35results about How to "Increase penetration depth" patented technology

The invention discloses a composite reinforcement type suction barrel device based on microorganism induction and a use method thereof. The composite reinforcement type suction barrel device based on microorganism induction comprises a suction barrel model system, a microorganism cement reinforcement system and a test monitoring system. The suction cylinder model system comprises a suction cylinder, a grouting pipeline and hydraulic equipment, and the grouting pipeline is laid on the inner wall of the suction cylinder and used for injecting microorganism cement grout; the hydraulic equipment is connected to the suction barrel and used for controlling lifting and pressing-in of the suction barrel. The microbial cement reinforcement system comprises liquid storage equipment and negative pressure equipment, and the liquid storage equipment is connected to the grouting pipeline and used for storing and providing microbial cement grout for the grouting pipeline; the negative pressure equipment is connected to the suction barrel and used for applying negative pressure to the interior of the suction barrel in the grouting process, and permeation of microorganism cement grout is promoted. The test monitoring system is used for testing mechanical parameters of a soil body, monitoring the suction barrel and carrying out a loading test on the suction barrel.

The invention provides an NIR-IIb / c rare earth nanoparticle fluorescent probe as well as a preparation method and application thereof. The fluorescent probe sequentially comprises a core, an active shell and an inert shell from inside to outside, wherein the core comprises Tm < 3 + > ions and Er < 3 + > ions, and the active shell comprises Er < 3 + > ions, Yb < 3 + > ions and Ce < 3 + > ions. The fluorescent probe provided by the invention has an efficient energy transfer system, not only has bright luminescence in an NIR-IIb wave band (1500-1700 nm), but also has luminous intensity increased by dozens of times in an NIR-IIc wave band (1700-1900 nm) compared with that of a traditional probe. The hydrophilic modification method of the probe is also improved, and the biocompatibility of the probe is improved by a multi-layer polymer cross coating method, so that the probe still has good luminescence property in an organism, and the penetration depth and resolution of biological tissues during imaging are improved.

The invention provides a transcranial light adjusting method and system based on a laser light source and transmitting energy through an optical fiber bundle, relates to the technical field of physiotherapy, and mainly comprises a power supply, a controller, a laser, an optical fiber coupler, the optical fiber bundle, a lens group and the like. The optical fiber coupler couples laser output by the laser into the incident end of the optical fiber bundle; the emergent end of the optical fiber bundle is set as one or more sub optical fiber bundles, and the tail end of each sub optical fiber bundle is selectively butted with one lens group; when the emergent end of the optical fiber bundle is provided with a plurality of sub optical fiber bundles, the plurality of sub optical fiber bundles are respectively and correspondingly arranged at the back of the prefrontal lobe, the belly of the prefrontal lobe, the temporal lobe, the apical lobe and other physiotherapy positions which are effective for light; and when the tail ends of the plurality of sub-optical fiber bundles are not butted with the lens group, the emergent end of each sub-optical fiber bundle is set as an optical fiber array, and the optical fiber array is embedded into the light supply effective head position and is in contact with the scalp, so that the absorption rate and the reflectivity of the hair to near-infrared light are reduced.

The invention belongs to the technical field of luminescent materials, and discloses an up-conversion nano material as well as a preparation method and application thereof. The up-conversion nano material comprises a core, the element composition of the core is NaErF4: Nd, Yb and Ce, and the molar weight of Nd accounts for 2%-15% of the total molar weight of rare earth elements of the core; the core is coated with a middle shell, the element composition of the middle shell is NaYF4: Yb, and the molar weight of Yb accounts for 20%-100% of the total molar weight of rare earth elements of the middle shell; the outer part of the middle shell is coated with a passivation shell, and the element composition of the passivation shell is NaYF4. According to the up-conversion nano material, through fine ion doping and a unique energy transfer mechanism, efficient up-conversion blue and ultraviolet light emission of Er < 3 + > can be achieved; the preparation method of the up-conversion nano material is simple in process, easy to operate, low in cost, short in period and suitable for mass production.

The invention discloses a fused ring tin porphyrin photosensitizer with high singlet oxygen sensitization efficiency and photothermal effect, and relates to the technical field of biological medicine. The invention provides a structural general formula and a preparation method of a fused ring tin porphyrin photosensitizer. According to the invention, the photosensitizer is endowed with strong absorption capacity in an NIR region through an isoquinoline fused ring on the periphery of porphyrin, < 1 > O2 sensitization activity and photothermal effect of the photosensitizer under light excitation are promoted through metal tin coordination in a parent nucleus, and an efficient photodynamic / photothermal synergistic killing effect on 4T1 cells of a mouse breast cancer cell line under NIR light irradiation is realized; the problems of poor light stability, reduced photosensitive activity and the like in the prior art are effectively solved.

The invention provides nano microspheres for targeted delivery of siRNA based on SFTSV-Gn and application of the nano microspheres, and belongs to the technical field of antiviral drugs. SiRNA is optimally designed, a nano microsphere delivery system is a nano compound formed by assembling optimally designed siRNA and cell-penetrating nano arginine, and the nano microspheres are used as a delivery carrier of siRNA to protect siRNA from enzymatic degradation, so that the siRNA delivery efficiency is improved, and the siRNA delivery efficiency is improved. And the target cells can be promoted to uptake, the replication of new bunyavirus RNA (Ribonucleic Acid) can be effectively inhibited, the injury of liver and lung tissues can be improved, and the survival rate can be increased. In addition, the surface-modified nano-microspheres have the advantages of high targeting, deep penetration, non-invasiveness and the like, and have wide application prospects in the antiviral field.

This invention discloses a snapshot-type hyperspectral three-dimensional skin imaging method and device, belonging to the field of biomedical imaging technology. The method includes: constructing a snapshot-type spectral-light field coupled imaging system containing a light source and an acquisition model; achieving full-domain skin illumination with broadband illumination; synchronously coupling and acquiring spectral and three-dimensional spatial information through the synergistic action of a lens group and a hyperspectral sensor to generate spectral coupled light field data; establishing a correlation dataset between the spectral coupled light field image and the hyperspectral light field image; training a spectral reconstruction network and solving the data; reconstructing the hyperspectral light field image and obtaining multi-view images through macro-pixel sampling; using a light field super-resolution network to improve image resolution; selecting the optimal skin penetration band image for stereo matching to obtain a target band depth map; and fusing the high-resolution center-view images from each channel with the target band depth map to complete the generation of a hyperspectral three-dimensional image. This invention achieves single-exposure hyperspectral three-dimensional imaging of the superficial skin layer.

The utility model provides a device of adding anti -caking agent before static atomization coupling type fluidized bed in potassium chloride production, including vibration feeder and static atomizer, and vibration feeder includes feeder body, is provided with vibration motor on feeder body, and feeder body is connected with support frame through composite damping system, still be provided with opening on feeder body, and static atomizer includes the multi -hole nozzle corresponding to the opening setting. According to the device of adding anti -caking agent before static atomization coupling type fluidized bed in potassium chloride production of the utility model, not only can the anti -caking agent be evenly sprayed on the salt particle surface, but also can ensure that the salt particle is fully loose in the conveying process, and further improve the uniform distribution effect of anti -caking agent addition.

This invention belongs to the field of rare-earth luminescent materials and optical sensing technology, specifically disclosing an upconversion temperature probe excited by NIR-I, its preparation method, and its application. The probe includes a matrix core material, which is a fluoride crystal; and dopant ions, specifically holmium ions (Ho) doped into the matrix core material. 3+ Ho 3+ As the sole luminescent center, it is excited by a near-infrared I light source with a wavelength of 880-920 nm to generate Ho. 3+ Characteristic green upconversion luminescence and red upconversion luminescence. This invention employs the aforementioned NIR-I excited upconversion temperature probe, its preparation method, and its application, utilizing Ho... 3+ The unique energy level competition mechanism of ions enables high-sensitivity temperature measurement over a wide temperature range, and the temperature measurement signal is unaffected by fluctuations in excitation power.

The invention discloses a salt-light alkali-reducing cultivation method for cotton in saline-alkali soil, and relates to the technical field of cotton planting. Comprising the following steps: deeply ploughing a cotton field, applying a base fertilizer, and irrigating to make entropy to obtain a to-be-sown cotton field; cotton sowing is carried out by adopting a direct-seeding plastic film mulching method and a machine-harvested cotton planting mode, the sowing depth is controlled to be 2.5-3.5 cm, the soil covering width is 5-7 cm, the soil covering thickness is 0.5-1 cm, the one-grain rate is larger than or equal to 95%, and the hole rate is smaller than or equal to 3%; after-sowing management is conducted in the cotton seedling stage, timely intertillage is conducted, and meanwhile leaf fertilizer is sprayed according to the cotton cotyledon stage to the two-leaf stage, the 3-4-leaf stage and the 4-leaf stage; performing water and fertilizer management in a cotton bud stage, performing intertillage, and performing foliage dressing at the same time; in the cotton flowering and boll-forming period, water dripping fertilizer is conducted according to the entropy condition, topping is conducted in good time, meanwhile, fertilizer is applied to regulate and control the plant type, and fertilizer is applied according to the premature senility trend and the snooze growth vigor; disease, pest and weed control is carried out in the sowing period. The cultivation method is suitable for saline-alkaline cotton fields in Xinjiang and is an effective means for increasing the cotton yield and improving soil conditions.

The application provides a suspension agent containing pyriproxyfen and clothianidin, which comprises pyriproxyfen 3-8%, clothianidin 30-40%, clove extract 1-1.5%, and astragalus polysaccharide 0.5-1% according to percentage by weight; and the weight ratio of the clove extract and the astragalus polysaccharide is 3:2. The suspension agent provided by the application has good wetting property, strong soil permeability, can improve the effective utilization rate of the liquid medicine, and improves the drug efficacy.

The invention relates to the field of concrete waterproof materials, in particular to an inorganic silicon deep permeable crystallization waterproof agent and a preparation process. The invention discloses an inorganic silicon deep permeable crystallization waterproof agent, which is prepared from the following raw materials in parts by mass: 40 to 60 parts of active sodium silicate, 20 to 35 parts of nano composite particles, 10 to 15 parts of aluminate cement, 1 to 3 parts of coagulation accelerator, 5 to 15 parts of dispersing agent, 3 to 5 parts of thickening agent, 0.1 to 0.3 part of preservative and 40 to 65 parts of deionized water. According to the inorganic silicon deep permeable crystallization waterproof agent and the preparation process provided by the invention, the finally prepared waterproof agent not only has excellent waterproof and anti-corrosion properties, but also can further improve the penetration depth, temperature resistance and aging resistance of the inorganic silicon waterproof agent in concrete; therefore, the waterproof agent has good long-term waterproof performance, can adapt to various application environments, and has very excellent application prospects.

The application relates to the technical field of industrial control systems, in particular to a multi-data real-time acquisition control system for wheat moistening, which comprises a segmented water injection control unit, which is used for controlling a water injection actuator according to a segmented water injection proportioning scheme, so as to inject water into wheat in a stirring or turning material state in multiple small-dose interval modes; and a moisture content calculation unit, which is used for introducing a moisture content index, collecting second data in the segmented water injection and wheat moistening standing stages, analyzing moisture distribution differences and time change trends of the wheat at different positions according to the second data, and calculating the moisture content index of the current batch of wheat according to a moisture content evaluation model. The moisture content index of the current batch of wheat is calculated according to the moisture content evaluation model, and the threshold value judgment unit compares the moisture content index with a preset moisture content target threshold value; when the threshold value is reached, a wheat moistening completion instruction is automatically output; and when the threshold value is not reached, an adjustment strategy is generated according to a moisture content index deviation and a multi-parameter change.

The invention relates to the technical field of medical instruments, in particular to a low-intensity pulsed ultrasound instrument for relieving ulcerative colitis inflammation and application of the low-intensity pulsed ultrasound instrument for relieving ulcerative colitis inflammation, low-intensity pulsed ultrasound can effectively reduce inflammatory response of the whole body in intervention treatment and relieving of ulcerative colitis, the conditions of weight loss, loose and loose excrement and stool bleeding are improved, and the treatment effect of ulcerative colitis is improved. The traditional Chinese medicine composition can be used for treating ulcerative colitis, improving the disease activity index (DAI) and improving the life quality of a patient in the acute attack period, has the advantages of no trauma, few side effects, high penetration depth and easiness in home operation of the patient, and provides brand-new effective treatment equipment for ulcerative colitis.

The application belongs to the technical field of hazardous waste pollution control, and discloses a synergistic penetration stable-effect fly ash selenium-fixing composite chelating agent and application thereof. The chelating agent is composed of the following components in percentage by mass: piperazine compound 10-30%, ferrous sulfate 15-35%, penetrating agent 3-12%, and borax-sodium hydroxide buffer 40-70%. In preparation, ferrous sulfate is dissolved in the buffer at room temperature, then the piperazine compound is added and stirred, and finally the penetrating agent is added, heated to 40-50 DEG C, and stirred for preservation, to obtain a red-brown transparent liquid with pH 9.5-11.5. The application realizes efficient and stable fixation of various forms of selenium in fly ash through the multi-mechanism synergy of penetrating agent reinforced diffusion of the medicament in fly ash micropores, a stable alkaline environment maintained by the buffer system, and Fe 2+ reduction precipitation and piperazine chelation adsorption, and the selenium leaching concentration of the treated fly ash is ≤0.1 mg / L, meeting the standard and having long-term stability.

The invention discloses a tension leg platform suction pile anchoring foundation and an offshore construction method, and relates to the technical field of ocean engineering. The base structure is fixed to the top of the mud entering steel structure. The base structure is of a double-wall cylindrical structure, a ballast tank is arranged in the base structure, and a ballast system is arranged in the ballast tank; a drainage pipeline is further arranged in the base structure and communicates with the interior of the mud inlet steel structure and the water suction pump. A lug plate structure is arranged on the side wall of the base structure; the mud entering steel structure is of a single-layer wall cylindrical structure, and the cylindrical opening direction of the mud entering steel structure is opposite to the cylindrical opening direction of the base structure; and a to-be-mounted counterweight is placed in the upper opening structure of the base structure. The technical problem that a traditional suction pile anchoring foundation is not suitable for a tension leg type floating platform including a floating wind power platform due to the fact that the axial pulling resistance capacity is limited by a suction barrel structure type, an installation mode and soil conditions is solved.

The application provides a medical waste high-temperature steam permeation control treatment method, relates to the field of harmless treatment of medical waste, and comprises the following steps: loading medical waste in a treatment cabin and performing vacuumization on the treatment cabin, so that the pressure in the treatment cabin is reduced to a first target negative pressure value; saturated steam is injected into the treatment cabin, and a multi-stage gradient pressure increasing program is performed, so that the working pressure of the treatment cabin is maintained in a slightly positive pressure state in which a slightly positive pressure offset of the target sterilization pressure is increased; the target sterilization temperature in the slightly positive pressure state is maintained to perform basic heat penetration, and the treatment cabin is subjected to periodic pressure pulse cycle treatment; the target sterilization temperature in the slightly positive pressure state is maintained to perform final sterilization, the treatment cabin is subjected to vacuum drying and air injection into the treatment cabin for cooling, and the treatment cabin is opened to unload the treatment product.

The invention provides a composite infiltrated layer as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out zinc impregnation treatment on a steel matrix by utilizing a zinc impregnation agent; and the steel matrix subjected to zinc impregnation treatment is subjected to swing laser melting treatment, and the abrasion-resistant and corrosion-resistant composite infiltrated layer is obtained. According to the method, laser melting with different swing tracks is carried out, so that the molten pool forms a vortex along the swing path of the laser, a more stable and uniform zincizing layer is formed on the surface of the zincizing steel and iron material, grains are further refined after remelting, and the hardness and wear resistance of the surface of the steel and iron material are improved.

The application discloses a long-afterglow nano carrier and a preparation method and application thereof, and belongs to the field of biomedical materials. The long-afterglow nano carrier comprises a near-infrared luminescent center, an organic mesoporous silica layer and an autophagy inhibitor; the organic mesoporous silica layer is coated on the outer layer of the near-infrared luminescent center, and the autophagy inhibitor is loaded in the mesopores of the organic mesoporous silica layer; the near-infrared luminescent center comprises a transition metal element; the organic mesoporous silica layer is prepared by co-condensation of an organic silane precursor and an inorganic silicon precursor, wherein the organic silane precursor is an organic silane containing a tetrasulfide bond, and the inorganic silicon precursor is a silicate compound. The carrier can specifically respond to excessively high concentration of hydrogen peroxide in a tumor microenvironment, and accurately release the loaded autophagy inhibitor; the release process can be observed by positioning with the aid of a high signal-to-noise ratio afterglow signal, thereby providing guidance for subsequent drug release, and finally realizing efficient radiotherapy sensitization.

The invention discloses a thermal strain alloy support plate flame stabilizer applied to an afterburner, and belongs to the field of aero-engine afterburner design. The thermal strain alloy flame stabilizer is composed of two thin-wall performance adjusting plates, the adjusting plates generate thermal bending moment and deform when forming a temperature gradient in the thickness direction, and therefore the divergence angle of the tail edge of the supporting plate is changed in a self-adaptive mode. Flow channel blockage is weakened, and the total pressure loss is reduced; under the afterburning working condition, high-temperature fuel gas in a backflow area heats the inner side of the adjusting plate to promote the adjusting plate to expand outwards, a larger trailing edge divergence angle and the backflow area are formed, fuel evaporation and mixing are accelerated, and the penetration depth and the space uniformity are improved; meanwhile, the temperature difference is further increased through liquid drop impact and evaporation heat absorption, and deformation and combustion efficiency is enhanced. An additional executing mechanism is not needed, the structure is simple and reliable, and stress application efficient combustion and non-stress application low-resistance operation can be both considered.

The invention belongs to the technical field of solar cells, and particularly relates to an organic solar cell using polystyrene as a donor additive and a preparation method of the organic solar cell. The structure of the organic solar cell sequentially comprises an anode layer, a hole transport layer, an active layer, an electron transport layer and a cathode layer from bottom to top, the active layer is composed of a donor layer and an acceptor layer; the donor layer is PM6 doped with polystyrene, and the acceptor layer is Y6. According to the invention, the PS is additionally introduced into the donor layer, and the good compatibility between the PS and PM6 is utilized to form the uniform and vertically-distributed nano-porous donor layer film, so that the improvement of the penetration depth of a subsequent acceptor solution and the generation of an acceptor continuous phase are facilitated, thereby forming an ideal vertically-distributed active layer structure.

This invention provides a transdermal follicular delivery system for active ingredients based on a protein carrier. The system comprises a composite structure of a small molecule active ingredient, a bioactive protein, and a polymer shell, with a size of 40-150 nm and a polymer shell thickness of 10-70 nm. The zeta potential of this protein carrier-based transdermal follicular delivery system is positively charged. The small molecule active ingredient is loaded within the bioactive protein, and the polymer shell coats the bioactive protein to form a protein nanogel. Both the small molecule active ingredient and the bioactive protein have beneficial effects on hair follicles. When this transdermal follicular delivery system is applied to the surface of a hair follicle or skin, the functional small molecules are delivered transdermally along with the nanogel to the interior of the hair follicle and surrounding tissues, where they are released in a controlled manner, thus effectively exerting their effects.

This invention discloses a method for full-cycle carbon dioxide sequestration based on multiphase reaction filling materials, relating to the field of carbon sequestration, comprising the following steps: adding gaseous SiO2 and nano-CaO particles to the filling material as gas-entraining agents and transport enhancers; injecting CO2 gas into the filling slurry to form a gas-liquid two-phase dispersion system, and adding a surfactant with a mass fraction of 0.05%-0.2% to the filling slurry; transporting the filling slurry to the downhole filling area through a delivery pipeline, and installing an online rheometer in the delivery pipeline; after the filling slurry is injected into the goaf, injecting CO2 into at least one of the top, bottom, and sidewalls of the goaf through a gas injection pipeline until a gas-liquid-solid three-phase reaction interface is formed; monitoring its strain and acoustic emission signals in real time, and when a sudden change in signal is detected, determining that a new fracture has been generated or an existing fracture has expanded, and injecting CO2 gas into the target fracture through a pre-embedded gas injection pipeline.

This invention discloses a device for high-precision measurement of blood oxygenation status in cerebral cortex tissue, comprising a light source module containing multiple near-infrared light sources, each of which emits three different wavelengths of near-infrared light into the brain tissue; a signal acquisition module containing multiple signal acquisition groups, each forming long and short-distance channels for acquiring near-infrared light signals emitted from the brain tissue by a single near-infrared light source; and a signal processing module that calculates the long and short optical path lengths of near-infrared light in the brain tissue, constructs expressions for the optical density changes of the long and short-distance channels based on the optical path lengths, eliminates the brain surface tissue absorption term in the optical density change of the long-distance channel by subtracting the two expressions, and obtains the noise-reduced optical density change expression. The noise-reduced optical density change expressions for the three near-infrared wavelengths are then solved to obtain the blood oxygenation status of the cerebral cortex tissue.

The utility model discloses ecological paving stone of imitating stone surface relates to paving stone technical field. Including the pavement base plate, the bottom surface is used to lay on the ground surface base soil, a plurality of processing filling body, even fixed in the pavement base plate top, and the drainage structure is reserved between two adjacent processing filling bodies, is provided with imitating stone convex between two adjacent drainage structures, and there is height difference between imitating stone convex and drainage structure, and imitating stone convex is fixed in the top of processing filling body, along with rainwater contact imitating stone convex's surface, and rainwater flows along the slope of imitating stone convex to adjacent drainage structure, and through the water gap of drainage structure rapid penetration to the base soil below the pavement base plate, the utility model discloses the slope design of imitating stone convex and the synergistic effect of drainage structure, effectively guide rainwater along the slope rapid convergence to the passageway gap, and then through the discharge port of gradually increasing aperture smooth infiltration base soil, has improved the drainage efficiency of paving stone significantly.

The invention relates to the technical field of printing equipment, in particular to a wood board ink-jet printing device which comprises a printing platform, a wood board is arranged on the printing platform, a printing system is installed above the wood board, the printing system comprises a printing assembly, the printing assembly is driven by a driving assembly to move horizontally, and the printing assembly comprises a printing module. A pre-printing processor is installed on one side of the printing module, a post-printing processor is installed on the other side of the printing module, a pre-printing heater is installed at the bottom of the pre-printing processor, and a post-printing heater is installed at the bottom of the post-printing processor. According to the wood board ink-jet printing device, many limitations in a traditional wood board coloring process are effectively solved, and particularly the problem of color deviation caused by dependence on manual color mixing is solved. The water-based ink or the weak-solubility ink is adopted, and the good permeability of the water-based ink or the weak-solubility ink to the wood board is utilized, so that the penetration depth of ink coloring is remarkably improved, the wood board can support the secondary grinding procedure, and the surface fineness and the color quality of a final finished product are greatly improved.

The application belongs to the technical field of slump detection, and particularly relates to an engineering quality detection device, which comprises a workbench, a first lifting mechanism and a second lifting mechanism are installed on the workbench; the first lifting mechanism is used for adjusting the height of a inserting and tamping assembly; the second lifting mechanism is used for adjusting the height of a slump cylinder; the inserting and tamping assembly comprises a mounting frame body, an inserting and tamping rod and a driving mechanism used for driving the inserting and tamping rod to extend and retract; a mounting plate is rotatably installed on the mounting frame body, a guide sleeve is rotatably installed on the mounting plate, and the inserting and tamping rod is arranged in the guide sleeve; the driving mechanism is used for driving the inserting and tamping rod to axially extend and retract along the guide sleeve; the application can improve the consistency of the inserting and tamping depth, the inserting and tamping direction and the inserting and tamping sequence, make the concrete slump detection process more standardized, reduce the human operation difference, and improve the stability and repeatability of the detection result.

The present application belongs to the technical field of plant fiber surface modification, and provides a method for atomization-induced in-situ modification of plant fiber. The method comprises: preparing an aqueous inorganic salt solution, the inorganic salt being selected from at least one of sodium silicate, potassium silicate, sodium aluminate, aluminum sulfate, magnesium chloride and magnesium sulfate, the concentration being 0.3-4.0 wt%, and the pH value being 9.0-11.2; putting dry plant fiber into a plow blade fly cutter mixer to make the fiber loose and layered; starting the plow blade fly cutter to make the solution drop to the high-speed rotating plow blade fly cutter blade surface and be atomized into microdroplets, the microdroplets impacting, coating and dispersing the plant fiber under the action of centrifugal force and shear flow field; and continuously mixing until semi-dry modified plant fiber material is obtained. The present application effectively reduces modification energy consumption, improves modification uniformity and penetration depth, generates a chemical bonding mineral layer on the fiber surface in-situ, and significantly improves the flame resistance and water resistance of the plant fiber.

The invention discloses a photo-thermal agent for treating allergic rhinitis and application of the photo-thermal agent in preparation of drugs for treating allergic rhinitis, a method comprises the following steps: firstly, reacting a compound 1 with two pyridine groups with diethyleneglycol-2-bromoethyl methyl ether to prepare an ether-oxygen chain substituted compound 2, then dissolving the prepared compound 2 and DSPE-mPEG5000 in tetrahydrofuran, and carrying out a reaction to obtain the photo-thermal agent for treating allergic rhinitis. According to the invention, the pyridinium salt group is taken as a carrier, self-assembly is carried out to form nano-particles, and the nano-particles promote intramolecular charge transfer and cause red shift of absorption wavelength due to the strong electron withdrawing effect of the pyridinium salt group, have deeper tissue penetrating power, and can effectively reach the deep part of nasal mucosa to treat deep inflammation; the RH-coated NPs prepared by the invention has both high-efficiency photothermal conversion performance and photodynamic therapy sensitivity, so that the synergistic effect of PTT and PDT on treatment of allergic rhinitis becomes possible, the treatment effect is greatly improved, and a new way is opened up for treatment of allergic rhinitis.

The application discloses a sample adding device and a sample adding method thereof, a sample analyzer and a sample adding method thereof. The sample adding device comprises a sampling needle, a first driving member, a second driving member and a controller. The controller is configured to control the first driving member to move the sampling needle to a liquid container, control the second driving member to draw liquid from the liquid container after the liquid in the liquid container is higher than a needle opening of the sampling needle, control the first driving member to move the needle opening of the sampling needle away from a liquid surface of the liquid container, control the second driving member to draw a preset volume of gas, control the first driving member to move the sampling needle to an empty cup container, and control the second driving member to discharge a liquid drop from the sampling needle when a distance between the needle opening of the sampling needle and a bottom wall of the empty cup container is within a preset range, and the speed of the liquid drop reaching the needle opening of the sampling needle is greater than 0. The sample adding device can improve the accuracy and repeatability of sample adding, and can also improve the efficiency of sample adding.