66 results about "Dual imaging" patented technology

A method and apparatus for obtaining an image to determine a three dimensional shape of a stationary or moving object using a bi dimensional coded light pattern having a plurality of distinct identifiable feature types. The coded light pattern is projected on the object such that each of the identifiable feature types appears at most once on predefined sections of distinguishable epipolar lines. An image of the object is captured and the reflected feature types are extracted along with their location on known epipolar lines in the captured image. Displacements of the reflected feature types along their epipolar lines from reference coordinates thereupon determine corresponding three dimensional coordinates in space and thus a 3D mapping or model of the shape of the object at any point in time.

The invention is directed to imaging apparatus for performing real-time assessment and monitoring. Embodiments of the device are useful in a plurality of settings including surgery, clinical procedures, tissue assessment, diagnostic procedures, forensic, health monitoring and medical evaluations.

Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1-Y-X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

The invention provides methods of detecting cancerous cells in biological samples using a double staining / dual imaging approach, which can be used to diagnose cancer. More specifically, the present invention provides methods of diagnosing bladder cancer by a simultaneous scanning of cell morphology and FISH signals of cells derived from a urine sample.

The invention discloses a thiol-polyethylene glycol modified magneto-optical composite nano-material and its application. An up-conversion nano material is taken as a basal layer, the surface of the basal layer is provided with a polyacrylic acid layer, the surface of the polypropylene layer is provided with a layer of dopamine modified ferriferrous oxide magnetic particles, a golden shell layer is covered on the dopamine modified ferriferrous oxide magnetic particles layer, and the thioctic acid modified polyethylene glycol is provided on the golden shell layer; the thiol-polyethylene glycolmodified magneto-optical composite nano-material has guidance functions of up-conversion imaging and magnetic resonance imaging dual imaging, under the physical induction action of the magnetic field, the nano-material of the invention enables magnetic targeting to the specific position, so that the distribution in other internal organs can be reduced, and the damage in other internal organs during the treatment process is reduced. The nano-material can be taken as a good reagent for photo-thermal treatment by using the strong absorption property on the surface. The magnetic targeting photo-thermal treatment is combined under the imaging guidance, thereby the composite nano-material of the invention plays an important effect in clinical medical science and biological technology in future.

A selectable high dynamic laser speckle blood flow imaging device and method include a laser source, a sample fixing table, a beam expander, a half-mirror, a first CCD camera, a second CCD camera anda stepping motor. Continuous acquisition of original speckle images using multi-exposure acquisition is carried out, which solves the shortcoming of the traditional laser speckle contrast imaging method that the original speckle image is captured by a fixed exposure time. In addition, the present invention provides a dual imaging system. The whole body blood flow image is obtained by the focusingsystem, the local area is enlarged by the zoom system to obtain the angiographic image with more blood vessel information, and the images obtained by the two optical systems are fused to obtain the angiographic image with higher imaging resolution. It will be of great significance in the fields of early diagnosis of diseases, disease analysis and dynamic monitoring of drug efficacy in vivo.

An imaging system for an imaging-based bar code reader for capturing an image of a target bar code. In one exemplary embodiment, the imaging system includes: a sensor array including an array of photosensitive elements for converting, light impinging on the array of photosensitive elements into electrical signals based on light intensity; an imaging lens system for focusing light from a field of view onto the sensor array, the imaging lens system including a first lens assembly and a second lens assembly, the first lens assembly defining a first field of view and the second lens assembly defining a second field of view, the first and second fields of view being different; and a control for selectively choosing between the first and second fields of view for imaging the target bar code.

The invention discloses a non-contact photoacoustic and optical coherence tomography dual-imaging device and a detection method thereof. The dual-imaging device comprises a signal detection assembly, a scanning delay line assembly, a scanning head assembly, a scanning head supporting assembly and a signal acquisition / processing assembly, wherein the signal detection assembly, the scanning head assembly and the scanning head supporting assembly are orderly connected with each other; the signal detection assembly is connected with the scanning delay line assembly and the signal acquisition / processing assembly, respectively; and the scanning head assembly and the signal acquisition / processing assembly are connected with each other. The non-contact photoacoustic and optical coherence tomography dual-imaging device is characterized in that the photoacoustic imaging device and the optical coherence tomography imaging device are organically combined with each other, the purpose of detecting the photoacoustic signal by detecting the vibration displacement on the biological tissue surface caused by the photoacoustic signal is achieved, the bandwidth limitation defect of the traditional transducer and the limitation on the detection of the coupled photoacoustic signal are avoided, and the respective imaging advantages of photoacoustic imaging and optical coherence tomography are complementary with each other; and the system is rational and effective in structural design and capable of providing more accurate information for clinical diagnosis.

A dual modality probe is disclosed having both a positron emission tomography sensor and a ultrasound sensor. A dual imaging system is provided having the probe and at least one external positron emission tomography detector and a data acquisition computer system for collecting data simultaneously from said positron emission sensor and said ultrasound sensor of said probe and said positron emission tomography detector. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

A composition useful as a PET and / or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof:wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.

The invention relates to the technical field of laser processing, and discloses an imaging system and method of a square scanning head of a dual-light-path dual-imaging visual galvanometer. The imaging method comprises the steps that external laser beams reach the galvanometer through a second lens, and act on a to-be-marked object through a first lens after being reflected by the galvanometer, and then the to-be-marked object is marked; a white light source emits an illuminating light path to brighten the to-be-marked object, the illuminating light path is reflected to the first lens, then partially reflected to a large-visual-field image acquisition module through the first lens, and used for acquiring the overall image of the to-be-marked object, coordinates of an image in a pre-marking position are obtained accordingly, the swinging angle of the galvanometer is further obtained, and the galvanometer is driven to rotate by the swinging angle; and part of the illuminating light path reaches the galvanometer through the first lens, enters a small-visual-field image acquisition module after being reflected to the second lens, and is used for acquiring detailed images of the to-be-marked object, and the accurate coordinates of the pre-marking position are obtained according to the detailed images. By adoption of the imaging system and method of the square scanning head of the dual-light-path dual-imaging visual galvanometer, the marking precision of the square marking head can be greatly improved.

This invention provides a vision system, typically having at least two imaging systems / image sensors that enable a multi-function unit. The first imaging system, typically a standard, on-axis optical configuration can be used for long distances and larger feature sets and the second imaging system is typically an extended-depth of focus / field (DOF) configuration. This second imaging system allows reading of smaller feature sets / objects and / or at shorter distances. The reading range of an overall (e.g.) ID-code-reading vison system is extended and relatively small objects can be accurately imaged. The extended-DOF imaging system sensor can be positioned with its longest dimension in the vertical axis. The system can allow vision system processes to compute the distance from the vision system to the object to generate an autofocus setting for variable optics in the standard imaging system. An aimer can project structured light onto the object surface around the system optical axis.

The present invention relates to nuclear medicine using fluorescent silica nanoparticle and detecting method of optical dual imaging, and more particularly to radioisotope labeled fluorescent silica nanoparticles which are used for PET (positron emission tomography) and fluorescence detecting, and detecting method of PET and fluorescent dual imaging using thereof. Functionalized silica nanoparticles of this invention have promising potential as a role for organic lymphatic tracer in biomedical imaging such as pre- and intra-operative surgical guidance.

The present invention discloses a skin imaging system. The skin imaging system comprises an OCT subsystem, an HSI subsystem and an image processing unit. The OCT subsystem is used for emitting opticalsignals, reflecting the optical signals to form reference light and sample light of a skin area, and interfering the sample light and the reference light to form interference spectrum information. The HSI subsystem is used for emitting white light signals to the skin area and splitting and converging reflected light generated by irradiating the skin area with the white light signals to obtain spectrograms in all wavelength ranges. The image processing unit is used for generating a depth image of the skin area according to the interference spectrum information, reconstructing and correcting the spectrograms to obtain a hyperspectral image of the skin area, and fusing the depth image and the hyperspectral image to obtain a skin image. The double imaging of the OCT technology and the hyperspectral technology is utilized, the defects of the respective imaging technologies can be overcome, and advantage complementation can be achieved.

A dual modality probe is disclosed having both a gamma probe sensor and an ultrasound sensor. A dual imaging system is provided having the probe and at least one external gamma imaging detector and a data acquisition computer system for collecting data simultaneously from the gamma probe sensor, the gamma imaging detector, and the ultrasound sensor of the probe. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

This invention provides a vision system, typically having at least two imaging systems / image sensors that enable a multi-function unit. The first imaging system, typically a standard, on-axis optical configuration can be used for long distances and larger feature sets and the second imaging system is typically an extended-depth of focus / field (DOF) configuration. This second imaging system allows reading of smaller feature sets / objects and / or at shorter distances. The reading range of an overall (e.g.) ID-code-reading vision system is extended and relatively small objects can be accurately imaged. The extended-DOF imaging system sensor can be positioned with its longest dimension in the vertical axis. The system allows vision system processes to compute the distance from the vision system to the object to generate an autofocus setting for variable optics in the standard imaging system. A single or dual aimer can project structured light onto the object surface around the system optical axis.

The invention relates to a dual-imaging method and system based on the radial polarization characteristic of a vector optical field. On the basis of a characteristic that a vector light beam of which the polarization state varies radially is utilized to generate to two focuses with an interval distance therebetween controlled by optical control parameters, a dual-image interval adjustable dual-imaging system is set up. The experimental system of the invention comprises a vector light source, a lens and an image detector; a spatial light modulator can modulate incident light carrying image information, and an optical system is used in cooperation to modulate the incident light in a subsequent stage, and therefore, the vector light beam of which the polarization state varies radially is obtained; the light beam passes through the lens; an image capturing device is utilized to receive spatial modulation light and detect the intensity values of different portions of the spatial modulation light passing through the lens; and therefore, an image of the modulation light is formed in the image capturing device. Double-focusing imaging is a major breakthrough in optical imaging. The dual-imaging method and system of the present invention are designed on the basis of the transmission characteristics of the vector optical field; and the optical parameters that affect the interval of the imaging focuses of the double-focusing imaging can be obtained. The method and system have a bright application prospect.

Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

The invention provides a dual-imaging magnetic tweezer system. The dual-imaging magnetic tweezer system comprises a bearing device, a magnetic tweezer device, a microscopic measuring and controlling device, a microscopic imaging device and a control device, wherein the bearing device bears sample molecules; the magnetic tweezer device performs mechanical manipulation on the sample molecules to enable the sample molecules to move; the microscopic measuring and controlling device collects first image data of the movement of the sample molecules from the side faces of the sample molecules; the microscopic imaging device collects second image data of the movement of the sample molecules from the positions above the sample molecules; the control device analyzes the first image data to obtain a first analysis result, analyzes the second image data to obtain a second analysis result and verifies the first analysis result and the second analysis result to determine a result of the sample molecules changing with time in the three-dimensional space. Accordingly, fluorescence signal detection can be performed on the sample molecules through the microscopic measuring and controlling device, and meanwhile the mechanical manipulation can be performed on the sample molecules through the microscopic imaging device; in addition, verification can be performed according to the obtained first image data and the obtained second image data, and the test precision is improved.

The invention discloses a dual-imaging-guided photothermal therapy multifunctional nano-hybrid and a preparation method. The preparation steps are: (1) preparing bismuth selenide nanoplate powder by solvent method: hyaluronic acid doped polypyrrole coated bismuth selenide Nanoplate: dissolve bismuth selenide nanoplate powder and polyvinylpyrrolidone with an average molecular weight of k13-18 in water, add pyrrole, stir, transfer to ice bath, add ferric chloride aqueous solution drop by drop, add hyaluronic acid Acid aqueous solution, reaction; dialyzed polymer solution, centrifuged, and dried precipitate, that is. The hybrid compound of the present invention has good physical stability, and exhibits good water solubility, biocompatibility, strong near-infrared absorption and good photothermal stability, and can be used for photothermal therapy guided by CT and PA imaging; Good in vivo targeting; simple preparation process, mild reaction conditions, strong reaction controllability, low toxicity, easy scale-up, readily available raw materials, and cheap prices.

The present invention includes embodiments for methods and compositions that identify the presence of or risk for developing heterotopic ossification, particularly prior to mineralization of the bone. In particular embodiments, MMP-9 and / or MMP-2 agents comprising dual imaging moieties are used to identify patterns of MMP-9 and / or MMP-2 localization, respectively, that is then predictive of heterotopic ossification.

The invention belongs to the technical field of medicine and relates to an albumin-bound near-infrared fluorescent dye-maleimide conjugate. The albumin-bound near-infrared fluorescent dye-maleimide conjugate specifically replaces chlorine in the conjugated chain of the cyanine dye with a group containing maleimide, and the optical properties are modified by intramolecular charge transfer effects to enable the conjugate to be used as a blue bio-dye. Secondly, the maleimide group in the conjugate can be covalently bound to a free sulfhydryl group at position 34 of cysteine on plasma albumin by aMichael addition reaction, so that the conjugate has excellent lymph node targeting. A near-infrared fluorescent biological imaging agent overcomes the defects of an imaging method used in clinical sentinel lymph node navigation surgery, and is safe, reliable, accurate in positioning, and high in imaging efficiency. The two imaging modes, blue-stained macroscopic recognition and near-infrared fluorescence imaging, are integrated to enable dual imaging function of lymph nodes in vivo.

Disclosed are an intravascular photoacoustic and ultrasonic dual-mode imaging system and an imaging method, wherein the intravascular photoacoustic and ultrasonic dual-mode imaging system comprises a laser (10), an endoscopic probe (50), an ultrasound transmitting and receiving device (60), a data acquisition system (70) and an image reconstruction and display system (80), wherein the laser (10) is used to output a laser beam and send a trigger signal, the ultrasound transmitting and receiving device (60) is used to control the transmission of an ultrasonic wave, according to the trigger signal, while receiving a photoacoustic signal and an ultrasonic signal, the endoscopic probe (50) is used to laterally reflect the laser beam, after it has been focused or collimated, to a lumen sample to generate the photoacoustic signal by excitation while laterally transmitting an ultrasonic wave and receiving the ultrasonic signal reflected by the lumen sample, the data acquisition system (70) is used to collect a lumen sample photoacoustic signal and ultrasonic signal, and the image reconstruction and display system (80) is used to reconstruct the photoacoustic image and ultrasonic image of the lumen sample. The above-mentioned intravascular photoacoustic and ultrasonic dual-mode imaging system and imaging method improve the utilization of light and the penetration depth of a target tissue, increase the depth and the signal to noise ratio of photoacoustic imaging, and have a better imaging quality.

The invention relates to a targeting nanomaterial as well as a preparation method and an application thereof. Specifically, Zn0.4Fe2.6O4 nanoparticles with high magnetic saturation value are subjected to pegylation modification and entrapped with anti-cancer drug molecules simultaneously, and a nanomaterial system integrating targeting, double-mode imaging and treatment is prepared. For the nanomaterial system, on one hand, double advantages including high magnetism of a central core as well as good biocompatibility and biodegradability of an external lipidosome can be shown, and on the other hand, the effects of targeting and double imaging of the nanoparticles can be realized by targeting molecules and fluorescent molecules linked to an outer-layer PEG polymeric molecules, so that the targeting nanomaterial has potential application prospect in the field of biomedicine and especially in the aspects of targeting diagnosis, drug loading and the like.

The invention relates to a curved glass pane, made of float glass, the area of a main face of which is greater than 1.5 m2 and the product of its two depths of bending is greater than 3000 mm2, and such that its point located on the normal to its surface passing through its center of gravity has a radius of curvature of less than 3 m in any direction, the variation in its thickness in the longitudinal float direction being less than 10 μm over 500 mm. This pane may be assembled into laminated glazing of the automobile windshield type. Such a windshield has a very small amount of double imaging even when it is fitted into the vehicle so as to be close to the horizontal.

A dual, imaging and radiation system provides for finely aligned movement of a subject through the use of a computer controlled mounting stage having separate, non-gantry translational and rotational controllable movement. The system cycles a subject tissue between a treatment position where radiation doses are applied and an imaging position where high-quality computed tomography (CT) imaging is performed. Selective dose profiles and dose depths are achievable around an isocenter of the system.

The invention discloses a manufacturing method of an advanced node rear-section metal through hole. The method comprises: manufacturing a first metal layer through a self-alignment dual imaging or Damascus process; sequentially depositing a cover layer, an etching stop layer and a low-k dielectric layer on a substrate; manufacturing a second metal channel through self-alignment dual imaging or Damascus process again; combing a plurality of through holes into a rectangle; etching by utilizing a load effect; after an etching stop layer is etched, removing the etching stop layer through a wet method, and etching the over layer; opening the through holes, and enlarging a process window; and finally carrying out metal filling on the second metal channel and the through holes through a Damascusprocess to complete the through hole manufacturing. According to the invention, the process window is enlarged, and the yield is increased.

The invention discloses a method for improving a process window of a rear-section metal wire through hole. The method comprises the following steps of: manufacturing a metal wire groove on a substrateby using a self-alignment dual imaging structure or a Damascus structure, performing deposition photoetching, exposing a self-alignment through hole by using a photoetching process, and etching a first hard mask; injecting boron ions into the side wall of the first hard mask in the key direction at a set inclination angle, and over-etching a second hard mask through the two obtained etching selections to increase the size of the second hard mask in the non-key direction; etching a planarization layer according to a pattern obtained by over-etching the second hard mask, and opening the throughhole; and finally after the through hole is filled with a metal by using a Damascus process, mechanically polishing the through hole. According to the invention, the etching process window is improved, and the yield is improved.