66 results about "Dual imaging" patented technology

The invention is directed to imaging apparatus for performing real-time assessment and monitoring. Embodiments of the device are useful in a plurality of settings including surgery, clinical procedures, tissue assessment, diagnostic procedures, forensic, health monitoring and medical evaluations.

Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X₁-Y-X₂, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X₁ and X₂ are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X₁ and X₂ are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

The invention provides methods of detecting cancerous cells in biological samples using a double staining/dual imaging approach, which can be used to diagnose cancer. More specifically, the present invention provides methods of diagnosing bladder cancer by a simultaneous scanning of cell morphology and FISH signals of cells derived from a urine sample.

A selectable high dynamic laser speckle blood flow imaging device and method include a laser source, a sample fixing table, a beam expander, a half-mirror, a first CCD camera, a second CCD camera anda stepping motor. Continuous acquisition of original speckle images using multi-exposure acquisition is carried out, which solves the shortcoming of the traditional laser speckle contrast imaging method that the original speckle image is captured by a fixed exposure time. In addition, the present invention provides a dual imaging system. The whole body blood flow image is obtained by the focusingsystem, the local area is enlarged by the zoom system to obtain the angiographic image with more blood vessel information, and the images obtained by the two optical systems are fused to obtain the angiographic image with higher imaging resolution. It will be of great significance in the fields of early diagnosis of diseases, disease analysis and dynamic monitoring of drug efficacy in vivo.

An imaging system for an imaging-based bar code reader for capturing an image of a target bar code. In one exemplary embodiment, the imaging system includes: a sensor array including an array of photosensitive elements for converting, light impinging on the array of photosensitive elements into electrical signals based on light intensity; an imaging lens system for focusing light from a field of view onto the sensor array, the imaging lens system including a first lens assembly and a second lens assembly, the first lens assembly defining a first field of view and the second lens assembly defining a second field of view, the first and second fields of view being different; and a control for selectively choosing between the first and second fields of view for imaging the target bar code.

The invention discloses a non-contact photoacoustic and optical coherence tomography dual-imaging device and a detection method thereof. The dual-imaging device comprises a signal detection assembly, a scanning delay line assembly, a scanning head assembly, a scanning head supporting assembly and a signal acquisition/processing assembly, wherein the signal detection assembly, the scanning head assembly and the scanning head supporting assembly are orderly connected with each other; the signal detection assembly is connected with the scanning delay line assembly and the signal acquisition/processing assembly, respectively; and the scanning head assembly and the signal acquisition/processing assembly are connected with each other. The non-contact photoacoustic and optical coherence tomography dual-imaging device is characterized in that the photoacoustic imaging device and the optical coherence tomography imaging device are organically combined with each other, the purpose of detecting the photoacoustic signal by detecting the vibration displacement on the biological tissue surface caused by the photoacoustic signal is achieved, the bandwidth limitation defect of the traditional transducer and the limitation on the detection of the coupled photoacoustic signal are avoided, and the respective imaging advantages of photoacoustic imaging and optical coherence tomography are complementary with each other; and the system is rational and effective in structural design and capable of providing more accurate information for clinical diagnosis.

A dual modality probe is disclosed having both a positron emission tomography sensor and a ultrasound sensor. A dual imaging system is provided having the probe and at least one external positron emission tomography detector and a data acquisition computer system for collecting data simultaneously from said positron emission sensor and said ultrasound sensor of said probe and said positron emission tomography detector. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof:

This invention provides a vision system, typically having at least two imaging systems/image sensors that enable a multi-function unit. The first imaging system, typically a standard, on-axis optical configuration can be used for long distances and larger feature sets and the second imaging system is typically an extended-depth of focus/field (DOF) configuration. This second imaging system allows reading of smaller feature sets/objects and/or at shorter distances. The reading range of an overall (e.g.) ID-code-reading vison system is extended and relatively small objects can be accurately imaged. The extended-DOF imaging system sensor can be positioned with its longest dimension in the vertical axis. The system can allow vision system processes to compute the distance from the vision system to the object to generate an autofocus setting for variable optics in the standard imaging system. An aimer can project structured light onto the object surface around the system optical axis.

The present invention relates to nuclear medicine using fluorescent silica nanoparticle and detecting method of optical dual imaging, and more particularly to radioisotope labeled fluorescent silica nanoparticles which are used for PET (positron emission tomography) and fluorescence detecting, and detecting method of PET and fluorescent dual imaging using thereof. Functionalized silica nanoparticles of this invention have promising potential as a role for organic lymphatic tracer in biomedical imaging such as pre- and intra-operative surgical guidance.

The present invention discloses a skin imaging system. The skin imaging system comprises an OCT subsystem, an HSI subsystem and an image processing unit. The OCT subsystem is used for emitting opticalsignals, reflecting the optical signals to form reference light and sample light of a skin area, and interfering the sample light and the reference light to form interference spectrum information. The HSI subsystem is used for emitting white light signals to the skin area and splitting and converging reflected light generated by irradiating the skin area with the white light signals to obtain spectrograms in all wavelength ranges. The image processing unit is used for generating a depth image of the skin area according to the interference spectrum information, reconstructing and correcting the spectrograms to obtain a hyperspectral image of the skin area, and fusing the depth image and the hyperspectral image to obtain a skin image. The double imaging of the OCT technology and the hyperspectral technology is utilized, the defects of the respective imaging technologies can be overcome, and advantage complementation can be achieved.

A dual modality probe is disclosed having both a gamma probe sensor and an ultrasound sensor. A dual imaging system is provided having the probe and at least one external gamma imaging detector and a data acquisition computer system for collecting data simultaneously from the gamma probe sensor, the gamma imaging detector, and the ultrasound sensor of the probe. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

This invention provides a vision system, typically having at least two imaging systems/image sensors that enable a multi-function unit. The first imaging system, typically a standard, on-axis optical configuration can be used for long distances and larger feature sets and the second imaging system is typically an extended-depth of focus/field (DOF) configuration. This second imaging system allows reading of smaller feature sets/objects and/or at shorter distances. The reading range of an overall (e.g.) ID-code-reading vision system is extended and relatively small objects can be accurately imaged. The extended-DOF imaging system sensor can be positioned with its longest dimension in the vertical axis. The system allows vision system processes to compute the distance from the vision system to the object to generate an autofocus setting for variable optics in the standard imaging system. A single or dual aimer can project structured light onto the object surface around the system optical axis.

The invention discloses a dual-imaging-guided photothermal therapy multifunctional nano-hybrid and a preparation method. The preparation steps are: (1) preparing bismuth selenide nanoplate powder by solvent method: hyaluronic acid doped polypyrrole coated bismuth selenide Nanoplate: dissolve bismuth selenide nanoplate powder and polyvinylpyrrolidone with an average molecular weight of k13-18 in water, add pyrrole, stir, transfer to ice bath, add ferric chloride aqueous solution drop by drop, add hyaluronic acid Acid aqueous solution, reaction; dialyzed polymer solution, centrifuged, and dried precipitate, that is. The hybrid compound of the present invention has good physical stability, and exhibits good water solubility, biocompatibility, strong near-infrared absorption and good photothermal stability, and can be used for photothermal therapy guided by CT and PA imaging; Good in vivo targeting; simple preparation process, mild reaction conditions, strong reaction controllability, low toxicity, easy scale-up, readily available raw materials, and cheap prices.

The present invention includes embodiments for methods and compositions that identify the presence of or risk for developing heterotopic ossification, particularly prior to mineralization of the bone. In particular embodiments, MMP-9 and/or MMP-2 agents comprising dual imaging moieties are used to identify patterns of MMP-9 and/or MMP-2 localization, respectively, that is then predictive of heterotopic ossification.

The invention belongs to the technical field of medicine and relates to an albumin-bound near-infrared fluorescent dye-maleimide conjugate. The albumin-bound near-infrared fluorescent dye-maleimide conjugate specifically replaces chlorine in the conjugated chain of the cyanine dye with a group containing maleimide, and the optical properties are modified by intramolecular charge transfer effects to enable the conjugate to be used as a blue bio-dye. Secondly, the maleimide group in the conjugate can be covalently bound to a free sulfhydryl group at position 34 of cysteine on plasma albumin by aMichael addition reaction, so that the conjugate has excellent lymph node targeting. A near-infrared fluorescent biological imaging agent overcomes the defects of an imaging method used in clinical sentinel lymph node navigation surgery, and is safe, reliable, accurate in positioning, and high in imaging efficiency. The two imaging modes, blue-stained macroscopic recognition and near-infrared fluorescence imaging, are integrated to enable dual imaging function of lymph nodes in vivo.

The invention relates to a curved glass pane, made of float glass, the area of a main face of which is greater than 1.5 m² and the product of its two depths of bending is greater than 3000 mm², and such that its point located on the normal to its surface passing through its center of gravity has a radius of curvature of less than 3 m in any direction, the variation in its thickness in the longitudinal float direction being less than 10 μm over 500 mm. This pane may be assembled into laminated glazing of the automobile windshield type. Such a windshield has a very small amount of double imaging even when it is fitted into the vehicle so as to be close to the horizontal.