samples are disclosed herein. The device and methods enable isolation and quantification of kidney tumor cells in urine samples from a subject in need thereof.

In the urine bottom visible component parameter and detection and identification AI training method, a urine sample is preprocessed to obtain a microscopic examination sample; precipitating visible components to the bottom layer; shooting the tiled microscopic examination sample image; identifying and marking the sediment visible components in the urine sediment visible components, obtaining a marked picture, carrying out AI training, and obtaining an AI feature data set A of the urine sediment visible components; the identification and labeling comprise unknown categories under the secondary classification and the primary classification; the unknown categories under the primary classification comprise unknown category casts, unknown category crystals and unknown category cells. Identifying bottom visible components in urine in the selected area S1 of the image by using an AI identification algorithm; the identified bottom visible components comprise unknown categories under the second-level classification and the first-level classification. According to the method, secondary classification recognition is carried out on recognizable visible components sinking to the bottom, primary classification of unknown categories is provided for some visible components which cannot be subjected to secondary classification recognition, the real situation can be reflected more accurately, and the utilization efficiency of subsequent data is improved.

The invention provides a urine HCG full-automatic detection and urine routine combined detection system, which comprises a host shell, an interactive interface, a sample interface, a USB interface, a sampling and sample introduction module, a urine detection module, a urine detection module, a urine detection module and a urine routine detection module, the microfluidic and reagent module is used for automatically distributing and reacting urine samples; the multifunctional automatic detection module is used for performing optical detection and electrochemical detection and completing combined detection of HCG and urine routine; the data processing module is used for collecting original signals and carrying out data processing and calculation to obtain HCG concentration, urine routine multi-parameter results and a detection report; and the intelligent diagnosis support module is used for performing medical correlation analysis and medical record intelligent diagnosis. Through combined detection of HCG and urine routine, HCG and urine routine results can be obtained at the same time, the detection efficiency is improved, and the detection accuracy and sensitivity are enhanced through optical detection and electrochemical detection processes.

A urine collecting device designed for collecting urine specimens includes a funnel, a compartment, and a urine flow segregating pathway unit The funnel is configured to automatically part a labia majora from a vulvar region to allow urine to pass through. The compartment is located below the funnel, contains multiple chambers arranged vertically side by side, with each chamber designed to collect a urine specimen. Each chamber houses a spherical floater that moves to securely retain the urine when the chamber is filled. The device also features a locking ring to operatively couple the funnel to the compartment. The urine flow segregating pathway unit sequentially directs urine into the chambers: the first chamber collects first-void urine (FVU), while the second and third chambers collect midstream urine (MSU1 and MSU2). The spherical floaters in each chamber rise to retain the urine securely, ensuring accurate MSU specimen collection for testing.

The present invention discloses a sampling and detection device for livestock and veterinary urine samples, which relates to the field of livestock and veterinary sampling and detection. It includes a box body, a plurality of sampling tubes, and a plurality of processing mechanisms. Each sampling tube is composed of a base and a tube wall. The outer wall of the base is provided with an external thread. The processing mechanism is used to disinfect the sampling tube and store and seal it after sampling. Each processing mechanism is composed of a disinfection component, a lifting component, and a sealing component. The disinfection component is arranged in the water storage and heating chamber and the disinfection and storage chamber. The disinfection component is used to perform high-temperature disinfection on the inner and outer walls of the inverted sampling tube. The lifting component is arranged in the placement groove, and the sealing component is arranged on the lifting component. The sealing component is used to seal the top opening of the sampling tube. The present invention can effectively solve the problems of sealing and storage of samples after collection, avoid damage or deterioration of samples during storage, ensure the quality and stability of samples, and thus improve the accuracy of detection results.

The invention belongs to the technical field of molecular biology, and particularly relates to a construction method and application of a streptococcus pneumoniae pneumonia animal model. The invention provides a construction method of a streptococcus pneumoniae infected rat pneumonia and kidney injury model. The method comprises the following steps: S1, applying a streptococcus pneumoniae liquid into the respiratory tract of a rat by adopting an atomization bacterium feeding mode; and S2, verifying whether the rat treated in the step S1 is infected with pneumonia or not and whether kidney injury exists or not. According to the method, whether pneumonia is infected or not is judged by detecting inflammatory factors in alveolar lavage and lung HE staining, and whether kidney injury exists or not is judged by detecting the urine protein / creatinine ratio in a rat urine sample and detecting kidney HE staining. The construction method provided by the invention is convenient to operate, accurate in model construction and high in survival rate.

The invention provides a method for synchronously detecting eight catecholamines and metabolites thereof based on liquid chromatography-tandem mass spectrometry and application of the method. The detection method comprises the following steps: mixing a plasma or urine sample to be detected with an internal standard and acetonitrile; centrifuging, taking supernate, blowing liquid with nitrogen, and adjusting the pH value; mixing the supernate with a propionic anhydride solution, and carrying out derivatization reaction to obtain a test solution; performing liquid chromatography-tandem mass spectrometry detection on the test solution and the standard solution, separating dopamine, epinephrine, noradrenaline, epinephrine, noradrenaline, 3-methoxytyramine, homovanillic acid and vanillic mandelic acid by liquid chromatography, and determining the concentration of the standard substance as an X axis by using a mass spectrometry isotope internal standard quantification method. The ratio of the peak area of the standard substance to the peak area of the internal standard substance is the Y axis, establishing a standard curve, and calculating the concentrations of catecholamine and the metabolites thereof in the test solution. The method is high in detection efficiency, high in sensitivity and good in equipment compatibility, the detection time is shortened, and the cost can also be saved.

The invention discloses a multi-nucleic acid probe rapid modification and multi-target detection device based on electric field regulation and control. An instrument main body in the device is integrated with an automatic liquid path system and a micro electrochemical workstation module, and is used for realizing programmable reagent and sample conveying and multi-channel electrochemical measurement. The detachable sensing chip is formed by bonding a microelectrode array chip and a micro-fluidic chip, and is switched through a PCB (Printed Circuit Board) to realize plug and play. According to the present invention, the positive suction-negative discharge strategy of the electric field is utilized, the preferred positive potential is applied to the target electrode to efficiently attract the probe, and the preferred negative potential is applied to the non-target electrode to inhibit the non-specific adsorption so as to achieve the spatial selective rapid fixation and the accurate density regulation and control of the multi-nucleic acid probe in the extremely short time; the device can be used for quantitatively detecting various body fluid disease markers in a plurality of urine samples at the same time in single operation, and an efficient, accurate and portable multi-marker comprehensive analysis solution is provided for early screening and instant diagnosis of tumors.

The invention relates to a urine metabolism combined marker for diagnosing bladder cancer and a screening method of the urine metabolism combined marker. The urine metabolism combined marker is prepared from 2-methyl furan, dimethyl disulfide, octylene and acetophenone. The method for screening the urine metabolism combined marker comprises the following steps: carrying out chromatographic separation and mass spectrometry detection on a urine sample on the basis of a headspace automatic sampler in combination with a chromatographic column and a photochemical ionization time-of-flight mass spectrometry, preprocessing mass spectrometry data, and extracting spectrum peak data of metabolites in urine; the urine metabolism combination marker for diagnosing bladder cancer is obtained through further statistical analysis. The screening method of the urine metabolism combined marker for diagnosing the bladder cancer has the advantages of non-invasiveness, high-throughput detection, simplicity in operation and accurate result, and has a wide application prospect.

The invention discloses an intelligent excrement and urine specimen placing box, and belongs to the technical field of medical equipment. A display screen capable of being intelligently controlled is arranged at the upper half section of the front side of the placement box, and the display screen is provided with a multi-mode medical information identification system; a voice player and a code scanner which are matched with the multi-mode medical information identification system are arranged on the placement box; a detection opening is formed in the lower half section of the placement box; a drawer type placing bin for placing a collecting tube is arranged in the detection opening, and a plurality of liquid level detectors capable of judging the liquid level of a sample in the collecting tube are sequentially arranged at the detection opening of the placing box and are positioned on the two sides of the placing bin; the liquid level detectors located on the two sides of the placement bin in the detection opening of the placement box can recognize the liquid level of the urine sample in the collection tube placed in the placement bin so as to judge whether the urine sample collected in the collection tube reaches the capacity enough for various routine urine inspection items or not.

The invention discloses a urine detection method based on lensless microscopic lamination imaging, which comprises the following steps of: acquiring a low-resolution image of a urine sample by using a lensless microscopic lamination imaging device, calculating an incident wave vector to obtain a light field, and performing Fourier transform on the light field; smooth processing is carried out through Gaussian filtering, and image enhancement is carried out through Laplacian sharpening; using the low-resolution image to obtain a final large-view-field high-resolution image through iterative updating; adaptive threshold segmentation is carried out on the image, and then cells and a background are separated to obtain a segmented image; performing edge detection on the image by using a Canny operator to output the image; carrying out edge detection on each pixel point by using a non-maximum suppression method, and segmenting by using double thresholds; and performing cell counting on the image after edge detection, calculating the cell density, and finally outputting the identified and calculated information. The improvement of the method is expected to promote wide application of lensless microscopic lamination imaging in urine detection.

The invention relates to the field of flush toilets, in particular to an intelligent closestool with a urine sample detection function. Comprising a closestool body, a penetrating hole is formed in the front end in the closestool body, and a conical plate is rotationally arranged at the lower end of the penetrating hole through a motor and can open the penetrating hole to allow midstream urine to penetrate through when rotating; an expansion plate for preventing urine from escaping is arranged at the lower end of the cone plate, a pressure sensor is arranged at the upper end of the cone plate, and an infrared sensor is arranged above the through hole; a urine guide mechanism is arranged on the side, away from the through hole, of the expansion plate and comprises a drainage arc plate fixedly connected with the closestool body, one end of the drainage arc plate is in movable sealing connection with the expansion plate, and a sampling pipe with two through ends is arranged below the other end of the drainage arc plate; the sampling pipe is coaxially provided with a sampling mechanism, the sampling mechanism comprises a plug which is in dynamic sealing connection with the inner wall of the sampling pipe, and the plug is coaxially provided with a probe for analyzing urine. The device can accurately collect midstream urine samples, realizes household automatic urine detection, is high in detection precision, and can effectively avoid sample pollution.

The utility model discloses an integrated 24-hour quantitative urine protein collecting container which is characterized by comprising a container body and a container cover, the container body is used for storing a urine sample, and the container cover is used for covering and sealing the container body; a telescopic strip-shaped body extends from one side, facing the interior of the container main body, of the container cover, a sampling structure is arranged at one end, facing the interior of the container main body, of the strip-shaped body, a handle part is arranged on one side, facing the exterior, of the container cover, a cavity is formed in the handle part, an elastic device is arranged in the cavity, and the elastic device is arranged in the cavity. One end of the elastic device is fixed to the inner side of the handle part, and the other side of the elastic device is fixed to the end, facing the container cover, of the strip-shaped body.

The invention relates to the technical field of test sample collection, in particular to an anti-pollution collection device for excrement and urine test samples. Comprising a sampling unit, the sampling unit comprises a sampling bedpan, and a urine sampling pool and an excrement sampling pool are arranged at the top of the sampling bedpan; the bottoms of the urine sampling pool and the excrement sampling pool are respectively communicated with a group of movable hoses, and the output ends of the two groups of movable hoses are respectively and movably connected with an excrement treatment unit and a urine treatment unit. Manual transfer and touch are not needed in the whole process, other external containers are not needed for transfer, excessive contact with external air is avoided, excrement and urine samples can be separately collected at the same time, the functionality of the device is improved, meanwhile, the purpose of pollution-free collection is achieved, the accuracy of follow-up inspection is guaranteed, and the detection efficiency is improved. And the automation degree of the device is also improved.

The invention discloses a urine sampling device, and relates to the technical field of medical care. Comprising a sampling tube, a liquid inlet formed in the bottom of the sampling tube, a liquid pumping handle slidably arranged in the sampling tube and used for pumping urine, a limiting block arranged on the outer wall of the sampling tube in a sleeving mode, a connecting frame fixedly connected to the outer wall of one side of the limiting block, a sliding rod allowing the connecting frame to vertically ascend, descend and slide, and a base fixedly connected to the bottom of the sliding rod. The shell is fixedly connected to the outer wall of one side of the sampling tube. By means of the midstream urine suction device, the problem that when midstream urine is sucked, urine close to the liquid level or urine at the liquid bottom is likely to be mixed due to the influence of factors such as the insertion angle of the suction pipe, the suction speed and the mobility of the urine is solved. The problems that urine is polluted by bacteria on the liquid level, and urine at the bottom of the liquid contains a large amount of precipitates which can interfere with the purity of a sample, so that the extracted sample cannot accurately represent the real condition of the middle area of the urine, and finally the actual data of urine detection is influenced are solved.