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Preparation method, product and application of targeting nanomaterial

A nano-material and targeted technology, applied in the field of nano-biomedical materials, can solve problems such as unsatisfactory effects, achieve good long-term blood circulation, satisfy production and application, and improve the effects of diagnosis and treatment

Inactive Publication Date: 2017-12-15
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Cancer is a serious disease that threatens human life. Conventional chemotherapy, radiotherapy and surgery are not effective.

Method used

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  • Preparation method, product and application of targeting nanomaterial
  • Preparation method, product and application of targeting nanomaterial
  • Preparation method, product and application of targeting nanomaterial

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Oily Zn 0.4 Fe 2.6 o 4 Preparation of nanoparticles

[0036] FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.73×10 -3 molFe 2+ and 2.67×10 -4 mol Zn 2+ The purpose; 10ml oleic acid, 10ml absolute ethanol and 1g NaOH were mixed, and magnetically stirred at room temperature until a uniform solution was obtained; the precursor Fe 2+ and Zn 2+ Pour into this homogeneous solution, and after stirring for a few minutes, the mixed solution turns dark brown. Finally, transfer the solution into a 50ml reactor, seal it, and heat it at 230 degrees for 15 hours. After the reaction, cool to room temperature, and the product oily Zn 0.4 Fe 2.6 o 4 Nanoparticles are deposited at the bottom of the kettle, and n-hexane is added to take out the nanoparticles; then ethanol is added to n-hexane to precipitate nanoparticles, and finally the nanoparticles are repeatedly washed with ethanol several times to remove impur...

Embodiment 2

[0043] 1. Oily Zn 0.4 Fe 2.6 o 4 Preparation of nanoparticles

[0044] FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.73×10 -3 mol Fe 2+ and 2.67×10 -4 mol Zn 2+ The purpose; 10ml oleic acid, 10ml absolute ethanol and 1g NaOH were mixed, and magnetically stirred at room temperature until a uniform solution was obtained; the precursor Fe 2+ and Zn 2+ Pour into the homogeneous solution, after stirring for a few minutes, the mixed solution turns dark brown, and finally transfer the solution into a 50ml reaction kettle, seal it, and heat it at 230 degrees for 15 hours. After the reaction, cool to room temperature, and the product is deposited on Add n-hexane to the bottom of the kettle, and take out the nanoparticles. Then add ethanol to n-hexane to precipitate nanoparticles, and finally wash the nanoparticles repeatedly with ethanol several times to remove impurities, oily Zn 0.4 Fe 2.6 o 4 Nanoparticles are...

Embodiment 3

[0051] 1. Oily Zn 0.4 Fe 2.6 o 4 Preparation of nanoparticles

[0052] FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.73×10 -3 mol Fe 2+ and 2.67×10 -4 mol Zn 2+ the goal of. Next, mix 10ml of oleic acid, 10ml of absolute ethanol and 1g of NaOH, and stir magnetically at room temperature until a uniform solution is obtained. Furthermore, the precursor Fe 2+ and Zn 2+ Pour into this homogeneous solution, and after stirring for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reaction kettle, sealed, and heated at 230 degrees for 15 hours. After the reaction, cool to room temperature. The product is deposited at the bottom of the kettle, and n-hexane is added to take out the nanoparticles. Add ethanol to n-hexane to precipitate nanoparticles, and finally wash the nanoparticles with ethanol several times to remove impurities. Nanoparticles are dispersed i...

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Abstract

The invention relates to a targeting nanomaterial as well as a preparation method and an application thereof. Specifically, Zn0.4Fe2.6O4 nanoparticles with high magnetic saturation value are subjected to pegylation modification and entrapped with anti-cancer drug molecules simultaneously, and a nanomaterial system integrating targeting, double-mode imaging and treatment is prepared. For the nanomaterial system, on one hand, double advantages including high magnetism of a central core as well as good biocompatibility and biodegradability of an external lipidosome can be shown, and on the other hand, the effects of targeting and double imaging of the nanoparticles can be realized by targeting molecules and fluorescent molecules linked to an outer-layer PEG polymeric molecules, so that the targeting nanomaterial has potential application prospect in the field of biomedicine and especially in the aspects of targeting diagnosis, drug loading and the like.

Description

technical field [0001] The invention belongs to the field of nano biomedical materials, and relates to a preparation method of targeting nano materials, products and applications thereof. Specifically, through the high magnetic saturation value of Zn 0.4 Fe 2.6 o 4 Nanoparticles are PEGylated and loaded with anticancer drug molecules to prepare a nanomaterial system integrating targeting, dual-mode imaging and treatment. Background technique [0002] Cancer is a serious disease that threatens human life. Conventional chemotherapy, radiotherapy, and surgical treatment are not effective. Therefore, it is imminent to develop new technologies for cancer diagnosis and treatment, and the ability to realize early diagnosis of cancer and efficient and non-toxic drug treatment is the key to urgent problems in cancer treatment. The small size effect of nanoparticles enables them to specifically penetrate deep into tumor tissue, so the development of nanomaterials brings new hope f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/12A61K49/16A61K49/14A61K49/10A61K9/51A61K47/10A61K47/24A61K47/42A61K47/22A61K47/26A61P35/00
CPCA61K9/5123A61K9/5146A61K9/5169A61K49/0002A61K49/0052A61K49/0054A61K49/0056A61K49/0058A61K49/0093A61K49/10A61K49/126A61K49/14A61K49/16
Inventor 何丹农祝闪闪王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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