508results about How to "Increase penetration depth" patented technology

The invention relates to an irradiation device and method for the treatment of totally or partially cell-mediated inflammations of the skin, the connective tissue and the viscera, viral and other infectious diseases such as HIV and prionic infections, fungal infections of the skin and the mucous membranes, bacterial diseases of the skin and the mucous membranes as well hand eczema and anal eczema which comprises at least one irradiation device to irradiate a surface treatment area where the wavelength of the emitted radiation to a treatment area is longer than 400 nm and comprises at least one spectral band between 400-500 nm while the radiation device contains means for the generation of optical pulses towards a treatment area with a power density of the optical pulse peaks larger than 0.5 W / cm2 and smaller than 100 kW / cm2. The energy of one pulse relates to 0.05-10 J / cm2.

Exemplary embodiments provide systems and methods for portable medical ultrasound imaging. Preferred embodiments utilize a tablet touchscreen display operative to control imaging and display operations without the need for using traditional keyboards or controls. Certain embodiments provide ultrasound imaging system in which the scan head includes a beamformer circuit that performs far field sub array beamforming or includes a sparse array selecting circuit that actuates selected elements. Exemplary embodiments also provide an ultrasound engine circuit board including one or more multi-chip modules, and a portable medical ultrasound imaging system including an ultrasound engine circuit board with one or more multi-chip modules. Exemplary embodiments also provide methods for using a hierarchical two-stage or three-stage beamforming system, three dimensional ultrasound images which can be generated in real-time.

Apparatus and method for high spatial resolution imaging of a sample's structure, including a diffraction-limited resolution volume with a plurality of dye molecules which can be switched between different states and have a distribution density which is greater than the inverse of the diffraction-limited resolution volume, where at least one state is fluorescing, the fluorescence being collected by an objective lens and imaged on a spatially resolving detector by an optical system. At least one light source provided for emitting a switching radiation and for emitting an excitation radiation. At least one of the light sources is arranged to radiate through the sample, and a switching and / or fluorescence excitation of the dye molecules is carried out. The switching is a photoactivation or a photodeactivation of the dye molecules. A focusing arrangement is provided for switching and / or for excitation to generate a line-like illumination region extending in a direction of illumination.

The present invention provide methods for treating acne by exposing affected follicles to at least one, and preferably two or all three, of the following radiation pulses: a radiation pulse (PC pulse) having a wavelength components in a range of about 360-700 nm; a radiation pulse (PTV pulse) having wavelength components in a range of about 470 nm to 650 nm and / or in a range of about 500 nm to about 620 nm; and a radiation pulse (PTIR pulse) having wavelength components in a range of about 900 nm to about 1800 nm. The irradiated treatment region is preferably maintained at a temperature of about 38 to 43 C in order to enhance the efficacy of the treatment.

A device for distributing substances includes distribution container (1) receiving a substance. The container has a closing unit (3) provided with a canula (11) for the substance to be distributed. The outer end (15) of the canula protrudes from the closing unit (3). A safety device (5, 17) can alternate between a protective state in which it covers the outer end (15) of the canula (11), and a user state for the distribution of the substance from the canula (11).

A needle assembly (10) includes a needle (14) attached to mounting structure (12), and is used to insert the needle into the body of a patient. A depth stop unit (50) of the needle assembly provides a stop surface (58) to limit the distance the needle can be inserted into the body. The depth stop unit may include a depth stop (52) that is adjustable to selectively change the depth to which the needle can be inserted. The entire depth stop unit can be removed from the needle assembly to permit the full length of the needle to penetrate into the body.

The invention provides 'core-shell-shell' rare earth upconversion nanoparticles (UCNPs) using Nd as a sensitizing agent. The rare earth UCNPs are characterized in that the shell layer of the rare earth UCNPs contains Nd<3+> and each layer contains Yb<3+>. The special microscopic nanostructure solves the problem about the quenching effect on upconversion fluorescence in an Nd doping process, so bright upconversion fluorescence can be obtained. Compared with the traditional Yb-sensitized UCNPs, the Nd-sensitized UCNPs have higher infrared absorption intensity so as to greatly improve upconversion efficiency and fluorescence. The Nd-sensitized UCNPs adopt 800-nanometer instead of 980-nanometer laser as an exciting light source, so the Nd-sensitized UCNPs have smaller overheating effect and stronger biological tissue penetrating power. Therefore, the novel rare earth upconversion material is expected to be widely applied in the field of biomedicines.

A method for manufacturing a multi-layer acoustic transducer with reduced total electrical impedance. The method is based on the bonding of two piezoelectric ceramic layers with confronting metallized surfaces to a thin electrical conductor, then electrically connecting the top and bottom surfaces to form a wrap-around electrode while a center conductor forms a second electrode. The total electrical impedance of a two-layer ceramic stack comprised of piezoelectric layers connected in this manner is one-fourth that of a solid ceramic element of the same size. This provides for better matching of the acoustic stack impedance to that of the electrical cable, increased penetration depth for imaging within the body, and improved acoustic element sensitivity.

The invention relates to a surface-enhanced Raman scattering optical fiber probe, comprising an optical fiber which can be simultaneously used for transmitting exciting light and receiving Raman scattering spectrum, a tapered optical fiber and one quartz microballoon, wherein the tapered optical fiber is formed on one end of the optical fiber, and then one quartz microballoon is thermally welded on the tip of the tapered optical fiber; when the exciting light passes through the tapered optical fiber and the quartz microballoon, evanescent waves transmitted by the tapered optical fiber and the quartz microballoon can excite the Raman spectrum of a solution or a gas molecule to be tested; meanwhile, metal nano particles are coated on the optical fiber and the surface of the quartz microballoon, so that the Raman scattering strength can be enhanced. In addition, a sensing structure of the combination of the tapered optical fiber and the quartz microballoon also has the functions of reflecting, focusing and collecting the surface-enhanced Raman scattering spectrum. The optical fiber probe is combined with a monochromatic source and a high-sensitivity Raman spectrometer so that a Raman detection sensing device can be formed. The invention has simple structure, strong capacity of resisting disturbance and high sensitivity, thereby being suitable for information acquisition and transmission of on-line analysis occasions, real-time detection occasions, live sample analysis occasions, trace hazardous and noxious substance measurement occasions and the like.

Brain-penetrating polymeric nanoparticles that can be loaded with drugs and are optimized for intracranial convection-enhanced delivery (CED) have been developed. In the preferred embodiment, these are loaded with FDA-approved compounds, identified through library screening to target brain cancer stem cells (BSCSs). The particles are formed by emulsifying a polymer-drug solution, then removing solvent and centrifuging at a first force to remove the larger particles, then collecting the smaller particles using a second higher force to sediment the smaller particles having a diameter of less than 100 nm, more preferably less than 90 nanometers average diameter, able to penetrate brain interstitial spaces.

A permanently plastic Plasticine for fire-protection applications is described, comprising a matrix composition, which contains fire-protection additives and conventional auxiliary materials and is based on organic polymers, and a method for its preparation and its use for the fire-protecting sealing of openings, cable and pipe bushings in walls, floors and / or ceilings, of joints between ceiling parts and wall parts, between masonry openings and construction parts, which are to be installed, such as window frames and door frames, between ceilings and walls and between exterior walls and curtaining facades, for the purpose of thermal insulation and / or fire protection, are described.

The invention provides an existing engineering pile bottom depth determination method based on a parallel seismic inflexion-point method in the field of civil engineering pile foundation construction quality inspection. Detection is carried out in an exploratory hole after the exploratory hole is drilled beside a pile, a time-depth signal diagram is generated according to different depth signals in the depth direction, an inflection point is determined in the time-depth signal diagram, and the pile bottom depth is obtained after the depth of the inflection point is modified through a inflection-point depth modifier formula. Through the method, the influence on wave form from an upper structure is avoided, the inspection is convenient, and the determination of position of the inflection point is simple and visual. Compared with the conventional parallel seismic method, by which the pile bottom depth is determined based on intersection of two lines, the parallel seismic inflexion-point method has a lower requirement on the depth of the drill hole, just 2-3 m deeper than a pile to be inspected, thereby reducing the requirement on the depth of the exploratory hole, saving cost, having better maneuverability for technical personnel without engineering experience, and better solving the current problem that the pile depth of an engineering pile is hard to determine.

Articles produced by laser shock processing exhibit various compressive residual stress distribution profiles. A gas turbine engine airfoil includes an asymmetrical stress profile formed through the thickness of its thin section. The articles include plural laser shock peened surfaces and plural regions having deep compressive residual stresses imparted by laser shock peening extending into the article from the laser peened surfaces. One article includes at least one set of simultaneously formed, adjacent non-overlapping laser shock peened surfaces. Another article includes at least one set of opposing laser shock peened surfaces formed at different times at opposite sides of the article. Another article includes at least one set of opposing laser shock peened surfaces formed simultaneously at opposite sides of the article using laser beams having different pulse lengths. Another article includes at least one set of laterally offset laser shock peened surfaces simultaneously formed at opposite sides of the article.

A penetration-crystallization type cement-base water-proof material for building is prepared from silicate cement, sodium methyl naphthalenesulfonate condensate, water silane emulsion, dodecahydrated aluminium potassium sulfate, magnesium hydroxide, calcium hydroxide, sodium silicate, bentone and quartz sand through proportional mixing. Its advantages are high penetrability and crystallinity, permanent water-proof effect, and self-repairing of fine cracking.

A method for manufacturing a multi-layer acoustic transducer with reduced total electrical impedance. The method is based on the bonding of two piezoelectric ceramic layers with confronting metallized surfaces to a thin electrical conductor, then electrically connecting the top and bottom surfaces to form a wrap-around electrode while a center conductor forms a second electrode. The total electrical impedance of a two-layer ceramic stack comprised of piezoelectric layers connected in this manner is one-fourth that of a solid ceramic element of the same size. This provides for better matching of the acoustic stack impedance to that of the electrical cable, increased penetration depth for imaging within the body, and improved acoustic element sensitivity.

The invention discloses a high solid content silane paste and a preparation thereof, the components and the quality ratio comprise: the ratio of siloxane monomer, emulsifier and de-ionized water is 70 percent to 85 percent: 5 percent to 10 percent: 10 percent to 25percent, wherein, the siloxane monomer is a mixed system of long-chain alkyl siloxane of C3-C18 or alkyl silane coupling agent of C3-C18; the emulsifier is one or several a fluorine-containing emulsifier, a Tween series emulsifier, a Span series emulsifier and a stearic acid-type emulsifier. The preparation method takes the long-chain alkyl siloxane as the main monomer, is assisted with proper quantities of organic alkyl silane coupling agent containing a functional group, and adopts means of a special composite emulsion to prepare poly organic silane paste having high penetrability and high stability. The invention is used for surface conservation of concrete, and greatly enhances anti-erosion ability to seawater, rain water and acid rain in the atmosphere.

Various laser shock processing systems are provided to establish selective compressive residual stress distribution profiles within a workpiece. An asymmetrical stress profile may be formed through the thickness of a thin section of a gas turbine engine airfoil. One system is configured to simultaneously irradiate a workpiece with a set of laser beams to form a corresponding set of adjacent non-overlapping laser shock peened surfaces, enabling the shockwaves to encounter one another. Another system irradiates opposite sides of the workpiece at different times to form opposing laser shock peened surfaces, enabling the shockwaves to meet at a location apart from the mid-plane. Another system simultaneously irradiates opposite sides of the workpiece using laser beams having different pulse lengths to form opposing laser shock peened surfaces. Another system simultaneously irradiates opposite sides of the workpiece to form a set of laterally offset laser shock peened surfaces.

Exemplary embodiments provide systems and methods for portable medical ultrasound imaging. Preferred embodiments utilize a hand portable, battery powered system having a display and a user interface operative to control imaging and display operations. A keyboard control panel can be used alone or in combination with touchscreen controls to actuate a graphical user interface. Exemplary embodiments also provide an ultrasound engine circuit board including one or more multi-chip modules, and a portable medical ultrasound imaging system including an ultrasound engine circuit board.

The present invention relates to rare earth upconversion nanoparticles, a preparation method and uses thereof, wherein the rare earth upconversion nanoparticles sequentially comprise an activator shell layer, an energy transfer agent shell layer and a sensitizing agent shell layer from inside to outside, each layer contains Yb<3+>, and the doping concentration of Yb<3+> is gradually reduced from inside to outside. According to the present invention, the ytterbium ion doping concentration gradient is set to effectively transfer the excitation state energy of the sensitizing agent to the activator, such that the upconversion luminescence quantum yield of the rare earth upconversion nanoparticles is effectively improved and achieves 0.22%, and the 800 nm continuous laser excitation at the excitation light source intensity of 2W / cm<2> is achieved; and the rare earth upconversion nanoparticles can produce strong upconversion luminescence under the infrared LED light source excitation, and the potable detection equipment based on the rare earth upconversion nanoparticle luminescence probe can be designed by using the unique packaging and array technology of the infrared LED light source so as to further expand the application of the upconversion luminescence material in the biomedical field.

Transesophageal echocardiography is implemented using a miniature transversely oriented transducer that is preferably small enough to fit in a 7.5 mm diameter probe, and most preferably small enough to fit in a 5 mm diameter probe. Signal processing techniques improve the depth of penetration to the point where the complete trans-gastric short axis view of the left ventricle can be obtained, despite the fact that the transducer is so small. The reduced diameter of the probe (as compared to prior art probes) reduces risks to patients, reduces or eliminates the need for anesthesia, and permits long term direct-visualization monitoring of patients' cardiac function.

The invention provides a method for detecting the corrosion of a component with a permeability magnetic material protective layer. The method comprises the following steps: the permeability magnetic material protective layer is magnetized to be saturated or deeply saturated, a reference area and a area to be detected are selected on the surface of a detected component, pulsed eddy current sensors are arranged on the protective layers of the two areas, the square-wave exciting is applied to exciting coils of the pulsed eddy current sensors, the attenuation curve of the induced voltage in the detecting coils of pulsed eddy current sensors is measured after the level of square waves is reduced to the low level, and the difference between the attenuation curves of the induced voltage in the two areas is compared, thus the corrosion condition of the area to be detected relative to the reference area can be further distinguished. The invention also provides a device for realizing the method, which comprises a pulsed eddy current sensor, a square-wave signal exciting circuit, a signal processing circuit, an A / D conversion circuit and a computer which are connected in sequence, wherein the pulsed eddy current sensor is provided with a magnetization unit. The invention improves the sensitivity of corrosion detection of the component with the permeability magnetic material protective layer and is suitable for detecting the corrosion of the component on-line without dismounting the protective layer and the cladding layer.

Provided are cone penetrometers for measuring the impedance of the ground. In an embodiment, the cone penetrometer comprises an inner electrode, an outer electrode, an insulator layer and a penetrating rod. The inner electrode includes a cone, a first contact portion to which terminal cables of an impedance meter are connected, and a metal rod. The metal rod has a diameter smaller than that of the cone. The metal rod has a front end connected to the bottom of the cone and a rear end connected to the first contact portion. The outer electrode has an inner diameter smaller than the diameter of the cone and is in the form of a hollow tube accommodating the metal rod. The insulator layer is formed between the inner electrode and the outer electrode to prevent short circuits between the two electrodes. The penetrating rod is in the form of a hollow tube accommodating the outer electrode. The use of the cone penetrometers improves the accuracy and reliability of the measured results. Further, the cone penetrometers can be miniaturized while maintaining high stiffness against buckling.

Various laser shock processing methods are provided to establish selective compressive residual stress distribution profiles within a workpiece. An asymmetrical stress distribution profile may be formed through the thickness of a thin section of a gas turbine engine airfoil. One method involves simultaneously irradiating a workpiece with a set of laser beams to form a corresponding set of adjacent non-overlapping laser shock peened surfaces, enabling the shockwaves to encounter one another. Additionally, opposite sides of the workpiece may be irradiated at different times to form opposing laser shock peened surfaces, enabling the shockwaves to meet at a location apart from the mid-plane. Furthermore, opposite sides of the workpiece may be irradiated simultaneously using laser beams having different pulse lengths to form opposing laser shock peened surfaces. Moreover, opposite sides of the workpiece may be irradiated simultaneously to form a set of laterally offset laser shock peened surfaces.

The invention provides a near infrared BODIPY (Boron Dipyrromethene) compound-based molecular fluorescence probe which has the following structure, wherein the substituent group Ar is one of the following four substituent groups described in the specification. The BODIPY probe with an alpha bit containing a strong electrondrawing group is synthesized for the first time, the absorption spectrum red shift of the fluorescence probe can achieve 606-633nm through the introduced substituent group, and the emission peak can achieve 616-646nm. The BODIPY molecule is a favorable fluorescence, can be used for specifically marking lysosome in biological cells, and can emit light through the self molecules, and the absorption and emission of the BODIPY molecule are close to the near-infrared zone; and in addition, the fluorescence probe has the advantages of high mole extinction coefficient, acute emission peak, high fluorescence quantum yield and the like, and has attractive application prospects on the lysosome marking application.

The invention discloses a pretreatment device for improving wood impregnation efficiency and a method for impregnating woods by utilizing the device. The device comprises a wood pretreatment chamber in which a cavity is formed, an ultrasonic treatment system and pretreatment liquid, wherein to-be-treated woods are subjected to ultrasonic pretreatment. The method disclosed by the invention comprises the following steps: pretreating to-be-impregnated woods by using ultrasonic waves under normal pressure, and getting through a liquid moving channel in the woods by utilizing a cavitation effect of the ultrasonic waves, so that the liquid permeability of the to-be-impregnated woods is enhanced, and the effective channel area inside the woods is enlarged; impregnating the woods, and impregnating a wood impregnation modifier into the woods, so that the absorption dose of the impregnated woods is improved, the agent penetration depth is increased, the impregnation period is shortened, and the impregnation effect is improved. The treatment device disclosed by the invention is simple, convenient to operate and is suitable for treating various woods, and process treatment conditions are controllable.

The invention discloses a high-molecular soil curing agent, and belongs to the building material technology field. The high-molecular soil curing agent is prepared from the following components, by weight, 4-8 parts of ordinary portland cement, 35-45 parts of binding agent, 15-25 parts of reinforcing agent, 4-6 parts of early strength agent, 4-9 parts of waterproof agent, 7-9 parts of filling agent, 2-4 parts of water reducer, 0.3-0.7 part of surfactant, 4-6 parts of dispersant and 0.01-0.03 part of air entraining agent. The soil curing agent has advantages of reasonable formula, large penetration depth (18mm), large compressive strength (the 7-day unconfined compressive strength is 12.42MPa), and high water resistance (the 7-day immersion water absorption is 0.86%), and can be applied to engineering of roads, railways, subways and the like.

The invention relates the method for electric spark deposition treatment on the copper or copper alloy surface. The method comprises the following steps: using copper or copper alloy as raw material, and using electric spark device to carry out deposition treatment, at the protection of argon gas, argon gas and helium. The output power is 400-1300W, the transmission voltage is 60-80V, the discharge frequency is 100-700Hz, the protection gas flow is 18-30L / min, and the deposition time is 3-15 min. The invention has not many complex devices as vapor deposition and vacuum sintering; the invention can deposit reiteratively, and has simple operation; the method has narrow heat-affected zone or no heat-affected zone; the method has not preheating before deposition and annealing treatment after deposition.